Yongxia Zhang
BACKGROUND: Chronic heart failure (CHF) is regarded as common clinical heart disease. This study aims to investigate the clinical diagnostic value of echocardiography (Echo) and serum C-reactive protein (CRP) levels in patients with CHF. METHODS: A total of 75 patients with CHF (42 males, 33 females, age 62.72 ± 1.06 years) were enrolled as study subjects, with 70 non-CHF subjects (38 males, 32 females, age 62.44 ± 1.28 years) as controls...
March 25, 2023: Journal of Cardiothoracic Surgery
Hiroaki Io, Masahiro Muto, Yu Sasaki, Masanori Ishizaka, Toshiki Kano, Haruna Fukuzaki, Takuya Maeda, Yuki Shimizu, Junichiro Nakata, Yusuke Suzuki
BACKGROUND: Anemia in patients with chronic kidney disease (p-CKDs) may initiate or exacerbate left ventricular hypertrophy (LVH). This study aimed to determine whether treatment using long-acting erythropoietin-stimulating agents (L-ESAs) is independently associated with LVH during the pre-dialysis to maintenance dialysis period in p-CKDs. METHODS: Physical and laboratory examinations were performed 120 days before initiating dialysis in p-CKDs (baseline)...
March 25, 2023: BMC Nephrology
Andrea Sonaglioni, Antonella Caminati, Margherita Re, Davide Elia, Roberta Trevisan, Alberto Granato, Maurizio Zompatori, Michele Lombardo, Sergio Harari
During the last decade, the CHA2 DS2 -VASc score has been used for stratifying the mortality risk in both atrial fibrillation (AF) and non-AF patients. However, no previous study considered this score as a prognostic indicator in non-AF patients with mild-to-moderate idiopathic pulmonary fibrosis (IPF). All consecutive non-AF patients with mild-to-moderate IPF, diagnosed between January 2016 and December 2018 at our Institution, entered this study. All patients underwent physical examination, blood tests, spirometry, high-resolution computed tomography and transthoracic echocardiography...
March 25, 2023: Internal and Emergency Medicine
Valentin Femenia, Victor Pommier, Helena Huguet, Xavier Iriart, Marie-Christine Picot, Charlene Bredy, Laura Lorca, Gregoire De La Villeon, Sophie Guillaumont, Jean-Luc Pasquie, Stefan Matecki, François Roubertie, Bertrand Leobon, Jean-Benoît Thambo, Zakaria Jalal, Julie Thomas, Jean-Baptiste Mouton, Martina Avesani, Pascal Amedro
BACKGROUND: The prognosis of patients with a functional single ventricle has improved, with better cardiopulmonary fitness, health-related quality of life and survival. Conventional echocardiography remains the first-line technique in single ventricle follow-up. Three-dimensional (3D) echocardiography has shown recent value in congenital cardiology, but its ability to predict functional status in patients with a single ventricle remains unknown. AIM: To evaluate, in patients with a single ventricle, the association between 3D echocardiography variables and functional status determined by cardiopulmonary fitness...
March 9, 2023: Archives of Cardiovascular Diseases
Katharina Hüfner, Piotr Tymoszuk, Sabina Sahanic, Anna Luger, Anna Boehm, Alex Pizzini, Christoph Schwabl, Sabine Koppelstätter, Katharina Kurz, Malte Asshoff, Birgit Mosheimer-Feistritzer, Bernhard Pfeifer, Verena Rass, Andrea Schroll, Sarah Iglseder, Alexander Egger, Ewald Wöll, Günter Weiss, Raimund Helbok, Gerlig Widmann, Thomas Sonnweber, Ivan Tancevski, Barbara Sperner-Unterweger, Judith Löffler-Ragg
OBJECTIVE: Subjective illness perception (IP) can differ from physician's clinical assessment results. Herein, we explored patient's IP during coronavirus disease 2019 (COVID-19) recovery. METHODS: Participants of the prospective observation CovILD study ( NCT04416100) with persistent somatic symptoms or cardiopulmonary findings one year after COVID-19 were analyzed (n = 74). Explanatory variables included demographic and comorbidity, COVID-19 course and one-year follow-up data of persistent somatic symptoms, physical performance, lung function testing, chest computed tomography and trans-thoracic echocardiography...
March 17, 2023: Journal of Psychosomatic Research
Sotiria Liori, Eleftherios Samiotis, Dionysia Birba, Pelagia Katsimbri, Maria Mademli, Eleni Bakola, Georgios Tsivgoulis, Estela Quris, Michael Bonios, Maria Kalabaliki, Dimitrios Farmakis, John Parissis, Alexandra Frogoudaki
We present a case of a 47-year-old woman with a history of asthma and mononeuritis who presented with shortness of breath and fatigue. Heart failure was diagnosed and echocardiography revealed large floating thrombi attached to the left ventricular walls. Cardiac magnetic resonance imaging showed evidence of myocarditis and angiitis. Blood count revealed eosinophilia. She was diagnosed with eosinophilic granulomatosis with polyangiitis or Churg-Strauss syndrome (CSS) according to recently updated criteria. Medical management with specific aetiology (anticoagulation or immunosuppression) and heart failure treatment resulted in clinical improvement...
March 25, 2023: ESC Heart Failure
Adrian Espejel-Guzman, Aldo Cabello-Ganem, Jose C Armendariz-Ferrari, Javier Serrano-Roman, Alexis D Aparicio-Ortiz, Nilda Espinola-Zavaleta
Atrial fibrillation (AF) is the most common cardiac arrhythmia. However, the relation between congenital heart defects and the predisposition to AF is not fully understood. A 65-year-old male was admitted into the emergency department due to progressive dyspnea, orthopnea, palpitations, and edema. Transthoracic echocardiogram showed bi-atrial enlargement and dysplasia of the mitral leaflets with severe mitral regurgitation. Also, a membrane was noted in the LA, dividing the chamber into two parts, suggestive of cor triatriatum sinister...
March 25, 2023: Echocardiography
Zilong Xiao, Ziqing Yu, Chaofeng Chen, Ruizhen Chen, Yangang Su
BACKGROUND: The severe unfavorable effects of doxorubicin on the heart restrict its clinical usage. Numerous investigations document that cyclic GMP-AMP synthase (cGAS) activator of interferon genes (STING) cascade influences inflammation along with the immune response in a variety of diseases. The pathophysiological function of the cGAS-STING cascade in Doxorubicin-induced cardiomyopathy (DIC) is, nevertheless, unknown. METHODS: In vivo, cardiotoxicity was triggered by a single dose of intra-peritoneal inoculation of doxorubicin (15 mg/kg) in wild-type C57BL/6J mice and STING knockdown animals...
March 24, 2023: BMC Pharmacology & Toxicology
Ahmet Kurtoğlu, Ertuğrul Kurtoğlu, Nurettin Konar, Bekir Çar, Özgür Eken, Pablo Prieto-González, Hadi Nobari
BACKGROUND: The purpose of this study is to compare the echocardiographic (ECHO) parameters of amputee football players (AF) with those of athletes without a disability (football players) (FP), and sedentary individuals (SI). METHODS: A total of 37 male participants (nAF = 12, nFP = 12, nSI = 13) were included in the study. All participants underwent a transthoracic echocardiographic examination. Aortic diameter in systole (ADs), aortic diameter in diastole (ADd), isovolumic contraction time (IVCT), isovolumic relaxation time (IVRT), left ventricular ejection fraction (LVEF), early (E) and late (A) wave velocities, myocardial systolic (S), early diastolic (E'), and late diastolic (A') myocardial rates, interventricular septal thickness (IVS), left ventricular end-diastolic diameter (LVDd) and left ventricular end-systole diameter (LVDs), left ventricular posterior wall thickness (LVPWd), left atrial diameter (LAD), and ascending aortic diameter (AAD) were measured...
March 24, 2023: BMC Sports Science, Medicine and Rehabilitation
Georgios A Christou, Christina E Andriopoulou, Alexandra Liakopoulou, Eirini Tsape, Efstratios Apostolakis, Alexandros D Tselepis, Maria Konstandi, Gema Frühbeck, Dimitrios N Kiortsis
PURPOSE: Adipokines produced by adipose tissue have been found to be involved in the pathophysiology of metabolic and cardiovascular diseases. We aimed to investigate the relationships of resistin, retinol-binding protein 4 (RBP4) and adiponectin produced by epicardial adipose tissue with coronary artery disease (CAD) and cardiac structure and function. METHODS: Forty-one non-diabetic males scheduled for cardiothoracic surgery were examined. Anthropometric measurements, echocardiography, coronary angiography, and blood analysis were performed preoperatively...
March 24, 2023: Hormones: International Journal of Endocrinology and Metabolism
Anne Herefoss Davidsen, Stian Andersen, Peder Andreas Halvorsen, Henrik Schirmer, Eirik Reierth, Hasse Melbye
OBJECTIVE: The objective of this study was to determine the diagnostic accuracy in detecting valvular heart disease (VHD) by heart auscultation, performed by medical doctors. DESIGN/METHODS: A systematic literature search for diagnostic studies comparing heart auscultation to echocardiography or angiography, to evaluate VHD in adults, was performed in MEDLINE (1947-November 2021) and EMBASE (1947-November 2021). Two reviewers screened all references by title and abstract, to select studies to be included...
March 24, 2023: BMJ Open
Shohei Fujii, Shigeki Kobayashi, Yaowei Chang, Junya Nawata, Ryosuke Yoshitomi, Shinji Tanaka, Michiaki Kohno, Yoshihide Nakamura, Hironori Ishiguchi, Takeshi Suetomi, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Takayuki Okamura, Takeshi Yamamoto, Masafumi Yano
BACKGROUND: Dantrolene binds to the Leu601 -Cys620 region of the N-terminal domain of cardiac ryanodine receptor (RyR2), which corresponds to the Leu590 -Cys609 region of the skeletal ryanodine receptor, and suppresses diastolic Ca2+ leakage through RyR2. OBJECTIVE: We investigated whether the chronic administration of dantrolene prevented left ventricular (LV) remodeling and ventricular tachycardia (VT) after myocardial infarction (MI) by the same mechanism with the mutation V3599K of RyR2, which indicated that the inhibition of diastolic Ca2+ leakage occurred by enhancing the binding affinity of calmodulin (CaM) to RyR2...
March 22, 2023: Journal of Molecular and Cellular Cardiology
Chisato Izumi, Rei Matsuyama, Miyoshi Asaoka, Kosuke Iwasaki, Tomomi Takeshima, Shannon Murphy, Lida Teng, Ataru Igarashi
BACKGROUND: Valvular heart disease (VHD) is one of the commonest causes of cardiovascular morbidity and mortality worldwide, with acquired VHD especially prevalent in countries with aging populations. The scope and pattern of disease are not well understood, as some patients are asymptomatic and available options for invasive treatment vary by affected valve. We sought to understand the burden of VHD in Japan including the distribution of patients by valve disease type and age, using administrative claims data from acute care hospitals...
March 22, 2023: Journal of Cardiology
Alessia Riccio, Camilla Mazzanti, Laura Vero, Teresa Vanessa Fiorentino, Elena Succurro, Sofia Miceli, Maria Perticone, Angela Sciacqua, Francesco Andreozzi, Chiara M A Cefalo, Giorgio Sesti
AIM: Decreased myocardial mechano-energetic efficiency (MEEi) is associated with NAFLD and poorer prognosis in liver cirrhosis. We aim to investigate the association between liver fibrosis severity and MEEi in individuals participating in the CATAnzaro MEtabolic RIsk factors (CATAMERI) study. METHODS: Myocardial MEEi, assessed by an echocardiography-derived measure, and fibrosis severity, estimated by the fibrosis-4 index (FIB-4), were evaluated in 2383 subjects with different degree of glucose tolerance...
March 22, 2023: Diabetes Research and Clinical Practice
Kosar Rahimi, Hamid Amoozgar, Soheila Zareifar, Mahdi Shahriari, Omid Reza Zekavat, Mehran Karimi, Gholamreza Fathpour, Fazl Saleh, Nader Shakibazad, Shayan Bordbar, Mohammadreza Bordbar
BACKGROUND: Cardiotoxicity is a major concern following doxorubicin (DOX) use in the treatment of malignancies. We aimed to investigate whether deferoxamine (DFO) can prevent acute cardiotoxicity in children with cancer who were treated with DOX as part of their chemotherapy. RESULTS: Sixty-two newly-diagnosed pediatric cancer patients aged 2-18 years with DOX as part of their treatment regimens were assigned to three groups: group 1 (no intervention, n = 21), group II (Deferoxamine (DFO) 10 times DOX dose, n = 20), and group III (DFO 50 mg/kg, n = 21)...
March 24, 2023: Egyptian Heart Journal: EHJ
Christine Meindl, Michael Paulus, Florian Poschenrieder, Okka W Hamer, Florian Zeman, Lars S Maier, Kurt Debl
PURPOSE: Data derived by cardiac magnetic resonance (CMR) feature tracking suggest that not only left ventricular but also left atrial function is impaired in patients with acute myocarditis. Therefore, we investigated the diagnostic value of speckle tracking echocardiography of the left ventricle and left atrium in patients with acute myocarditis and normal left ventricular ejection fraction (LVEF). METHODS AND RESULTS: 30 patients with acute myocarditis confirmed by CMR according to the Lake Louise criteria and 20 healthy controls were analyzed including global longitudinal strain (GLS) and left atrial (LA) strain parameters...
March 24, 2023: International Journal of Cardiovascular Imaging
Waldemar Elikowski, Dariusz Angerer, Natalia Fertała, Magdalena Zawodna-Marszałek, Weronika Greberska, Teresa Ganowicz-Kaatz, Marek Słomczyński
Takotsubo syndrome (TTS) has been reported in various clinical conditions. Coronary artery fistula (CAF) is diagnosed in 0.2- 0.4% of patients undergoing coronary angiography. Pathologic communication between coronary artery (e.g., left anterior de¬scending coronary artery - LAD) and cardiac chambers (e.g., left ventricle - LV) is cameral type of CAF which particularly predis¬pose to myocardial ischemia due to a steal syndrome. Eight cases of coexistent TTS and CAF have been reported so far; in 6 of them LAD cameral fistulas drained LV, in 2 others communications between coronary arteries and pulmonary artery were found...
2023: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
Sabina Sahanic, Piotr Tymoszuk, Anna K Luger, Katharina Hüfner, Anna Boehm, Alex Pizzini, Christoph Schwabl, Sabine Koppelstätter, Katharina Kurz, Malte Asshoff, Birgit Mosheimer-Feistritzer, Maximilian Coen, Bernhard Pfeifer, Verena Rass, Alexander Egger, Gregor Hörmann, Barbara Sperner-Unterweger, Raimund Helbok, Ewald Wöll, Günter Weiss, Gerlig Widmann, Ivan Tancevski, Thomas Sonnweber, Judith Löffler-Ragg
BACKGROUND: Recovery trajectories from coronavirus disease 2019 (COVID-19) call for longitudinal investigation. We aimed to characterise the kinetics and status of clinical, cardiopulmonary and mental health recovery up to 1 year following COVID-19. METHODS: Clinical evaluation, lung function testing (LFT), chest computed tomography (CT) and transthoracic echocardiography were conducted at 2, 3, 6 and 12 months after disease onset. Submaximal exercise capacity, mental health status and quality of life were assessed at 12 months...
March 2023: ERJ Open Research
Vicky A Cameron, Gregory T Jones, L John Horwood, Anna P Pilbrow, Julia Martin, Chris Frampton, Wendy T Ip, Richard W Troughton, Charlotte Greer, Jun Yang, Michael J Epton, Sarah L Harris, Brian A Darlow
BACKGROUND: Individuals born very low birthweight (VLBW) are at increased risk of impaired cardiovascular and respiratory function in adulthood. To identify markers to predict future risk for VLBW individuals, we analyzed DNA methylation at birth and at 28 years in the New Zealand (NZ) VLBW cohort (all infants born < 1500 g in NZ in 1986) compared with age-matched, normal birthweight controls. Associations between neonatal methylation and cardiac structure and function (echocardiography), vascular function and respiratory outcomes at age 28 years were documented...
March 23, 2023: Clinical Epigenetics
Takahiro Doi, Atunari Utusgi, Koki Kikuchi, Yoshio Kazuno, Satoshi Yuda
BACKGROUND: The number of patients with heart disease who can benefit from treatment is continuing to increase due to the widespread use of cardiac implantable devices. Accordingly, the number of cardiac device-related infective endocarditis (CDRIE) cases has been increasing year by year. We report a very rare experience of performing an autopsy on a patient who died of CDRIE at the site of MitraClip ® implantation, which has recently been developed as a treatment option for severe mitral regurgitation...
March 24, 2023: BMC Cardiovascular Disorders
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