keyword
https://read.qxmd.com/read/38547453/fibrinogen-levels-and-clot-properties-identify-patients-that-benefit-from-catheter-directed-thrombolysis-after-dvt
#1
JOURNAL ARTICLE
Aaron F J Iding, Ghadir Alkarithi, Hugo Ten Cate, Robert A S Ariëns, Arina J Ten Cate-Hoek
Ultrasound-accelerated catheter-directed thrombolysis (UA-CDT) to improve patency after deep vein thrombosis (DVT) has not conclusively been shown to prevent post-thrombotic syndrome (PTS) but might benefit patients who are unlikely to obtain patency with standard treatment. We hypothesized that these patients could be selected based on their fibrin clot properties. To study this, patients with acute iliofemoral DVT from the CAVA trial had blood samples taken at inclusion. Fibrin clot properties in plasma were determined by turbidimetric clotting (lag time and maximal turbidity) and lysis assays (time to 50% lysis and lysis rate), permeation assay (Ks), and confocal microscopy (fiber density), as well as levels of fibrin clot modifiers fibrinogen and C-reactive protein (CRP)...
March 28, 2024: Blood Advances
https://read.qxmd.com/read/38547447/association-of-biomarkers-of-neuronal-injury-and-inflammation-with-insomnia-trajectories-after-traumatic-brain-injury-a-track-tbi-study
#2
JOURNAL ARTICLE
J Kent Werner, Jennifer Albrecht, Vincent F Capaldi, Sonia Jain, Xiaoying Sun, Pratik Mukherjee, Scott G Williams, Jacob Collen, Ramon Diaz-Arrastia, Geoffrey T Manley, Andrew D Krystal, Emerson Wickwire
BACKGROUND AND OBJECTIVES: Insomnia affects about one-third of patients with traumatic brain injury and is associated with worsened outcomes after injury. We hypothesized that higher levels of plasma neuroinflammation biomarkers at the time of TBI would be associated with worse 12-month insomnia trajectories. METHODS: Participants were prospectively enrolled from 18 level-1 trauma centers participating in the Transforming Research and Clinical Knowledge in Traumatic Brain Injury study from February 26, 2014, to August 8, 2018...
April 23, 2024: Neurology
https://read.qxmd.com/read/38547046/the-use-of-biomarkers-to-quantify-clinical-response-to-total-knee-arthroplasty-interventions-a-systematic-review
#3
JOURNAL ARTICLE
Mark Mackie, Kristen I Barton, Darek Sokol-Randell, Brent Lanting
The primary objective of this review was to determine whether the attenuation of the postoperative inflammatory response (PIR) after total knee arthroplasty (TKA) leads to a notable improvement in clinical outcome scores. The secondary objective of this review was to determine the optimal approach in using inflammatory biomarkers, clinical inflammatory assessments, and imaging to quantify the PIR. A systematic literature search of eight major databases was conducted using a predetermined search strategy. C-reactive protein (CRP), interleukin-6 (IL-6), erythrocyte sedimentation rate (ESR), knee surface temperature (KST), and clinical outcome data were collected and graphically displayed...
April 1, 2024: Journal of the American Academy of Orthopaedic Surgeons. Global Research & Reviews
https://read.qxmd.com/read/38546095/intersecting-pathways-evaluating-inflammatory-markers-and-metabolism-in-chronic-spontaneous-urticaria-with-a-multi-marker-approach
#4
JOURNAL ARTICLE
Zuhal Metin, Hanife Merve Akca, Kaan Tur, Serkan Akogul
BACKGROUND: Chronic spontaneous urticaria (CSU) is an inflammatory skin disease with intricate mechanisms. This study comprehensively assessed markers from diverse metabolic pathways, including novel inflammatory indicators, to evaluate their potential for diagnosing and monitoring CSU. MATERIALS AND METHODS: In the study involving 90 CSU patients and 90 healthy controls, the levels of albumin, high-density lipoprotein (HDL), fibrinogen, uric acid, D-dimer, C-reactive protein (CRP), and white blood cells (WBC) values were analyzed...
March 28, 2024: International Journal of Dermatology
https://read.qxmd.com/read/38546034/risk-factors-for-amputation-in-diabetic-foot-ulcers-a-retrospective-analysis
#5
JOURNAL ARTICLE
Xiaoyu Zhang, Qiwei Li, Xianpei Zhou, Yu Xu, Zizhen Shu, Hongyu Deng
Diabetic foot ulcers (DFUs) are chronic, difficult-to-heal wounds with a very high incidence of amputation. For patients with DFUs, prevention of amputation is crucial. However, the risk factors associated with DFU amputation and the extent to which different risk factors increase the risk of amputation are still uncertain. This study intends to provide a clinical basis for early intervention in DFU by retrospectively analysing the risk factors for DFU amputation. A retrospective analysis of 200 patients with DFUs admitted between October 2019 and October 2023 was conducted...
April 2024: International Wound Journal
https://read.qxmd.com/read/38546019/the-crp-troponin-test-ctt-stratifies-mortality-risk-in-patients-with-non-st-elevation-myocardial-infarction-nstemi
#6
JOURNAL ARTICLE
Rafael Y Brzezinski, Shmuel Banai, Malka Katz Shalhav, Moshe Stark, Ilana Goldiner, Ori Rogowski, Itzhak Shapira, David Zeltser, Noa Sasson, Shlomo Berliner, Yacov Shacham
INTRODUCTION: The C-reactive protein (CRP)-troponin-test (CTT) comprises simultaneous serial measurements of CRP and cardiac troponin and might reflect the systemic inflammatory response in patients with acute coronary syndrome. We sought to test its ability to stratify the short- and long-term mortality risk in patients with non-ST elevation myocardial infarction (NSTEMI). METHODS: We examined 1,675 patients diagnosed with NSTEMI on discharge who had at least two successive measurements of combined CRP and cardiac troponin within 48 h of admission...
April 2024: Clinical Cardiology
https://read.qxmd.com/read/38545560/case-report-necrotizing-leukomyelitis-and-meningitis-in-a-pomeranian
#7
Koen M Santifort, Laurent Garosi, Erik A W S Weerts
A 2.5-year-old female entire Pomeranian dog was presented for acute paraparesis progressing within 2 days to paraplegia. General physical examination was unremarkable. Neurological examination showed paraplegia without nociception, a mass reflex upon testing perineal reflexes and withdrawal reflexes in the pelvic limbs and patellar hyperreflexia. Cutaneous trunci reflexes were absent caudal to the level of the 6th thoracic vertebra. Spinal hyperesthesia was present. Neuroanatomical localization was consistent with a T3-L3 myelopathy...
2024: Frontiers in Veterinary Science
https://read.qxmd.com/read/38545128/changes-in-fibrin-clot-properties-in-patients-after-roux-en-y-gastric-bypass-surgery
#8
JOURNAL ARTICLE
Kazim Abbas, Stephen J Hierons, Nikoletta Pechlivani, Fladia Phoenix, Robin Alexander, Rhodri King, Ramzi A Ajjan, Alan J Stewart
BACKGROUND: Obesity is a complex condition associated with prothrombotic fibrin networks that are resistant to fibrinolysis. Altered fibrin clot properties enhance cardiovascular risk and associate with a poorer prognosis following acute ischemic events. Bariatric surgery is commonly employed to improve cardiometabolic outcomes in individuals with obesity. However, the effects of this surgical intervention on fibrin clot properties have not been comprehensively studied. OBJECTIVES: To examine fibrin clot and lysis parameters in Roux-en-Y gastric bypass (RYGB) patients before and after surgery...
February 2024: Research and Practice in Thrombosis and Haemostasis
https://read.qxmd.com/read/38545120/corrigendum-urokinase-type-plasminogen-activator-and-plasminogen-activator-inhibitor-1-complex-as-a-serum-biomarker-for-covid-19
#9
Tetiana Yatsenko, Ricardo Rios, Tatiane Nogueira, Yousef Salama, Satoshi Takahashi, Yoko Tabe, Toshio Naito, Kazuhisa Takahashi, Koichi Hattori, Beate Heissig
[This corrects the article DOI: 10.3389/fimmu.2023.1299792.].
2024: Frontiers in Immunology
https://read.qxmd.com/read/38545098/the-effects-of-vitamin-d-supplementation-on-inflammatory-biomarkers-in-patients-with-asthma-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#10
Asmae El Abd, Harika Dasari, Philippe Dodin, Helen Trottier, Francine M Ducharme
BACKGROUND: While the association between vitamin D and several inflammatory biomarkers in asthma patients has been extensively reported, it remains unclear whether supplementation modifies these biomarkers. This review aims to evaluate the impact of vitamin D supplementation on inflammatory biomarkers measured in vivo in individuals with asthma. METHODS: We conducted a systematic review of randomized controlled trials (RCTs) published until November 2022 in six electronic databases evaluating the impact of vitamin D supplementation (any dose, form, administration route, frequency, or duration) compared to placebo in children or adults...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38545029/different-doses-of-atorvastatin-in-the-treatment-of-patients-with-cardiorenal-syndrome-type-2-a-retrospective-cohort-study
#11
JOURNAL ARTICLE
Ermiao Zhang, Tao Xu, Bin Zhang, Lei Meng
OBJECTIVE: To assess the cardiorenal protective effects of different doses of atorvastatin in patients with cardiorenal syndrome (CRS) Type-2. METHODS: Medical records of 113 patients with CRS Type-2, admitted to First Affiliated Hospital of Hebei North University from August 2021 to August 2022 and treated with atorvastatin, were retrospectively analyzed. Patients were retrospectively grouped based on the dosage of atorvastatin. A total of 38 patients who received 10mg/day atorvastatin were selected as a Low-dose group, 36 patients who received 20mg/day atorvastatin comprised a Medium-dose group, and 39 patients who received 40mg/day atorvastatin comprised a High-dose group...
2024: Pakistan Journal of Medical Sciences Quarterly
https://read.qxmd.com/read/38544907/subcutaneous-vedolizumab-treatment-in-a-real-world-inflammatory-bowel-disease-cohort-switched-from-intravenous-vedolizumab-eighteen-month-prospective-follow-up-study
#12
JOURNAL ARTICLE
Thea H Wiken, Marte L Høivik, Karoline Anisdahl, Lydia Buer, David J Warren, Nils Bolstad, Milada Hagen, Bjørn A Moum, Asle W Medhus
BACKGROUND: Vedolizumab has since 2021 been available as a subcutaneous formulation. We aimed to assess 18-month drug persistence and possible predictive factors associated with discontinuation, safety, serum drug profile, drug dosing, and disease activity in a real-world cohort of patients with inflammatory bowel disease switched from intravenous to subcutaneous vedolizumab maintenance treatment. METHODS: Eligible patients were switched to subcutaneous vedolizumab and followed for 18 months or until discontinuation of subcutaneous treatment...
January 2024: Crohn's & colitis 360
https://read.qxmd.com/read/38544721/how-is-inflammation-biology-truly-associated-with-depression-in-patients-with-stable-coronary-heart-disease-insights-from-the-heart-and-soul-study
#13
JOURNAL ARTICLE
Chiyoung Lee, Mary Whooley, Qing Yang, Daniel P Moriarity
Depression is known to be associated with inflammation among patients with established coronary heart disease (CHD), but it is unclear whether this is due to individual depression symptoms or to the broader construct of depression. We addressed this gap by using moderated non-linear factor analysis (MNLFA) to determine the extent that inflammation is associated with latent depression and/or individual symptoms in this patient group. We evaluated 1,024 outpatients with stable CHD from the baseline cross-sectional data of the Heart and Soul Study...
May 2024: Brain, behavior, & immunity health
https://read.qxmd.com/read/38544555/retrospective-study-of-the-impact-of-diabetes-on-the-severity-and-prognosis-of-covid%C3%A2-19
#14
JOURNAL ARTICLE
Lijun Sun, Xiaoli Yang, Bowei Cao, Xiaodong Su, Jianhua Wang, Cuixiang Xu
Patients with diabetes coexisting with viral infection tend to have poor outcomes, but the association between diabetes and coronavirus disease 2019 (COVID-19) prognosis is controversial at present. The present study reviewed and analyzed the data of 1,892 patients with COVID-19 admitted to Shaanxi Provincial People's Hospital (Xi'an, China). Demographic, clinical, laboratory and treatment data as well as clinical outcomes were extracted from the electronic medical records and compared between patients with and without diabetes...
May 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38544553/effect-of-plasma-exchange-with-albumin-replacement-on-albumin-functionality-and-organ-dysfunction-in-acute-on-chronic-liver-failure
#15
JOURNAL ARTICLE
Javier Fernández, Miquel Lozano, Mireia Torres, Raquel Horrillo, Natalia Afonso, Laura Núñez, Anna Mestre, Alba Pérez, Joan Cid, Montserrat Costa, Vicente Arroyo, Antonio Páez
BACKGROUND & AIMS: Effective treatments for acute-on-chronic liver failure (ACLF) are a major unmet need. This proof-of-concept pilot study was aimed at evaluating the effects of plasma exchange (PE) with albumin 5% (PE-A5%) on albumin functional capacity and organ dysfunction in patients with ACLF. METHODS: Ten adult patients were enrolled in a single-center phase II, prospective, open-label, non-controlled study. Six PE-A5% sessions were performed in 10 days followed by a 1-month follow-up visit...
April 2024: JHEP reports: innovation in hepatology
https://read.qxmd.com/read/38543800/understanding-the-impact-of-covid-19-on-roma-vulnerable-communities-in-western-romania-insights-and-predictive-factors-from-a-retrospective-study
#16
JOURNAL ARTICLE
Ionut Dragos Capraru, Catalin Marian, Dan Dumitru Vulcanescu, Sonia Tanasescu, Tiberiu Liviu Dragomir, Teodora Daniela Marti, Casiana Boru, Cecilia Roberta Avram, Monica Susan, Cristian Sebastian Vlad
BACKGROUND: The COVID-19 pandemic disproportionately affected vulnerable populations like Roma patients in Western Romania due to marginalization and limited healthcare access. METHODS: A retrospective study analyzed COVID-19 cases between March 2020 and August 2022 using data from the Directorate of Public Health in Timis county. Demographic, epidemiological, clinical, and laboratory data were assessed, along with risk factors and biomarkers for ICU admission and mortality prediction...
March 12, 2024: Viruses
https://read.qxmd.com/read/38543674/antimicrobial-use-during-the-sars-cov-2-pandemic-in-a-greek-tertiary-university-hospital
#17
JOURNAL ARTICLE
Dimitrios Biros, Sempastian Filippas-Ntekouan, Diamantina Limperatou, Angelos Liontos, Rafail Matzaras, Konstantina-Helen Tsarapatsani, Nikolaos-Gavriel Kolios, Christiana Pappa, Maria Nasiou, Eleni Pargana, Ilias Tsiakas, Valentini Samanidou, Lazaros Athanasiou, Revekka Konstantopoulou, Haralampos Milionis, Eirini Christaki
In cases of SARS-CoV-2 hospitalization, despite low bacterial co-infection rates, antimicrobial use may be disproportionately high. Our aim was to quantify such usage in COVID-19 patients and identify factors linked to increased antibiotic use. We retrospectively studied patients with SARS-CoV-2 infection who were hospitalized at our institution during the pandemic. In the initial two waves of the pandemic, antimicrobial use was notably high (89% in the first wave and 92% in the second), but it decreased in subsequent waves...
March 20, 2024: Microorganisms
https://read.qxmd.com/read/38543601/the-kocher-caird-criteria-for-pediatric-septic-arthritis-of-the-hip-time-for-a-change-in-the-kingella-era
#18
REVIEW
Silvia Valisena, Giacomo De Marco, Oscar Vazquez, Blaise Cochard, Christina Steiger, Romain Dayer, Dimitri Ceroni
Pediatric septic arthritis of the hip (SAH) in children is a severe pathology, requiring prompt diagnosis and treatment to avoid destructive sequelae of the joint. Its diagnosis can be challenging, however, due to its spectrum of manifestations and differential diagnosis. Last century, multiple research teams studied the curves of systemic inflammation markers to aid the differential diagnosis. Kocher showed that a history of fever >38.5 °C, non-weight bearing, an erythrocyte sedimentation rate >40 mm/h, and serum white blood cells >12,000/mm3 were highly suggestive of SAH, with a predicted probability of 99...
March 10, 2024: Microorganisms
https://read.qxmd.com/read/38542799/association-of-dietary-fiber-and-measures-of-physical-fitness-with-high-sensitivity-c-reactive-protein
#19
JOURNAL ARTICLE
Ming-Zhen Su, Suyeon Lee, Dayeon Shin
Dietary fiber intake and physical fitness are independently associated with high-sensitivity C-reactive protein (hs-CRP) levels. Nevertheless, the association between dietary fiber intake, measures of physical fitness, and hs-CRP levels has not yet been fully evaluated. We investigated the influence of a combination of dietary fiber intake and measures of physical fitness, including hand grip strength, resistance training, and metabolic equivalents of tasks, on hs-CRP levels. Data collected from the Korea National Health and Nutrition Examination Survey (KNHANES) spanning 2015 to 2018 were used in this study...
March 19, 2024: Nutrients
https://read.qxmd.com/read/38542724/effect-of-a-12-week-multi-exercise-community-program-on-muscle-strength-and-lipid-profile-in-elderly-women
#20
JOURNAL ARTICLE
Hee-Sook Lim, Tae-Hee Kim, Hyun-Joo Kang, Hae-Hyeog Lee
This study targeted elderly women over 60 years old (109 persons), divided them into an exercise group and a control group, and implemented a 12-week physical activity program for the exercise group. Body composition, muscle, blood tests, depression, quality of life (QoL), nutritional status, and physical strength were compared and analyzed. The physical activity program was organized through a consultative body of experts, was performed for about 60 min each time in the type and order of exercise appropriate for elderly women, and consisted of a combination of exercise using a band, gymnastics, and stretching...
March 13, 2024: Nutrients
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