Mariko Fukui, Takeshi Matsunaga, Aritoshi Hattori, Kazuya Takamochi, Shuko Nojiri, Kenji Suzuki
OBJECTIVE: The phase III trial, JCOG0802, illustrated the superiority of sublobar resection for early-stage lung cancer in terms of overall survival, with more non-lung cancer-related deaths after lobectomy. The advantages of sublobar resection may be more pronounced in high-risk patients. This study aimed to elucidate the prognoses of high-risk patients. METHODS: Patients with a risk of being ineligible of JCOG0802 for general condition were classified as the 'high-risk group', and those who were not at risk of being ineligible were classified as the 'normal-risk group'...
September 26, 2023: European Journal of Cardio-thoracic Surgery
Alban Bessede, Florent Peyraud, Sylvestre Le Moulec, Sophie Cousin, Mathilde Cabart, François Chomy, Christophe Rey, Oren Lara, Ophélie Odin, Imane Nafia, Jean-Philippe Guégan, Antoine Italiano
PURPOSE: Overexpression of the tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase 1 (IDO1) has been reported in several tumor types, including NSCLC, and has been shown to promote tumor immune evasion and inhibit T-cell activation through increased tryptophan degradation and the production of several immunosuppressive metabolites collectively known as kynurenines. However, it remains unclear whether IDO1 expression by tumor cells is detrimental specifically in the context of PD1/PD-L1 axis blockade...
September 26, 2023: Clinical Cancer Research
Phuong The Nguyen, Megumi Hori, Tomohiro Matsuda, Kota Katanoda
BACKGROUND: We provide comprehensive sex-stratified projections of cancer prevalence for 22 cancer sites in Japan from 2020 to 2050. METHODS: Using a scenario-based approach, we projected cancer prevalence by combining projected incidence cases and survival probabilities. Age-specific incidences were forecasted using age-period-cohort models, while survival rates were estimated using a period-analysis approach and multiple parametric survival models. To understand changes in cancer prevalence, decomposition analysis was conducted, assessing the contributions of incidence, survival, and population demographics...
September 27, 2023: Cancer Epidemiology, Biomarkers & Prevention
Margaret C Weber, Luke T Izzo, Trudy G Oliver
Small cell lung cancer (SCLC) is a neuroendocrine tumor type with limited treatment options and poor prognosis. SCLC comprises multiple molecular subtypes that are defined by the expression of the lineage-related transcription factors ASCL1, NEUROD1, POU2F3 and more controversially, YAP1. SCLC exhibits remarkable plasticity with the capacity to transition between molecular states; because these states are associated with unique therapeutic susceptibilities, SCLC has been likened to a moving therapeutic target...
September 26, 2023: Cancer Research
Ido Yofe, Tamar Shami, Noam Cohen, Tomer Landsberger, Fadi Sheban, Liat Stoler-Barak, Adam Yalin, Truong San Phan, Baoguo Li, Lea Monteran, Ye'ela Scharff, Amir Giladi, Miriam Elbaz, Eyal David, Anna Gurevich-Shapiro, Chamutal Gur, Ziv Shulman, Neta Erez, Ido Amit
Cancer mortality primarily stems from metastatic recurrence, emphasizing the urgent need for developing effective metastasis targeted immunotherapies. To better understand the cellular and molecular events shaping metastatic niches, we used a spontaneous breast cancer lung metastasis model to create a single-cell atlas spanning different metastatic stages and regions. We found that pre-metastatic lungs are infiltrated by inflammatory neutrophils and monocytes, followed by accumulation of suppressive macrophages with the emergence of metastases...
September 27, 2023: Cancer Discovery
Anastasios Dimou
HLA evolutionary divergence reflects the ability to recognize diverse neoantigens as non-self, and as a biomarker is conceptually distinct from programmed cell death ligand 1 expression and tumor mutation burden. HLA based assays to predict benefit from immunotherapy in lung cancer require prospective validation.
September 26, 2023: Clinical Cancer Research
Anne Clancy, Emma V Rusilowicz-Jones, Iona Wallace, Kirby Swatek, Sylvie Urbe, Michael J Clague
Type 1 interferon stimulation highly up-regulates all elements of a ubiquitin-like conjugation system that leads to ISGylation of target proteins. An ISG15-specific member of the deubiquitylase family, USP18, is up-regulated in a co-ordinated manner. USP18 can also provide a negative feedback by inhibiting JAK-STAT signaling through protein interactions independently of DUB activity. Here, we provide an acute example of this phenomenon, whereby the early expression of USP18, post-interferon treatment of HCT116 colon cancer cells is sufficient to fully suppress the expression of the ISG15 E1 enzyme, UBA7...
September 26, 2023: Biochemical Journal
Deirdre K Tobias, Alisa K Manning, Jennifer Wessel, Sridharan Raghavan, Kenneth E Westerman, Alexander G Bick, Daniel Dicorpo, Eric A Whitsel, Jason Collins, Adolfo Correa, L Adrienne Cupples, Josée Dupuis, Mark O Goodarzi, Xiuqing Guo, Barbara Howard, Leslie A Lange, Simin Liu, Laura M Raffield, Alex P Reiner, Stephen S Rich, Kent D Taylor, Lesley Tinker, James G Wilson, Peitao Wu, April P Carson, Ramachandran S Vasan, Myriam Fornage, Bruce M Psaty, Charles Kooperberg, Jerome I Rotter, James Meigs, JoAnn E Manson
OBJECTIVE: Clonal hematopoiesis of indeterminate potential (CHIP) is an aging-related accumulation of somatic mutations in hematopoietic stem cells, leading to clonal expansion. CHIP presence has been implicated in atherosclerotic coronary heart disease (CHD) and all-cause mortality, but its association with incident type 2 diabetes (T2D) is unknown. We hypothesized that CHIP is associated with elevated risk of T2D. RESEARCH DESIGN AND METHODS: CHIP was derived from whole-genome sequencing of blood DNA in the National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine (TOPMed) prospective cohorts...
September 27, 2023: Diabetes Care
Carlos Pardo-Pastor, Jody Rosenblatt
EGFR-ERK signaling controls cell cycle progression during development, homeostasis, and disease. While EGF ligand and mechanical inputs can activate EGFR-ERK signaling, the molecules linking mechanical force to this axis have remained mysterious. We previously found that stretch promotes mitosis via the stretch-activated ion channel Piezo1 and ERK signaling. Here, we show that Piezo1 provides the missing link between mechanical signals and EGFR-ERK activation. While both EGF- and Piezo1-dependent activation trigger clathrin-mediated EGFR endocytosis and ERK activation, EGF relies on canonical tyrosine autophosphorylation, whereas Piezo1 involves Src-p38 kinase-dependent serine phosphorylation...
September 29, 2023: Science Advances
Therese Nitter Moazami, Rikke Bramming Jørgensen, Kristin V Hirsch Svendsen, Krister Aune Teigen, Marit Nøst Hegseth
Exposure to polycyclic aromatic hydrocarbons (PAHs) of high molecular weight from chimney soot can cause cancer among chimney sweepers. These sweepers may also be exposed to high concentrations of nanosized particles, which can cause significant inflammatory responses due to their relatively greater surface area per mass. In this study, the authors aimed to assess the exposure profiles of airborne personal exposure to gaseous and particulate PAHs, and real-time samples of the particle number concentrations (PNCs), particle sizes, and lung-deposited surface areas (LDSAs), for chimney sweepers in Norway...
September 27, 2023: Journal of Occupational and Environmental Hygiene
Thao Vu, Souvik Seal, Tusharkanti Ghosh, Mansooreh Ahmadian, Julia Wrobel, Debashis Ghosh
Spatial heterogeneity in the tumor microenvironment (TME) plays a critical role in gaining insights into tumor development and progression. Conventional metrics typically capture the spatial differential between TME cellular patterns by either exploring the cell distributions in a pairwise fashion or aggregating the heterogeneity across multiple cell distributions without considering the spatial contribution. As such, none of the existing approaches has fully accounted for the simultaneous heterogeneity caused by both cellular diversity and spatial configurations of multiple cell categories...
September 27, 2023: PLoS Computational Biology
Wenkan Zhang, Hao Zhou, Hengyuan Li, Haochen Mou, Eloy Yinwang, Yucheng Xue, Shengdong Wang, Yongxing Zhang, Zenan Wang, Tao Chen, Hangxiang Sun, Fangqian Wang, Jiahao Zhang, Xupeng Chai, Shixin Chen, Binghao Li, Changqing Zhang, Junjie Gao, Zhaoming Ye
Metastasis is the major cause of cancer deaths, and cancer cells evolve to adapt to various tumor microenvironments, which hinders the treatment of tumor metastasis. Platelets play critical roles in tumor development, especially during metastasis. Here, we elucidate the role of platelet mitochondria in tumor metastasis. Cancer cells are reprogrammed to a metastatic state through the acquisition of platelet mitochondria via the PINK1/Parkin-Mfn2 pathway. Furthermore, platelet mitochondria regulate the GSH/GSSG ratio and reactive oxygen species (ROS) in cancer cells to promote lung metastasis of osteosarcoma...
September 19, 2023: Cell Reports
Serban Negoita, Huann-Sheng Chen, Pamela V Sanchez, Recinda L Sherman, S Jane Henley, Rebecca L Siegel, Hyuna Sung, Susan Scott, Vicki B Benard, Betsy A Kohler, Ahmedin Jemal, Kathleen A Cronin
BACKGROUND: With access to cancer care services limited because of coronavirus disease 2019 control measures, cancer diagnosis and treatment have been delayed. The authors explored changes in the counts of US incident cases by cancer type, age, sex, race, and disease stage in 2020. METHODS: Data were extracted from selected US population-based cancer registries for diagnosis years 2015-2020 using first-submission data from the North American Association of Central Cancer Registries...
September 27, 2023: Cancer
Eitaro Kidera, Sho Koyasu, Kenji Hirata, Masatsugu Hamaji, Ryusuke Nakamoto, Yuji Nakamoto
PURPOSE: To develop a convolutional neural network (CNN)-based program to analyze maximum intensity projection (MIP) images of 2-deoxy-2-[F-18]fluoro-D-glucose (FDG) positron emission tomography (PET) scans, aimed at predicting lymph node metastasis of non-small cell lung cancer (NSCLC), and to evaluate its effectiveness in providing diagnostic assistance to radiologists. METHODS: We obtained PET images of NSCLC from public datasets, including those of 435 patients with available N-stage information, which were divided into a training set (n = 304) and a test set (n = 131)...
September 27, 2023: Annals of Nuclear Medicine
Siyi He, Changfa Xia, He Li, Maomao Cao, Fan Yang, Xinxin Yan, Shaoli Zhang, Yi Teng, Qianru Li, Wanqing Chen
China faces a disproportionate cancer burden to the population size and is undergoing a transition in the cancer spectrum. We extracted data in five aspects of cancer incidence, mortality, survival, staging distributions, and attribution to risk factors in China, the USA and worldwide from open-source databases. We conducted a comprehensive secondary analysis of cancer profiles in China in the above aspects, and compared cancer statistics between China and the USA. A total of 4,546,400 new cancer cases and 2,992,600 deaths occurred in China in 2020, accounting for 25...
September 21, 2023: Science China. Life Sciences
Xian Chang, Juanjuan Zhao, Ya Zhou, Mengmeng Guo, Yaping Yan, Ya Wang, Xu Zhao, Jing Yang, Chao Chen, Lin Tang, Ming Qin, Lin Xu
Adoptive-cell-therapy (ACT) is important therapeutic approach against cancer. We previously showed that miR-7 deficiency endowed CD4+ T cells with hyperactivation status in liver injury. However, whether CD4+ T cells with miR-7 deficiency could elicit antitumor effect in ACT is still unclear. Naïve CD4+ CD62Lhi T cells were purified from CD45.2 WT or CD45.2 miR-7def mice and transferred into syngeneic CD45.1WT mice bearing with lung tumor cells. The infiltration and function of T cells were measured by FCM and immunofluorescence assay...
September 27, 2023: Immunologic Research
Michelle R Ju, John D Karalis, Grey Leonard, John C Mansour, Georgios Karagkounis, Sam C Wang, Scott I Reznik, Matthew R Porembka
BACKGROUND: Performance of complex cancer surgeries at high-volume (HV) centers has been shown to reduce operative mortality. However, the case volume threshold that should be used to define HV centers is unknown. In this study, we determined thresholds to define HV pancreaticoduodenectomy, esophagectomy, and major lung resection centers based on clinical parameters. Then, we assessed the association of hospital volume with oncologic outcomes and overall survival. METHODS: We identified adult NCDB patients undergoing pancreaticoduodenectomy, esophagectomy, and major lung resections between 2004 and 2015...
September 27, 2023: Annals of Surgical Oncology
Fangqiu Fu, Yang Zhang, Haiquan Chen
No abstract text is available yet for this article.
September 27, 2023: Annals of Surgical Oncology
Hongsheng Deng, Juan Zhou, Hualin Chen, Xiuyu Cai, Ran Zhong, Feng Li, Bo Cheng, Caichen Li, Qingzhu Jia, Caicun Zhou, René Horsleben Petersen, Gaetano Rocco, Alex Brunelli, Calvin S H Ng, Thomas A D'Amico, Chunxia Su, Jianxing He, Wenhua Liang, Bo Zhu
BACKGROUND: Lymph node (LN) dissection is a common procedure for non-small cell lung cancer (NSCLC) to ascertain disease severity and treatment options. However, murine studies have indicated that excising tumor-draining LNs diminished immunotherapy effectiveness, though its applicability to clinical patients remains uncertain. Hence, we aim to illustrate the immunological implications of LN dissection by analyzing the impact of dissected LN (DLN) count on immunotherapy efficacy, and to propose a novel "immunotherapy-driven" LN dissection strategy...
September 27, 2023: International Journal of Surgery
Long Xu, Haojie Si, Hang Su, Fang Wang, Junqi Wu, Yunlang She, Xuefei Hu, Dong Xie, Deping Zhao, Qiuyuan Li, Jianbo Guo, Chang Chen
BACKGROUND: The eighth edition of nodal classification is defined only by anatomical location of metastatic lymph nodes and has limited prognostic discrimination power. We aimed to evaluate the prognostic significance and discriminatory capability of the number of metastatic lymph nodes (nN) in resected non-small cell lung cancer. MATERIALS AND METHODS: Patients with stage IA to IIIB resected non-small cell lung cancer between January 1, 2009 to December 31, 2013 were analyzed as Chinese cohort...
September 27, 2023: International Journal of Surgery
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