Zuxing Wang, Xiandong Lin, Xinqun Luo, Jun Xiao, Yong Zhang, Jianying Xu, Shibin Wang, Fen Zhao, Huifen Wang, Hangxiao Zheng, Wei Zhang, Chen Lin, Zewen Tan, Liping Cao, Zhiren Wang, Yunlong Tan, Wenzhong Chen, Yuping Cao, Xiaoyun Guo, Christopher Pittenger, Xingguang Luo
BACKGROUND: Neuropsychiatric disorders are highly heritable and have overlapping genetic underpinnings. Single nucleotide polymorphisms (SNPs) in the gene CACNA1C have been associated with several neuropsychiatric disorders, across multiple genome-wide association studies. METHOD: A total of 70,711 subjects from 37 independent cohorts with 13 different neuropsychiatric disorders were meta-analyzed to identify overlap of disorder-associated SNPs within CACNA1C. The differential expression of CACNA1C mRNA in five independent postmortem brain cohorts was examined...
June 12, 2023: Schizophrenia Bulletin