Yiyan Chen, Xiaoyan Lin, Xuhan Liu, Yifan Liu, Liem Bui-Le, Anna K Blakney, Jonathan Yeow, Yunqing Zhu, Molly M Stevens, Robin J Shattock, Rongjun Chen, Alex P S Brogan, Jason P Hallett
Nucleic acid therapeutics have attracted recent attention as promising preventative solutions for a broad range of diseases. Nonviral delivery vectors, such as cationic polymers, improve the cellular uptake of nucleic acids without suffering the drawbacks of viral delivery vectors. However, these delivery systems are faced with a major challenge for worldwide deployment, as their poor thermal stability elicits the need for cold chain transportation. Here, we demonstrate a biomaterial strategy to drastically improve the thermal stability of DNA polyplexes...
April 29, 2024: Biomacromolecules