Roshni C Mansfield, Nandita Kaza, Anna Charalambous, Andrew C Milne, Sundar Sathiyamurthy, Jayanta Banerjee
OBJECTIVE: To systematically review and meta-analyze the validity of electrical bioimpedance-based noninvasive cardiac output monitoring in pediatrics compared with standard methods such as thermodilution and echocardiography. DATA SOURCES: Systematic searches were conducted in MEDLINE and EMBASE (2000-2019). STUDY SELECTION: Method-comparison studies of transthoracic electrical velocimetry or whole body electrical bioimpedance versus standard cardiac output monitoring methods in children (0-18 yr old) were included...
July 29, 2021: Critical Care Medicine
Liang Tang, Kevin M Harris, Ross Garberich, Mario Gössl, Joao L Cavalcante, Steven M Bradley, Aisha Ahmed, John R Lesser, Richard Bae, Benjamin Sun, Karol Mudy, Paul Sorajja
Current guidelines empirically recommend serial clinical evaluations for asymptomatic patients with severe mitral regurgitation (MR). However, there is a paucity of data on the effectiveness of such monitoring. This study sought to examine the potential benefit of guideline adherence among asymptomatic patients with severe primary MR. Asymptomatic patients with severe primary MR who had been evaluated in the Allina Health system between January 1, 2012 and May 30, 2018 were examined. The medical records were manually reviewed for demographics, comorbidities, echocardiographic data, subsequent interventions, and clinical outcomes...
July 26, 2021: American Journal of Cardiology
Jamie K Harrington, Alessandra M Ferraro, Steven D Colan, Lynn A Sleeper, Minmin Lu, Adi Adar, Andrew J Powell, Philip T Levy, David M Harrild
BACKGROUND: Strain rate (SR) parameters derived from two-dimensional speckle-tracking echocardiography (2DSTE) have prognostic value in children with heart disease. Routine use is hindered by a lack of normative data. Our aim was to determine reference values and Z-scores for left ventricular systolic and diastolic SR in a large cohort of healthy children. METHODS: Echocardiograms from 577 subjects <18 years of age (mean age 9.6 ± 5.6 years, range, 1 day to 18...
July 26, 2021: Journal of the American Society of Echocardiography
Kamilla P Bjerre, Tor S Clemmensen, Steen H Poulsen, Anne-Mette Hvas, Brian B Løgstrup, Erik L Grove, Frederik Flyvholm, Steen D Kristensen, Hans Eiskjær
BACKGROUND: After heart transplantation (HTx), invasive coronary angiography is gold standard for surveillance of cardiac allograft vasculopathy (CAV). Non-invasive CAV surveillance is desirable. PURPOSE: We examined left ventricular global longitudinal strain (LVGLS) and non-invasive coronary flow velocity reserve (CFVR) related to CAV and prognosis after heart transplantation (HTx). METHODS: Echocardiographic Doppler coronary flow velocity reserve (CFVR) and left ventricular global longitudinal strain (LVGLS) were evaluated in 98 HTx patients...
July 26, 2021: Journal of the American Society of Echocardiography
Daniela Melichova, Thuy M Nguyen, Ivar M Salte, Lars Gunnar Klaeboe, Benthe Sjøli, Sigve Karlsen, Thomas Dahlslett, Ida S Leren, Thor Edvardsen, Harald Brunvand, Kristina H Haugaa
BACKGROUND: Recent evidence suggests that an implantable cardioverter defibrillator (ICD) in non-ischemic cardiomyopathy (NICM) may not offer mortality benefit. We aimed to investigate if etiology of heart failure and strain echocardiography can improve risk stratification of life threatening ventricular arrhythmia (VA) in heart failure patients. METHODS: This prospective multi-center follow-up study consecutively included NICM and ischemic cardiomyopathy (ICM) patients with left ventricular ejection fraction (LVEF) <40%...
July 26, 2021: International Journal of Cardiology
Baoyin Zhao, Rihab Bouchareb, Djamel Lebeche
AIMS: Increased Resistin (Retn) levels are associated with development of cardiovascular diseases. However, the role of Retn in heart failure (HF) is still unclear. Here we probed the functional and molecular mechanism underlying the beneficial effect of Retn deletion in HF. METHODS AND RESULTS: Wildtype (WT) and adipose tissue-specific Retn-knockout (RKO) mice were subjected to transverse aortic constriction (TAC) induced HF. Cardiac function and hemodynamic changes were measured by echocardiography and left ventricular catheterization...
July 29, 2021: Cardiovascular Research
Felix Sebastian Nettersheim, Julian Lemties, Simon Braumann, Simon Geißen, Senai Bokredenghel, Richard Nies, Alexander Hof, Holger Winkels, Bruce A Freeman, Anna Klinke, Volker Rudolph, Stephan Baldus, Dennis Mehrkens, Martin Mollenhauer, Matti Adam
AIMS: Marfan syndrome (MFS) is a connective tissue disorder caused by mutations in the Fibrillin-1 gene. It is associated with formation of thoracic aortic aneurysms that can potentially be a life-threatening condition due to aortic rupture or dissection. Excessive non-canonical transforming growth factor beta signalling, mediated by activation of extracellular-signal regulated kinases 1/2 (ERK1/2), as well as inducible nitric oxide synthase (NOS2)-dependent nitric oxide production have been identified to drive aortic pathology in MFS through induction of elastin fragmentation and smooth muscle cell apoptosis...
July 29, 2021: Cardiovascular Research
S Purra, A A Lone, M H Bhat, R A Misgar, A I Wani, M I Bashir, S R Masoodi, W Purra
PURPOSE: Studies on cardiac structural and functional abnormalities in primary hyperparathyroidism (PHPT) have yielded conflicting and inconsistent results. In this prospective case-control study, we sought to compare cardiac structure and function in symptomatic PHPT patients and controls. METHODS: One hundred consecutive symptomatic PHPT patients and 113 matched controls underwent echocardiographic evaluation by the same operator. RESULTS: Left ventricular mass index (LVMI) was significantly higher in patients as compared to controls, (median of 90...
July 29, 2021: Journal of Endocrinological Investigation
Jan-Per Wenzel, Elina Petersen, Julius Nikorowitsch, Juliana Senftinger, Christoph Sinning, Matthias Theissen, Johannes Petersen, Hermann Reichenspurner, Evaldas Girdauskas
Here we generate up-to-date reference values of transthoracic echocardiographic aortic root dimensions matched by sex, age, and body surface area (BSA) derived from the population-based Hamburg City Health Study (HCHS) cohort. In 1687 healthy subjects (mean age 57.1 ± 7.7, 681 male and 1006 female), derived from the first prospectively-recruited 10,000 HCHS participants, dimensions of the aortic root were measured in systole and diastole using state-of-the-art 2-dimensional transthoracic echocardiography...
July 29, 2021: International Journal of Cardiovascular Imaging
M L Boutet, G Casals, B Valenzuela-Alcaraz, L García-Otero, F Crovetto, M S Cívico, A Borrás, D Manau, E Gratacós, F Crispi
STUDY QUESTION: Do fetuses from frozen embryo transfer (FET) present signs of cardiac remodeling and suboptimal function similar to those observed in fetuses from fresh embryo transfer (ET)? SUMMARY ANSWER: Fetuses from both fresh ET and FET present signs of fetal cardiac remodeling and suboptimal function, with more pronounced changes after fresh ET as compared to FET. WHAT IS KNOWN ALREADY: Our group and others have previously demonstrated that fetuses and children conceived by ARTs present cardiac remodeling and suboptimal function...
July 27, 2021: Human Reproduction
Cullen Soares, Pinar Arikan, Michael Gilson
A 79-year-old male with a history of ESRD and treated MRSA endocarditis was found to have a recurrence of MRSA bacteremia. He was treated with antibiotics. During his hospitalization, he suddenly developed complete heart block requiring transcutaneous pacing, and subsequently transvenous pacing wires were placed. Transesophageal echocardiography demonstrated pseudo- aneurysm of the mitral-aortic intervalvular fibrosa as well as aortic valve thickening, and a mitral vegetation. Cardiothoracic surgery was consulted to obtain source control, but the patient was deemed to be a poor surgical candidate...
August 2, 2021: Rhode Island Medical Journal
Céline Occelli, Gauthier Carrio, Morgan Driessens, Charlotte Turquay, Nicolas Azulay, Laura Grau-Mercier, Jacques Levraut, Pierre-Géraud Claret, Julie Contenti, Xavier Bobbia
PURPOSE: Point-of-care ultrasound using a pocket-ultrasound-device (PUD) is increasing in clinical medicine but the optimal way to teach focused cardiac ultrasound is not clear. We evaluated whether teaching using a PUD or a conventional-ultrasound-device (CUD) is different when the final exam was conducted on a PUD. The primary aim was to compare the weighted total quality scale (WTQS, out of 100) obtained by participants in the two groups (CUD and PUD) on a live volunteer 2-4 weeks after their initial training...
July 28, 2021: Journal of Clinical Ultrasound: JCU
Kenya Kusunose, Robert Zheng, Hirotsugu Yamada, Masataka Sata
Despite recent advances in imaging for myocardial deformation, left ventricular ejection fraction (LVEF) is still the most important index for systolic function in daily practice. Its role in multiple fields (e.g., valvular heart disease, myocardial infarction, cancer therapy-related cardiac dysfunction) has been a mainstay in guidelines. In addition, assessment of LVEF is vital to clinical decision-making in patients with heart failure. However, notable limitations to LVEF include poor inter-observer reproducibility dependent on observer skill, poor acoustic windows, and variations in measurement techniques...
July 28, 2021: Journal of Medical Ultrasonics
Karen Sliwa, Johann Bauersachs, Zolt Arany, Timothy F Spracklen, Denise Hilfiker-Kleiner
Peripartum cardiomyopathy (PPCM) is a disease that occurs globally in all ethnic groups and should be suspected in any peripartum women presenting with symptoms and signs of heart failure, towards the end of pregnancy or in the months following delivery, with confirmed left ventricular dysfunction. After good history taking, all women should be thoroughly assessed, and alternative causes should be excluded. Urgent cardiac investigations with electrocardiogram and natriuretic peptide measurement (if available) should be performed...
July 28, 2021: European Heart Journal
Mao Liu, Jiao Ai, Zhuang Shuai, Kai Tang, Zongyu Li, Yin Huang
Aim: Adropin (ADR) is a novel regulatory polypeptide and has important effects on energy metabolism in the heart. However, it is still unclear whether ADR can relieve ventricular remodeling in DCM. Therefore, this study was conducted to assess the effect of ADR on myocardial fibrosis in DCM rats. Materials and Methods: Twenty Wistar rats were randomly assigned into four groups: healthy control group (CON), DCM model group (DCM), DCM model treated with ADR group (ADR) and DCM model treated with perindopril group (PER)...
2021: Frontiers in Cardiovascular Medicine
Yujiao Deng, Xin Huang, Guangyi Wang, Jian Cao, Shengshu Wang, Yue Li, Yiru Wang, Jing Ye, Peifang Zhang, Xiaotian Chen, Yukun Luo, Kunlun He
Objective: To explore the preferred test to screen for pulmonary arteriovenous malformations (PAVMs) and to predict the probability of interventional embolization. Methods: We performed a retrospective observational study evaluating patients with idiopathic PAVMs from 2009 to 2019. After clinical evaluation, a total of 105 patients were studied, including 71 patients with positive digital subtraction pulmonary angiography (DSPA) findings and 34 with negative DSPA findings. The following patient data were assessed: blood test, chest radiograph, transthoracic contrast echocardiography (TTCE), and DSPA findings...
2021: Frontiers in Cardiovascular Medicine
Daniel J Kersten, Kyla D'Angelo, Juana Vargas, Gagan Verma, Uzma Malik, Schlomo Shavolian, Roman Zeltser, Ofek Hai, Amgad N Makaryus
BACKGROUND: Computerized electrocardiogram (EKG) interpretation technology was developed in the mid-20th century, but its use continues to be controversial. This study aims to determine clinical factors which indicate greater odds of clinical significance of an abnormal computerized EKG interpretation. METHODS: The inclusion criteria for this retrospective study were patients who underwent outpatient echocardiography for the indication of an abnormal EKG and had an EKG abnormality diagnosed by the computerized EKG system...
2021: American Journal of Cardiovascular Disease
Giampiero Vizzari, Fausto Pizzino, Dianne Zwicke, A Jamil Tajik, Scipione Carerj, Gianluca Di Bella, Antonio Micari, Bijoy K Khandheria, Concetta Zito
Patent foramen ovale (PFO) is present in about one-quarter of the population and should be considered an anatomical variant rather than a malformation. The association of PFO with cryptogenic stroke, migraine, peripheral embolism and other pathologies is still controversial. The evaluation of anatomical complexity, and particularly the long-tunnel morphology, is crucial for the assessment of the risk profile and for a targeted therapeutic management. Long-tunnel PFOs seem to be more prone to clot formation and complications related to percutaneous closure procedures...
2021: American Journal of Cardiovascular Disease
Vera V Ferreira, Sílvia A Rosa, Tiago Pereira-da-Silva, Inês Rodrigues, António V Gonçalves, Tiago Mendonça, Alexandra Castelo, Luísa M Branco, Ana Galrinho, António Fiarresga, Ruben Ramos, Lino Patrício, Duarte Cacela, Rui C Ferreira
INTRODUCTION: Prolonged afterload increase in aortic stenosis (AS) may alter left ventricular (LV) contractility, irrespective of LV ejection fraction (LVEF). The prevalence and morbimortality associated with the apical sparing strain pattern (ASP), a typical finding of cardiac amyloidosis (CA), are not fully understood in patients with AS. We assessed the prevalence of the ASP in patients with severe AS and its clinical impact after transcatheter aortic valve implantation (TAVI). METHODS: Eighty-nine consecutive patients with severe AS and LV hypertrophy referred for TAVI were included...
2021: American Journal of Cardiovascular Disease
Petra Merkely, Marcell Bakos, Bálint Bányai, Anna Monori-Kiss, Eszter M Horváth, Judit Bognár, Rita Benkő, Attila Oláh, Tamás Radovits, Béla Merkely, Nándor Ács, György L Nádasy, Marianna Török, Szabolcs Várbíró
Background: The cardiovascular effects of training have been widely investigated; however, few studies have addressed sex differences in arteriolar adaptation. In the current study, we examined the adaptation of the gracilis arterioles of male and female rats in response to intensive training. Methods: Wistar rats were divided into four groups: male exercise (ME) and female exercise (FE) animals that underwent a 12-week intensive swim-training program (5 days/week, 200 min/day); and male control (MC) and female control (FC) animals that were placed in water for 5 min daily...
2021: Frontiers in Physiology
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