Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#41
JOURNAL ARTICLE
Simon K B Spohn, Gianluca Radicioni, Marcio Eisfelder, Constantinos Zamboglou, Dimos Baltas, Anca-Ligia Grosu, Ilias Sachpazidis
INTRODUCTION: Prostate cancer (PCa) is a prevalent malignancy in European men, often treated with radiotherapy (RT) for localized disease. While modern RT achieves high success rates, concerns about late gastrointestinal (GI) toxicities persist. This retrospective study aims to identify predictors for late GI toxicities following definitive conventionally fractionated external beam RT (EBRT) for PCa, specifically exploring the dose to the rectal wall. MATERIALS AND METHODS: A cohort of 96 intermediate- to high-risk PCa patients underwent EBRT between 2008 and 2016...
2024: Frontiers in Oncology
#42
Ralah Alharbi, Anna Suchet-Dechaud, Inès Harzallah, Renaud Touraine, Francis Ramond
Anorectal malformations (ARMs) represent a wide spectrum of congenital anomalies of the anus and rectum, of which more than half are syndromic. Their etiology is highly heterogeneous and still poorly understood. We report a 4-year-old girl who initially presented with an isolated ARM, and subsequently developed a global developmental delay as part of an ARID1B-related Coffin-Siris syndrome (CSS). A co-occurrence of ARMs and CSS in an individual by chance is unexpected since both diseases are very rare. A review of the literature enabled us to identify 10 other individuals with both CSS and ARMs...
May 10, 2024: European Journal of Medical Genetics
#43
JOURNAL ARTICLE
Koichi Nagata, Emily A Janik, Jishnu Rao Gutti
Variability in prostate gland positioning during RT for prostate tumors is a recognized challenge in both human and veterinary oncology. This retrospective study investigates the interfractional variability in prostate gland positioning in relation to rectal and bladder volumes in dogs undergoing radiation therapy (RT) for prostate tumors. The study tracked 10 dogs undergoing five RT sessions from February 2016 to November 2021, delivering a total of 25 Gy each. Each dog underwent CT scans for treatment simulation, and cone-beam CT (CBCT) images were acquired before each RT...
May 12, 2024: Veterinary Radiology & Ultrasound
#44
JOURNAL ARTICLE
Yoyos Dias Ismiarto, Mochammad Ridho Nur Hidayah, Daniel Wirawan, Ardicho Irfantian, Hilmi Muhammad
BACKGROUND The rarity of ischiopagus tripus conjoined twins complicates the surgical separation, owing to the lack of cases and high complexity. We aim to report our experience in performing orthopedic correction for ischiopagus tripus twins. CASE REPORT A pair of 3-year-old conjoined boys presented with a fused body at the pelvis region and only 1 umbilicus. There were 2 legs separated by shared genitalia and an anus at the midline, and 1 fused leg, which could be felt and moved by both of the patients. The twins also shared internal organs of the bladder, intestine, and rectum, as visualized through angiography computerized tomography scan...
May 12, 2024: American Journal of Case Reports
#45
JOURNAL ARTICLE
Hidde Swartjes, Femke P C Sijtsma, Marloes A G Elferink, Felice N van Erning, Leon M G Moons, Henk M W Verheul, Maaike Berbée, Pauline A J Vissers, Johannes H W de Wilt
BACKGROUND: The epidemiology of colorectal cancer (CRC) has changed rapidly over the years. The aim of this study was to assess the trends in incidence, treatment, and relative survival (RS) of patients diagnosed with CRC in the Netherlands between 2000 and 2021. PATIENTS AND METHODS: 2 75667 patients diagnosed with CRC between 2000 and 2021 were included from the Netherlands Cancer Registry. Analyses were stratified for disease extent (localised: T1-3N0M0; regional: T4N0M0/T1-4N1-2M0; distant: T1-4N0-2M1) and localisation (colon; rectum)...
May 7, 2024: European Journal of Cancer
#46
JOURNAL ARTICLE
Aimee K Huang, Tabor Hoatson, Payal Chakraborty, Sarah McKetta, Kodiak R S Soled, Colleen A Reynolds, Ulrike Boehmer, Alexis R Miranda, Carl G Streed, Shail Maingi, Sebastien Haneuse, Jessica G Young, Jae H Kang, S Bryn Austin, A Heather Eliassen, Brittany M Charlton
INTRODUCTION: Cancer risk factors are more common among sexual minority populations (e.g., lesbian, bisexual) than their heterosexual peers, yet little is known about cancer incidence across sexual orientation groups. METHODS: The 1989-2017 data from the Nurses' Health Study II, a longitudinal cohort of female nurses across the United States, were analyzed (N = 101,543). Sexual orientation-related cancer disparities were quantified by comparing any cancer incidence among four sexual minority groups based on self-disclosure-(1) heterosexual with past same-sex attractions/partners/identity; (2) mostly heterosexual; (3) bisexual; and (4) lesbian women-to completely heterosexual women using age-adjusted incidence rate ratios (aIRR) calculated by the Mantel-Haenszel method...
May 11, 2024: Cancer
#47
JOURNAL ARTICLE
Dunja Putniković, Jovan Jevtić, Nina Ristić, Ivan D Milovanovich, Miloš Đuknić, Milica Radusinović, Nevena Popovac, Irena Đorđić, Zoran Leković, Radmila Janković
Crohn's disease (CD) is a progressive, multifactorial, immune-mediated disease characterized by chronic inflammation of any part of the gastrointestinal (GI) tract. Pediatric patients present with a more extensive form of the disease, especially in the upper GI tract with various histopathological inflammatory patterns. Our study aims to analyze the clinical, laboratory, endoscopic, and histopathological findings in children with diagnosed CD and compare results on the initial and follow-up tests. We have included 100 children and adolescents with CD, with performed endoscopic and histopathological (HP) procedures...
April 24, 2024: Diagnostics
#48
JOURNAL ARTICLE
Minae Kawasaki, Yoko M Ambrosini
Enterohemorrhagic Escherichia coli (EHEC) is a critical public health concern due to its role in severe gastrointestinal illnesses in humans, including hemorrhagic colitis and the life-threatening hemolytic uremic syndrome. While highly pathogenic to humans, cattle, the main reservoir for EHEC, often remain asymptomatic carriers, complicating efforts to control its spread. Our study introduces a novel method to investigate EHEC using organoid-derived monolayers from adult bovine ileum and rectum. These polarized epithelial monolayers were exposed to EHEC for four hours, allowing us to perform comparative analyses between the ileal and rectal tissues...
April 30, 2024: International Journal of Molecular Sciences
#49
JOURNAL ARTICLE
Elisabetta Dell'Unto, Matteo Marasco, Mirta Mosca, Camilla Gallo, Gianluca Esposito, Maria Rinzivillo, Emanuela Pilozzi, Federica Orrù, Davide Campana, Sara Massironi, Bruno Annibale, Francesco Panzuto
Objectives: Our aim was to investigate the clinical outcome of patients with well-differentiated gastric, duodenal, and rectal neuroendocrine tumors after treatment with incomplete endoscopic resection due to the finding of microscopic positive resection margins (R1). Methods: This is a retrospective analysis of consecutive patients with type 1 gastric, non-ampullary non-functioning duodenal, or rectal neuroendocrine neoplasms with positive R1 margins after endoscopic resection. The rate of tumor recurrence and progression-free survival were considered to be the study's main endpoints...
April 25, 2024: Journal of Clinical Medicine
#50
JOURNAL ARTICLE
Mario Serradilla-Martín, Celia Villodre, Laia Falgueras-Verdaguer, Natalia Zambudio-Carroll, José T Castell-Gómez, Juan L Blas-Laina, Vicente Borrego-Estella, Carlos Domingo-Del-Pozo, Gabriel García-Plaza, Francisco J González-Rodríguez, Eva M Montalvá-Orón, Ángel Moya-Herraiz, Sandra Paterna-López, Miguel A Suárez-Muñoz, Maialen Alkorta-Zuloaga, Gerardo Blanco-Fernández, Enrique Dabán-Collado, Miguel A Gómez-Bravo, José I Miota-de-Llamas, Fernando Rotellar, Belinda Sánchez-Pérez, Santiago Sánchez-Cabús, David Pacheco-Sánchez, Juan C Rodríguez-Sanjuan, María A Varona-Bosque, Lucía Carrión-Álvarez, Sofía de la Serna-Esteban, Cristina Dopazo, Elena Martín-Pérez, David Martínez-Cecilia, María J Castro-Santiago, Dimitri Dorcaratto, Marta L Gutiérrez-Díaz, José M Asencio-Pascual, Fernando Burdío-Pinilla, Roberto Carracedo-Iglesias, Alfredo Escartín-Arias, Benedetto Ielpo, Gonzalo Rodríguez-Laiz, Andrés Valdivieso-López, Emilio De-Vicente-López, Vicente Alonso-Orduña, José M Ramia
(1) Background: The liver-first approach may be indicated for colorectal cancer patients with synchronous liver metastases to whom preoperative chemotherapy opens a potential window in which liver resection may be undertaken. This study aims to present the data of feasibility and short-term outcomes in the liver-first approach. (2) Methods: A prospective observational study was performed in Spanish hospitals that had a medium/high-volume of HPB surgeries from 1 June 2019 to 31 August 2020. (3) Results: In total, 40 hospitals participated, including a total of 2288 hepatectomies, 1350 for colorectal liver metastases, 150 of them (11...
April 26, 2024: Cancers
#51
JOURNAL ARTICLE
Akihiko Tamaki, Kenichi Kohashi, Koichiro Yoshimaru, Yuko Hino, Hiroshi Hamada, Naonori Kawakubo, Tomoaki Taguchi, Tatsuro Tajiri, Yoshinao Oda
Isolated hypoganglionosis (IHG) is histologically characterized by small numbers of myenteric ganglion cells and small myenteric ganglia; however, no numerical diagnostic criteria for IHG have been established. Therefore, this study aimed to develop quantitative pathologic criteria for IHG. We evaluated 160 resected intestinal tissue specimens from 29 pediatric autopsies and 10 IHG cases. These specimens were obtained from the jejunum, ileum, ascending colon, transverse colon, and rectum. Morphologic features of the myenteric ganglion cells and myenteric ganglia were quantified and analyzed in digitized HuC/HuD-immunostained and CD56-immunostained sections, respectively...
May 10, 2024: American Journal of Surgical Pathology
#52
JOURNAL ARTICLE
Olivia Peuchant, Cécile Laurier-Nadalié, Laura Albucher, Carla Balcon, Amandine Dolzy, Nadège Hénin, Arabella Touati, Cécile Bébéar
BackgroundIn France, lymphogranuloma venereum (LGV) testing switched from universal to selective testing in 2016.AimTo investigate changes in LGV-affected populations, we performed a nationwide survey based on temporarily reinstated universal LGV testing from 2020 to 2022.MethodsEach year, during three consecutive months, laboratories voluntarily sent anorectal Chlamydia trachomatis -positive samples from men and women to the National Reference Centre for bacterial sexually transmitted infections. We collected patients' demographic, clinical and biological data...
May 2024: Euro Surveillance
#53
JOURNAL ARTICLE
Fatimah Aldabali, Batool Alotibi, Ali Alkhaldi, Afnan Alrashdi, Fatimah Alnashri, Ghaday Alqarni, Abdullah Alsllami, Basem Alshareef
Colorectal cancer (CRC) is a malignant tumor of the colon and rectum. It can be cured if detected in the early stage through established screening programs. CRC screening is the best way to improve cancer morbidity and mortality. Various approaches such as stool tests, virtual colonoscopy, and sigmoidoscopy are available for early detection. On average, a person after reaching the age of 45 should begin the screening process for CRC periodically for 5 years. Our study aims to measure the population's awareness and knowledge of the effect of CRC screening on CRC outcomes...
2024: American Journal of Cancer Research
#54
REVIEW
Ahmed Farag, Sidi Muctar, Peter Petros
The thesis that functional/dysfunctional male/female pelvic floor anatomy are parallel, originated from two studies: a successful retropubic perineal male sling for post-prostatectomy stress urinary incontinence (SUI) and discovery of a male uterosacral ligament (USL) analogue, we named "prostatosacral ligament" (PSL). In 25 out of the studied 27 males (92.6%), it starts on both sides of the median sulcus of the prostate the ligament passes lateral to the rectum being fused with the lateral margin of the mesorectum before leaving it as it thins out to be attached posteriorly similar to the USL...
April 22, 2024: Annals of Translational Medicine
#55
REVIEW
Darren M Gold, Michael Swash, Ahmed Farag, Shuqing Ding, Giulio Santoro, Giuseppe Dodi
The remit of this review is confined to the experimental scientific works and surgeries based on the Integral Theory paradigm. The video abstract summarizes the anorectal function, how ligaments cause dysfunction and cure of fecal incontinence and obstructed defecation by ligament repair. Anorectal function is reflex and binary, with cortical and peripheral components. The same three oppositely acting reflex muscle forces which open and close the bladder, contract against the pubourethral (PUL) and uterosacral (USL) ligaments: (I) to close the anorectum for continence when the puborectalis muscle (PRM) contracts forwards; (II) to open the anorectum prior to evacuation when the PRM relaxes; (III) to stretch the rectum in opposite directions to support the anorectal stretch receptors "N" to prevent premature activation of the defecation reflex, (fecal urgency)...
April 22, 2024: Annals of Translational Medicine
#56
REVIEW
Ray Hodgson, Florian Wagenlehner, Elisabeth Del Amo, Hiromi Inoue, Burghard Abendstein
Descending perineal syndrome (DPS) was described by Parks et al. as descent of the anus on straining, typically 3-4 cm below a line drawn from the coccyx to the lower end of the. DPS is associated with obstructed defecation, with increased bulging of the perineum with straining, although perineal descent can also be seen at rest. In their review, Chaudhry and Tarnay stated: " It is controversial whether surgical management is even an option for patients with DPS ". The deep transversus perinei (DTP) ligaments are the suspensory ligaments of the perineal body (PB)...
April 22, 2024: Annals of Translational Medicine
#57
JOURNAL ARTICLE
Bao-Lan Lu, Dian-Qi Yao, Yì Xiáng J Wáng, Zhi-Wen Zhang, Zi-Qiang Wen, Ben-Heng Xiao, Shen-Ping Yu
BACKGROUND: Diffusion-derived vessel density (DDVD) is a physiological surrogate of the area of micro-vessels per unit tissue area. DDVD is calculated according to: DDVD(b0b5) = Sb0/ROIarea0 - Sb5/ROIarea5, where Sb0 and Sb5 refer to the tissue signal when b is 0 or 5 s/mm2 . This study applied DDVD to assess the perfusion of rectal carcinoma (RC). METHODS: MRI was performed with a 3.0-T magnet. Diffusion weighted image with b -values of 0, 5 s/mm2 were acquired in 113 patients with non-mucinous RC and 15 patients with mucinous RC...
May 1, 2024: Quantitative Imaging in Medicine and Surgery
#58
JOURNAL ARTICLE
Jeongseok Kim, Tae-Geun Gweon, Min Seob Kwak, Su Young Kim, Seong Jung Kim, Hyun Gun Kim, Eun Ran Kim, Sung Noh Hong, Eun Sun Kim, Chang Mo Moon, Dae Seong Myung, Dong Hoon Baek, Shin Ju Oh, Hyun Jung Lee, Ji Young Lee, Yunho Jung, Jaeyoung Chun, Dong-Hoon Yang
BACKGROUND/AIMS: We investigated the clinical practice patterns of post-polypectomy colonoscopic surveillance among Korean endoscopists. METHODS: In a web-based survey conducted between September and November 2021, participants were asked about their preferred surveillance intervals and the patient age at which surveillance was discontinued. Adherence to the recent guidelines of the U.S. Multi-Society Task Force on Colorectal Cancer (USMSTF) was also analyzed. RESULTS: In total, 196 endoscopists completed the survey...
April 2024: Intestinal Research
#59
JOURNAL ARTICLE
Felix Bjerregaard, Daniel Asklid, Olle Ljungqvist, Anders H Elliot, Klas Pekkari, Ulf O Gustafsson
BACKGROUND: Research on anastomotic leakage (AL) in colonic procedures within an Enhanced Recovery After Surgery (ERAS) protocol has not yet been conducted. The aim of this study was to identify risk factors for AL after colonic surgery. METHODS: The study included all consecutively recorded patients operated with colonic resection surgery in the Swedish part of the international ERAS® Interactive Audit System (EIAS) between September 2009 and June 2022. The cohort was analyzed and evaluated regarding risk factors for AL...
May 8, 2024: World Journal of Surgery
#60
JOURNAL ARTICLE
Jason B Cook, Raymond Piatt, Edward Burgard, Karl B Thor, Lesley Marson
Substantial clinical and preclinical evidence indicates that transient receptor potential vanilloid 1 (TRPV1) receptors are expressed on terminals of colorectal chemoreceptors and mechanoreceptors and are involved in various rectal hypersensitivity disorders with common features of colorectal overactivity. These stimulatory properties of TRPV1 receptors on colorectal function suggested that brief stimulation of TRPV1 might provide a means of pharmacologically activating the colorectum to induce defecation in patients with an "unresponsive" colorectum...
May 6, 2024: Journal of Pharmacology and Experimental Therapeutics
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
