Leonardo Buttice, Maryam Ghani, Janahan Suthakar, Sathyan Gnanalingham, Elliott Carande, Brett W C Kennedy, Alex Pitcher, James H P Gamble, Mahmood Ahmad, Andrew Lewis, Peter Jüni, Oliver J Rider, Jeffrey W Stephens, Jonathan J H Bray
AIMS: To conduct a meta-analysis of randomized controlled trials (RCTs) to assess the effect of sodium-glucose cotransporter-2 (SGLT2) inhibitors on inflammatory biomarkers. METHODS: Medline, Embase and the Cochrane Library were searched for RCTs investigating the effect of SGLT2 inhibitors on inflammatory biomarkers, adipokine profiles and insulin sensitivity. RESULTS: Thirty-eight RCTs were included (14 967 participants, 63.3% male, mean age 62 ± 8...
April 11, 2024: Diabetes, Obesity & Metabolism