Wei-Pang Chung, Hsin-Lun Yang, Ya-Ting Hsu, Ching-Hsia Hung, Ping-Yen Liu, Yen-Wen Liu, Shih-Hung Chan, Kun-Ling Tsai
BACKGROUND: Previous studies have reported that chemotherapy results in substantial long-term risk of heart failure. Exercise ameliorates exercise responses and exercise tolerance in patients receiving chemotherapy. The cardioprotective effect of real-time exercise in breast cancer is still unclear. OBJECTIVES: The aim of the present study was to determine the effect of real-time moderate-to-high-intensity exercise training in women with breast cancer undergoing chemotherapy and to follow up on parameters of cardiac function and exercise capacity at different times...
January 13, 2021: Annals of Physical and Rehabilitation Medicine
Alan C Kwan, Gerran Salto, Susan Cheng
No abstract text is available yet for this article.
January 13, 2021: Journal of the American Society of Echocardiography
Francesco Melillo, Andrea Fisicaro, Stefano Stella, Francesco Ancona, Cristina Capogrosso, Giacomo Ingallina, Davive Maccagni, Vittorio Romano, Stefania Ruggeri, Cosmo Godino, Azeem Latib, Matteo Montorfano, Antonio Colombo, Eustachio Agricola
BACKGROUND: Whether fluoroscopic-echocardiographic fusion imaging (FI) might represent an added value for intraprocedural guidance during transcatheter edge-to-edge mitral valve repair (TMVr) is yet unknown and few data exist regarding safety and feasibility of the novel technology. METHODS: The aim of this single-centre study was to test and validate a FI protocol for intraprocedural monitoring of TMVr and assess its clinical usefulness. Eighty patients underwent MitraClip procedure using FI guidance (FI+) for either degenerative (DMR) (35%) or functional (FMR) (65%) mitral regurgitation and were compared to the last 80 patients before FI introduction treated with conventional echo and fluoroscopic monitoring (FI-)...
January 13, 2021: Journal of the American Society of Echocardiography
Zahra Hoodbhoy, Nuruddin Mohammed, Shafquat Rozi, Nadeem Aslam, Shazia Mohsin, Salima Ashiqali, Hina Ali, Saima Sattar, Devyani Chowdhury, Babar Sultan Hasan
OBJECTIVE: Keeping in view the Developmental Origin of Health and Disease hypothesis, this study aimed to assess differences in cardiac and vascular structure and function in children exposed to preeclampsia in-utero as compared to those of normotensive mothers. We hypothesized that children exposed to preeclampsia had altered cardiac and vascular structure and function as compared to the unexposed group. METHODS: This was a retrospective cohort study which included children between 2-10 years of age born to mothers with and without exposure to preeclampsia in-utero (n= 80 in each group)...
January 13, 2021: Journal of the American Society of Echocardiography
M Bannehr, U Kahn, J Liebchen, M Okamoto, V Hähnel, C Georgi, V Dworok, C Edlinger, M Lichtenauer, T Kücken, S Kropf, A Haase-Fielitz, C Butter
BACKGROUND: Functional tricuspid regurgitation (TR) is a frequent finding in echocardiography. Despite general consent that right ventricular (RV) dysfunction impacts the outcome of patients with TR, it is still unknown which echocardiographic parameters most accurately reflect prognosis. This study aimed to evaluate the prevalence of RV dysfunction and its prognostic value in patients with TR. METHODS: Data from 1,089 consecutive patients were analyzed. Tricuspid annular plane systolic excursion (TAPSE), fractional area change and right ventricular free wall longitudinal strain (RV strain) were used to define RV dysfunction...
January 13, 2021: Canadian Journal of Cardiology
Angela Chen, Rajesh Punn, R Thomas Collins, Jonathan H Chen, Katie Jo Stauffer, Rena Wang, Samantha Alexander, Kirstie MacMillen Lechich, Daniel Jerome Murphy, Sukyung Chung, Elif Seda Selamet Tierney
OBJECTIVE: To test feasibility of tele-clinic visits using parentally-acquired vital signs and focused echocardiographic (echo) images in patients with Marfan syndrome. STUDY DESIGN: We included patients with MFS 5-19 years old followed in our clinic. We excluded patients with MFS and history of prior aortic root (AoR) surgery, cardiomyopathy, arrhythmia, or AoR≥4.5 cm. We trained parents in-person to acquire focused echo images on their children using a hand-held device as well as how to use a stadiometer, scale, blood pressure (BP) machine, and a digital stethoscope...
January 13, 2021: Journal of Pediatrics
George S Yankey, Larry R Jackson, Colin Marts, Karen Chiswell, Angie Wu, Francis Ugowe, Jimica Wilson, Sreekanth Vemulapalli, Zainab Samad, Kevin L Thomas
BACKGROUND: Among patients with severe aortic stenosis (AS), there are limited data on aortic valve replacement (AVR), reasons for non-receipt and mortality by race. METHODS: Utilizing the Duke Echocardiography Laboratory Database, we analyzed data from 110,711 patients who underwent echocardiography at Duke University Medical Center between 1999-2013. We identified 1,111 patients with severe AS who met ≥1 of 3 criteria for AVR: ejection fraction ≤50%, diagnosis of heart failure, or need for coronary artery bypass surgery...
January 13, 2021: American Heart Journal
Amam C Mbakwem, Johann Bauersachs, Charle Viljoen, Julian Hoevelmann, Peter van der Meer, Mark C Petrie, Alexandre Mebazaa, Sorel Goland, Kamilu Karaye, Cécile Laroche, Karen Sliwa
AIMS: In peripartum cardiomyopathy (PPCM), electrocardiography (ECG) and its relationship to echocardiography have not yet been investigated in large multi-centre and multi-ethnic studies. We aimed to identify ECG abnormalities associated with PPCM, including regional and ethnic differences, and their correlation with echocardiographic features. METHODS AND RESULTS: We studied 411 patients from the EURObservational PPCM registry. Baseline demographic, clinical, and echocardiographic data were collected...
January 16, 2021: ESC Heart Failure
Dimitrios Asvestas, Theodoros Xenos, Christina Goga, Stylianos Tzeis
No abstract text is available yet for this article.
January 16, 2021: Journal of Echocardiography
Scott E Janus, Brian D Hoit
When pericardial fluid accumulates and exceed the reserve volume of the pericardium or when the pericardium becomes scarred and inelastic, one of three pericardial compressive syndromes may ensue, namely, cardiac tamponade (CT), characterised by the accumulation of pericardial fluid under pressure; constrictive pericarditis (CP), the result of scarring and loss of the normal elasticity of the pericardial sac; and effusive-constrictive pericarditis (ECP), characterised by the concurrence of a tense pericardial effusion and constriction of the heart by the visceral pericardium...
January 15, 2021: Heart
Tjitske E Zandstra, Marieke Nederend, Monique R M Jongbloed, Philippine Kiès, Hubert W Vliegen, Berto J Bouma, Laurens F Tops, Martin J Schalij, Anastasia D Egorova
OBJECTIVE: Pharmacological options for patients with a failing systemic right ventricle (RV) in the context of transposition of the great arteries (TGA) after atrial switch or congenitally corrected TGA (ccTGA) are not well defined. This study aims to investigate the feasibility and effects of sacubitril/valsartan treatment in a single-centre cohort of patients. METHODS: Data on all consecutive adult patients (n=20, mean age 46 years, 50% women) with a failing systemic RV in a biventricular circulation treated with sacubitril/valsartan in our centre are reported...
January 15, 2021: Heart
Milad Baniaamam, Alexandre E Voskuyl, Michael T Nurmohamed, M Louis Handoko
We present a 51-year-old Caucasian woman, with a medical history of systemic lupus erythematosus (SLE) who had dyspnoea at exertion. The SLE was clinically quiescent but serologically active. Echocardiography showed preserved left ventricular (LV) systolic function, pseudonormal mitral inflow pattern (diastolic dysfunction grade III), absence of wall motion abnormalities and elevated E/e' at exercise. An exercise right heart catheterisation was performed, confirming the diagnosis of heart failure with preserved ejection fraction (HFpEF)...
January 15, 2021: BMJ Case Reports
Mickaël Bobot, Laurent Zieleskiewicz, Noémie Jourde-Chiche, Clarissa Von Kotze, Manon Ebersolt, Bertrand Dussol, Marion Sallée, Sophie Chopinet, Yvon Berland, Philippe Brunet, Thomas Robert
INTRODUCTION: There is no feasible benchmark in daily routine to estimate the hydration status of haemodialysis patients, which is essential to their management. OBJECTIVE: We performed a study in haemodialysis patients to assess the diagnostic performance of pulmonary ultrasound and clinical examination for the evaluation of fluid overload using transthoracic echocardiography as a gold standard. METHODS: Thirty-one patients receiving chronic haemodialysis patients were included...
January 12, 2021: Néphrologie & Thérapeutique
Han-Xiao Zhang, Cheng-Shun Zhang, Rui-Zhen Huang, Xin Cao, Xiao-Qin Dai, Chuan-Yi Zuo, Peng Lv, Li-Juan Zhu, Shu-Guang Yu
Manganese chloride (MnCl2 ) has been shown to inhibit the Yes-associated protein (YAP) in high-fat diet-fed ApoE-/- mice. Although YAP has been implicated in atherogenesis, there are limited data on the effects of MnCl2 on cardiac remodeling. In this study, we discovered, by electrocardiography, that hyperlipidemia led to spontaneous supraventricular arrhythmia (SVA) in ApoE-/- (KO) mice, with 3 of 9 KO + MnCl2 mice (33%) exhibiting lower incidence of spontaneous SVA than KO mice (6 of 10 mice, 60%). Echocardiography revealed that reduced systolic function in KO mice was reversed by MnCl2 treatment...
February 2021: Journal of Pharmacological Sciences
Birte Weber, Ina Lackner, Florian Gebhard, Theodore Miclau, Miriam Kalbitz
Trauma remains a leading global cause of mortality, particularly in the young population. In the United States, approximately 30,000 patients with blunt cardiac trauma were recorded annually. Cardiac damage is a predictor for poor outcome after multiple trauma, with a poor prognosis and prolonged in-hospitalization. Systemic elevation of cardiac troponins was correlated with survival, injury severity score, and catecholamine consumption of patients after multiple trauma. The clinical features of the so-called "commotio cordis" are dysrhythmias, including ventricular fibrillation and sudden cardiac arrest as well as wall motion disorders...
January 13, 2021: International Journal of Molecular Sciences
Aleksandra Paterek, Barbara Sochanowicz, Marta Oknińska, Witold Śmigielski, Marcin Kruszewski, Urszula Mackiewicz, Michał Mączewski, Przemysław Leszek
BACKGROUND: Exacerbations of chronic heart failure (CHF) are often treated with catecholamines to provide short term inotropic support, but this strategy is associated with long-term detrimental hemodynamic effects and increased ventricular arrhythmias (VA), possibly related to increased heart rate (HR). We hypothesized that ivabradine may prevent adverse effects of short-term dopamine treatment in CHF. METHODS: Rats with post-myocardial infarction CHF received 2-week infusion of saline, dopamine(D), ivabradine(I) or D&I; cardiac function was assessed using echocardiography and pressure-volume loops while VA were assessed using telemetric ECG recording...
January 12, 2021: Biomedicine & Pharmacotherapy
Abhishek Makkar, Jennifer Milsten, Mike McCoy, Edgardo G Szyld, Maria C Lapadula, Abhrajit Ganguly, Lise A DeShea, Umakumaran Ponniah
Introduction: The nationwide shortage of pediatric cardiologists in medically underserved areas poses a challenge to congenital heart disease (CHD) screening requiring echocardiography, resulting in transfer of neonates to regional Level III/IV Neonatal Intensive Care Units (NICUs). This study aimed to evaluate the accuracy, safety, and cost-effectiveness of tele-echocardiography for advanced CHD screening at a Level II NICU managed by a hybrid telemedicine system. Methods: Retrospective chart review of infants requiring tele-echocardiography at a Level II NICU...
January 15, 2021: Telemedicine Journal and E-health
Covadonga Fernández-Golfín, Rocío Hinojar-Baydes, Ariana González-Gómez, Juan Manuel Monteagudo, Amparo Esteban, Gonzalo Alonso-Salinas, Maria Angeles Fernández, Ana García-Martín, Ciro Santoro, Marina Pascual-Izco, Jose Julio Jiménez-Nacher, Jose Luis Zamorano
OBJECTIVE: Speckle-tracking echocardiography (STE) deformation parameters detect latent LV dysfunction in chronic aortic regurgitation (AR) and are associated with outcomes. The aim of the study was to evaluate cardiac magnetic resonance (CMR) feature tracking (FT) deformation parameters in asymptomatic patients with AR and implications in outcomes. METHODS: Fifty-five patients with AR and 54 controls were included. Conventional functional CMR parameters, aortic regurgitant volume, and fraction were assessed...
January 15, 2021: European Radiology
Jing Zheng, Manyun Long, Zhenbai Qin, Fen Wang, Zhiqing Chen, Lang Li
Cardiomyocyte apoptosis is a key factor in the deterioration of cardiac function after coronary microembolization (CME). Nicorandil (NIC) affects myocardial injury, which may be related to the inhibition of apoptosis. However, the specific mechanism of cardioprotection has not been elucidated. Therefore, we analyzed the impact of NIC on cardiac function in rats subjected to CME and its effect on the high-temperature requirement peptidase 2/X-linked inhibitor of apoptosis protein/poly ADP-ribose polymerase (HtrA2/XIAP/PARP) pathway...
February 2021: Pharmacology Research & Perspectives
Moniek Maarse, Lisette I S Wintgens, Andrey Ponomarenko, Karen P Phillips, Aleksandr B Romanov, Gabriel Ballesteros, Martin J Swaans, Richard J Folkeringa, Ignacio Garcia-Bolao, Lucas V A Boersma
INTRODUCTION: Current guidelines recommend adequate anticoagulation for at least 3 weeks pre- and 4 weeks post-DCCV to reduce thrombo-embolic risk in patients with atrial fibrillation (AF) lasting >48 hours. No specific recommendations exist for DCCV in patients that have undergone left atrial appendage occlusion (LAAO), many of whom are ineligible for anticoagulation. This study aims to observe the efficacy and safety of DCCV post-LAAO in everyday clinical practice. METHODS: This prospective multicenter registry included DCCVs in patients post-LAAO...
January 15, 2021: Journal of Cardiovascular Electrophysiology
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