Marcela Morales, Karol Zapata, Carlos A Sagaste, Alberto A Angulo, Benjamín Rojano
BACKGROUND: Emerging extraction techniques for bioactive compounds have been cataloged as efficient and cost effective compared to conventional ones. The objective of this research was to define the time and temperature that will guarantee a higher mangiferin content and antioxidant potential in Colombian Criollo mango peel through Ultrasound Assisted Extraction (UAE). METHODS: To find the optimal extraction conditions, response surface methodology was used, proposing a 32 factorial experimental design having as response variables the content of mangiferin and total phenols, and the antioxidant activity measured through ABTS and ORAC techniques...
January 2020: Acta Scientiarum Polonorum. Technologia Alimentaria
Jmn Duffy, M Hirsch, M Vercoe, J Abbott, C Barker, B Collura, R Drake, Jlh Evers, M Hickey, A W Horne, M L Hull, S Kolekar, S Lensen, N P Johnson, V Mahajan, B W Mol, A-S Otter, L Puscasiu, M B Rodriguez, L Rombauts, A Vail, R Wang, C M Farquhar
OBJECTIVE: To develop a core outcome set for endometriosis. DESIGN: Consensus development study. SETTING: International. POPULATION: One hundred and sixteen healthcare professionals, 31 researchers, and 206 patient representatives. METHODS: Modified Delphi method and modified nominal group technique. RESULTS: The final core outcome set includes three core outcomes for trials evaluating potential treatments for pain and other symptoms associated with endometriosis: overall pain; improvement in the most troublesome symptom; and quality of life...
March 30, 2020: BJOG: An International Journal of Obstetrics and Gynaecology
Rhiannon Mellis, Natalie Chandler, Lucy Jenkins, Lyn S Chitty
OBJECTIVES: To evaluate the diagnostic yield of non-invasive prenatal diagnosis (NIPD) for FGFR3-related skeletal dysplasias and assess the accuracy of referrals based on sonographic findings to inform guidelines for referral. METHODS: We retrospectively reviewed laboratory and referral records from 2012-2018 to ascertain all NIPD tests performed using our next generation sequencing panel to detect FGFR3 mutations. We calculated the diagnostic yield of the test overall and when sub-divided according to the phenotypic features identified on ultrasound before testing...
March 30, 2020: Prenatal Diagnosis
Lung W Lau, Avinash Eranki, Haydar Celik, AeRang Kim, Peter C W Kim, Karun V Sharma, Pavel S Yarmolenko
Certain technical criteria must be met to ensure the treatment safety of magnetic resonance-guided high-intensity focused ultrasound. We retrospectively reviewed how our enrollment criteria were applied from 2014 to 2017 in a clinical trial of magnetic resonance-guided high-intensity focused ultrasound ablation of recurrent malignant and locally aggressive benign solid tumors. Among the 36 screened patients between 2014 and 2017, more than one-third were excluded for technical exclusion criteria such as the anatomic location and proximity to prosthetics...
March 30, 2020: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Jennifer Nguyen, Warren Clements, Catriona McLean, Andrew Haydon, Maggie Moore, Kenneth Sk Yap, Victoria Mar, Mark Shackleton
Tumour thrombus is a complication that occurs when a malignancy invades into the vasculature, occluding its lumen. Here, we present a rare case of melanoma tumour thrombus of the great saphenous vein of the left thigh, which was diagnosed on 18 F-fluorodeoxyglucose positron emission tomography/computed tomography and ultrasound-guided biopsy, and responded well to immunotherapy with pembrolizumab.
March 30, 2020: Journal of Medical Imaging and Radiation Oncology
Raimundo Holanda Carneiro Filho, Fernando Linhares Pereira, Wagner Iared
OBJECTIVES: To evaluate two-dimensional (2D) shear wave elastography (SWE) performance as an independent predictor of malignancy in the diagnostic differentiation of thyroid nodules (TNs), including subgroup analyses of different manufacturers and respective cutoffs points. METHODS: The online databases MEDLINE (PubMed), Embase, and the Cochrane Library were searched for articles using 2D SWE in TN evaluation. After good-quality relevant thyroid-specific articles were selected, the main data, plus their sensitivity and specificity, were tabulated...
March 30, 2020: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Gino Soldati, Andrea Smargiassi, Riccardo Inchingolo, Danilo Buonsenso, Tiziano Perrone, Domenica Federica Briganti, Stefano Perlini, Elena Torri, Alberto Mariani, Elisa Eleonora Mossolani, Francesco Tursi, Federico Mento, Libertario Demi
Growing evidences are showing the usefulness of lung ultrasound in patients with COVID-19. Sars-CoV-2 has now spread in almost every country in the world. In this study, we share our experience and propose a standardized approach in order to optimize the use of lung ultrasound in covid-19 patients. We focus on equipment, procedure, classification and data-sharing. This article is protected by copyright. All rights reserved.
March 30, 2020: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Beatriu Reig, Laura Heacock, Alana Lewin, Nariya Cho, Linda Moy
The goals of imaging after neoadjuvant therapy for breast cancer are to monitor the response to therapy and facilitate surgical planning. MRI has been found to be more accurate than mammography, ultrasound, or clinical exam in evaluating treatment response. However, MRI may both overestimate and underestimate residual disease. The accuracy of MRI is dependent on tumor morphology, histology, shrinkage pattern, and molecular subtype. Emerging MRI techniques that combine functional information such as diffusion, metabolism, and hypoxia may improve MR accuracy...
March 29, 2020: Journal of Magnetic Resonance Imaging: JMRI
Andrea Monte, Vasilios Baltzopoulos, Constantinos N Maganaris, Paola Zamparo
This study combines in vivo ultrasound measurements of the Vastus Lateralis (VL) and Gastrocnemius Medialis (GM) muscles with electromyographic, kinematic and kinetic measurements during treadmill running at different speeds (10, 13 and 16 km⋅h-1 ) to better understand the role of muscle and tendon behaviour in two functionally different muscle-tendon units. In addition, the Force-Length and Force-Velocity relationships of VL and GM were experimentally assessed by combining dynamometry and EMG data with ultrasound measurements...
March 29, 2020: Scandinavian Journal of Medicine & Science in Sports
Jian Jin, Hongbin Lin, Abu ElGasim A Yagoub, Shuangli Xiong, Liang Xu, Chibuike C Udenigwe
BACKGROUND: The general enzymatic method to produce reducing sugar is firstly by liquefaction and subsequently followed by saccharification of starch. This method results in lower yields, consumes high energy and time. Therefore, the present study evaluated a new approach to produce reducing sugar from sweet potato starch (SPS), including simultaneous liquefaction (by α-amylase) and saccharification (by glucoamylase) of SPS pretreated with high power ultrasound. The effects of ultrasound parameters on the conversion rate of SPS and mechanism were studied...
March 29, 2020: Journal of the Science of Food and Agriculture
Christian Dorfer, Bertil Rydenhag, Gordon Baltuch, Vivek Buch, Jeffrey Blount, Robert Bollo, Jason Gerrard, Daniel Nilsson, Karl Roessler, James Rutka, Ashwini Sharan, Dennis Spencer, Arthur Cukiert
This article emphasizes the role of the technological progress in changing the landscape of epilepsy surgery and provides a critical appraisal of robotic applications, laser interstitial thermal therapy, intraoperative imaging, wireless recording, new neuromodulation techniques, and high-intensity focused ultrasound. Specifically, (a) it relativizes the current hype in using robots for stereo-electroencephalography (SEEG) to increase the accuracy of depth electrode placement and save operating time; (b) discusses the drawback of laser interstitial thermal therapy (LITT) when it comes to the need for adequate histopathologic specimen and the fact that the concept of stereotactic disconnection is not new; (c) addresses the ratio between the benefits and expenditure of using intraoperative magnetic resonance imaging (MRI), that is, the high technical and personnel expertise needed that might restrict its use to centers with a high case load, including those unrelated to epilepsy; (d) soberly reviews the advantages, disadvantages, and future potentials of neuromodulation techniques with special emphasis on the differences between closed and open-loop systems; and (e) provides a critical outlook on the clinical implications of focused ultrasound, wireless recording, and multipurpose electrodes that are already on the horizon...
March 29, 2020: Epilepsia
Daniela Angerame Yela, Iuri de Paula Quagliato, Cristina Laguna Benetti-Pinto
OBJECTIVE:  To describe clinical and sociodemographic characteristics of women with deep infiltrating endometriosis (DIE) and assess their quality of life (QOL) during 6 months of medical treatment. METHODS:  A descriptive cross-sectional study of 60 women diagnosed with DIE either by surgery or image methods (ultrasound or magnetic resonance), who received clinical treatment for at least 6 months in the Universidade de Campinas, Campinas, state of São Paulo, Brazil...
February 2020: Revista Brasileira de Ginecologia e Obstetrícia
Roozbeh Shams, Fabien Picot, David Grajales, Guillaume Sheehy, Frederick Dallaire, Mirela Birlea, Fred Saad, Dominique Trudel, Cynthia Menard, Frederic Leblond, Samuel Kadoury
PURPOSE: Transrectal ultrasound (TRUS) image guidance is the standard of care for diagnostic and therapeutic interventions in prostate cancer (PCa) patients, but can lead to high false-negative rates, compromising downstream effectiveness of therapeutic choices. A promising approach to improve in-situ detection of PCa lies in using the optical properties of the tissue to discern cancer from healthy tissue. In this work, we present the first in-situ image-guided navigation system for a spatially tracked Raman spectroscopy probe integrated in a PCa workflow, capturing the optical tissue fingerprint...
March 29, 2020: International Journal of Computer Assisted Radiology and Surgery
Wei Liu, Wei Li, Ziyao Li, Lei Shi, Peng Zhao, Zihong Guo, Jiawei Tian, Zhenzhen Wang
BACKGROUND: Sclerosing adenosis (SA) is a benign lesion with complicated pathological components and could mimic breast carcinoma in both clinical palpation and medical imaging findings. The present study was conducted to assess the value of ultrasound (US) characteristics in diagnosing SA and their differentiation from breast carcinoma. METHODS: We retrospectively reviewed the medical records of 305 women (347 lesions) with invasive ductal carcinoma (IDC) and 54 women with single SA lesion, who had breast excision between April 2016 and July 2018...
March 29, 2020: Breast Cancer Research and Treatment
J C Nwanaji-Enwerem, A Landry
A 29-year-old woman with a history of obesity status post Roux-en-Y gastric bypass greater than five years prior presented to the emergency department with four hours of sudden-onset stabbing left-sided abdominal pain associated with nausea and non-bloody emesis. She denied melaena and hematochezia, but did report two weeks of diarrhoea that was unchanged with this new onset abdominal pain.
2020: Acute Medicine
James P Howard, Jeremy Tan, Matthew J Shun-Shin, Dina Mahdi, Alexandra N Nowbar, Ahran D Arnold, Yousif Ahmad, Peter McCartney, Massoud Zolgharni, Nick W F Linton, Nilesh Sutaria, Bushra Rana, Jamil Mayet, Daniel Rueckert, Graham D Cole, Darrel P Francis
Echocardiography is the commonest medical ultrasound examination, but automated interpretation is challenging and hinges on correct recognition of the 'view' (imaging plane and orientation). Current state-of-the-art methods for identifying the view computationally involve 2-dimensional convolutional neural networks (CNNs), but these merely classify individual frames of a video in isolation, and ignore information describing the movement of structures throughout the cardiac cycle. Here we explore the efficacy of novel CNN architectures, including time-distributed networks and two-stream networks, which are inspired by advances in human action recognition...
March 25, 2020: Journal of medical artificial intelligence
Sarah Baur, Christina Rufener, Michael J Toscano, Urs Geissbühler
The keel bone of commercially kept laying hens is known to be frequently affected by morphologic changes such as fractures and deformations with important implications for animal welfare. To detect morphologic changes, various methods such as palpation, computed tomography, and ultrasound are available, though radiography allows for the greatest level of detail in combination with the most ease of use. To explore the benefits of radiography in providing objective data on keel fractures from the age of 22-61 weeks within a single laying period, the keel bones of 75 Lohmann Brown and 75 Lohmann Selected Leghorns were radiographed every 3 to 5 weeks...
2020: Frontiers in Veterinary Science
Alyssa Lorenze, William Hsueh, John Nasr
While drug-induced pancreatitis from corticosteroids has been well described in the medical literature, the exact mechanism is unclear. We present the first reported case of drug-induced pancreatitis from beta-sitosterol, a naturally occurring plant sterol structurally similar to cholesterol, obtained primarily through Western diet and supplementation. A 57-year-old male with a history of situs inversus and benign prostatic hyperplasia presented from an outside facility with a two-day history of worsening epigastric pain radiating to the right upper quadrant...
March 25, 2020: Curēus
Javier Rosario, David Lebowitz, Amanda L Webb, Latha Ganti, Ariel Vera, Tracy Macintosh, Ayanna Walker, Jose Rubero
Background Education is undergoing a transformation. The traditional passive lectures are failing to capture and inspire the new generation of learners who value more active and collaborative learning techniques. Objective We sought to create a novel educational technique to integrate into our curriculum that would be more personalized, employ more active learning and collaboration, and allow for an effective assessment of resident strengths and weaknesses. Discussion We created a monthly assembly line education academic half-day that evolved to replace one of the typical in-classroom didactics each month...
February 21, 2020: Curēus
Shuxin Li, Ali H Mohamedi, Jon Senkowsky, Ashwin Nair, Liping Tang
Significance: Chronic wounds affect millions of patients worldwide, placing a huge burden on health care resources. Although significant progress has been made in the development of wound treatments, very few advances have been made in wound diagnosis. Recent Advances: Standard imaging methods like computed tomography, single-photon emission computed tomography, magnetic resonance imaging, terahertz imaging, and ultrasound imaging have been widely employed in wound diagnostics. A number of noninvasive optical imaging modalities like optical coherence tomography, near-infrared spectroscopy, laser Doppler imaging, spatial frequency domain imaging, digital camera imaging, and thermal and fluorescence imaging have emerged over the years...
May 1, 2020: Advances in Wound Care
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