U Gomez-Pinedo, J A Matías-Guiu, L Torre-Fuentes, P Montero-Escribano, L Hernández, V Pytel, P Maietta, S Alvarez, I Sanclemente-Alamán, L Moreno-Jimenez, D Ojeda-Hernandez, N Villar-Gómez, M S Benito-Martin, B Selma-Calvo, L Vidorreta-Ballesteros, R Madrid, J Matías-Guiu
INTRODUCTION: Genomic studies have identified numerous genetic variants associated with susceptibility to multiple sclerosis (MS); however, each one explains only a small percentage of the risk of developing the disease. These variants are located in genes involved in specific pathways, which supports the hypothesis that the risk of developing MS may be linked to alterations in these pathways, rather than in specific genes. We analyzed the role of the TNFRSF1A gene, which encodes one of the TNF-α receptors involved in a signaling pathway previously linked to autoimmune disease...
August 10, 2022: Neurología