M Scavone, V Tallarico, E Stefanelli, F Parisi, R De Sarro, C Salpietro, G Ceravolo, S Sestito, L Pensabene, R Chimenz, M P Calabrò, E Gitto, L Giancotti, D Concolino
Congenital hypothyroidism (CH) is the most common endocrine disease in children, according to literature, infants with CH have an increased risk of associated congenital malformations (CM), especially cardiac defects (CD), compared to the general population. We retrospectively analyzed medical records of 255 patients with a positive screening result for CH in the period 1991-2016 followed at our Center. At the time of enrollment, the clinical examination included looking for the presence of heart murmurs and dysmorphic features...
July 2020: Journal of Biological Regulators and Homeostatic Agents
Nicolas Ariel Brozzi, Renzo Otoniel Cifuentes, Ali Ghodsizad, Amanda Saab, Salih Yasin, Mathias Loebe
Patients with surgically repaired complex congenital cardiac anomalies present unique characteristics that can make the implementation of extracorporeal membrane oxygenation (ECMO) support especially challenging. Very few series have reported the outcomes of ECMO support during pregnancy and peripartum. We report a case of successful extracorporeal cardiopulmonary resuscitation during cesarean delivery in a patient with surgically repaired d-transposition of the great arteries, and we discuss particular aspects that contributed to successful implementation of ECMO support and hospital discharge...
September 28, 2020: World Journal for Pediatric & Congenital Heart Surgery
Y Truba, M Radchenko, O Golovenko, M Beridze, V Lazoryshynets
Aortic arch hypoplasia is a congenital anomaly of the development of the aortic arch, characterized by hemodynamically significant narrowing of one or more segments of the aortic arch. The combination of simple transposition of the great arteries (TGA) and obstruction at the level of the aortic arch is not very common. However, when transposition is combined with the VSD, Taussig-Bing anomaly, this combination is more common. The degree of obstruction at the level of the aortic arch may vary from discrete coarctation of the aorta, tubular hypoplasia of the aortic arch, to interruption...
July 2020: Georgian Medical News
Chuong V Pham, Dinh H Nguyen, Anh T Vo, Trang T Nguyen, Ly H Phan, Bac H Nguyen
INTRODUCTION: Situs inversus totalis (SIT) is an uncommon congenital condition characterized by total transposition of abdominal and thoracic viscera. Performing minimally invasive cardiac surgery on individuals with SIT requires different surgical planning because of the unfamiliar positions of the heart and great vessels. PRESENTATION OF CASE: A 52-year-old female was admitted to our center with palpitations and dyspnea on exertion. Chest X-ray showed dextrocardia...
July 18, 2020: International Journal of Surgery Case Reports
Clément Batteux, Samya Abakka, Régis Gaudin, Pascal Vouhé, Olivier Raisky, Damien Bonnet
OBJECTIVE: Using 3-dimensional (3D) modeling to predict late coronary events after the arterial switch operation (ASO) for transposition of the great arteries (TGA). METHOD: We reviewed 100 coronary computed tomography scans performed after ASO randomly selected from free-from-coronary-event patients and 21 coronary computed tomography scans from patients who had a coronary event later than 3 years after ASO. Using 3D modeling software, we defined and measured 6 geometric criteria for each coronary artery: Clockwise position of coronary ostium, First centimeter angle defined as the angle between of the coronary artery ostium and the first centimeter of the vessel, Minimal 3D angle between the coronary first centimeter and the aortic wall, ostium height defined as the distance between the ostium and the aortic valve, distance between the coronary ostium and the pulmonary artery, and distance between the coronary first centimeter and the pulmonary artery...
June 29, 2020: Journal of Thoracic and Cardiovascular Surgery
Nathalie Jeanne Bravo-Valenzuela, Alberto Borges Peixoto, Edward Araujo Júnior
The simple transposition of the great arteries (TGA) is a cyanotic heart disease that accounts for 5% to 7% of all congenital heart diseases (CHDs). It is one of the CHDs that is commonly underdiagnosed in utero, with prenatal detection rates of less than 50%. The simple TGA is characterized by ventriculoarterial discordance and atrioventricular concordance with the great arteries in a parallel relationship. The prenatal diagnosis of TGA influences the postnatal outcome, thus, requiring planned delivery and perinatal management...
June 8, 2020: Ultrasonography
Mumun Sinha, Niraj Nirmal Pandey, Arun Sharma, Priya Jagia
Isolation of the right subclavian artery (RSCA), defined as loss of continuity between the RSCA and aorta, is a rare anomaly and its association with dextrotransposition of great arteries (D-TGA) is exceedingly unusual. We present the case of a 5-day-old neonate with cyanosis from birth and a transthoracic echocardiographic diagnosis of D-TGA, where on computed tomography angiography, the RSCA was seen arising from the proximal part of the ipsilateral pulmonary artery via a patent right ductus arteriosus.
April 2020: Annals of Pediatric Cardiology
Aine McManus, Tim Moloney, Pamela Kelly, Conor Rowan, Cliona Skelly, Catherine I McAloon
BACKGROUND: Congenital heart diseases are occasionally encountered in the bovine species. Ventricular septal defects (VSD) and atrial septal defects (ASD) are reported to be the most common; however, a vast collection have been reported [1, 2]. Congenital heart diseases is thought to represent less than 3% of all congenital abnormalities in calves [3]. Various cardiac anomalies arise due to defective embryologic development such as defects of the septae or the cardiac chambers [2]. The exact aetiology of these congenial heart anomalies remains to be fully elucidated [4]...
June 30, 2020: BMC Veterinary Research
Linda J Wang, Sarah C Crofts, Thomas P Nixon, Bernadette J Goudreau, David C Chang, Mark F Conrad, Matthew J Eagleton, W Darrin Clouse
OBJECTIVES: Up to 20% of patients requiring open supra-aortic trunk reconstruction (SAT) have significant carotid artery stenosis. The addition of carotid endarterectomy (CEA) to SAT has been described. Yet, additive risks are not well defined and controversy remains as to whether concomitant CEA increases stroke risk. This study assessed the perioperative effects of adding CEA to SAT. METHODS: Using the National Surgical Quality Improvement Program (NSQIP), patients who underwent SAT from 2005-2015 were evaluated...
June 26, 2020: Annals of Vascular Surgery
Zied Daoud, Halkawt Ali Nuri, Ambra Miette, Giuseppe Pomè
OBJECTIVE: Prognosis of the transposition of the great arteries has completely changed since the introduction of the arterial switch. Time limit to perform this intervention is still controversial. The aim of this study is to demonstrate the early and late outcome of primary arterial switch operation beyond the age of months. METHODS: We included all patients with the diagnosis of transposition of the great arteries with intact ventricular septum beyond the age of 8 weeks who underwent primary arterial switch operation...
July 2020: Cardiology in the Young
Michelle L Miles, Natasha Cowan, Gavin Jackson
Objective: To report a case of diabetes mellitus (DM) associated with partial pancreatic agenesis and congenital heart disease (CHD) in a patient found to have a nonsense mutation of the GATA6 gene. Methods: We present the imaging, laboratory, and genetic findings, and describe the clinical course of a patient with an atypical presentation of DM as well as CHD, who was found to have partial pancreatic agenesis on computed tomography (CT) imaging. Genetic testing was performed to identify monogenic DM...
May 2020: AACE Clinical Case Reports
S Hascoet, J Le Pavec, A De Lemos, M Pontailler, L Savale, O Mercier, S Mussot, S Feuillet, F Stephan, M Humbert, D Bonnet, E Fadel
PURPOSE: Heart and lung transplantation (HLT) or double lung transplantation (DLT) with shunt closure is an end-stage therapeutic option in patients with pulmonary arterial hypertension (PAH) due to congenital heart diseases (CHD). Its benefit remains controversial METHODS: We retrospectively investigated outcomes of 108 patients with PAH-CHD listed for transplantation over 32 years and assessed the impact of defects complexity. RESULTS: Complex defects (n=47; 43...
April 2020: Journal of Heart and Lung Transplantation
Payton Kendsersky, Cary Ward
Survivorship into adulthood of patients with congenital heart disease is due to improvements in prenatal detection, novel surgeries, and specialized adult congenital heart disease care. As patients survive further into adulthood, long-term complications of congenital and repaired physiology have been more clearly elucidated. The overall mortality of patients with adult congenital heart disease with heart failure is around 4%. Congenital malformations, palliations, residual defects, and resultant physiology impact the right ventricle...
May 2020: Cardiology Clinics
Zhen-Juan Yang, Greggory R DeVore, Qiu-Yan Pei, Ya-Ni Yan, Yun-Tao Li, Yan Wang
OBJECTIVES: Establish a fetal heart anatomical cross-sectional database that correlates with screening transverse ultrasound images suggested by international professional organizations to detect congenital heart defects. METHODS: Fetuses with suspected congenital heart defects identified using the following cardiac image sequences obtained from transverse slices beginning from the upper abdomen and ending in the upper thorax were the subjects of this study: (1) four-chamber view, (2) left ventricular outflow tract view, (3) three-vessel right ventricular outflow tract view, and (4) the three-vessel tracheal view...
June 2020: Prenatal Diagnosis
Gerardo Vargas-Camacho, Verónica Contreras-Cepeda, Rene Gómez-Gutierrez, Guillermo Quezada-Valenzuela, Adriana Nieto-Sanjuanero, Jesús Santos-Guzmán, Francisco González-Salazar
Objectives: Extracorporeal membrane oxygenation is a life support procedure developed to offer cardiorespiratory support when conventional therapies have failed. The purpose of this study is to describe the findings during the first years using venoarterial extracorporeal membrane oxygenation in pediatric patients after cardiovascular surgery at Christus Muguerza High Specialty Hospital in Monterrey, Mexico. Methods: This is a retrospective, observational, and descriptive study...
2020: SAGE Open Medicine
Nathalie Jeanne Bravo-Valenzuela, Alberto Borges Peixoto, Edward Araujo Júnior
Congenitally corrected transposition of the great arteries is a rare and complex congenital heart disease. It essentially occurs with atrioventricular and ventriculoarterial discordance, in which the great vessels become parallel. Cases of corrected transposition of the great arteries are more frequently associated with other cardiac anomalies. In the fetus, corrected transposition of the great arteries may not be diagnosed on obstetric cardiac ultrasound, especially in the absence of other cardiac malformations (isolated corrected transposition of the great arteries)...
December 2019: Journal of Ultrasonography
Muhammad Shabbir Rawala, Amna Saleem Ahmed, Syed Bilal Rizvi
Patients with single-ventricle physiology encompass a wide array of anatomic subtypes, including but not limited to: tricuspid atresia, hypoplastic left heart syndrome, double-outlet or double-inlet ventricles. The outcomes for patients with single ventricle born before 1990 are relatively poor. An 81-year-old female presented to the hospital as non-ST elevation myocardial infarction. She was started on antiplatelet and anticoagulation. Echocardiogram revealed a single ventricle which was thought to be left ventricle with possible transposition of great vessels...
2019: Journal of Community Hospital Internal Medicine Perspectives
Chao Huang, Bo Wen Zhao, Ran Chen, Hai Su Pang, Mei Pan, Xiao Hui Peng, Bei Wang
OBJECTIVES: To evaluate the performance of fetal intelligent navigation echocardiography (FINE) applied to spatiotemporal image correlation (STIC) volumes in generating 3 specific abnormal cardiac views (left ventricular outflow tract, right ventricular outflow tract, and 3-vessel and trachea) used to screen for d-transposition of the great arteries (d-TGA). METHODS: In this prospective study, 1 or more STIC volumes were obtained from the 4-chamber view in 34 second- and third-trimester fetuses with d-TGA...
November 1, 2019: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Abdul Majid, Syed Hamza Bin Waqar, Farah Yasmin, Osama Mohiuddin, Anosh Aslam Khan
L-looped transposition of great arteries (L-TGA) is an extremely rare heart condition. It is associated with physiologically corrected transposition of great vessels, leading to the normal return of deoxygenated systemic venous blood to the heart and transport of oxygenated pulmonary venous blood to the main systemic circulation. Anatomic discordancy and anomalous coronary artery distribution predispose the right ventricle to excessive workload and eventual heart failure. This mandates anatomic correction or proper medical management of heart failure...
August 18, 2019: Curēus
Roel L F van der Palen, Quirine S Deurvorst, Lucia J M Kroft, Pieter J van den Boogaard, Mark G Hazekamp, Nico A Blom, Hildo J Lamb, Jos J M Westenberg, Arno A W Roest
BACKGROUND: Patients with transposition of the great arteries (TGA) have an altered aortic geometry after an arterial switch operation (ASO), with neo-aortic root dilatation as an important complication. Geometry-related aortic hemodynamics have been assumed to contribute to pathology of the ascending aorta (AAo). PURPOSE: To evaluate aortic flow displacement (FD) and regional wall shear stress (WSS) in relation to ascending neo-aortic geometry in children after ASO...
October 7, 2019: Journal of Magnetic Resonance Imaging: JMRI
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