keyword
https://read.qxmd.com/read/38532827/biomarkers-of-chronic-inflammation-and-cognitive-decline-a-prospective-observational-study
#21
JOURNAL ARTICLE
Bhavna A Guduguntla, Alexi Vasbinder, Elizabeth Anderson, Tariq U Azam, Pennelope Blakely, Noah J Webster, Richard Gonzalez, Toni Atonucci, Judith L Heidebrink, Bruno Giordani, Laura Zahodne, Benjamin M Hampstead, Kristine J Ajrouch, Salim S Hayek
We sought to determine whether the biomarkers of chronic inflammation predict cognitive decline in a prospective observational study. We measured baseline serum soluble urokinase plasminogen activator receptor (suPAR) and high sensitivity C-reactive protein (hs-CRP) levels in 282 participants of the University of Michigan Memory and Aging Project. Cognitive function was measured using the Montreal Cognitive Assessment (MoCA) and the Clinical Dementia Rating (CDR) scale for up to five time points. SuPAR and hs-CRP levels were not significantly higher in participants with mild cognitive impairment ( n  = 97) or dementia ( n  = 59), compared to those with normal cognitive function ( n  = 126)...
2024: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://read.qxmd.com/read/38532748/influencing-factors-of-healthy-aging-risk-assessed-using-biomarkers-a-life-course-perspective
#22
JOURNAL ARTICLE
Cedric Zhang Bo Lua, Yajie Gao, Jinming Li, Xingqi Cao, Xinwei Lyu, Yinuo Tu, Shuyi Jin, Zuyun Liu
Assessing individual risks of healthy aging using biomarkers and identifying associated factors have become important areas of research. In this study, we conducted a literature review of relevant publications between 2018 and 2023 in both Chinese and English databases. Previous studies have predominantly used single biomarkers, such as C-reactive protein, or focused on specific life course stages and factors such as socioeconomic status, mental health, educational levels, and unhealthy lifestyles. By summarizing the progress in this field, our study provides valuable insights and future directions for promoting healthy aging from a life course perspective...
March 15, 2024: China CDC weekly
https://read.qxmd.com/read/38532586/-evaluation-of-safety-of-early-enteral-nutrition-in-patients-with-severe-intra-abdominal-infection-and-intestinal-fistulas
#23
JOURNAL ARTICLE
T Xie, C Chen, D L Yang, W Y Wang, F Chen, Y N He, P F Wang, Y S Li
Objective: To evaluate the safety of early enteral nutrition (EEN) support in patients with severe intra-abdominal infection and intestinal fistulas. Methods: This was a retrospective cohort study. We collected relevant clinical data of 204 patients with severe intra-abdominal infection and intestinal fistulas who had been managed in the No. 1 Department of General Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University between 1 January 2017 and 1 January 2020. The patients were allocated to EEN or delayed enteral nutrition (DEN) groups depending on whether enteral nutrition had been instituted within 48 hours of admission to the intensive care unit...
March 25, 2024: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://read.qxmd.com/read/38532424/efficacy-of-different-doses-of-corticosteroids-in-treating-severe-covid-19-pneumonia
#24
JOURNAL ARTICLE
Ge Zhang, Lin Su, Wenwen Wu, Qing Qiao, Shuncui Gao, Yan Zhang, Yanmei Zhang
BACKGROUND: To investigate the efficacy of different doses of corticosteroids in treating severe coronavirus disease 2019 (COVID-19) pneumonia. METHODS: Between May 01, 2023, and June 20, 2023, 48 patients with severe COVID-19 pneumonia were treated at the Department of Respiratory and Critical Care Medicine of Jinan Fourth People's Hospital. The observation group (21 patients) received standard care and high-dose corticosteroids, (high-dose group). The control group (27 patients) received standard care and low-dose corticosteroids (low-dose group)...
March 26, 2024: Virology Journal
https://read.qxmd.com/read/38532316/impact-of-resistance-exercise-on-patients-with-chronic-kidney-disease
#25
JOURNAL ARTICLE
Chong-Cheng Chen, Yue-Yang Huang, Hua-Zhang, Xia-Liu, Xue-Qin Li, Yan-Qiong Long, Zheng-Wen Chen, Tao Jin
BACKGROUND: Chronic kidney disease (CKD) has become an increasingly important public health disease with a high incidence rate and mortality. Although several studies have explored the effectiveness of resistance exercise in improving the prognosis of CKD patients, the number of studies is still limited and the results are still controversial. OBJECTIVES: We conducted this meta-analysis of randomized controlled trials (RCT) studies to evaluate the effectiveness of resistance exercise on CKD patients...
March 26, 2024: BMC Nephrology
https://read.qxmd.com/read/38532309/contribution-of-nutritional-lifestyle-and-metabolic-risk-factors-to-parkinson-s-disease
#26
JOURNAL ARTICLE
Nicola Veronese, Andrea Nova, Teresa Fazia, Emilia Riggi, Lin Yang, Laura Piccio, Bo-Huei Huang, Matthew Ahmadi, Mario Barbagallo, Maria Notarnicola, Gianluigi Giannelli, Giovanni De Pergola, Emmanuel Stamatakis, Emanuele Cereda, Luisa Bernardinelli, Luigi Fontana
BACKGROUND: Modifiable risk factors for Parkinson's disease (PD) are poorly known. OBJECTIVES: The aim is to evaluate independent associations of different nutritional components, physical activity, and sedentary behavior and metabolic factors with the risk of PD. METHODS: In this population-based prospective cohort study using the data of the United Kingdom Biobank (from 2006-2010), 502,017 men and women who were free from PD (International Classification of Diseases 10th edition; "G20") at baseline were included...
March 26, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
https://read.qxmd.com/read/38532280/procalcitonin-and-c-reactive-protein-as-early-markers-of-anastomotic-leakage-in-intestinal-resections-for-advanced-ovarian-cancer-edmocs
#27
JOURNAL ARTICLE
José Luis Sánchez-Iglesias, Clara Morales-Coma, Lucas Minig, Víctor Lago, Santiago Domingo, Gemma Mancebo, Jaime Siegrist, María Soledad Fidalgo García, Antoni Llueca, Anna Serra, Paloma Cobas Lozano, Arantza Lekuona Artola, Natalia R Gómez-Hidalgo, Úrsula Acosta, Roser Ferrer-Costa, Melissa Bradbury, Assumpció Pérez-Benavente, Antonio Gil-Moreno
INTRODUCTION: Serum levels of procalcitonin and C-reactive protein (CRP) have been used to predict anastomotic leakage after colorectal surgery, but information is scarce in advanced ovarian cancer (AOC) surgery with bowel resection. This study aimed to assess the predictive value of procalcitonin and CRP in detecting anastomotic leakage after AOC surgery with bowel resection. The study also aimed to determine the optimal postoperative reference values and the best day for evaluating these markers...
March 26, 2024: Acta Obstetricia et Gynecologica Scandinavica
https://read.qxmd.com/read/38532244/modifiable-lifestyle-sedentary-behaviors-and-the-risk-of-frailty-a-univariate-and-multivariate-mendelian-randomization-study
#28
JOURNAL ARTICLE
Ling Yu, Zeyi Guo, Qing Long, Xinling Zhao, Yilin Liu, Xiang Cao, Yunqiao Zhang, Weimin Yan, Qing Qing Qian, Jian Chen, Zhaowei Teng, Yong Zeng
This research conducted a two-sample univariate and multivariate Mendelian Randomization (MR) analysis to explore the causal link between different types of leisure sedentary behavior (LSB) and frailty. Independent instrumental variables significantly associated with sedentary behaviors (p < 5 × 10-8 ) are obtained from a genome-wide association study (GWAS) of 422,218 individuals, and Frailty Index (FI) are derived from the latest GWAS dataset of 175,226 individuals. MR analysis is conducted using inverse variance weighting, MR-Egger, weighted median, simple mode, and weighted mode, supplemented by MRAPSS...
March 26, 2024: Advanced biology
https://read.qxmd.com/read/38531621/guselkumab-provides-durable-improvement-across-psoriatic-arthritis-disease-domains-post-hoc-analysis-of-a-phase-3-randomised-double-blind-placebo-controlled-study
#29
JOURNAL ARTICLE
Laura C Coates, Laure Gossec, Miriam Zimmermann, May Shawi, Emmanouil Rampakakis, Natalie J Shiff, Alexa P Kollmeier, Xie L Xu, Peter Nash, Philip J Mease, Philip S Helliwell
OBJECTIVE: Evaluate long-term guselkumab effectiveness across Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA)-recognised domains/related conditions of psoriatic arthritis (PsA). METHODS: Post hoc analyses used data from DISCOVER-2 (NCT03158285) biologic/Janus-kinase inhibitor-naïve participants with active PsA (≥5 swollen/≥5 tender joints, C-reactive protein ≥0.6 mg/dL), randomised (1:1:1) to guselkumab every 4 or 8 weeks (Q4W/Q8W) or placebo with crossover to guselkumab...
March 26, 2024: RMD Open
https://read.qxmd.com/read/38531501/effects-of-moderate-ethanol-exposure-on-risk-factors-for-cardiovascular-disease-and-colorectal-cancer-in-adult-wistar-rats
#30
JOURNAL ARTICLE
Anna J Kwon, Lani Morales, Louise Chatagnier, Jacqueline Quigley, Jeremy Pascua, Natalie Pinkowski, Susan M Brasser, Mee Young Hong
While past studies have provided evidence linking excessive alcohol consumption to increased risk for cardiovascular diseases (CVDs) and colorectal cancer (CRC), existing data on the effects of moderate alcohol use on these conditions have produced mixed results. The purpose of this study was to investigate the effects of moderate alcohol consumption on risk factors associated with the development of CVDs and CRC in adult rats. Twenty-four, 14-month-old, non-deprived male Wistar rats were randomly assigned to either an ethanol group, which consisted of voluntary access to a 20% (v/v) ethanol solution on alternate days, or a water control group (n = 12/group) for 13 weeks...
March 24, 2024: Alcohol
https://read.qxmd.com/read/38531354/antibiotic-bone-cement-accelerates-diabetic-foot-wound-healing-elucidating-the-role-of-rock1-protein-expression
#31
JOURNAL ARTICLE
Chenglan Yang, Dali Wang
Clinical studies indicate antibiotic bone cement with propeller flaps improves diabetic foot wound repair and reduces amputation rates, but the molecular mechanisms, particularly key proteins' role remain largely unexplored. This study assessed the efficacy of antibiotic bone cement for treating diabetic foot wounds, focusing on molecular impact on ROCK1. Sixty patients were randomized into experimental (EXP, n = 40) and control (CON, n = 20) groups, treated with antibiotic bone cement and negative pressure...
April 2024: International Wound Journal
https://read.qxmd.com/read/38531171/efficacy-and-safety-of-mesenchymal-stem-cell-derived-microvesicles-in-mouse-inflammatory-arthritis
#32
JOURNAL ARTICLE
Shixiong Wei, Chenyang Lu, Sujia Li, Qiuping Zhang, Ruijuan Cheng, ShuYue Pan, QiuHong Wu, Xueting Zhao, Xinping Tian, Xiaofeng Zeng, Yi Liu
OBJECTIVE: To determine the effective and safe intravenous doses of mesenchymal stem cells (MSCs)-derived microvesicles (MVs) and to elucidate the possible causes of death in mice receiving high-dose MVs. METHODS: MVs were isolated from human MSCs by gradient centrifugation. Mice with collagen-induced arthritis were treated with different doses of intravenous MVs or MSCs. Arthritis severity, white blood cell count, and serum C-reactive protein levels were measured...
March 25, 2024: International Immunopharmacology
https://read.qxmd.com/read/38531068/real-world-effectiveness-of-ustekinumab-in-ulcerative-colitis-in-a-united-states-multicenter-cohort-consortium
#33
JOURNAL ARTICLE
Andres J Yarur, Ryan Ungaro, Katherine Huang, Wenfei Wang, Priya Sasankan, Mir Zulqarnain, Amanda M Johnson, Geoffrey Bader, Carl Kay, Nicholas Costable, David Dulaney, Marc Fenster, Poonam Beniwal-Patel, Gaurav Syal, Anish Patel, Edward Loftus, Joel Pekow, Benjamin Cohen, Parakkal Deepak
BACKGROUND: Pivotal trials have shown that ustekinumab is effective in ulcerative colitis (UC). However, the population included in these trials do not represent the cohort of patients treated in the real world. In this study, we aimed to describe the effectiveness and safety of ustekinumab in a clinical cohort of patients with UC. METHODS: We performed a multicenter retrospective cohort study and included patients with active UC starting ustekinumab. Variables collected included demographics, clinical data, and disease activity (measured using partial Mayo score [PMS] and endoscopic Mayo score) at follow-up...
March 26, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38531051/irreversible-transmural-intestinal-necrosis-in-acute-mesenteric-ischemia-retrospective-cohort-study-from-a-high-volume-hospital
#34
JOURNAL ARTICLE
Zhiyuan Yu, Xiaoyu Dong, Rui Li, Chun Xiao, Sixin Zhou, Zhen Yuan, Yunhe Gao, Peiyu Li
Background: Owing to the low incidence rate and nonspecific symptoms of acute mesenteric ischemia (AMI), the identification and prediction of irreversible transmural intestinal necrosis (ITIN) and extensive bowel resection (≥100 cm) (EBR) are difficult and critical. This study aimed to investigate the risk factors for ITIN and EBR in patients with AMI. Methods: The clinical data of 254 AMI patients were retrospectively analyzed. Furthermore, the incidence of ITIN and EBR were set as dependent variables, and relevant risk factors were screened using univariate and multivariate logistic regression analyses...
March 27, 2024: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://read.qxmd.com/read/38530743/risk-factors-and-mortality-outcomes-of-covid-19-in-people-living-with-hiv-a-systematic-review-and-meta-analysis
#35
JOURNAL ARTICLE
Mahmoud Kandeel
This study was performed to reveal the risk factors associated with mortality in people living with HIV (PLHIV) who were diagnosed with COVID-19. Studies reporting deaths among PLHIV and infected with SARS-CoV-2 were investigated. After protocol setup and registration, the extracted sources were categorized and assessed for quality. This study examined ten articles with a total of 46,136 patients. Patients aged ≥ 60 years (hazard ratio [HR] = 2.22; 95% CI: 1.617, 3.050; p < 0.001), male (HR = 1.668; 95% CI: 1...
2024: AIDS Reviews
https://read.qxmd.com/read/38530490/factors-affecting-responsiveness-of-vadadustat-in-patients-with-anemia-associated-with-chronic-kidney-disease-a-post-hoc-subgroup-analysis-of-japanese-phase-3-randomized-studies
#36
JOURNAL ARTICLE
Masaomi Nangaku, Kiichiro Ueta, Kenichi Nishimura, Kazuyo Sasaki, Takafumi Hashimoto
BACKGROUND: Vadadustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor developed for treating anemia in chronic kidney disease (CKD). The purpose of this post-hoc analysis was to investigate the factors affecting the responsiveness to vadadustat in anemia patients with nondialysis-dependent (NDD) or hemodialysis-dependent (HDD) CKD in two Japanese phase 3 studies. METHODS: Of 151 and 162 patients enrolled in NDD-CKD and HDD-CKD studies, 136 and 140 patients, respectively, were included and divided into subgroups for the analysis...
March 26, 2024: Clinical and Experimental Nephrology
https://read.qxmd.com/read/38530466/crp-under-130-mg-l-rules-out-the-diagnosis-of-legionella-pneumophila-serogroup-1-urinella-study
#37
JOURNAL ARTICLE
Timothée Klopfenstein, Souheil Zayet, Samantha Poloni, Vincent Gendrin, Damien Fournier, Jean-Baptiste Vuillemenot, Philippe Selles, Alain Dussaucy, Gaelle Coureau, Marta Avalos-Fernandez, Lynda Toko, Pierre-Yves Royer, Charles-Eric Lavoignet, Bouchra Amari, Marc Puyraveau, Catherine Chirouze
INTRODUCTION: In case of pneumonia, some biological findings are suggestive for Legionnaire's disease (LD) including C-reactive protein (CRP). A low level of CRP is predictive for negative Legionella Urinary-Antigen-Test (L-UAT). METHOD: Observational retrospective study in Nord-Franche-Comté Hospital with external validation in Besançon University Hospital, France which included all adults with L-UAT performed during January 2018 to December 2022. The objective was to determine CRP optimal threshold to predict a L-UAT negative result...
March 26, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38530178/case-323-minute-pulmonary-meningothelial-like-nodules
#38
JOURNAL ARTICLE
Furkan Ufuk, Emel Kilicarslan, Ferda Bir, Goksel Altinisik
A 70-year-old woman with a 6-year history of asthma, a 12-year history of diabetes mellitus, and who did not smoke presented to the pulmonology clinic with dyspnea and cough. Chest CT performed 5 years earlier for similar symptoms revealed multiple pulmonary nodules. However, she was lost to follow-up before the work-up was concluded. Otherwise, her medical history was unremarkable. Family history included maternal endometrial cancer. Physical examination revealed partial oxygen saturation of 98%, respiratory rate of 18 breaths per minute, and heart rate of 77 beats per minute...
March 2024: Radiology
https://read.qxmd.com/read/38530043/albumin-and-c-reactive-protein-as-diagnostic-markers-for-neonatal-sepsis-a-retrospective-study
#39
JOURNAL ARTICLE
Wei Yin, ChengChao Fang, Xiaoping Fan, YanLin Chen
OBJECTIVE: To assess the applicability of albumin (ALB) and C-reactive protein (CRP) concentrations in the diagnosis of sepsis in neonates on the day of admission, and to help with early identification and intervention in the development of sepsis. METHODS: This retrospective study included all neonates who were admitted to the neonatal intensive care unit from January 2020 to June 2023. We studied 160 full-term neonates, including 80 with sepsis and 80 healthy controls...
March 2024: Journal of International Medical Research
https://read.qxmd.com/read/38529345/factors-most-strongly-associated-with-breathlessness-in-a-population-aged-50-64-years
#40
JOURNAL ARTICLE
Max Olsson, Anders J Björkelund, Jacob Sandberg, Anders Blomberg, Mats Börjesson, David Currow, Andrei Malinovschi, Magnus Sköld, Per Wollmer, Kjell Torén, Carl Johan Östgren, Gunnar Engström, Magnus Ekström
BACKGROUND: Breathlessness is a troublesome and prevalent symptom in the population, but knowledge of related factors is scarce. The aim of this study was to identify the factors most strongly associated with breathlessness in the general population and to describe the shapes of the associations between the main factors and breathlessness. METHODS: A cross-sectional analysis was carried out of the multicentre population-based Swedish CArdioPulmonary bioImage Study (SCAPIS) of adults aged 50 to 64 years...
March 2024: ERJ Open Research
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