Pieter Martens, Guido Claessen, Alexander Van De Bruaene, Frederik H Verbrugge, Lieven Herbots, Paul Dendale, Jan Verwerft
BACKGROUND: Iron deficiency (ID) is frequent and associated with diminished exercise capacity in heart failure (HF), but its contribution to unexplained dyspnea without a HF diagnosis at rest remains unclear. METHODS: Consecutive patients with unexplained dyspnea and normal echocardiography and pulmonary function tests at rest underwent prospective standardized cardiopulmonary exercise testing with echocardiography (CPETecho) in a tertiary care dyspnea clinic. ID was defined as ferritin <300µg/l and transferrin saturation (TSAT)<20% and its impact on peak oxygen uptake (peakVO2 ), biventricular response to exercise, and peripheral oxygen extraction was assessed...
April 7, 2021: Journal of Cardiac Failure
Marie-Eve Piché, Marie-Annick Clavel, Audrey Auclair, Marcela Rodríguez-Flores, Kim O'Connor, Patrick Garceau, Harry Rakowski, Paul Poirier
AIMS: We explored the early effects of bariatric surgery on subclinical myocardial function in individuals with severe obesity and preserved left ventricular (LV) ejection fraction. METHODS: Thirty-eight patients with severe obesity [body mass index (BMI) ≥35kg/m2 ] and preserved LV ejection fraction (≥ 50%) who underwent bariatric surgery (biliopancreatic diversion with duodenal switch [BPD-DS]) (Surgery group), 19 patients with severe obesity managed with usual care (Medical group), and 18 age and sex-matched non-obese controls (non-obese group) were included...
April 7, 2021: Metabolism: Clinical and Experimental
Marcio Scorsin, Martin Andreas, Silvia Corona, Andrada Camelia Guta, Patrizia Aruta, Luigi Paolo Badano
BACKGROUND: Current mitral bioprostheses are akin to the aortic valve and therefore abolish the left ventricular (LV) physiological vortex. We evaluated the hemodynamic performance and the effects on intraventricular flow dynamics (IFD) of a novel mitral bioprosthesis that presents an innovative design, mimicking the native valve. METHODS: A D-shaped self-expandable stent-bovine pericardium monoleaflet valve was designed to provide physiological asymmetric intraventricular flow...
April 7, 2021: Annals of Thoracic Surgery
James S Gammie, Paul A Grayburn, Rachael W Quinn, Judy Hung, Sari D Holmes
BACKGROUND: There is an established relationship between the degree of mitral regurgitation (MR) and prognosis. Quantitation of MR severity guides therapeutic approaches. Inconsistent definitions and categorization of MR severity in clinical studies limit meaningful comparisons between trials and compromise development of an effective evidence base. The purpose of this study was to quantify heterogeneity in grading systems for MR severity in the contemporary literature. METHODS: We performed a systematic review of randomized (RCT) and propensity score (PS) adjusted clinical studies of MV interventions (surgical or percutaneous)...
April 7, 2021: Annals of Thoracic Surgery
Turkan Seda Tan, Irem Muge Akbulut, Ayse Irem Demirtola, Nazli Turan Serifler, Nil Ozyuncu, Kerim Esenboga, Haci Ali Kurklu, Volkan Kozluca, Aydan Ongun, Demet Menekse Gerede Uludag, D Eralp Tutar, Irem Dincer
An elevated left ventricular (LV) filling pressure is the main finding in patients with heart failure with preserved ejection fraction (HFpEF), and LV filling pressure is estimated with an algorithm in the recent American Society of Echocardiography (ASE)/European Association of Cardiovascular Imaging (EACVI) guideline. In this study, we sought to determine the efficacy of LA global longitudinal strain to estimate elevated LV filling pressure. Seventy-one consecutive patients (mean age of 63.2  ±  9...
April 10, 2021: International Journal of Cardiovascular Imaging
Yukako Homma, Yasunobu Hayabuchi
No abstract text is available yet for this article.
April 9, 2021: Journal of Echocardiography
Harshita Narang, Bruno V Rego, Amir H Khalighi, Ahmed Aly, Alison M Pouch, Robert C Gorman, Joseph H Gorman Iii, Michael S Sacks
Ischemic mitral regurgitation (IMR) is a prevalent cardiac disease associated with substantial morbidity and mortality. Contemporary surgical treatments continue to have limited long-term success, in part due to the complex and multi-factorial nature of IMR. There is thus a need to better understand IMR etiology to guide optimal patient specific treatments. Herein, we applied our finite element-based shape-matching technique to non-invasively estimate peak systolic leaflet strains in human mitral valves (MVs) from in-vivo 3D echocardiographic images taken immediately prior to and post-annuloplasty repair...
April 9, 2021: Annals of Biomedical Engineering
Miguel Oyonarte Gómez, Cesar Del Castillo Gordillo, Manuel Rojas Romero, Kenyin Loo Urbina
Human bites are an infrequent cause of emergency department visits and hospital admissions. There are rarely published cases of complicated infection, such as infective endocarditis. We present a rare case of a patient with acute infective endocarditis in a healthy native valve and purulent pericarditis from a human bite. A 40-year-old man with obesity suffered deep human bites by an adult woman, with two deep lesions in the anterior thorax and one superficial lesion in the upper abdomen and admitted in intensive care unit with septic shock and a persistent aortic murmur...
April 9, 2021: BMJ Case Reports
Hemamalini Palani, Govini Balasubramani
OBJECTIVES: This study sought to determine the utility of donor left ventricular function assessment by echocardiographic left ventricular global longitudinal strain (LV GLS) in predicting primary graft failure (PGF) after orthotopic heart transplantation (HT). DESIGN: Retrospective, observational study. SETTING: Tertiary referral hospital. PARTICIPANTS: Adult patients (>18 years) who underwent isolated HT. INTERVENTIONS: Demographic, clinical, and echocardiographic data were collected on 100 patients who underwent HT between January 2010 and December 2019 at the authors' institution...
March 17, 2021: Journal of Cardiothoracic and Vascular Anesthesia
Orsolya Kiss, Mate Babity, Attila Kovacs, Judit Skopal, Hajnalka Vago, Balint Karoly Lakatos, Csaba Bognar, Reka Rakoczi, Mark Zamodics, Lorinc Frivaldszky, Anna Menyhart-Hetenyi, Zsofia Dohy, Csilla Czimbalmos, Liliana Szabo, Bela Merkely
The significance of cardiology screening of referees is not well established. Cardiovascular risk factors and diseases were examined in asymptomatic Hungarian elite handball referees undergoing extended screening: personal/family history, physical examination, 12-lead ECG, laboratory tests, body-composition analysis, echocardiography, and cardiopulmonary exercise testing. Holter-ECG (n = 8), blood pressure monitorization (n = 10), cardiac magnetic resonance imaging (CMR; n = 27) and computer tomography (CCT; n = 4) were also carried out if needed...
2021: PloS One
Fatemeh Taheri Dezaki, Christina Luong, Tom Ginsberg, Robert Rohling, Ken Gin, Purang Abolmaesumi, Teresa Tsang
In echocardiography (echo), an electrocardiogram (ECG) is conventionally used to temporally align different cardiac views for assessing critical measurements. However, in emergencies or point-of-care situations, acquiring an ECG is often not an option, hence motivating the need for alternative temporal synchronization methods. Here, we propose Echo-SyncNet, a self-supervised learning framework to synchronize various cross-sectional 2D echo series without any human supervision or external inputs. The proposed framework takes advantage of two types of supervisory signals derived from the input data: spatiotemporal patterns found between the frames of a single cine (intra-view self-supervision) and interdependencies between multiple cines (inter-view self-supervision)...
April 9, 2021: IEEE Transactions on Medical Imaging
Hilmi Alnsasra, Brian C Case, Michael Yang, Toby Rogers, Lowell F Satler, Federico M Asch, Ron Waksman, Preetham Kumar, Itsik Ben-Dor, Diego Medvedofsky
BACKGROUND: Pericardial effusion drainage in patients with significant pulmonary hypertension (PH) has been questioned because of hemodynamic collapse concern, mainly because of right ventricular (RV) function challenging assessment. We aimed to assess RV function changes related to pericardiocentesis in patients with and without PH. METHODS: Consecutive patients with symptomatic moderate-to-large pericardial effusion who had either echocardiographic or clinical signs of cardiac tamponade and who underwent pericardiocentesis from 2013 to 2018 were included...
April 9, 2021: Echocardiography
Munevver Sari, Zubeyde Bayram, Mehmet Ayturk, Emrah Bayam, Semih Kalkan, Ahmet Guner, Macit Kalcik, Mustafa Ozan Gursoy, Sabahattin Gunduz, Mehmet Ozkan
Three-dimensional transesophageal echocardiography (3D-TEE) provides detailed images of prosthetic valve thrombosis (PVT). However, data regarding PVT localization patterns based on 3D-TEE and their association with clinical findings among various bileaflet mitral prosthetic valve brands is lacking. The locations of thrombi were classified into 4 groups according to hinge and annulus involvement based on 3D-TEE: ring-like PVT involving entire mitral annulus (type-1), PVT involving peri-hinge(s) region and extends through some part of the annulus (type-2), PVT involving mitral annulus without involving hinge(s) region (type-3), and PVT involving only (peri)hinge(s) area (type-4)...
April 9, 2021: International Journal of Cardiovascular Imaging
Summit D Bloria, Nidhi B Panda, Kiran Jangra, Hemant Bhagat, Banashree Mandal, Ketan Kataria, Rajeev Chauhan, Ankur Luthra, Shiv Lal Soni, Narender Kaloria, Shalvi Mahajan, Shamik Kr Paul, Shailesh Gupta, Sanket Agrawal, Navneet Singla
BACKGROUND: Fluid imbalance is common after aneurysmal subarachnoid hemorrhage and negatively impacts clinical outcomes. We compared intraoperative goal-directed fluid therapy (GDFT) using left ventricular outflow tract velocity time integral (LVOT-VTI) measured by transesophageal echocardiography with central venous pressure (CVP)-guided fluid therapy during aneurysm clipping in aneurysmal subarachnoid hemorrhage patients. METHODS: Fifty adults scheduled for urgent craniotomy for aneurysm clipping were randomly allocated to 2 groups: group G (n=25) received GDFT guided by LVOT-VTI and group C (n=25) received CVP-guided fluid management...
April 8, 2021: Journal of Neurosurgical Anesthesiology
C C Lin, C H Lai, W S Lin, C S Lin
Chest pain complicated with electrocardiographic changes is not an uncommon scenario in emergency departments, which should be examined cautiously. We describe a 51-years-old man with a myocardial bridge of coronary artery presenting with simultaneous Mobitz type I atrioventricular block on electrocardiography. Echocardiography excluded valvular abnormality and systolic/diastolic dysfunction. Coronary angiography confirmed the diagnosis of a myocardial bridge at the middle segment of the left anterior descending artery, involving the most dominant septal perforator branch with marked systolic compression...
April 8, 2021: Journal of Postgraduate Medicine
Yuki Hayama, Hisayoshi Imanishi, Naoki Yoshimoto, Koji Sugawara, Daisuke Tsuruta
Dear Editor, Dapsone is a dual-function drug with antimicrobial and antiprotozoal effects and anti-inflammatory features (1). In dermatology, it is a first choice for conditions such as leprosy, IgA pemphigus, dermatitis herpetiformis, and linear IgA bullous dermatosis, or an adjunctive treatment for, e.g. bullous pemphigoid (BP) and pemphigus vulgaris (1). However, dapsone is associated with some adverse effects, including methemoglobinemia (1). Methemoglobin (MetHb) concentrations of less than 15% usually cause no symptoms in patients with normal hemoglobin concentrations (2)...
December 2020: Acta Dermatovenerologica Croatica: ADC
Hien Luong, Sarojini Singh, Mallikarjun Patil, Prasanna Krishnamurthy
Major depressive disorder (MDD) is an independent risk factor for cardiovascular disease (CVD) and its complications; however, causal mechanisms remain unclear. In the present study, we investigate cardiac structural and functional alterations and associated changes in myocardial glycosaminoglycans (GAGs) disaccharide profile in mice that exhibit depression-like behavior. Mice were assigned to chronic mild stress group (CMS) and non-stress control group (CT). The CMS group was exposed to a series of mild, unpredictable stressors for 7 weeks...
April 9, 2021: American Journal of Physiology. Heart and Circulatory Physiology
Jay Ramchand, Pooja Podugu, Nancy Obuchowski, Serge C Harb, Michael Chetrit, Alex Milinovich, Brian Griffin, Louise M Burrell, W H Wilson Tang, Deborah H Kwon, Scott D Flamm
Background Left ventricular non-compaction remains a poorly described entity, which has led to challenges of overdiagnosis. We aimed to evaluate if the presence of a thin compacted myocardial layer portends poorer outcomes in individuals meeting cardiac magnetic resonance criteria for left ventricular non-compaction . Methods and Results This was an observational, retrospective cohort study involving individuals selected from the Cleveland Clinic Foundation cardiac magnetic resonance database (N=26 531). Between 2000 and 2018, 328 individuals ≥12 years, with left ventricular non-compaction or excessive trabeculations based on the cardiac magnetic resonance Petersen criteria were included...
April 9, 2021: Journal of the American Heart Association
Keith A Dufendach, Toby Zhu, Carlos Diaz Castrillon, Yeahwa Hong, Malamo E Countouris, Gavin Hickey, Mary Keebler, Floyd W Thoma, Arman Kilic
BACKGROUND: The aim of this study is to evaluate the predictive utility of preoperative right ventricular (RV) global longitudinal strain (GLS) and free wall strain (FWS) on outcomes following left ventricular assist devices (LVADs) implantation. METHODS: Preoperative transthoracic echocardiograms were retrospectively reviewed in adults undergoing continuous-flow LVAD implantation between 2004 and 2018 at a single center. Patients undergoing pump exchange were excluded...
April 8, 2021: Journal of Cardiac Surgery
Ke Li, Leonardo Wagner, Angel Moctezuma-Ramirez, Deborah Vela, Emerson Perin
In this study, we created a reproducible myocardial infarction (MI) model in pigs characterized by a low mortality rate and significant changes in left ventricular function. After administering an arrhythmia prevention regimen, we created a 90-min balloon-induced percutaneous MI in 42 pigs below the first diagonal branch (D1) of the left anterior descending artery. Echocardiograms were performed before and 14 days after MI induction. Pigs with a > 30% decrease in left ventricular ejection fraction (LVEF) underwent electrophysiological mapping by the NOGA system...
April 8, 2021: Journal of Cardiovascular Translational Research
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