Ningjie Yang, Yang Sun, Bing Han, Na Deng, Gaizhen Li, Qian Han, Yinan Wang, Han Cai, Fan Liu, Bin Cao, Wenbo Deng, Haili Bao, Shuangbo Kong, Jinhua Lu, Haibin Wang
The decidua plays a crucial role in providing structural and trophic support to the developing conceptus before placentation. Following embryo attachment, embryonic components intimately interact with the decidual tissue. While evidence indicates the participation of embryo-derived factors in crosstalk with the uterus, the extent of their impact on post-implantation decidual development requires further investigation. Here, we utilize transgenic mouse models to selectively eliminate primary trophoblast giant cells (pTGCs), the embryonic cells that interface with maternal tissue at the forefront...
May 18, 2024: Cell Reports