Kaichuan He, Huaxing Zhang, Bo Tan, Chengqing Song, Zihui Liang, Lixia Zhang, Danyang Tian, Lin Xiao, Hongmei Xue, Qi Guo, Xu Teng, Sheng Jin, Cuixia An, Yuming Wu
PURPOSE: Aging contributes significantly to cardiovascular diseases and cardiac dysfunction, leading to the upregulation of matrix metalloproteinase-9 (MMP-9) in the heart and a significant decrease in hydrogen sulfide (H2 S) content, coupled with impaired cardiac diastolic function. This study explores whether supplementing exogenous hydrogen sulfide during aging ameliorates the decline in H2 S concentration in the heart, suppresses MMP-9 expression, and improves the age-associated impairment in cardiac morphology and function...
June 17, 2024: Cardiovascular Drugs and Therapy
Saubhagya Srivastava, Manish Dhyani, Manjiri Dighe
Contrast-enhanced ultrasound (CEUS) is an advanced ultrasound (US) technique utilizing ultrasound contrast agents (UCAs) to provide detailed visualization of anatomic and vascular architecture, including the depiction of microcirculation. CEUS has been well-established in echocardiography and imaging of focal hepatic lesions and recent studies have also shown the utility of CEUS in non-hepatic applications like the urinary system. The updated guidelines by the European Federation of Societies for Ultrasound in Medicine and Biology (EFSUMB) from 2018 describe the use of CEUS for non-hepatic applications...
June 17, 2024: Abdominal Radiology
Nikolaus A Haas, David J Driscoll, Silke Rickert-Sperling
Situs abnormalities may occur in many and most often more complex congenital cardiac malformations. These conditions are collectively referred to as heterotaxy syndromes, derived from the Greek words "heteros" meaning different and "taxos" meaning orientation or arrangement. Clinically, heterotaxy spectrum encompasses defects in the left-right laterality and arrangement of visceral organs. "Situs" is derived from Latin and is the place where something exists or originates. In human anatomy, situs can be solitus (derived from Latin, meaning "normal"), inversus, or ambiguus...
2024: Advances in Experimental Medicine and Biology
Hua Li, Yaxiong Li, Zheng Jia, Le Ren, Francesco Nappi, Xiao Ma, Yu Jiang, Shen Han
BACKGROUND: Despite improvements in management, infective endocarditis (IE) is still associated with high mortality and morbidity. The outcome of patients with IE remains unclear in high-altitude areas of China. To characterize the epidemiological features and surgical outcomes, a retrospective analysis was conducted to 221 patients diagnosed with IE from a single center. In addition, to assess the prognosis of patients, a multivariate logistic regression model was performed to analyze the affecting risk factors...
May 31, 2024: Journal of Thoracic Disease
Kun Xu, Xiaoguang Tian, Meifang Hao, Yiying Li, Jingxuan Zhang, Randolph H L Wong, Adrianna Othmani, Quanbin Zhang
BACKGROUND: Patent foramen ovale (PFO) has been associated with migraine, cryptogenic stroke (CS), and hypoxemia. However, which examination method is most reliable remains controversial. This study sought to investigate the diagnostic value of contrast-enhanced ultrasonography (cU), including contrast-enhanced transcranial Doppler (cTCD), contrast transthoracic echocardiography (cTTE), and contrast transesophageal echocardiography (cTEE), for PFO; and to determine the best diagnostic strategy...
May 31, 2024: Journal of Thoracic Disease
Zahid Khan
Cardiac angiosarcoma is a malignant cardiac tumour. We present the case of a young patient in his mid-30s with recurrent pericardial effusion. He had flu-like symptoms a month earlier and had shortness of breath, lethargy, and tightness in his throat for the past ten days. Echocardiography demonstrated global pericardial effusion > 4 cm with tamponade features, and the patient was blue-lighted to our hospital. He underwent emergency pericardiocentesis, and > 1 litre of pericardial fluid was drained...
May 2024: Curēus
Babak Payami, Nehzat Akiash, Mohammadreza Kiarsi, Amir Moradi, Mohammad Kheradmandpour, Somayeh Abbaspour
BACKGROUND: Atrial fibrillation (AF) represents the most prevalent cardiac arrhythmia globally, with a significant burden on mortality and morbidity. While rhythm control strategies, particularly electrical cardioversion (EC), have gained traction in recent years, the precise impact of sinus rhythm (SR) restoration on cardiac reverse remodeling remains a subject of debate. METHODS: In this study, 23 AF patients underwent elective EC. AF diagnosis was made via ECG by a cardiologist, and candidates for cardioversion were selected by an electrophysiologist...
May 2024: Curēus
Hassnae Tkak, Aziza Elouali, Ayad Ghanam, Imane Kamaoui, Maria Rkain, Abdeladim Babakhouya
Total anomalous pulmonary venous return (TAPVR) represents a group of anomalies consisting of a lack of connection between the pulmonary veins and the left atrium. All oxygenated pulmonary venous return flows directly or indirectly into the right atrium. Survival is only possible with a right-to-left atrial shunt. It remains rare, accounting for less than 1% of all congenital heart diseases. Its association with tetralogy of Fallot is much rarer and has been documented in medical literature as isolated cases...
May 2024: Curēus
Hiromasa Nakamura, Yujiro Miura, Keisuke Yoshida, Ren Saito, Kazumasa Orihashi
A 78-year-old woman with liver cirrhosis due to chronic hepatitis C visited our department for treatment of a thoracic aortic aneurysm. Her Child-Pugh classification was class A, and her model for end-stage liver (MELD) disease score was 8. As she also had thrombocytopenia associated with splenomegaly and esophageal varices, endoscopic injection sclerotherapy and partial splenic embolization were performed before total arch replacement surgery for treating esophageal varices to reduce the bleeding risk during transesophageal echocardiography and for thrombocytopenia, respectively...
May 2024: Curēus
Kexin Tong, Huating Luo, Haifeng Dai, Wenxiang Huang
The escalating incidence of infective endocarditis (IE) caused by aminoglycoside-resistant Enterococcus is a growing concern for clinicians. This issue is particularly pronounced in elderly patients, who face an elevated risk of renal damage during antibiotic treatment, thereby limiting available pharmacological options. Furthermore, elderly patients often present with multiple comorbidities, leading to heightened mortality rates. In this article, we present a case involving an elderly male patient who sought medical attention on two separate occasions due to inflammation of the lower extremities and lumbosacral pain...
2024: Infection and Drug Resistance
Shao-Fu Chien, Chih-Hui Chin
Septal reduction therapy (SRT) is indicated for drug-refractory hypertrophic obstructive cardiomyopathy (HOCM). SRT includes surgical myectomy and alcohol septal ablation (ASA). The outcome between SRTs are similar except complete atrioventricular (AV) block. Intracoronary myocardial contrast echocardiography is used to minimize myocardial damage by ASA. We report a case of 40-year-old male who was diagnosed of HOCM with progressed symptoms under optimal medication. Echocardiography revealed peak velocity cross left ventricular outflow tract (LVOT) 5...
2024: Journal of Medical Ultrasound
Phillip Suwalski, Finn Wilke, DeLisa Fairweather, Ulf Landmesser, Bettina Heidecker
BACKGROUND: The diagnosis of myocarditis remains challenging due to its diverse clinical manifestations. We recently demonstrated the ability of magnetocardiography (MCG) to screen for myocarditis and applied it successfully to detect myocarditis in this case study of a female-to-male (FtM) patient who had undergone sexual reassignment surgery. This case highlights two significant points: first, sex differences in myocarditis may be promoted by higher levels of testosterone, and second, the ability of MCG to diagnose myocarditis...
July 2024: American heart journal plus: cardiology research and practice
Ye Zhu, Zisang Zhang, Junqiang Ma, Yiwei Zhang, Shuangshuang Zhu, Manwei Liu, Ziming Zhang, Chun Wu, Chunyan Xu, Anjun Wu, Chenchen Sun, Xin Yang, Yonghuai Wang, Chunyan Ma, Jun Cheng, Dong Ni, Jing Wang, Mingxing Xie, Wufeng Xue, Li Zhang
BACKGROUND: Left ventricular opacification (LVO) improves the accuracy of left ventricular ejection fraction (LVEF) by enhancing the visualization of the endocardium. Manual delineation of the endocardium by sonographers has observer variability. Artificial intelligence (AI) has the potential to improve the reproducibility of LVO to assess LVEF. OBJECTIVES: The aim was to develop an AI model and evaluate the feasibility and reproducibility of LVO in the assessment of LVEF...
2024: Digital Health
Hikari Ishii, Nobuyasu Awano, Minoru Inomata, Yuan Bae, Takehiro Izumo
A 45-year-old male was diagnosed with arrhythmia during a routine health examination. Findings from different modalities, such as echocardiography and radiography, were consistent with cardiac involvement in sarcoidosis. There was no ocular involvement or superficial lymph node enlargement. A chest computed tomography scan did not reveal any pulmonary lesions or bilateral hilar lymphadenopathy. To pathologically diagnose systemic sarcoidosis, transbronchial lung cryobiopsy was performed. Results showed pathological evidence of noncaseating epithelioid granulomas...
2024: Respiratory Medicine Case Reports
Kramer J Wahlberg, Matthew A Kluge, William E Hopkins
Aorto-atrial fistula is a rare and life-threatening complication of infective endocarditis, classically diagnosed by visualizing a connection between the aorta and atrium with associated continuous flow. A patient presented with bioprosthetic and native valve enterococcal endocarditis with multiple complications, including an aorto-atrial fistula that was diagnosed by color M-mode on transesophageal echocardiography. We review the features of aorto-atrial fistula and utilize this case to demonstrate how M-mode can be leveraged to provide improved temporal resolution in the setting of diagnostic uncertainty...
2024: Case Reports in Cardiology
Aaron Long, Christopher M Haggerty, Joshua Finer, Dustin Hartzel, Linyuan Jing, Azadeh Keivani, Christopher Kelsey, Daniel Rocha, Jeffrey Ruhl, David vanMaanen, Gil Metser, Eamon Duffy, Thomas Mawson, Mathew Maurer, Andrew J Einstein, Ashley Beecy, Deepa Kumaraiah, Shunichi Homma, Qi Liu, Vratika Agarwal, Mark Lebehn, Martin Leon, Rebecca Hahn, Pierre Elias, Timothy J Poterucha
BACKGROUND: Artificial intelligence, particularly deep learning (DL), has immense potential to improve the interpretation of transthoracic echocardiography (TTE). Mitral regurgitation (MR) is the most common valvular heart disease and presents unique challenges for DL, including the integration of multiple video-level assessments into a final study-level classification. METHODS: A novel DL system was developed to intake complete TTEs, identify color MR Doppler videos, and determine MR severity on a 4-step ordinal scale (none/trace, mild, moderate, and severe) using the reading cardiologist as a reference standard...
June 17, 2024: Circulation
Claudio Sanfilippo, Marco Frazzetto, Giuliano Costa, Claudia Contrafatto, Chiara Giacalone, Giovanni Tricomi, Chiara Barbera, Sofia Rizzo, Jessica De Santis, Maria Sanfilippo, Giuseppe Castania, Maria Elena Di Salvo, Salvatore Scandura, Corrado Tamburino, Marco Barbanti, Carmelo Grasso
No abstract text is available yet for this article.
June 17, 2024: Circulation. Cardiovascular Interventions
Qiuqing Ke, Guoxing Weng, Qi Xie, Jiayin Bao, Fuzhen Zheng, Jie Huang, Licheng Yan, Haiyu Chen
This study aimed to compare the long-term clinical outcomes and costs between using either transesophageal echocardiography (TEE) or X-ray fluoroscopy for Percutaneous atrial septal defect (ASD) closure in children. An analysis was conducted on clinical data from children undergoing TEE-guided (n = 168) and X-ray-guided (n = 139) percutaneous ASD closure. Demographic characteristics, technical indices, acute complications, follow-up outcomes, and costs were compared between the groups...
June 17, 2024: Pediatric Cardiology
Xander Jacquemyn, Rita Long, Sruti Rao, David Danford, Benjamin T Barnes, Shelby Kutty
Echocardiography is pivotal for diagnosis and monitoring of hypertrophic cardiomyopathy (HCM) and can evaluate myocardial function using myocardial work (MW) calculations. Echocardiography is often supplemented by cardiovascular magnetic resonance (CMR) imaging, which can detect myocardial fibrosis using late gadolinium enhancement (LGE). We sought to study the relationship between baseline LGE and MW at baseline and during follow-up in pediatric HCM patients. During the study period (2008-2023), 75 patients were followed up for HCM...
June 17, 2024: Pediatric Cardiology
Mihyun Choi, Namsoon Lee
A 2-year-old castrated Russian Blue cat presented with inappetence, depression, and labored respirations. Radiography findings suggested left lung atelectasis; however, the ultrasonography findings did not indicate lung atelectasis. The left pulmonary artery (PA) was abnormally small on echocardiography; further, there were no other cardiac anomalies. Computed tomography revealed an abnormally small left PA and left lung. Furthermore, bronchiectasis and tree-in-bud patterns were observed in the lung lobes. Based on these findings, the cat was diagnosed with isolated left PA hypoplasia, presumed left lung hypoplasia, and feline chronic bronchial disease...
June 14, 2024: Journal of Veterinary Medical Science
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