Jaewoo Son, Jun Hong Jang, In Hyeok Choi, Chang Gyu Lim, Eun Jung Jeon, Hyun Bae Bang, Ki Jun Jeong
BACKGROUND: trans-cinnamic acid (t-CA) is a phenylpropanoid with a broad spectrum of biological activities including antioxidant and antibacterial activities, and it also has high potential in food and cosmetic applications. Although significant progress has been made in the production of t-CA using microorganisms, its relatively low product titers still need to be improved. In this study, we engineered Corynebacterium glutamicum as a whole-cell catalyst for the bioconversion of L-phenylalanine (L-Phe) into t-CA and developed a repeated bioconversion process...
July 24, 2021: Microbial Cell Factories
Marja K Puurunen, Jerry Vockley, Shawn L Searle, Stephanie J Sacharow, John A Phillips, William S Denney, Benjamin D Goodlett, David A Wagner, Larry Blankstein, Mary J Castillo, Mark R Charbonneau, Vincent M Isabella, Vasu V Sethuraman, Richard J Riese, Caroline B Kurtz, Aoife M Brennan
Phenylketonuria (PKU) is a rare disease caused by biallelic mutations in the PAH gene that result in an inability to convert phenylalanine (Phe) to tyrosine, elevated blood Phe levels and severe neurological complications if untreated. Most patients are unable to adhere to the protein-restricted diet, and thus do not achieve target blood Phe levels. We engineered a strain of E. coli Nissle 1917, designated SYNB1618, through insertion of the genes encoding phenylalanine ammonia lyase and L-amino acid deaminase into the genome, which allow for bacterial consumption of Phe within the gastrointestinal tract...
July 22, 2021: Nature metabolism
A M Swaraz, Fariha Sultana, Md Wasim Bari, Khondoker Shahin Ahmed, Mehedi Hasan, Md Monirul Islam, Mohammad Amirul Islam, Mohammed A Satter, Md Hemayet Hossain, Md Shofiqul Islam, Md Iqbal Khan, Md Obayed Raihan
Blumea laciniata (Roxb.) DC. is a folk medicinal annual herb of the Asteraceae family that grows in South and Southeast Asia. In order to evaluate its phytopharmaceutical potential against diabetic, obesity, and Alzheimer's, a comprehensive phytochemical profile, in vitro and in silico enzyme inhibitory activity against α-amylase, α-glucosidase, lipase, cholinesterases, and tyrosinase along with in vitro antioxidant activity were performed. Additionally, in vivo antidiabetic activity and acute toxicity were also evaluated...
July 8, 2021: Biomedicine & Pharmacotherapy
Jelena Šuran, Ivica Cepanec, Tomislav Mašek, Kristina Starčević, Ivana Tlak Gajger, Mihaela Vranješ, Božo Radić, Saša Radić, Ivan Kosalec, Josipa Vlainić
We compared the chemical composition, antioxidant and antimicrobial activity of two propolis extracts: one obtained with nonaqueous polyethylene glycol, PEG 400 (PgEP), and the other obtained with ethanol (EEP) . We analyzed the total phenolic content (TPC) and the concentrations of ten markers of propolis antioxidant activity with HPLC-UV: caffeic acid, p -coumaric acid, trans -ferulic acid, trans -cinnamic acid, kaempferol, apigenin, pinocembrin, chrysin, CAPE, and galangin. Antioxidant activity was tested using DPPH and FRAP assay, and antimicrobial activity was assessed through minimum inhibitory concentrations (MICs) and minimum biofilm eradication concentration (MBEC) determination...
June 18, 2021: Antioxidants (Basel, Switzerland)
Zlata V Ogneva, Vlada V Volkonskaia, Alexandra S Dubrovina, Andrey R Suprun, Olga A Aleynova, Konstantin V Kiselev
Excessive ultraviolet B (UV-B) irradiation is one of the most serious threats leading to severe crop production losses. It is known that secondary metabolite biosynthesis plays an important role in plant defense and forms a protective shield against excessive UV-B irradiation. The contents of stilbenes and other plant phenolics are known to sharply increase after UV-B irradiation, but there is little direct evidence for the involvement of stilbenes and other plant phenolics in plant UV-B protection. This study showed that foliar application of trans -resveratrol (1 and 5 mM) and trans -piceid (5 mM) considerably increased tolerance to a shock of UV-B (10 min at 1800 µW cm-2 of irradiation intensity) of four-week-old Arabidopsis thaliana plants that are naturally incapable of stilbene production...
June 24, 2021: Plants (Basel, Switzerland)
Yuji Oka
BACKGROUND: Nematode attractants could serve in nematode control strategies by combining with chemical or biological nematicides or by interrupting nematodes' host-finding process. Attractiveness of some benzenoid aromatic compounds, mainly benzoic acids, alcohols, aldehydes, and phenols, to second-stage juveniles (J2) of four Meloidogyne species (M. hapla, M. incognita, M. javanica, and M. marylandi) was evaluated by using trap tubes and balls filled with washed dune sand buried in nematode-inoculated sand in Petri dishes...
June 6, 2021: Pest Management Science
Douglas I King, Kaiser Hamid, Van H Tran, Rujee K Duke, Colin C Duke
The endemic Australian plants Lepidosperma sp. Flinders Chase (Cyperaceae), Lepidosperma viscidum (Cyperaceae) and Dodonaea humilis (Sapindaceae) were found to be the botanical origin of three propolis types found on Kangaroo Island identified by TLC and 1 H NMR matching of propolis and plant resin analytical profiles. Resin samples extracted from the plant, Lepidosperma sp. Flinders Chase, were chromatographically fractionated to give: methyl 3-phenyl-2-(E-cinnamoyloxy)propanoate (1), 3-(E-8-methoxy-8-oxo-3,7-dimethyloct-2-enyl)-4-hydroxy-E-cinnamic acid (2), 3-(E-6,7-dihydroxy-3,7-dimethyloct-2-enyl)-4-hydroxy-E-cinnamic acid (3), previously undescribed; and the known stilbenes, 2-prenyl-3,5-dihydroxy-E-stilbene (6) and 2-prenyl-3-methoxy-5-hydroxy-E-stilbene (7)...
June 1, 2021: Phytochemistry
Ewa Habza-Kowalska, Agnieszka A Kaczor, Damian Bartuzi, Jacek Piłat, Urszula Gawlik-Dziki
The presented research concerns the triple activity of trans -cinnamic (tCA), ferulic (FA) and syringic acids (SA). They act as thyroid peroxidase (TPO) activators, lipoxygenase (LOX) inhibitors and show antiradical activity. All compounds showed a dose-dependent TPO activatory effect, thus the AC50 value (the concentration resulting in 50% activation) was determined. The tested compounds can be ranked as follows: tCA > FA > SA with AC50 = 0.10, 0.39, 0.69 mM, respectively. Strong synergism was found between FA and SA...
May 12, 2021: International Journal of Molecular Sciences
Fernanda Lima Torres de Aquino, Juliane Pereira da Silva, Jamylle Nunes de Souza Ferro, Vincent Lagente, Emiliano Barreto
AIM: Hydroxycinnamic acids their derivatives have various pharmacological properties. The hydroxycinnamic acid derivatives, methyl cinnamate, trans-cinnamic, and p-coumaric acids have been the object of study in the treatment of skin wounds. However, it is unclear whether these derivatives exert a direct beneficial effect on fibroblast function. In this study, we evaluated the effects of methyl cinnamate, trans-cinnamic, and p-coumaric acids on fibroblast migration in vitro. MATERIALS AND METHODS: NIH 3T3 and L929 fibroblast cell lines were exposed to each drug at several concentrations and the effect on cell viability, cell cycle, and extracellular matrix production were assessed by MTT assay, flow cytometry, and immunofluorescence staining, respectively...
May 24, 2021: Journal of Tissue Viability
Andrea Zubrova, Klara Michalikova, Jaroslav Semerad, Michal Strejcek, Tomas Cajthaml, Jachym Suman, Ondrej Uhlik
The involvement of bacterial aromatic ring-hydroxylating dioxygenases (ARHDs) in the degradation of aromatic pollutants, such as polychlorinated biphenyls (PCBs), has been well studied. However, there is considerable speculation as to the origin of this ability. One hypothesis is centered on a connection between the ability to degrade aromatic pollutants and the necessity of soil bacteria to cope with and/or utilize secondary plant metabolites (SPMs). To investigate this connection, we researched the involvement of biphenyl 2,3-dioxygenase (BPDO), an ARHD essential for the degradation of PCBs, in the metabolism of SPMs in the soil bacterium Pseudomonas alcaliphila JAB1, a versatile degrader of PCBs...
2021: Frontiers in Microbiology
Lanya Shui, Kaisen Huo, Yan Chen, Zilin Zhang, Yanfang Li, Jun Niu
Background: Vernonia amygdalina as a tropical horticultural crop has been widely used for medicinal herb, feed, and vegetable. Recently, increasing studies revealed that this species possesses multiple pharmacological properties. Notably, V. amygdalina leaves possess an abundance of flavonoids, but the specific profiles of flavonoids and the mechanisms of fl avonoid bi osynthesis in developing leaves are largely unknown. Methods: The total flavonoids of V. amygdalina leaves were detected using ultraviolet spectrophotometer...
2021: PeerJ
Muhammed Amanat, Md Sharif Reza, Md Sadikur Rahman Shuvo, Khondoker Shahin Ahmed, Hemayet Hossain, Muhammad Tawhid, Md Saifuzzaman, Mohammad Shariful Islam, Tanoy Mazumder, Md Amirul Islam, A F M Shahid Ud Daula
Zingiber roseum is native to Bangladesh and widely used in folk medicine. This present study was designed to assess the ameliorative potential of Zingiber roseum rhizome extract in carbon tetrachloride (CCl4 ) induced hepatotoxicity in mice model. Seven phenolic compounds were identified and quantified by HPLC analysis in the plant extract, including quercetin, myricetin, catechin hydrate, trans-ferulic acid, trans-cinnamic acid, (-) epicatechin, and rosmarinic acid. Hepatotoxicity was induced by administrating a single intraperitoneal injection of CCl4 (10 mL/kg) on 7th day of treatment...
May 6, 2021: Biomedicine & Pharmacotherapy
Na Li, Zong-Wen Zhang, Jia-Ni Zhang, Yue Ma, Xiao-Yu Chen, Yang Fan
The Ti-based metal-organic framework (Ti-MOF) MIL-125 with tunable crystalline size in the range of ca. 50 nm to 1500 nm was synthesized by the coordination modulation method using trans-cinnamic acid (CA) as a modulator. The coordination modulation also induced hierarchical porosity and structure defects on the nanocrystals. A significant size-dependent catalytic activity towards the oxidative desulfurization (ODS) reaction was observed for these MIL-125 nanocrystals. In particular, the MIL-125 nanocrystals with a mean size of ca...
April 27, 2021: Dalton Transactions: An International Journal of Inorganic Chemistry
Elif Ayşe Erdoğan Eliuz
The aim of the present work was the comparison of antimicrobial activity, mechanism and components of the ethanol extract (EE) from Lentinula edodes Berk (Pegler) and Agaricus bisporus Sing (Lange). The main component of EE of A. bisporus was dianhydromannitol (20.1%), while isosorbide/dianhydromannitol (21.8%) was detected at a high rate in L. edodes ethanol extract by GC-MS . The common phenolic acids were determined as chlorogenic acid, syringic acid, rutin, p-coumaric acid, ferulic acid, 2-hydroxy cinnamic acid, protocatechuic acid, abscisic acid, and trans-cinnamic acid in both mushroom extract by HPLC-MWD ...
April 24, 2021: International Journal of Environmental Health Research
Aslı Özkök, Merve Keskin, Aslı Elif Tanuğur Samancı, Elif Yorulmaz Önder, Çiğdem Takma
This study aimed to determine the standard amount of antioxidant content and compounds of the propolis for the standardization of propolis. For this purpose, the total flavonoids, total phenolic, CUPRAC antioxidant capacity content and the diversity of phenolic and flavonoid components of these propolis samples were found by HPLC determined at the 23 propolis samples which were collected different regions of Turkey. Beside that, the similarities and differences of these 23 provinces to each other according to their antioxidant capacities were investigated by multidimensional scaling analysis...
2021: Applied biological chemistry
Ty Viet Pham, Hanh Nhu Thi Hoang, Hoai Thi Nguyen, Hien Minh Nguyen, Cong Thang Huynh, Thien Y Vu, Anh Thu Do, Nguyen Hoai Nguyen, Bich Hang Do
Distichochlamys benenica is a native black ginger that grows in Vietnam. In point of fact, there is limitation of available information in the literature making mention of the chemical constituents and bioactive properties of this plant. This study is aimed at isolating trans-o -coumaric acid ( 1 ), trans -cinnamic acid ( 2 ), and borneol ( 3 ) from the rhizomes of D. benenica Q.B.Nguyen & Škorničk and evaluate the anti-inflammatory and antimicrobial activities of 1-3 using the carrageenan paw edema model and the dilution broth method, respectively...
2021: BioMed Research International
Hyeon Ji Yeo, Chang Ha Park, Ye Eun Park, Hyejin Hyeon, Jae Kwang Kim, Sook Young Lee, Sang Un Park
Our previous study showed that flowers of Agastache rugosa had higher phenolic levels and higher antibacterial and antioxidant capacity compared to those of the leaves and stems. The aim of this study was to provide information on the variation in primary and secondary metabolites during flower development in A. rugosa by using high performance liquid chromatography (HPLC) and assays of total anthocyanin (TAC), flavonoid (TFC), and phenolic content (TPC), as well as gas chromatography time-of-flight mass spectrometry (GC-TOFMS) analysis...
March 2021: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
Loorthuraja Rasu, Mona Amiri, Steven H Bergens
The organic carbazole-cyanobenzene push-pull dye 1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene was derivatized and attached to carbon or indium-doped tin oxide (ITO) electrodes by simple diazonium electrografting. The surface-bound dye is active and stable for the visible light photosynthetic isomerization of a wide range of functionalized stilbene and cinnamic acid derivatives. Up to 87,000 net turnovers were obtained for the isomerization of trans -stilbene. The isomerizations can be carried out in air with a 33% reduction in the rate...
April 7, 2021: ACS Applied Materials & Interfaces
Juana Rozalén, M Mercedes García-Martínez, Maria Engracia Carrión, Amaya Zalacain, Horacio López-Córcoles, Manuel Carmona
The guayulins are a family of sesquiterpene compounds that consist of an isoprenoid nucleus substituted either by trans -cinnamic or p -anisic acid, and are present only in the resinous fraction of the rubber plant guayule ( Parthenium argentatum , Gray). While the natural role of the guayulins remains enigmatic, they may serve as a defense function against other plants or herbivores by virtue of the accumulation of cinnamic acid. Prior research has suggested seasonal variation in guayulin content, which has been shown to decrease as winter arrives in two different varieties...
March 12, 2021: Plants (Basel, Switzerland)
Kenji Takada, Katsuaki Yasaki, Sakshi Rawat, Kosuke Okeyoshi, Amit Kumar, Hideyuki Murata, Tatsuo Kaneko
Cinnamate-based polyesters were synthesized, including poly(4-hydroxycinnamic acid), poly(4-hydroxy-3-methoxycinnamic acid), poly(3-hydroxycinnamic acid) (P3HCA), and hyperbranched poly(3,4-dihydroxycinnamic acid) (PdHCA). These materials were further processed into hard and dry membranes by casting and underwent photoreactions by ultraviolet (UV) light. The photodeformation behavior of the linear and hyperbranched polyester containing membranes with cinnamate derivatives in the main chain was observed macroscopically and microscopically...
March 16, 2021: ACS Applied Materials & Interfaces
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