Manabu Yoshimura, Hiroko Shiramoto, Mami Koga, Yasuhiro Morimoto
PURPOSE: Hypotension is a risk factor for adverse perioperative outcomes. Preoperative transthoracic echocardiography has been extended for preoperative risk assessment before noncardiac surgery. This study aimed to develop a machine learning model to predict postinduction hypotension risk using preoperative echocardiographic data and compared it with conventional statistic models. We also aimed to identify preoperative echocardiographic factors that cause postinduction hypotension. METHODS: In this retrospective observational study, we extracted data from electronic health records of patients aged >18 years who underwent general anesthesia at a single tertiary care center between April 2014 and September 2019...
2022: PloS One
Masatoyo Nakajo, Yoshihisa Horizoe, Kodai Kawaji, Megumi Jinguji, Atsushi Tani, Yoshihiko Fukukura, Mitsuru Ohishi, Takashi Yoshiura
PURPOSE: This study examined the usefulness of the maximum standardized uptake value (SUVmax) of myocardial [123 I]-metaiodobenzylguanidine ([123 I]-MIBG) to characterize myocardial function by comparing it with echocardiographic parameters in patients with pheochromocytoma. MATERIALS AND METHODS: This study included 18 patients with pheochromocytoma who underwent both planar and [123 I]-MIBG single-photon emission computed tomography/computed tomography scans and echocardiography before surgery...
November 28, 2022: Japanese Journal of Radiology
Hagai D Yavin, Koji Higuchi, Arwa Younis, Elad Anter
BACKGROUND: A compressible lattice-tip catheter designed for focal ablation using radiofrequency or pulsed-field energies has been recently described. The objective of this study is to describe a new lattice catheter designed for single-shot pulmonary vein isolation (PVI). METHODS: This 8F catheter consists of a compressible lattice tip that is delivered over the wire and is expandable up to 34 mm (SpherePVI™, Affera Inc.). Pulsed field ablation (PFA) was applied from 6 elements using a biphasic waveform of microsecond scale (± 1...
November 28, 2022: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Giorgio Faganello, Linda Pagura, Dario Collia, Giulia Barbati, Alessia Paldino, Matteo Dal Ferro, Elisa Croatto, Gianfranco Sinagra, Gianni Pedrizzetti, Andrea Di Lenarda
Left ventricular ejection function (LVEF) is not reliable in identifying subtle systolic dysfunction. Speckle Tracking (ST) plays a promising role and hemodynamic forces (HDFs) are emerging as marker of LV function. The role of LV myocardial deformation and HDFs was investigated in a cohort of patients with aortic stenosis (AS) and normal LVEF. Two hundred fifty three patients (median age 79 years, IQR 73 - 83 years) with mild (n = 87), moderate (n =77) and severe AS (n =89) were retrospectively enrolled. 2D echocardiographic global longitudinal strain (GLS), circumferential strain (GCS) and HDFs were determined...
November 28, 2022: International Journal of Cardiovascular Imaging
Eugene S J Tan, Xuanyi Jin, Yen Yee Oon, Siew Pang Chan, Lingli Gong, Josephine B Lunaria, Oi-Wah Liew, Jenny Pek-Ching Chong, Edgar L W Tay, Wern Miin Soo, James Wei-Luen Yip, Quek Wei Yong, Evelyn Min Lee, Daniel Poh-Shuan Yeo, Zee Pin Ding, Hak Chiaw Tang, See Hooi Ewe, Calvin W L Chin, Siang Chew Chai, Ping Ping Goh, Lee Fong Ling, Hean Yee Ong, A Mark Richards, Lieng-Hsi Ling
BACKGROUND: The role of left atrial (LA) strain as an imaging biomarker in aortic stenosis is not well established. The aim of this study was to investigate the prognostic performance of phasic LA strain in relation to clinical and echocardiographic variables and N-terminal pro-B-type natriuretic peptide in asymptomatic and minimally symptomatic patients with moderate to severe aortic stenosis and left ventricular ejection fraction > 50%. METHODS: LA reservoir strain (LASr), LA conduit strain (LAScd), and LA contractile strain (LASct) were measured using speckle-tracking echocardiography...
November 22, 2022: Journal of the American Society of Echocardiography
Won-Keun Kim, Corrado Tamburino, Helge Möllmann, Matteo Montorfano, Julia Ellert-Gregersen, Tanja K Rudolph, Nicolas M Van Mieghem, Michael Hilker, Ignacio J Amat-Santos, Christian Juhl Terkelsen, Anna Sonia Petronio, Pieter R Stella, Matthias Götberg, Andreas Rück, A Markus Kasel, Ramiro Trillo, Clare Appleby, Marco Barbanti, Philipp Blanke, Rodrigo Modolo, Dominic J Allocco, Lars Sondergaard
BACKGROUND: The next-generation ACURATE neo2 transcatheter aortic valve was designed for simplified implantation and to mitigate the risk of paravalvular leak (PVL) compared to the earlier device. AIMS: To collect clinical outcomes and device performance data, including echocardiography and 4-dimensional computed tomography (4D-CT) data, with the ACURATE neo2 transcatheter heart valve in patients with severe aortic stenosis (AS). METHODS: ACURATE neo2 PMCF is a single-arm, multicentre study of patients with severe AS treated in routine clinical practice...
November 27, 2022: EuroIntervention
Kara S Motonaga, Loren Sacks, Inger Olson, Sowmya Balasubramanian, Sharon Chen, Lynn Peng, Jeffrey A Feinstein, Norman H Silverman, Frank L Hanley, David M Axelrod, Catherine D Krawczeski, Alisa Arunamata, David M Kwiatkowski, Scott R Ceresnak
BACKGROUND: The transition from residency to paediatric cardiology fellowship is challenging due to the new knowledge and technical skills required. Online learning can be an effective didactic modality that can be widely accessed by trainees. We sought to evaluate the effectiveness of a paediatric cardiology Fellowship Online Preparatory Course prior to the start of fellowship. METHODS: The Online Preparatory Course contained 18 online learning modules covering basic concepts in anatomy, auscultation, echocardiography, catheterisation, cardiovascular intensive care, electrophysiology, pulmonary hypertension, heart failure, and cardiac surgery...
November 28, 2022: Cardiology in the Young
Sulafa Ali, Mohamed Eamin A M E Medani
Pediatric cardiology (PC) is a rapidly advancing specialty addressing a large population of children as well as adults with congenital heart disease. It requires huge technical and financial resources; therefore, establishing, maintaining, and developing such services in limited resource settings are challenging. A PC program that includes clinical aspects, echocardiography, diagnostic and interventional cardiac catheterization and cardiac surgery, and rheumatic heart disease control was established in Sudan in 2004...
2022: Frontiers in Pediatrics
Murat Akcay, Ufuk Yildirim
BACKGROUND: Atrial electromechanical delay (EMD) and left atrial (LA) phasic function have been demonstrated to be predictors for the development of atrial fibrillation (AF). In the present study, we aimed to evaluate atrial EMD and LA phasic function in individuals with electrocardiographic early repolarization pattern (ERP). METHODS: Eighty consecutive individuals with ERP and 40 age- and gender-matched control subjects without ERP were compared in this cross-sectional study...
November 2022: Acta Cardiologica Sinica
Mi Zhou, Ka-Chun Un, Chun Ka Wong, On Yat Wong, David Chung Wah Siu, Lixue Yin, Daniel Tai-Leung Chan, Simon Cheung Chi Lam
Transapical Neochord mitral valve repair has been proven to be a technically safe procedure to correct primary mitral regurgitation (MR). Recurrent MR due to ruptured artificial chords is rare. Here, we present 2 cases of recurrent severe MR due to the detached or partially ruptured artificial chords after the Neochord procedure.
2022: Frontiers in Cardiovascular Medicine
Chenlu Song, Yiqiu Zhang, Qing Pei, Li Zheng, Meiyu Wang, Youzhen Shi, Shan Wu, Wei Ni, Xiujun Fu, Yinbo Peng, Wen Zhang, Min Yao
BACKGROUND: Sepsis-induced cardiomyopathy (SIC) is an identified serious complication of sepsis that is associated with adverse outcomes and high mortality. Heat shock proteins (HSPs) have been implicated in suppressing septic inflammation. The aim of this study was to investigate whether HSP70 can attenuate cellular mitochondrial dysfunction, exuberated inflammation and inflammasome-mediated pyroptosis for SIC intervention. METHODS: Mice with cecal ligation plus perforation (CLP) and lipopolysaccharide (LPS)-treated H9C2 cardiomyocytes were used as models of SIC...
2022: Burns and Trauma
Jeffrey T Jensen, Philberta Leung, Mackenzie Roberts, Jian Guo, Shan Yao, Emily Mishler, Tanner Grenz, James Hodovan, Ov D Slayden, Jonathan R Lindner
OBJECTIVE: Fatal allergic responses and cardiac arrhythmias have been reported with the intravenous (IV) administration of polidocanol. We sought to identify the physiologic mechanism of systemic cardiovascular response after transcervical (TC) and IV administration of polidocanol. METHODS: We continuously monitored blood pressure (BP) and heart rate using an arterial line during IV and intraperitoneal (IP) administration of polidocanol solution (PS) and polidocanol doxycycline solution in female rats and TC and IP administration of polidocanol foam (PF) and PDF (TC only) in female baboons...
2022: Journal of vascular surgery. Vascular science
Abdulkader M Alsharif, Yasser A Bhat, Abdulrahman Al Mesned, Abdullah Al Qwaee, Ali Al Akhfash
Objective This study aims to evaluate the radiation dose for transcatheter patent ductus arteriosus (PDA) via the arterial route and compare it with previously published benchmarks. Background Exposure to radiation in the catheterization lab can cause skin injury and cancer in the long run, especially in pediatric patients with complex heart conditions, which necessitate serial catheterizations. Therefore, measuring the patient radiation dose and establishing a benchmark for each cardiac interventional procedure is essential...
October 2022: Curēus
Aijiao Sun, Sihua Ren, Yangjie Xiao, Yixin Chen, Nan Wang, Chendi Li, Xueying Tan, Yilong Pan, Feifei Sun, Weidong Ren
Aims: This study investigated the feasibility and accuracy of real-time three-dimensional (3D) echocardiographic transilluminated imaging (TrueVue Glass) in left atrial appendage (LAA) anatomical morphology and artificial intelligence (AI)-assisted 3D automated LAA measurement (3D Auto LAA) software in the preoperative evaluation of LAA occlusion (LAAO) in patients with atrial fibrillation (AF). Method and results: Thirty-seven patients with AF were selected. Two-dimensional (2D) and real-time 3D transesophageal echocardiography (RT3D-TEE) were performed preoperatively, using conventional 3D, the new 3D TrueVue Glass mode, and cardiac computed tomography angiography (CCTA) to assess and type the morphology of LAA...
2022: Frontiers in Physiology
Kumral Cagli, Havva Tugba Gursoy, Funda Basyigit, Etga Koprucu, Zehra Golbasi
In this clinical vignette, we describe a case of a patient with windsock-like posterior mitral annulus perforation at the site of annular calcification caused by infective endocarditis. Three-dimensional transesophageal images of the perforation resembling an "alien's mouth" are very striking for how 3-dimensional imaging can improve visualization of anatomy of the heart. ( Level of Difficulty: Intermediate. ).
December 21, 2022: JACC. Case reports
Michael Khorsandi, Hassan Khan, Gerald Colern, Rosemary Hansen, Soraya Arzhan, Hashmat Ashraf, Lawrence D Jacobs, Scott M Katzen, Adnan H Siddiqui, Vijay Iyer
We describe the novel transcatheter approach, with off-label application of LAA closure device, coiling, and concurrent left anterior descending stenting in the setting of left ventricular (LV) pseudoaneurysm. This case underlines collaboration among interventional cardiology, cardiothoracic, and neurosurgery teams in a challenging, nonsurgical candidate with high risk of LV pseudoaneurysm rupture, and death. ( Level of Difficulty: Advanced. ).
December 21, 2022: JACC. Case reports
Melissa A Lyle, Subir Bhatia, Eric Fenstad, Darrell Schroeder, Robert B McCully, Martha Q Lacy, Wayne Feyereisn
OBJECTIVE: To determine the prevalence of monoclonal gammopathy of undetermined significance (MGUS) in patients with PH as well as precapillary PH. METHODS: Olmsted County residents with PH, diagnosed between 1/1/1995 and 9/30/2017, were identified, and age and sex were matched to a normal control group. The PH group and normal control group were then cross-referenced with the Mayo Clinic MGUS database. Charts were reviewed to verify MGUS and PH. Heart catheterization data were then analyzed in these patients for reference to the gold standard for diagnosis...
2022: Advances in Hematology
Hideyuki Maeda, Jun Hosomichi, Akihiro Hasumi, Ken-Ichi Yoshida
A high-fat diet (HFD) accumulates fat in the cardiovascular system, alters the metabolism, and affects cardiac function. Dyslipidemia is associated with the development of sleep apnea syndrome (SAS), which is associated with intermittent hypoxia (IH); however, it is unclear whether SAS affects cardiac function in patients with dyslipidemia. The purpose of this study was to evaluate how IH affects cardiac function in rats fed with a HFD. Male 5-week-old Sprague-Dawley rats of two groups (normal diet (SD) and HFD) were divided into IH-exposed and unexposed groups...
December 2022: Biochemistry and Biophysics Reports
Chen-Ju Lin, Yu-Che Cheng, Hung-Chih Chen, Yu-Kai Chao, Martin W Nicholson, Eric C L Yen, Timothy J Kamp, Patrick C H Hsieh
Background: The gut microbiota plays a vital role in maintaining tissue homeostasis and regulating disease pathophysiology; however, the underlying mechanisms remain to be elucidated. We previously showed that mice depleted of gut microbiota with antibiotics (ABX mice) were more prone to cardiac rupture after infarction, suggesting that the gut microbiota impacts cardiac structural remodeling following injury. Here, we aimed to determine whether the gut microbiota is required for adaptive cardiac remodeling in response to pressure overload stress...
2022: Theranostics
Fengzhi Ding, Lin Lu, Chengjie Wu, Xiangbin Pan, Bin Liu, Yu Zhang, Yanli Wang, Weiliang Wu, Bing Yan, Yuqing Zhang, Xi-Yong Yu, Yangxin Li
Rational: Senescence is a major aging process that contributes to the development of cardiovascular diseases, but the underlying molecular mechanisms remain largely unknown. One reason is due to the lack of suitable animal models. We aimed to generate a cardiomyocyte (CM)-specific senescent animal model, uncover the underlying mechanisms, and develop new therapies for aging associated cardiac dysfunction. Methods: The gain/loss of circHIPK3 approach was used to explore the role of circHIPK3 in cardiomyocyte (CM) senescence...
2022: Theranostics
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