Johanna C Bendell, Tamara Sauri, Antonio Cubillo Gracián, Rafael Alvarez, Carlos López-López, Pilar García-Alfonso, Maen Hussein, Maria-Luisa Limon Miron, Andrés Cervantes, Clara Montagut, Cristina Santos Vivas, Alberto Bessudo, Patricia Plezia, Veerle Moons, Johannes Andel, Jaafar Bennouna, Andre van der Westhuizen, Leslie Samuel, Simona Rossomanno, Christophe Boetsch, Angelika Lahr, Izolda Franjkovic, Florian Heil, Katharina Lechner, Oliver Krieter, Herbert Hurwitz
BACKGROUND: Bevacizumab, a VEGF-A inhibitor, in combination with chemotherapy, has proven to increase progression-free survival (PFS) and overall survival in multiple lines of therapy of metastatic colorectal cancer (mCRC). The angiogenic factor angiopoetin-2 (Ang-2) is associated with poor prognosis in many cancers, including mCRC. Preclinical models demonstrate improved activity when inhibiting both VEGF-A and Ang-2, suggesting that the dual VEGF-A and Ang-2 blocker vanucizumab (RO5520985 or RG-7221) may improve clinical outcomes...
September 30, 2019: Oncologist