Ellen H Singleton, Yolande A L Pijnenburg, Carole H Sudre, Colin Groot, Elena Kochova, Frederik Barkhof, Renaud La Joie, Howard J Rosen, William W Seeley, Bruce Miller, M Jorge Cardoso, Janne Papma, Philip Scheltens, Gil D Rabinovici, Rik Ossenkoppele
BACKGROUND: We previously found temporoparietal-predominant atrophy patterns in the behavioral variant of Alzheimer's disease (bvAD), with relative sparing of frontal regions. Here, we aimed to understand the clinico-anatomical dissociation in bvAD based on alternative neuroimaging markers. METHODS: We retrospectively included 150 participants, including 29 bvAD, 28 "typical" amnestic-predominant AD (tAD), 28 behavioral variant of frontotemporal dementia (bvFTD), and 65 cognitively normal participants...
November 14, 2020: Alzheimer's Research & Therapy