Lilian H Lo, Coco Y Lam, Jeffrey C To, Cynthia H Chiu, Vincent W Keng
A forward genetic Sleeping Beauty (SB) insertional mutagenesis screen, followed by high-throughput transcriptome sequencing, was used to identify driver genes responsible for hepatocellular carcinoma (HCC)-associated metastasis. Using RNA-sequencing (RNA-seq) to identify transposon-endogenous transcriptome fusion genes, the phylogenetic lineage between the parental liver tumor and secondary metastasis can be determined to provide mechanistic insight to genetic changes involved in the metastatic evolution process...
January 18, 2021: Biochemical and Biophysical Research Communications
Dali Chen, Poming Kang, Shaolin Tao, Qingyuan Li, Ruwen Wang, Qunyou Tan
BACKGROUND: This study aimed to evaluate the cost-effectiveness of robotic-assisted thoracoscopic surgery (RATS) over open thoracotomy (OT) and video-assisted thoracoscopic surgery (VATS) for operable non-small cell lung cancer (NSCLC) from the perspective of Chinese healthcare payer. METHODS: The Markov decision model was developed to assess the 5-year costs and quality-adjusted life year (QALY) of RATS versus OT and VATS for operable NSCLC patients. The propensity-matched cohorts were generated from our clinical center to determine the surgical costs and complication rates...
January 10, 2021: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Yoichi Ohtaki, Kimihiro Shimizu, Hiroyuki Suzuki, Kenji Suzuki, Masahiro Tsuboi, Tetsuya Mitsudomi, Motoshi Takao, Tomohiro Murakawa, Hiroyuki Ito, Kenichi Yoshimura, Morihito Okada, Masayuki Chida
OBJECTIVES: The prognostic impact of surgical intervention for recurrent or residual non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutation or anaplastic lymphoma kinase (ALK) rearrangement after tyrosine-kinase inhibitor (TKI) treatment remains unclear. We aimed to describe the characteristics and outcomes of patients undergoing salvage surgery in this setting. METHODS: We retrospectively collected and analyzed nationwide Japanese data on perioperative and postoperative outcomes of patients who underwent salvage surgery after EGFR or ALK-TKI during 2010-2015...
January 10, 2021: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Cristina Lucidi, Marco Biolato, Quirino Lai, Barbara Lattanzi, Ilaria Lenci, Martina Milana, Raffaella Lionetti, Antonio Liguori, Mario Angelico, Giuseppe Tisone, Alfonso Wolfango Avolio, Salvatore Agnes, Massimo Rossi, Antonio Grieco, Manuela Merli
BACKGROUND: Recent innovations in the field of liver transplantation have led to a wealth of new treatment regimes, with potential impact on the onset ofde novo malignancies (DNM). The aim of this multicenter cohort study was to provide contemporary figures for the cumulative incidences of solid and hematological DNM after liver transplantation. METHODS: We designed a retrospective cohort study including patients undergoing LT between 2000 and 2015 in three Italian transplant centers...
January 19, 2021: Annals of Hepatology
Julia Lai-Kwon, Crescens Tiu, Abhijit Pal, Sachin Khurana, Anna Minchom
Epidermal Growth Factor Receptor (EGFR) mutations are the most common targetable oncogenic driver mutation in metastatic non-small lung cancer (NSCLC). There have been significant advances in the management of metastatic EGFR-mutant NSCLC, from the advent of first and second generation EGFR inhibitors to, more recently, the third-generation inhibitor osimertinib. Osimeritinib is now established as first-line therapy on the basis of improved outcomes compared to first and second generation agents. However, despite excellent initial response rates, responses may not be durable due to the development of acquired resistance...
January 19, 2021: Critical Reviews in Oncology/hematology
Giulio Cavalli, Serena Colafrancesco, Giacomo Emmi, Massimo Imazio, Giuseppe Lopalco, Maria Cristina Maggio, Jurgen Sota, Charles A Dinarello
The interleukin (IL)-1 family member IL-1α is a ubiquitous and pivotal pro-inflammatory cytokine. The IL-1α precursor is constitutively present in nearly all cell types in health, but is released upon necrotic cell death as a bioactive mediator. IL-1α is also expressed by infiltrating myeloid cells within injured tissues. The cytokine binds the IL-1 receptor 1 (IL-1R1), as does IL-1β, and induces the same pro-inflammatory effects. Being a bioactive precursor released upon tissue damage and necrotic cell death, IL-1α is central to the pathogenesis of numerous conditions characterized by organ or tissue inflammation...
January 19, 2021: Autoimmunity Reviews
Carl M Gay, C Allison Stewart, Elizabeth M Park, Lixia Diao, Sarah M Groves, Simon Heeke, Barzin Y Nabet, Junya Fujimoto, Luisa M Solis, Wei Lu, Yuanxin Xi, Robert J Cardnell, Qi Wang, Giulia Fabbri, Kasey R Cargill, Natalie I Vokes, Kavya Ramkumar, Bingnan Zhang, Carminia M Della Corte, Paul Robson, Stephen G Swisher, Jack A Roth, Bonnie S Glisson, David S Shames, Ignacio I Wistuba, Jing Wang, Vito Quaranta, John Minna, John V Heymach, Lauren Averett Byers
Despite molecular and clinical heterogeneity, small cell lung cancer (SCLC) is treated as a single entity with predictably poor results. Using tumor expression data and non-negative matrix factorization, we identify four SCLC subtypes defined largely by differential expression of transcription factors ASCL1, NEUROD1, and POU2F3 or low expression of all three transcription factor signatures accompanied by an Inflamed gene signature (SCLC-A, N, P, and I, respectively). SCLC-I experiences the greatest benefit from the addition of immunotherapy to chemotherapy, while the other subtypes each have distinct vulnerabilities, including to inhibitors of PARP, Aurora kinases, or BCL-2...
January 5, 2021: Cancer Cell
Scott J Adams, Prosanta Mondal, Erika Penz, Chung-Chun Anderson Tyan, Hyun Lim, Paul Babyn
OBJECTIVES: To develop a lung nodule management strategy combining the Lung CT Screening Reporting and Data System (Lung-RADS) with an artificial intelligence (AI) malignancy risk score and determine its impact on follow-up investigations and associated costs in a baseline lung cancer screening population. MATERIALS AND METHODS: Secondary analysis was undertaken of a data set consisting of AI malignancy risk scores and Lung-RADS classifications from six radiologists for 192 baseline low-dose CT studies...
January 19, 2021: Journal of the American College of Radiology: JACR
Akshay Sharma, Neel S Bhatt, Andrew St Martin, Muhammad Bilal Abid, Jenni Bloomquist, Roy F Chemaly, Christopher Dandoy, Jordan Gauthier, Lohith Gowda, Miguel-Angel Perales, Stuart Seropian, Bronwen E Shaw, Eileen E Tuschl, Amer M Zeidan, Marcie L Riches, Gunjan L Shah
BACKGROUND: Haematopoietic stem-cell transplantation (HSCT) recipients are considered at high risk of poor outcomes after COVID-19 on the basis of their immunosuppressed status, but data from large studies in HSCT recipients are lacking. This study describes the characteristics and outcomes of HSCT recipients after developing COVID-19. METHODS: In response to the pandemic, the Center for International Blood and Marrow Transplant Research (CIBMTR) implemented a special form for COVID-19-related data capture on March 27, 2020...
January 19, 2021: Lancet Haematology
Nicole El-Turk, Michael S H Chou, Natasha C H Ting, Afaf Girgis, Shalini K Vinod, Victoria Bray, Claudia C Dobler
INTRODUCTION: Patients' burden from lung cancer treatment is not well researched, but this understanding can facilitate a patient-centred treatment approach. Current models of treatment burden suggest it is influenced by a patient's perception of their disease and treatment and their capacity to do the work required to treat their disease. METHODS: Sixteen patients and 1 carer who were undergoing or had completed conventional or stereotactic ablative radiotherapy, chemotherapy or immunotherapy for lung cancer in the last 6 months participated in a semi-structured interview...
2021: PloS One
Deborah K Johnson, Kaylia M Reynolds, Brian D Poole, Matthew D Montierth, Vera M Todd, April Barnado, Mary F Davis
Patients with autoimmune disorders (AD) have altered cancer risks compared to the general population. Systemic lupus erythematosus and multiple sclerosis lead to a heightened risk for hematological malignancies and decreased risk for breast, ovarian, and prostate malignancies. Often patients with autoimmune disease have dysregulated antiviral immune responses, including against oncogenic viruses. To uncover the relationship between viral incidence and cancer risk in the context of autoimmune disease, we extracted electronic health records (EHR) from Vanderbilt University...
2021: PloS One
Jun Liu, Yongping Liu, Cheng Gu, Lei Zhang, Xujing Lu
Background: This study aimed to investigate the association of circulating tumor cells (CTCs) change during chemoradiation with the treatment response and survival profiles in advanced nonsmall-cell lung cancer (NSCLC) patients. Materials and Methods: Fifty-eight advanced NSCLC patients who underwent concurrent chemoradiation were enrolled, then their peripheral blood samples were collected before chemoradiation, and at 1 month postchemoradiation assessed the CTCs using a CTC-Biopsy system. Moreover, CTCs were classified as CTCs positive and CTCs negative according to CTCs' count, and change of CTCs was calculated...
January 22, 2021: Cancer Biotherapy & Radiopharmaceuticals
Lei Xu, Hou-Nai Xie, Xian-Kai Chen, Nan Bi, Jian-Jun Qin, Yin Li
BACKGROUND: Currently, there is no consensus on the role of postoperative adjuvant radiotherapy (PORT) for resected stage IIIA/N2 non-small cell lung cancer (NSCLC). Our study sought to determine which patients may be able to benefit from PORT, based on a patient prognostic score. METHODS: A retrospective cohort study was conducted to identify patients diagnosed with IIIA/N2 NSCLC between 1988 and 2016 in the SEER database. Eligible patients were divided into the following two groups: PORT group and non-PORT group...
January 22, 2021: Thoracic Cancer
Fuguo Yan, Bin Fan, Jianchu Wang, Wang Wei, Qianli Tang, Libai Lu, Zongjiang Luo, Jian Pu, Shan-Shan Yang
Increasing circRNAs have attracted a lot of attention because of their significant biological effects in many diseases. It has been reported that circ_0008305 can modulate lung cancer progression. However, the association between circ_0008305 and hepatocellular carcinoma (HCC) needs to be well explored. In this current research, we studied the molecular function and potential mechanism of circ_0008305 in HCC progression. First, it was demonstrated that circ_0008305 was greatly increased in HCC tissues and cells...
January 22, 2021: Cancer Medicine
Jinming Zhu, Shichao Han
Dysfunction of histone deacetylase 10 (HDAC10) has been suggested in the carcinogenesis of cervical cancer (CC). However, its association with microRNAs (miRNAs) in CC remains exclusive. Hence, this study aims to probe the role of HDAC10 in regulating CC cell proliferation, migration, and invasion and its correlation with the screened-out miRNA target. Microarray analysis and RT-qPCR revealed that HDAC10 expressed poorly in CC cells relative to human immortalized endocervical cells (End1/E6E7). Moreover, HDAC10 downregulation predicted poor survival for patients with CC...
January 22, 2021: IUBMB Life
Jinming Zhu, Shichao Han
Dysfunction of histone deacetylase 10 (HDAC10) has been suggested in the carcinogenesis of cervical cancer (CC). However, its association with microRNAs (miRNAs) in CC remains exclusive. Hence, this study aims to probe the role of HDAC10 in regulating CC cell proliferation, migration, and invasion and its correlation with the screened-out miRNA target. Microarray analysis and RT-qPCR revealed that HDAC10 expressed poorly in CC cells relative to human immortalized endocervical cells (End1/E6E7). Moreover, HDAC10 downregulation predicted poor survival for patients with CC...
January 22, 2021: IUBMB Life
Bing Zhao, Mengfang Wu, Zhihuang Hu, Tianfa Wang, Jin Chao Yu, Yixin Ma, Qi Wang, Yanling Zhang, Di Chen, Tianyu Li, Yaran Li, Min Yu, Huijie Wang, Wei Mo
BACKGROUND AND PURPOSE: Cancer cachexia and cancer-associated thrombosis are potentially fatal outcomes of advanced cancer. Nevertheless, thrombin expression in NSCLC primary tumor tissues and the association between prognosis of NSCLC patients remain largely unknown. EXPERIMENTAL APPROACH: Clinical pathological analysis was performed to determine the relationship between thrombin and tumor progression. Effect of r-hirudin and DTIP on cancer progression were evaluated...
January 22, 2021: British Journal of Pharmacology
Yanqi Li, Jun Qin, Zhaocai He, Guang Cui, Kun Zhang, Buqiang Wu
BACKGROUND: Circular RNAs (circRNAs) are a crucial class of regulatory RNAs in cancer procession, including papillary thyroid cancer (PTC). Circ-Pumilio 1 (circPUM1) is a novel circRNA with the oncogenic function in ovarian cancer and lung cancer. However, the role of circPUM1 in PTC is undiscovered. OBJECTIVE: This study was performed to investigate the biological function and molecular mechanism of circPUM1 in PTC. METHODS: CircPUM1 and microRNA-21-5p (miR-21-5p) levels were analyzed via quantitative real-time polymerase chain reaction (qRT-PCR)...
January 22, 2021: Genes & Genomics
Anthony L Asher, Mohammed Ali Alvi, Mohamad Bydon, Nader Pouratian, Ronald E Warnick, James McInerney, Inga S Grills, Jason Sheehan
INTRODUCTION: Stereotactic radiosurgery (SRS) has been increasingly employed to treat patients with intracranial metastasis, both as a salvage treatment after failed whole brain radiation therapy (WBRT) and as an initial treatment. "Several studies have shown that SRS may be as effective as WBRT with the added benefit of preserving neuro-cognition". However, some patients may have local failure following SRS for intracranial metastasis, defined as increase in total lesion volume by 25% after at least 3 months of follow up...
January 22, 2021: Journal of Neuro-oncology
Kan Wu, Zhihong Liu, Xiang Li, Yiping Lu
BACKGROUND: Metastatic adrenocortical carcinoma (ACC) is an aggressive cancer with poor prognosis, with limited treatment options. The survival benefit of adrenal surgery in patients with synchronous metastatic disease has not been well explored. METHODS: Patients with ACC with synchronous metastases were identified from the Surveillance, Epidemiology, and End Results database (2010-2016). The effect of adrenal surgery on different patterns of distant metastases was assessed...
January 22, 2021: World Journal of Surgery
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