Ziyad Alsugair, Maxime Fieux, Françoise Descotes, Jonathan Lopez, Carolle Cordonnier, Juliette Russel, Anne Champagnac, Daniel Pissaloux, Philippe Céruse, Pierre Philouze, Nazim Benzerdjeb
AIMS: Salivary gland neoplasms (SGN) exhibiting the HMGA2::WIF1 fusion are recognized by their resemblance to histology found in canalicular adenoma. Recently, ~20% of cases among 28 HMGA2::WIF1-rearranged-SGN showed malignancy and adverse outcomes (recurrence, distant metastasis, and disease-specific mortality). Among them, MDM2/CDK4 amplifications were identified in one case. This outcome suggests that the MDM2/CDK4 amplifications could be useful to predict an aggressive course of carcinoma ex-pleomorphic adenoma (CEPA)...
May 6, 2024: Histopathology