Kentaro Inamura
No abstract text is available yet for this article.
February 25, 2021: JAMA Oncology
Xia Zhou, Wuan Bao, Danhong Zhang, Yang Yang, Xianghui Du, Guoqin Qiu
Lung squamous cell carcinoma (LUSC) is a prevalent subtype of nonsmall cell lung cancer (NSCLC). Dysregulated long noncoding RNAs (lncRNAs) are increasingly identified as pivotal modulators in cancer progression. NCK1 divergent transcript (NCK1-AS1) is a lncRNA that has been proven to be oncogenic in different types of human cancers. However, whether it exerts similar functions in LUSC remains to be elusive. The present study focused on investigating the influence of NCK1-AS1 on the cellular process in LUSC and exploring its underlying mechanism...
February 25, 2021: Cancer Biology & Therapy
David J Elzi, William E Bauta, Jamila R Sanchez, Trisha Das, Shweta Mogare, Peter Zannes Fatland, Moises Iza, Alexander Pertsemlidis, Vivienne I Rebel
Porphyrins are used for cancer diagnostic and therapeutic applications, but the mechanism of how porphyrins accumulate in cancer cells remains elusive. Knowledge of how porphyrins enter cancer cells can aid the development of more accurate cancer diagnostics and therapeutics. To gain insight into porphyrin uptake mechanisms in cancer cells, we developed a flow cytometry assay to quantify cellular uptake of meso-tetra (4-carboxyphenyl) porphyrin (TCPP), a porphyrin that is currently being developed for cancer diagnostics...
March 2021: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
Songbai Zheng, Xiaodan Wang, Ying Fu, Beibei Li, Jianhua Xu, Haifang Wang, Zhen Huang, Hui Xu, Yurong Qiu, Yaozhou Shi, Kui Li
The knowledge of genetic variation in Chinese patients with non-small-cell lung cancer (NSCLC) is still limited. We aimed to profile this genetic variation in 206 Chinese patients with NSCLC using next-generation sequencing. Tumor tissues or whole-blood samples were collected and subjected to whole-exome targeted next-generation sequencing, which included 565 tumor-associated genes, for somatic gene mutation screening and copy number variation (CNV) detection. Potential functions of most commonly mutated genes and genes with CNV were predicted by Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses...
December 2021: Bioengineered
Xoan Nguyen, Morgan Hooper, Jared Paul Borlagdan, Alison Palumbo
OBJECTIVE: To review the pharmacology, efficacy, and safety of antibody-drug conjugate fam-trastuzumab deruxtecan-nxki in the treatment of advanced, unresectable, or metastatic breast cancer. DATA SOURCES: Relevant information was identified through a MEDLINE/PubMed (January 2015 to December 2020) literature search. The new drug application, prescribing information, clinical practice guideline, and abstracts from scientific meetings were also reviewed. STUDY SELECTION AND DATA EXTRACTION: The literature search was limited to human studies published in the English language...
February 25, 2021: Annals of Pharmacotherapy
Lisa M Hess, Xiaohong Li, Yixun Wu, Robert J Goodloe, Zhanglin Lin Cui
Retrospective observational research relies on databases that do not routinely record lines of therapy or reasons for treatment change. Standardized approaches to estimate lines of therapy were developed and evaluated in this study. A number of rules were developed, assumptions varied and macros developed to apply to large datasets. Results were investigated in an iterative process to refine line of therapy algorithms in three different cancers (lung, colorectal and gastric). Three primary factors were evaluated and included in the estimation of lines of therapy in oncology: defining a treatment regimen, addition/removal of drugs and gap periods...
February 25, 2021: Future Oncology
Tatsuya Imabayashi, Yuji Matsumoto, Midori Tanaka, Toshiyuki Nakai, Takaaki Tsuchida
BACKGROUND: Dry pleural dissemination (DPD) and minimal (<10 mm thick) pleural effusion (PE) may be discovered intraoperatively as unexpected metastases. A definitive diagnostic procedure such as pleural biopsy is rarely attempted in such patients preoperatively. We retrospectively investigated the use and safety of local anesthetic thoracoscopy (LAT) as a pleural staging tool in the diagnosis of DPD and minimal PE. METHODS: We reviewed 18 patients with non-small cell lung cancer (radiological DPD and minimal PE in 13 and five patients, respectively) who underwent LAT using a flex-rigid pleuroscope for pleural staging from April 2015 to September 2020...
February 25, 2021: Thoracic Cancer
Yi-Chung Chen, Yi-Han Lin, Hung-Che Chien, Po-Kuei Hsu, Jung-Jyh Hung, Chien-Sheng Huang, Chih-Cheng Hsieh, Wen-Hu Hsu, Han-Shui Hsu
BACKGROUND: Preoperative positron emission tomography/computed tomography (PET/CT) is recommended as a guideline for staging of lung cancer. However, for patients with pulmonary ground-glass opacity (GGO) nodules who are supposed to have a relatively low risk of incidence of lymphatic metastasis, it remains uncertain whether PET/CT is more effective than consolidation-to-tumor ratio (CTR) in the prediction of regional lymphatic metastasis. METHODS: The data on patients who underwent surgery for lung cancer from 2011 to 2016 were collected retrospectively, which included CTR, results of PET/CT, and pathological characteristics...
February 25, 2021: Thoracic Cancer
Shuai Li, Dezuo Dong, Jianhao Geng, Xianggao Zhu, Chen Shi, Yangzi Zhang, Hongzhi Wang, Shun Zhou, Hao Wu, Yong Cai, Yongheng Li, Weihu Wang
PURPOSE: To analyze the effect of stereotactic body radiotherapy (SBRT) on colorectal cancer (CRC) patients with lung oligoprogression (OP). METHOD: Patients with lung OP from CRC treated by SBRT at our center were included in this retrospective analysis. The progression-free survival (PFS), change of systemic therapy (CST), local control (LC), and overall survival (OS) were analyzed. Cumulative incidence was used to report CST, and the Kaplan-Meier method was used to evaluate PFS and LC...
February 25, 2021: Asia-Pacific Journal of Clinical Oncology
Seyed Hossein Mahfouzi, Ghassem Amoabediny, Seyed Hamid Safiabadi Tali
Lung bioengineering has emerged to resolve the current lung transplantation limitations and risks, including the shortage of donor organs and the high rejection rate of transplanted lungs. One of the most critical elements of lung bioengineering is bioreactors. Bioreactors with different applications have been developed in the last decade for lung bioengineering approaches, aiming to produce functional reproducible tissue constructs. In this paper, the current status and advances made in the development and application of bioreactors for bioengineering lungs are comprehensively reviewed...
February 25, 2021: Biotechnology and Bioengineering
H Zhang, B Zhao, Z-G Zhai, J-D Zheng, Y-K Wang, Y-Y Zhao
OBJECTIVE: This study aimed to investigate the expression of MMP-9 (matrix metalloproteinases 9) and P53 (tumor suppressor proteins, tumor protein P53) in serum of patients with lung cancer. The relation between the two factors and their clinical pathological features were also explored. PATIENTS AND METHODS: 150 patients were selected as the experimental group. They were diagnosed with lung cancer in Shandong Province Chest Hospital from January 2014 to January 2017...
February 2021: European Review for Medical and Pharmacological Sciences
L-F Zha, L-D Zhang, H-M Pan, H-D Ma
OBJECTIVE: To detect the expression of long non-coding ribonucleic acid (lncRNA) NCK1-AS1 in non-small cell lung cancer (NSCLC), analyze the association between its expression and the clinicopathological characteristics of NSCLC patients, and study the biological function of NCK1-AS1 in vitro. PATIENTS AND METHODS: The relative expression of NCK1-AS1 in NSCLC tissues and cells was detected via quantitative reverse transcription-polymerase chain reaction (qRT-PCR)...
February 2021: European Review for Medical and Pharmacological Sciences
Kei Ito, Shurei Sugita, Yujiro Nakajima, Takahiro Hozumi, Kiyofumi Yamakawa, Masanori Fujiwara, Katsuyuki Karasawa
To assess the additional effects of intraoperative radiotherapy (IORT) with decompression surgery and adjuvant external beam radiotherapy (EBRT) for metastatic epidural spinal cord compression (MESCC). This single-arm institutional prospective observational study recruited patients between June 2017 and March 2020 and included those with symptoms of spinal cord compression owing to metastases, who were diagnosed using MRI. Patients with radiation-sensitive primary tumors and those who could not tolerate surgery were excluded...
February 24, 2021: Clinical & Experimental Metastasis
Kosuke Kashiwabara, Shinji Fujii, Shinsuke Tsumura, Kazuhiko Sakamoto, Hiroshi Semba
BACKGROUND: The safety and efficacy of transbronchial microwave ablation (TMA) therapy in patients with malignant central airway obstruction (CAO) with respiratory failure remains unclear. METHODS: A total of 38 patients with advanced non-small cell lung cancer (NSCLC) or lung metastases with malignant endoluminal obstruction received TMA therapy under moderate sedation and high fractions of inspired oxygen (FiO2 ). The success rate of airway patency restoration, complication rate, and overall survival time (OS) from the initiation of TMA therapy were compared in the following two groups of patients with malignant CAO patients: the group with respiratory failure (PaO2 /FiO2  ≤ 300) (RF group, n = 10) and the group without respiratory failure (PaO2 /FiO2  > 300) (non-RF group, n = 28) at the time of the TMA therapy...
February 24, 2021: Journal of Cancer Research and Clinical Oncology
Andra Piciu, Simona Manole, Doina Piciu, Teodora Dreve, Andrei Roman
Background: The aim of the study was to present the PET/CT imaging features in a small series of asymptomatic patients with known cancer pathologies, infected with the SARS-CoV-2 virus, which were incidentally discovered during their monitoring scan of F18-FDG PET/CT. Methods: We included in our study a number of five cases (3 female and 2 male) out of 478 patients examined by F18-FDG PET/CT between March - April 2020, with confirmed diagnostic of cancer. Four patients had lung damages suggestive for the mentioned viral infection and 1 patient had multiple lung metastases from thyroid cancer...
January 2021: Medicine and pharmacy reports
Steve Antoine, Monique Oye
No abstract text is available yet for this article.
December 2020: European Heart Journal. Case Reports
Jiayin Li, Rui Han, Jing Li, Linzhu Zhai, Xinying Xie, Jing Zhang, Yao Chen, Jiamin Luo, Sisi Wang, Zhe Sun, Yang Cao, Lizhu Lin, Qiuye Yang
In order to explore the specific mechanism of YiqiChutan formula (YQCTF) in inhibiting the angiogenesis of lung cancer and its relationship with delta-like ligand 4- (DLL4-) Notch signaling, 30 healthy BALB/c-nu/nu rats were selected and divided into three groups: A549 group (implanted with lung adenocarcinoma cell line A549), NCI-H460 group (implanted with human lung large-cell carcinoma cell line NCI-H460), and NCI-H446 group (implanted with human lung small cell carcinoma cell line NCI-H446) for constructing lung cancer transplanted tumor models...
2021: BioMed Research International
Cuijuan Zheng, Jiayu Wang, Shouxiang Xie
Objectives: Our study will investigate the effect of ultrasound-guided thoracic paravertebral block (UG-TPVB) on postoperative pain, quality of life, and enhanced recovery in patients with non-small-cell lung cancer (NSCLC) undergoing lobectomy surgery. Methods: Our study included 100 patients aged 52 to 75 years who underwent lobectomy surgery with pathological diagnosis of NSCLC. Patients received ultrasound-guided thoracic paravertebral block or general anesthesia with tracheal intubation...
2021: BioMed Research International
Hassnain R Syed, Suman Shekar, Avinash Aravantagi
Malignant melanoma is a life-threatening malignant tumor deriving from melanocytes, regarded as the most lethal form of skin cancer. One of the attributing factors to this fact is its propensity to metastasize to all organs of the human body. The strongest risk factors for melanoma include exposure to UV rays, family history of melanoma, and a prior history of melanoma. Malignant melanoma is thought to metastasize first to the local lymph nodes and then to secondary sites, most commonly skin, lung, and to the brain...
February 18, 2021: Curēus
Nouf Akeel, Wafaa A Toonsi
Intestinal obstruction is a common acute presentation of advanced rectal cancer, which could be managed with surgical or non-surgical techniques including metallic stenting. Bevacizumab has been gaining popularity in the treatment of advanced colorectal cancer (CRC) in combination with different chemotherapeutic agents, to improve the overall survival rate; however, data regarding the adverse effects of bevacizumab in combination with other treatment modalities have been insufficient. Herein, we present a case of a 37-year-old man diagnosed with advanced rectal cancer with concurrent liver and lung metastases...
January 21, 2021: Curēus
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