lung cancer

Lizhe Zhu, Siyuan Jiang, Shibo Yu, Xiaoxu Liu, Shengyu Pu, Peiling Xie, Heyan Chen, Xiaoqin Liao, Ke Wang, Bin Wang
Patients with advanced breast cancer (BC) showed a higher incidence of regional and distant metastases. Sine oculis homeobox homolog 1 (SIX-1) has been confirmed to be a key tumorigenic and metastatic regulator in BC progression. Yet, molecular mechanisms behind SIX-1-induced BC metastases remain largely unknown. Here we found that SIX-1 was frequently up-regulated in BC and correlated with poor outcomes when tested in human BC tissue microarray. Then, we manipulated the expression of SIX-1 by via shRNA-mediated knockdown and lentivirus-mediated overexpression...
March 30, 2020: Journal of Cellular and Molecular Medicine
Jie Cui, Ru-Yi Shang, Mei Sun, Yi-Xuan Li, Hong-Yan Liu, Hou-Wen Lin, Wei-Hua Jiao
Three new cadinane sesquiterpenes, trichodermaloids A (1), B (2), and C (5) were isolated from a symbiotic fungus Trichoderma sp. SM16 derived from the marine sponge Dysidea sp., together with three known ones, aspergilloid G (3), rhinomilisin E (4), and rhinomilisin G (6). The complete structures of three new compounds were determined by HR-MS and NMR spectroscopic analyses coupled with ECD calculations. The absolute configurations of two known compounds (4 and 6) were determined for the first time. The six isolates were inactive as antibacterial agents...
March 30, 2020: Chemistry & Biodiversity
Na Li, Weiwei Hao, Junfang Yang, Yali Guo, Yonggang Guo, Ying Du
AIM: Lung cancer serves as one of the most common cancers in the world, and approximately 50% of non-small-cell lung cancer (NSCLC) patients are found to be aged >70 when diagnosed. In this study, we aimed to explore the effect of long non-coding RNAs colon cancer-associated transcript-1 (CCAT1) in NSCLC. METHODS: A total of 72 clinical samples from older NSCLC patients were collected for analysis. The relative mRNA level of CCAT1 was detected through real-time polymerase chain reaction...
March 30, 2020: Geriatrics & Gerontology International
Deng-Xing Lun, Nai-Wang Chen, Jiang-Tao Feng, Xion-Gang Yang, Zhao-Wan Xu, Feng Li, Yong-Cheng Hu
OBJECTIVE: To characterize the visceral metastasis as a predictive tool for the survival of patients with spinal metastases through an exploratory meta-analysis. METHODS: Two investigators independently searched PubMed and Embase databases for eligible studies from 2000-2016. The effect estimates for the hazard ratio (HR) or risk ratio (RR) and 95% confidence interval (CI) were collected and pooled with a random- or fixed-effect model. RESULTS: In total, 18 eligible studies were retrieved with 5468 participants from nine countries...
March 29, 2020: Orthopaedic Surgery
Hironori Ishida, Masanori Yasuda, Hiroyuki Nitanda, Akitoshi Yanagihara, Ryo Taguchi, Ryuichi Yoshimura, Tetsuya Umesaki, Hirozo Sakaguchi, Yoshihiko Shimizu
Lung cancers associated with cystic airspaces have a life-threatening risk of a missed or delayed diagnosis. Here, we report a case of pulmonary high-grade fetal adenocarcinoma, a rare lung carcinoma associated with cystic airspaces, as confirmed by computed tomography (CT) scan. A 73-year-old asymptomatic male with a 52-pack a year smoking habit was referred to our hospital. Lung CT showed a thin-walled cystic space with exophytic and endophytic solid nodules along the cyst wall. After surgery, histological analysis of a resected lung specimen revealed a pure high-grade fetal adenocarcinoma probably associated with emphysematous bullae in pulmonary emphysema, suggesting smoking contributed to this pure form, as well as the emphysema...
March 29, 2020: Thoracic Cancer
Niels Hadrup, Vadim Zhernovkov, Nicklas Raun Jacobsen, Carola Voss, Maximilian Strunz, Meshal Ansari, Herbert B Schiller, Sabina Halappanavar, Sarah S Poulsen, Boris Kholodenko, Tobias Stoeger, Anne Thoustrup Saber, Ulla Vogel
Inhaled nanoparticles constitute a potential health hazard due to their size-dependent lung deposition and large surface to mass ratio. Exposure to high levels contributes to the risk of developing respiratory and cardiovascular diseases, as well as of lung cancer. Particle-induced acute phase response may be an important mechanism of action of particle-induced cardiovascular disease. Here, the authors review new important scientific evidence showing causal relationships between inhalation of particle and nanomaterials, induction of acute phase response, and risk of cardiovascular disease...
March 29, 2020: Small
Kuo-Hwa Chiang, Jiunn-Min Shieh, Chih-Jie Shen, Ting-Wei Chang, Pei-Ting Wu, Jinn-Yuan Hsu, Jhih-Peng Tsai, Wen-Chang Chang, Ben-Kuen Chen
Epidermal growth factor receptor (EGFR) expression and activation are the major causes of metastasis in cancers such as head and neck squamous cell carcinoma (HNSCC). However, the reciprocal effect of EGF-induced cyclooxygenase-2 (COX-2) and angiopoietin-like 4 (ANGPTL4) on HNSCC metastasis remains unclear. In this study, we revealed that the expression of ANGPTL4 is essential for COX-2-derived prostaglandin E2 (PGE2 )-induced tumor cell metastasis. We showed that EGF-induced ANGPTL4 expression was dramatically inhibited with the depletion and inactivation of COX-2 by knockdown of COX-2 and celecoxib treatment, respectively...
March 29, 2020: Cancer Science
Ping Du, Ting Hu, Zhuoling An, Pengfei Li, Lihong Liu
Both ceritinib (CER) and PD-1/PD-L1 have brought significant breakthrough for ALK-rearranged non-small-cell lung cancer (NSCLC). However, the overall clinical efficacy of either CER or PD-1/PD-L1 inhibitor monotherapy has been limited to a large extent. Besides, the antitumor effect of combined CER with PD-L1 inhibitor in ALK-rearranged NSCLC are not fully understood. In H2228 cells, we examined the tumor killing effect of CER plus PD-L1 inhibitor in vitro by quantitative RT-PCR, flow cytometry, ELISA, western blotting, peripheral blood mononuclear cells (PBMC) co-culture system, plasmid and transfection experiments...
March 29, 2020: Cancer Science
Qifeng Gui, Hanyu Li, Ange Wang, Xinxiu Zhao, Zhongju Tan, Lufang Chen, Keying Xu, Chi Xiao
BACKGROUND: Recently, it has been found that the gut microbiota may affect the development of lung cancer through the "gut-lung axis." To investigate this relationship, we performed this study to determine whether the gut microbiota in non-small-cell lung cancer (NSCLC) patients is different from that in healthy adults. METHODS: Quantitative PCR (qPCR) was used to detect the expression levels of eight gut butyrate-producing bacteria in healthy adults and NSCLC patients...
March 29, 2020: Journal of Clinical Laboratory Analysis
Nathalia Ferreira, Inês Mesquita, Fátima Baltazar, Ricardo Silvestre, Sara Granja
PURPOSE: Previously, inflammation has been found to be associated with the development of lung cancer. Despite their well-characterized pro-inflammatory functions, the putative roles of interleukin-17 (IL-17) cytokine family members in tumorigenesis have remained controversial. While IL-17A exhibits both pro- and anti-tumor effects, IL-17F has been suggested to serve as a candidate for cancer therapy. Thus, we aimed at clarifying the involvement of IL-17A/F in lung cancer. METHODS: IL-17 receptor expression in human and murine lung cancer cells was assessed using immunofluorescence...
March 29, 2020: Cellular Oncology (Dordrecht)
Ilona Gurgul, Olga Mazuryk, Michał Łomzik, Philippe C Gros, Dorota Rutkowska-Zbik, Małgorzata Brindell
The well-documented cytotoxic activity of coordinatively saturated and substitutionally inert polypyridyl Ru(ii) complexes substantiates their high potency as antiproliferative agents against primary tumors. However, the primary cause of cancer morbidity and mortality responsible for about 90% of cancer deaths is the occurrence of metastasis. Therefore, scientists have to concentrate their efforts on designing compounds affecting not only the primary tumor, but also efficiently inhibiting metastasis. Herein, we report two families of Ru(ii) polypyridyl complexes bearing 2,2'-bipyridine substituted by a semicarbazone 2-formylopyridine moiety as one of the ligands and 4,4'-di-tert-butyl-2,2'-dipyridyl or 4,7-diphenyl-1,10-phenanthroline as auxiliary ligands...
March 30, 2020: Metallomics: Integrated Biometal Science
Bo Hang, Pin Wang, Yue Zhao, Hang Chang, Jian-Hua Mao, Antoine M Snijders
Thirdhand smoke (THS), the residual tobacco smoke remaining in the environment after tobacco has been smoked, represents a hidden and underestimated public health hazard. Evidence supports its widespread presence in indoor environments. Exposure to secondhand smoke (SHS), a precursor of THS, has been well documented as a risk factor for human cancers, especially lung cancer. However, the concept of THS as a distinct entity that poses health risks for small children has developed only recently and the associations of THS with cancer risk and other chronic diseases are poorly understood due to limited numbers of studies to date...
March 2020: Chronic Diseases and Translational Medicine
Ling Zhang, Hui Xu, Chunping Ma, Jieru Zhang, Yuanjie Zhao, Xiaomei Yang, Shusheng Wang, Dawei Li
PSMD14 is a 19S-proteasome-associated deubiquitinating enzyme that facilitates protein degradation by the 20S proteasome core particle. Although accumulating evidence indicates that PSMD14 has emerged as a critical oncogenic factor by promoting tumor growth, the expression and function of PSMD14 in non-small cell lung cancer (NSCLC) remain largely unknown. In this study, we assessed PSMD14 expression and correlated it with clinical-pathological features and patient survival in NSCLC. We also determined the roles of PSMD14 in the regulation of lung adenocarcinoma (LUAD) cell growth...
2020: Journal of Cancer
Zhong-Yi Sun, Wei Wang, Han Gao, Quan-Fang Chen
Background : Lung cancer is the most common cancer worldwide, both in terms of the incidence and mortality. NDC80 complex comprising of NDC80, NUF2, SPC24, and SPC25 is a heterotetrameric protein complex located in the outer layer of the kinetochore and plays a critical role in mitosis. This study focuses on the effects of NDC80 complex genes on clinical features and prognosis in lung adenocarcinoma (LUAD). Materials and methods : Expression of NDC80 complex in LUAD and related clinical information was extracted from the TCGA website...
2020: Journal of Cancer
Tomoyuki Nakagiri, Tomio Nakayama, Toshiteru Tokunaga, Akemi Takenaka, Hidenori Kunoh, Hiroto Ishida, Yasuhiko Tomita, Shin-Ichi Nakatsuka, Harumi Nakamura, Jiro Okami, Masahiko Higashiyama
Objectives : Small-size lung lesions suspected of being cancer are now often being identified on computed tomography. Correspondingly, a new lung cancer staging system has been proposed by the International Association for the Study of Lung Cancer (IASLC), in which the T1 factor and adenocarcinoma are re-subclassified. Previously, we proposed an intraoperative cytological diagnosis and its classification of small-size lung adenocarcinoma, which correlated significantly with clinical malignancy, to be used for selecting the surgical strategy...
2020: Journal of Cancer
Joon Young Hur, Ha Yeon Lee, Hye Jung Chang, Cheon Woong Choi, Dae Hyun Kim, Wan Kyu Eo
Objectives: Several factors associated with the prognosis of patients with NSCLC have been reported in the literature; however, most of these factors cannot be examined preoperatively. In this study, the clinical utility of platelet parameters in patients with NSCLC who underwent curative resection was evaluated. Materials and Methods: A retrospective study on patients with NSCLC who underwent curative resection from July 2006 to September 2016 was conducted. The Cox proportional hazard regression model was applied to evaluate the variables that demonstrated effects on disease-free and overall survival (DFS and OS)...
2020: Journal of Cancer
Biao Li, Qing Yuan, Yu-Ting Zou, Ting Su, Qi Lin, Yu-Qing Zhang, Wen-Qing Shi, Rong-Bin Liang, Qian-Min Ge, Qiu-Yu Li, Yi Shao
Despite recent improvements in diagnosis and therapy, lung cancer remains the most common malignant tumor in males, with high morbidity and mortality. As the annual incidence continues to increase worldwide, the prognosis for male patients with lung cancer remains unsatisfactory. Interestingly, smoking is associated with lung cancer and ocular lesions by altering risk factors such as carbohydrate antigen (CA)-125, CA-153 and cytokeratin-19 fragment (CYFRA21-1). A diagnostic standard for serum biomarker levels of ocular metastasis (OM) in males with lung cancer is therefore urgently needed...
2020: Journal of Cancer
Tomoyuki Nakagiri, Tomio Nakayama, Toshiteru Tokunaga, Akemi Takenaka, Hidenori Kunoh, Hiroto Ishida, Yasuhiko Tomita, Shin-Ichi Nakatsuka, Harumi Nakamura, Jiro Okami, Masahiko Higashiyama
Objectives : For patients with multiple small-sized pulmonary cancers, a lobectomy can disrupt future therapeutic options for other lesions. It was recently reported that limited pulmonary resections were not inferior to lobectomy for the management of selected peripheral small-sized pulmonary adenocarcinomas. Patients with adenocarcinoma in situ or minimally invasive adenocarcinoma, as proposed by the International Association for the Study of Cancer classification, have been reported to have 100% survival after 5 years...
2020: Journal of Cancer
Xiaodong Huo, Huixing Wang, Bin Huo, Lei Wang, Kuo Yang, Jinhuan Wang, Lili Wang, Haitao Wang
Background: Extensive studies revealed that long non-coding RNAs (lncRNAs) could act as a regulator in tumors, including lung adenocarcinoma (LUAD). LncRNA FTX transcript, XIST regulator (FTX) has been reported to regulate the biological behaviors of some cancers. Nevertheless, its functional role and molecular mechanism remain obscure in LUAD. Our current study concentrates on exploring the biological function of FTX in LUAD. Methods: RT-qPCR was used to test the expression of FTX, miR-335-5p or NUCB2 in LUAD cells...
2020: Cancer Cell International
Ning Dou, Qingqing Hu, Li Li, Qiong Wu, Yandong Li, Yong Gao
USP32, a member of the ubiquitin-specific proteases family, has been implicated in the development of breast cancer and small lung cancer. However, its biological functions and clinical significance in gastric cancer (GC) remain unclear. In the present study, we reported that knockdown or depletion of USP32 significantly inhibited GC cell proliferation and migration in vitro and in vivo, indicating that USP32 functions as an oncogene in GC. Importantly, results from immunohistochemical staining in a tissue microarray revealed that USP32 was upregulated in GC tissues compared with paracancerous tissues...
2020: International Journal of Biological Sciences
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