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JOURNAL ARTICLE
Suguru Nakajima, Shuntaro Araki, Ryo Sasamoto, Yasuharu Kanda, Shinya Yamanaka
Previous studies on cadmium adsorption of calcium carbonate have found that polymorph, and, crystallinity are influential factors for adsorbing cadmium ions. The predominant factor for cadmium adsorption has yet to be elucidated because these factors are linked. To overcome this, here each factor is investigated separately. First, atmospheric grinding prepared surf clam (aragonite phase) and scallop (calcite phase) shells with similar crystallite sizes and specific surface areas. Using adsorption isotherm models, kinetics, X-ray diffraction analysis, and TEM observations, both calcite and aragonite react with cadmium to form cadmium carbonate...
September 16, 2021: Chemosphere
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JOURNAL ARTICLE
Keiko Sugai, Miho Sumida, Tomoko Shofuda, Ryo Yamaguchi, Takashi Tamura, Tsuneo Kohzuki, Takayuki Abe, Reo Shibata, Yasuhiro Kamata, Shuhei Ito, Toshiki Okubo, Osahiko Tsuji, Satoshi Nori, Narihito Nagoshi, Shinya Yamanaka, Shin Kawamata, Yonehiro Kanemura, Masaya Nakamura, Hideyuki Okano
Introduction: Our group has conducted extensive basic and preclinical studies of the use of human induced pluripotent cell (iPSC)-derived neural stem/progenitor cell (hiPSC-NS/PC) grafts in models of spinal cord injury (SCI). Evidence from animal experiments suggests this approach is safe and effective. We are preparing to initiate a first-in-human clinical study of hiPSC-NS/PC transplantation in subacute SCI. Setting: NS/PCs were prepared at a Good Manufacturing Practice-grade cell processing facility at Osaka National Hospital using a clinical-grade integration-free hiPSC line established by the iPSC Stock Project organized by the Kyoto University Center for iPS Cell Research and Application...
December 2021: Regenerative Therapy
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JOURNAL ARTICLE
Kazuki Kon, Kaiji Uchida, Kentaro Fuku, Shuntaro Yamanaka, Bin Wu, Daiki Yamazui, Hiroaki Iguchi, Hiroaki Kobayashi, Yoshiyuki Gambe, Itaru Honma, Shinya Takaishi
Redox-active metal-organic frameworks (MOFs) have great potential for use as cathode materials in lithium-ion batteries (LIBs) with large capacities because the organic ligands can undergo multiple-electron redox processes. However, most MOFs are electrical insulators, limiting their application as electrode materials. Here, we report an electron-conductive MOF with a 2,5-dihydroxy-1,4-benzoquinone (dhbq) ligand, Fe(dhbq). This compound had an electrical conductivity of 5 × 10-6 S cm-1 at room temperature due to d-π interactions between the Fe ion and the ligand and the permanent microporosity...
August 5, 2021: ACS Applied Materials & Interfaces
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JOURNAL ARTICLE
Chikako Okubo, Megumi Narita, Azusa Inagaki, Misato Nishikawa, Akitsu Hotta, Shinya Yamanaka, Yoshinori Yoshida
Hand1 and Hand2 are transcriptional factors, and knockout mice of these genes show left and right ventricular hypoplasia, respectively. However, their function and expression in human cardiogenesis are not well studied. To delineate their expressions and assess their functions in human cardiomyocytes (CMs) in vitro, we established two triple-reporter human induced pluripotent stem cell lines that express HAND1mCherry , HAND2EGFP and either MYH6-driven iRFP670 or tagBFP constitutively and investigated their expression dynamics during cardiac differentiation...
July 8, 2021: Stem Cell Reports
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REVIEW
Gaku Yamanaka, Fuyuko Takata, Yasufumi Kataoka, Kanako Kanou, Shinichiro Morichi, Shinya Dohgu, Hisashi Kawashima
Pericytes are a component of the blood-brain barrier (BBB) neurovascular unit, in which they play a crucial role in BBB integrity and are also implicated in neuroinflammation. The association between pericytes, BBB dysfunction, and the pathophysiology of epilepsy has been investigated, and links between epilepsy and pericytes have been identified. Here, we review current knowledge about the role of pericytes in epilepsy. Clinical evidence has shown an accumulation of pericytes with altered morphology in the cerebral vascular territories of patients with intractable epilepsy...
June 30, 2021: Biomedicines
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JOURNAL ARTICLE
Michika Sawada, Kandi Sridhar, Yasuharu Kanda, Shinya Yamanaka
We report a synthesis strategy for pure hydroxyapatite (HAp) using an amorphous calcium carbonate (ACC) colloid as the starting source. Room-temperature phosphorylation and subsequent calcination produce pure HAp via intermediate amorphous calcium phosphate (ACP). The pre-calcined sample undergoes a competitive transformation from ACC to ACP and crystalline calcium carbonate. The water content, ACC concentration, Ca/P molar ratio, and pH during the phosphorylation reaction play crucial roles in the final phase of the crystalline phosphate compound...
June 2, 2021: Scientific Reports
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JOURNAL ARTICLE
Kazutoshi Takahashi, Michiko Nakamura, Chikako Okubo, Zane Kliesmete, Mari Ohnuki, Megumi Narita, Akira Watanabe, Mai Ueda, Yasuhiro Takashima, Ines Hellmann, Shinya Yamanaka
Human pluripotent stem cells (PSCs) express human endogenous retrovirus type-H (HERV-H), which exists as more than a thousand copies on the human genome and frequently produces chimeric transcripts as long-non-coding RNAs (lncRNAs) fused with downstream neighbor genes. Previous studies showed that HERV-H expression is required for the maintenance of PSC identity, and aberrant HERV-H expression attenuates neural differentiation potentials, however, little is known about the actual of function of HERV-H. In this study, we focused on ESRG, which is known as a PSC-related HERV-H-driven lncRNA...
May 25, 2021: PLoS Genetics
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JOURNAL ARTICLE
Tomoki Komiyama, Yoko Harada, Takayuki Hase, Sota Mori, Shinya Kimura, Masashi Yokoya, Masamichi Yamanaka
Urea derivatives that were substituted with a 2-benzylphenyl group and an alkyl group functioned as low molecular weight gelators for various organic solvents and ionic liquids. Urea derivatives with long alkyl chains were effective for the gelation of polar solvents. However, they were not suitable for the gelation of non-polar solvents, whereas urea derivatives with short alkyl chains were effective. Ionic liquids were similar to polar solvents in that urea derivatives with long alkyl chains were the most effective gelators...
May 18, 2021: Chemistry, An Asian Journal
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JOURNAL ARTICLE
Masamichi Yamanaka, Ryohei Yoshisaki, Shinya Kimura, Masashi Yokoya
Maltose is a ubiquitous disaccharide produced by the hydrolysis of starch. Amphiphilic ureas bearing hydrophilic maltose moiety were synthesized via the following three steps: I) construction of urea derivatives by the condensation of 4-nitrophenyl isocyanate and alkylamines, II) reduction of the nitro group by hydrogenation, and III) an aminoglycosylation reaction of the amino group and the unprotected maltose. These amphiphilic ureas functioned as low molecular weight hydrogelators, and the mixtures of the amphipathic ureas and water formed supramolecular hydrogels...
May 18, 2021: Chemistry, An Asian Journal
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JOURNAL ARTICLE
Shinya Sato, Satoshi Maki, Takashi Yamanaka, Daisuke Hoshino, Yukihide Ota, Emi Yoshioka, Kae Kawachi, Kota Washimi, Masaki Suzuki, Yoichiro Ohkubo, Tomoyuki Yokose, Toshinari Yamashita, Seiji Ohtori, Yohei Miyagi
PURPOSE: Diagnosis of breast preneoplastic and neoplastic lesions is difficult due to their similar morphology in breast biopsy specimens. To diagnose these lesions, pathologists perform immunohistochemical analysis and consult with expert breast pathologists. These additional examinations are time-consuming and expensive. Artificial intelligence (AI)-based image analysis has recently improved, and may help in ordinal pathological diagnosis. Here, we showed the significance of machine learning-based image analysis of breast preneoplastic and neoplastic lesions for facilitating high-throughput diagnosis...
May 1, 2021: Breast Cancer Research and Treatment
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JOURNAL ARTICLE
Yu Igarashi, Kotaro Nochioka, Yasuhiko Sakata, Tokiwa Tamai, Shinya Ohkouchi, Toshiya Irokawa, Hiromasa Ogawa, Hideka Hayashi, Takahide Fujihashi, Shinsuke Yamanaka, Takashi Shiroto, Satoshi Miyata, Jun Hata, Shogo Yamada, Toshiharu Ninomiya, Satoshi Yasuda, Hajime Kurosawa, Hiroaki Shimokawa
Background: Few risk models are available to predict future onset of atrial fibrillation (AF) in workers. We aimed to develop risk prediction models for new-onset AF, using annual health checkup (HC) data with electrocardiogram findings. Methods and Results: We retrospectively included 56,288 factory or office workers (mean age = 51.5 years, 33.0% women) who underwent a HC at a medical center and fulfilled the following criteria; age ≥ 40 years, no history of AF, and greater than 1 annual follow-up HC in 2013-2016...
June 2021: IJC Heart & Vasculature
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JOURNAL ARTICLE
Chen Shen, Yasufumi Oda, Masaki Matsubara, Jun Yabuki, Shinya Yamanaka, Hiroya Abe, Makio Naito, Atsushi Muramatsu, Kiyoshi Kanie
This study is focused on surface-modified Fe3 O4 @SiO2 particles with precisely controlled sizes and shapes applied in magnetorheological (MR) fluids. After the preparation of the monodisperse spindle-shaped and cubic Fe3 O4 @SiO2 particles, surface modification with dodecyltrimethoxysilane (DTM) was carried out via a silane coupling reaction to increase the dispersion stability of the particles. Afterward, MR fluids were prepared by mixing the DTM-modified Fe3 O4 @SiO2 particles with silicon oil. Transmission electron microscopy observations demonstrated that spindle-shaped Fe3 O4 @SiO2 particles could form a more stable chain-like structure than cubic Fe3 O4 @SiO2 particles upon application of an external magnetic field...
April 20, 2021: ACS Applied Materials & Interfaces
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JOURNAL ARTICLE
Shinji Matsuzaki, Kento Azuma, Xuguang Lin, Masahiro Kuragano, Koji Uwai, Shinya Yamanaka, Kiyotaka Tokuraku
Livestock farming is affected by the occurrence of infectious diseases, but outbreaks can be prevented by proper sanitary control measures. Calcium hydroxide (Ca(OH)2 ), commonly called slaked lime, powder is traditionally used as a disinfectant to prevent infectious diseases in livestock. Since Ca(OH)2 can inactivate a wide variety of pathogens, has a small environmental impact, does not require a disinfection tank (i.e., can be spread directly on the ground) and is produced inexpensively worldwide, it is used for the prevention of epidemics on farms worldwide...
April 12, 2021: Scientific Reports
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JOURNAL ARTICLE
Ryo Yamanaka, Shinya Wakasawa, Koya Yamashiro, Naoki Kodama, Daisuke Sato
PURPOSE: The study determined whether the increase in the cross-sectional area (CSA) of psoas major, which is known as a hip-flexion muscle, by resistance training combined with running training improves the performance of long-distance runners. METHODS: Subjects were 8 well-trained male long-distance runners. The personal best time in a 5000-m race was 15:10.0 (0:20.5) (mean [SD]). Each subject performed resistance training twice per week with running training for 12 weeks...
March 5, 2021: International Journal of Sports Physiology and Performance
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JOURNAL ARTICLE
Peter Karagiannis, Shinya Yamanaka
Japanese students' seeming low proficiency of English is not caused by lack of efforts to internationalize, but rather changing career preferences.
March 2, 2021: EMBO Reports
#56
JOURNAL ARTICLE
Kentaro Ito, Takeharu Yamanaka, Hidetoshi Hayashi, Yoshihiro Hattori, Kazumi Nishino, Haruki Kobayashi, Yuko Oya, Toshihide Yokoyama, Takashi Seto, Koichi Azuma, Tomoya Fukui, Toshiyuki Kozuki, Atsushi Nakamura, Kentaro Tanaka, Katsuya Hirano, Takashi Yokoi, Haruko Daga, Shinya Sakata, Daichi Fujimoto, Masahide Mori, Ken Maeno, Takuya Aoki, Atsuhisa Tamura, Satoru Miura, Satoshi Watanabe, Hiroaki Akamatsu, Osamu Hataji, Kensuke Suzuki, Shigeto Hontsu, Koji Azuma, Akihiro Bessho, Akihito Kubo, Motoyasu Okuno, Kazuhiko Nakagawa, Nobuyuki Yamamoto
BACKGROUND: The data of sequential therapy of anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) in clinical practice have been limited. METHODS: We reviewed the clinical data of patients with ALK-rearranged non-small cell lung cancer who received crizotinib (CRZ) or alectinib (ALEC) between May 2012 and December 2016. Patients were divided into two groups based on the first-administered ALK-TKI, the CRZ or ALEC group. The combined time-to-treatment failure (TTF) was defined as the sum of the 'TTF of CRZ' plus the 'TTF of ALEC' if patients were treated with CRZ followed by ALEC in the CRZ group...
January 21, 2021: European Journal of Cancer
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JOURNAL ARTICLE
Kenta Sakai, Fuyuko Takata, Gaku Yamanaka, Miho Yasunaga, Kana Hashiguchi, Kazuki Tominaga, Kouichi Itoh, Yasufumi Kataoka, Atsushi Yamauchi, Shinya Dohgu
In this study, among neurovascular unit (NVU) cells, we focused on pericyte reactivity in mice subjected to controlled cortical impact (CCI) to understand how traumatic brain injury (TBI) causes uncoordinated crosstalk in the NVU and alters neuronal activity. Histological analyses of brain pericytes, microglia and astrocytes were performed for up to 28 days after CCI in the injured ipsilateral hippocampus. To evaluate altered neuronal activity caused by CCI, we measured seizure susceptibility to a sub-threshold dose of pilocarpine on postoperative day 7, 14, 21 and 28...
January 2021: Journal of Pharmacological Sciences
#58
JOURNAL ARTICLE
Kayoko Hayakawa, Satoshi Kutsuna, Takeo Kawamata, Yuko Sugiki, Chiharu Nonaka, Keiko Tanaka, Michi Shoji, Masaki Nagai, Shunsuke Tezuka, Kazuyuki Shinya, Hiroki Saito, Takahiro Harada, Nin Moriya, Motoyuki Tsuboi, Masataro Norizuki, Yasuo Sugiura, Yasuyo Osanai, Masaya Sugiyama, Ayako Okuhama, Kohei Kanda, Yuji Wakimoto, Mugen Ujiie, Shinichiro Morioka, Kei Yamamoto, Noriko Kinoshita, Masahiro Ishikane, Sho Saito, Yuki Moriyama, Masayuki Ota, Keiji Nakamura, Takato Nakamoto, Satoshi Ide, Hidetoshi Nomoto, Yutaro Akiyama, Tetsuya Suzuki, Yusuke Miyazato, Yoshiaki Gu, Nobuaki Matsunaga, Shinya Tsuzuki, Yumiko Fujitomo, Yoshiki Kusama, Hiroyuki Shichino, Masao Kaneshige, Junko Yamanaka, Miki Saito, Masayuki Hojo, Masao Hashimoto, Shinyu Izumi, Jin Takasaki, Manabu Suzuki, Keita Sakamoto, Yukio Hiroi, Sakurako Emoto, Makoto Tokuhara, Toshiaki Kobayashi, Koichiro Tomiyama, Fumihiko Nakamura, Norio Ohmagari, Haruhito Sugiyama
Due to the significant spread of a new type of coronavirus (SARS-CoV-2) infection (COVID-19) in China, the Chinese government blockaded several cities in Hubei Province. Japanese citizens lost a means of transportation to return back to Japan. The National Center for Global Health and Medicine (NCGM) helped the operation of charter flights for evacuation of Japanese residents from Hubei Province, and this article outlines our experiences. A total of five charter flights were dispatched, and the majority of returnees (793/829 [95...
April 30, 2020: Global health & medicine
#59
JOURNAL ARTICLE
Shinya Sugimoto, Kunitoshi Yamanaka, Tatsuya Niwa, Yurika Terasawa, Yuki Kinjo, Yoshimitsu Mizunoe, Teru Ogura
In Escherichia coli, the major bacterial Hsp70 system consists of DnaK, three J-domain proteins (JDPs: DnaJ, CbpA, and DjlA), and nucleotide exchange factor GrpE. JDPs determine substrate specificity for the Hsp70 system; however, knowledge on their specific role in bacterial cellular functions is limited. In this study, we demonstrated the role of JDPs in bacterial survival during heat stress and the DnaK-regulated formation of curli-extracellular amyloid fibers involved in biofilm formation. Genetic analysis demonstrate that only DnaJ is essential for survival at high temperature...
February 5, 2021: Journal of Molecular Biology
#60
REVIEW
Romana Zahumenska, Vladimir Nosal, Marek Smolar, Terezia Okajcekova, Henrieta Skovierova, Jan Strnadel, Erika Halasova
One of the greatest breakthroughs of regenerative medicine in this century was the discovery of induced pluripotent stem cell (iPSC) technology in 2006 by Shinya Yamanaka. iPSCs originate from terminally differentiated somatic cells that have newly acquired the developmental capacity of self-renewal and differentiation into any cells of three germ layers. Before iPSCs can be used routinely in clinical practice, their efficacy and safety need to be rigorously tested; however, iPSCs have already become effective and fully-fledged tools for application under in vitro conditions...
November 24, 2020: International Journal of Molecular Sciences
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