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JOURNAL ARTICLE
João Marcos Gonçalves Barbosa, Ana Flávia Machado Botelho, Rayanne Henrique Santana da Silva, Sara Sueli Ferreira de Almeida, Elci Rincon Ferreira, Lurian Caetano David, Danielly Alves Fortuna Lima, Taynara Cavalcante E Silva, Paulo Henrique Jorge da Cunha, Nelson Roberto Antoniosi Filho
The use of pyrethroids has increased over the last years, which corresponds to a higher exposure of animals to pesticide residues in the environment and diet. Here, an outbreak of pyrethroid poisoning in beef cattle was reported occurring in Midwestern Brazil. After veterinary evaluation, it was observed that the bovines presented common pyrethroids intoxication symptoms. Aiming to identify the cattle poising by pyrethroid, earwax samples were collected from two groups: exposed and non-exposed animals from the same farm...
October 30, 2020: Biomedical Chromatography: BMC
#2
JOURNAL ARTICLE
Ignacio García-Bolao, David Moñino, Roger Marsal, Pablo Ramos, Ane Erkiaga, Joana Irezabal, Ramón Albarrán-Rincón
PURPOSE: Remote system operation technology was developed and applied to a non-fluoroscopic navigation system in order to overcome Spanish mobility restrictions caused by Covid-19 pandemic infection and subsequently used routinely. METHODS AND RESULTS: Fifty consecutive complex ablations were performed in different days using this technology. All these procedures were assisted remotely with the only intervention of a field clinical specialist located at his home who took full control of the navigation system (keyboard, mouse, and screen) and had bidirectional real-time audio/video feedback with the operating physician...
November 2021: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
#3
REVIEW
Laura J Lee, David Papadopoli, Michael Jewer, Sonia Del Rincon, Ivan Topisirovic, Mitchell G Lawrence, Lynne-Marie Postovit
Tumor progression is associated with dedifferentiated histopathologies concomitant with cancer cell survival within a changing, and often hostile, tumor microenvironment. These processes are enabled by cellular plasticity, whereby intracellular cues and extracellular signals are integrated to enable rapid shifts in cancer cell phenotypes. Cancer cell plasticity, at least in part, fuels tumor heterogeneity and facilitates metastasis and drug resistance. Protein synthesis is frequently dysregulated in cancer, and emerging data suggest that translational reprograming collaborates with epigenetic and metabolic programs to effectuate phenotypic plasticity of neoplasia...
October 13, 2020: Trends in Cancer
#4
JOURNAL ARTICLE
Francisco Javier Carrasco-Sánchez, Mª Dolores López-Carmona, Francisco Javier Martínez-Marcos, Luis M Pérez-Belmonte, Alicia Hidalgo-Jiménez, Verónica Buonaiuto, Carmen Suárez Fernández, Santiago Jesús Freire Castro, Davide Luordo, Paula Maria Pesqueira Fontan, Julio César Blázquez Encinar, Jeffrey Oskar Magallanes Gamboa, Andrés de la Peña Fernández, José David Torres Peña, Joaquim Fernández Solà, Jose Javier Napal Lecumberri, Francisco Amorós Martínez, María Esther Guisado Espartero, Carlos Jorge Ripper, Raquel Gómez Méndez, Natalia Vicente López, Berta Román Bernal, María Gloria Rojano Rivero, José Manuel Ramos Rincón, Ricardo Gómez Huelgas
BACKGROUND: Hyperglycaemia has emerged as an important risk factor for death in coronavirus disease 2019 (COVID-19). The aim of this study was to evaluate the association between blood glucose (BG) levels and in-hospital mortality in non-critically patients hospitalized with COVID-19. METHODS: This is a retrospective multi-centre study involving patients hospitalized in Spain. Patients were categorized into three groups according to admission BG levels: <140 mg/dL, 140-180 mg/dL and >180 mg/dL...
December 2021: Annals of Medicine
#5
RANDOMIZED CONTROLLED TRIAL
Miriam Martinez-Canton, Angel Gallego-Selles, Miriam Gelabert-Rebato, Marcos Martin-Rincon, Fernando Pareja-Blanco, David Rodriguez-Rosell, David Morales-Alamo, Joaquin Sanchis-Moysi, Cecilia Dorado, Juan Jose Gonzalez-Badillo, Jose A L Calbet
Strength training promotes a IIX-to-IIA shift in myosin heavy chain (MHC) composition, likely due to changes in sarcoplasmic [Ca2+ ] which are sensed by CaMKII. Sarcoplasmic [Ca2+ ] is in part regulated by sarcolipin (SLN), a small protein that when overexpressed in rodents stimulates mitochondrial biogenesis and a fast-to-slow fiber type shift. The purpose of this study was to determine whether CaMKII and SLN are involved in muscle phenotype and performance changes elicited by strength training. Twenty-two men followed an 8-week velocity-based resistance training program using the full squat exercise while monitoring repetition velocity...
January 2021: Scandinavian Journal of Medicine & Science in Sports
#6
JOURNAL ARTICLE
Angel Gallego-Selles, Marcos Martin-Rincon, Miriam Martinez-Canton, Mario Perez-Valera, Saúl Martín-Rodríguez, Miriam Gelabert-Rebato, Alfredo Santana, David Morales-Alamo, Cecilia Dorado, Jose A L Calbet
The Nrf2 transcription factor is induced by reactive oxygen and nitrogen species and is necessary for the adaptive response to exercise in mice. It remains unknown whether Nrf2 signalling is activated by exercise in human skeletal muscle. Here we show that Nrf2 signalling is activated by exercise to exhaustion with similar responses in normoxia (PI O2 : 143 mmHg) and severe acute hypoxia (PI O2 : 73 mmHg). CaMKII and AMPKα phosphorylation were similarly induced in both conditions. Enhanced Nrf2 signalling was achieved by raising Nrf2 total protein and Ser40 Nrf2 phosphorylation, accompanied by a reduction of Keap1...
June 30, 2020: Redox Biology
#7
JOURNAL ARTICLE
Francisco Alejandro Paredes-Sánchez, Ana María Sifuentes-Rincón, Eduardo Casas, Williams Arellano-Vera, G Manuel Parra-Bracamonte, David G Riley, Thomas H Welsh, Ronald D Randel
Cattle temperament is a complex and economically relevant trait. The objective of this study was to identify genomic regions and genes associated with cattle temperament. From a Brahman cattle population of 1,370 animals evaluated for temperament traits (Exit velocity-EV, Pen Score-PS, Temperament Score-TS), two groups of temperament-contrasting animals were identified based on their EV-average values ±1/2 standard deviation (SD). To be considered in the calm group, the EV of females ranged between 0.16-1...
2020: PloS One
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JOURNAL ARTICLE
Katherine E Menson, Madeleine M Mank, Leah F Reed, Camille J Walton, Katherine E Van Der Vliet, Jennifer L Ather, David G Chapman, Bradford J Smith, Mercedes Rincon, Matthew E Poynter
Many mouse models of allergic asthma exhibit eosinophil-predominant cellularity rather than the mixed granulocytic cytology in steroid-unresponsive severe disease. Therefore, we sought to implement a novel mouse model of antigen-driven, mixed-granulocytic, severe allergic asthma to determine biomarkers of the disease process and potential therapeutic targets. C57BL/6J, IL-6-/-, and IL-6R-/- mice were injected with an emulsion of Complete Freund's Adjuvant and House Dust Mite antigen (CFA/HDM) on day 1. Dexamethasone, a lymphocyte-depleting biological, or anti-IL-17A were administered during intranasal HDM challenge on days 19-22...
August 12, 2020: American Journal of Physiology. Lung Cellular and Molecular Physiology
#9
JOURNAL ARTICLE
Maged Younes, Gabriele Aquilina, Karl-Heinz Engel, Paul Fowler, Maria Jose Frutos Fernandez, Peter Fürst, Rainer Gürtler, Ursula Gundert-Remy, Trine Husøy, Wim Mennes, Peter Moldeus, Agneta Oskarsson, Romina Shah, Ine Waalkens-Berendsen, Detlef Wölfle, Gisela Degen, Lieve Herman, David Gott, Jean-Charles Leblanc, Alessandra Giarola, Ana Maria Rincon, Alexandra Tard, Laurence Castle
The EFSA Panel on Food Additives and Flavourings (FAF) provides a scientific opinion on the safety of Monk fruit extract proposed for use as a new food additive in different food categories. Monk fruit extracts are prepared by water extraction of the fruits of Siraitia grosvenorii . Cucurbitane glycosides, mogrosides, are the main components of the S. grosvenorii fruit and mogroside V is the main mogroside in the Monk fruit extract. Mogroside V is absorbed to some extent and is systemically bioavailable...
December 2019: EFSA journal
#10
JOURNAL ARTICLE
Maged Younes, Gabriele Aquilina, Karl-Heinz Engel, Paul Fowler, Maria Jose Frutos Fernandez, Peter Fürst, Rainer Gürtler, Ursula Gundert-Remy, Trine Husøy, Wim Mennes, Peter Moldeus, Agneta Oskarsson, Romina Shah, Ine Waalkens-Berendsen, Detlef Wölfle, Gisela Degen, David Gott, Jean-Charles Leblanc, Lieve Herman, Jaime Aguilera, Alessandra Giarola, Ana M Rincon, Laurence Castle
The EFSA Panel on Food Additives and Flavourings (FAF) provides a scientific opinion on the safety of the proposed amendment of the specifications for steviol glycosides (E 960) as a food additive, in particular related to rebaudioside M produced via enzyme-catalysed bioconversion of purified stevia leaf extract. Rebaudioside M (95% on dry basis) is produced via enzymatic bioconversion of purified stevia leaf extract using uridine diphosphate (UDP)-glucosyltransferase and sucrose synthase enzymes produced by the genetically modified yeasts K...
October 2019: EFSA journal
#11
JOURNAL ARTICLE
Lucía Barbier-Torres, Karen A Fortner, Paula Iruzubieta, Teresa C Delgado, Emily Giddings, Youdinghuan Chen, Devin Champagne, David Fernández-Ramos, Daniela Mestre, Beatriz Gomez-Santos, Marta Varela-Rey, Virginia Gutiérrez de Juan, Pablo Fernández-Tussy, Imanol Zubiete-Franco, Carmelo García-Monzón, Águeda González-Rodríguez, Dhaval Oza, Felipe Valença-Pereira, Qian Fang, Javier Crespo, Patricia Aspichueta, Frederic Tremblay, Brock C Christensen, Juan Anguita, María Luz Martínez-Chantar, Mercedes Rincón
Nonalcoholic fatty liver disease (NAFLD) is considered the next major health epidemic with an estimated 25% worldwide prevalence. No drugs have yet been approved and NAFLD remains a major unmet need. Here, we identify MCJ (Methylation-Controlled J protein) as a target for non-alcoholic steatohepatitis (NASH), an advanced phase of NAFLD. MCJ is an endogenous negative regulator of the respiratory chain Complex I that acts to restrain mitochondrial respiration. We show that therapeutic targeting of MCJ in the liver with nanoparticle- and GalNAc-formulated siRNA efficiently reduces liver lipid accumulation and fibrosis in multiple NASH mouse models...
July 3, 2020: Nature Communications
#12
JOURNAL ARTICLE
Hans Ter Steege, Paulo I Prado, Renato A F de Lima, Edwin Pos, Luiz de Souza Coelho, Diogenes de Andrade Lima Filho, Rafael P Salomão, Iêda Leão Amaral, Francisca Dionízia de Almeida Matos, Carolina V Castilho, Oliver L Phillips, Juan Ernesto Guevara, Marcelo de Jesus Veiga Carim, Dairon Cárdenas López, William E Magnusson, Florian Wittmann, Maria Pires Martins, Daniel Sabatier, Mariana Victória Irume, José Renan da Silva Guimarães, Jean-François Molino, Olaf S Bánki, Maria Teresa Fernandez Piedade, Nigel C A Pitman, José Ferreira Ramos, Abel Monteagudo Mendoza, Eduardo Martins Venticinque, Bruno Garcia Luize, Percy Núñez Vargas, Thiago Sanna Freire Silva, Evlyn Márcia Moraes de Leão Novo, Neidiane Farias Costa Reis, John Terborgh, Angelo Gilberto Manzatto, Katia Regina Casula, Euridice N Honorio Coronado, Juan Carlos Montero, Alvaro Duque, Flávia R C Costa, Nicolás Castaño Arboleda, Jochen Schöngart, Charles Eugene Zartman, Timothy J Killeen, Beatriz S Marimon, Ben Hur Marimon-Junior, Rodolfo Vasquez, Bonifacio Mostacedo, Layon O Demarchi, Ted R Feldpausch, Julien Engel, Pascal Petronelli, Chris Baraloto, Rafael L Assis, Hernán Castellanos, Marcelo Fragomeni Simon, Marcelo Brilhante de Medeiros, Adriano Quaresma, Susan G W Laurance, Lorena M Rincón, Ana Andrade, Thaiane R Sousa, José Luís Camargo, Juliana Schietti, William F Laurance, Helder Lima de Queiroz, Henrique Eduardo Mendonça Nascimento, Maria Aparecida Lopes, Emanuelle de Sousa Farias, José Leonardo Lima Magalhães, Roel Brienen, Gerardo A Aymard C, Juan David Cardenas Revilla, Ima Célia Guimarães Vieira, Bruno Barçante Ladvocat Cintra, Pablo R Stevenson, Yuri Oliveira Feitosa, Joost F Duivenvoorden, Hugo F Mogollón, Alejandro Araujo-Murakami, Leandro Valle Ferreira, José Rafael Lozada, James A Comiskey, José Julio de Toledo, Gabriel Damasco, Nállarett Dávila, Aline Lopes, Roosevelt García-Villacorta, Freddie Draper, Alberto Vicentini, Fernando Cornejo Valverde, Jon Lloyd, Vitor H F Gomes, David Neill, Alfonso Alonso, Francisco Dallmeier, Fernanda Coelho de Souza, Rogerio Gribel, Luzmila Arroyo, Fernanda Antunes Carvalho, Daniel Praia Portela de Aguiar, Dário Dantas do Amaral, Marcelo Petratti Pansonato, Kenneth J Feeley, Erika Berenguer, Paul V A Fine, Marcelino Carneiro Guedes, Jos Barlow, Joice Ferreira, Boris Villa, Maria Cristina Peñuela Mora, Eliana M Jimenez, Juan Carlos Licona, Carlos Cerón, Raquel Thomas, Paul Maas, Marcos Silveira, Terry W Henkel, Juliana Stropp, Marcos Ríos Paredes, Kyle G Dexter, Doug Daly, Tim R Baker, Isau Huamantupa-Chuquimaco, William Milliken, Toby Pennington, J Sebastián Tello, José Luis Marcelo Pena, Carlos A Peres, Bente Klitgaard, Alfredo Fuentes, Miles R Silman, Anthony Di Fiore, Patricio von Hildebrand, Jerome Chave, Tinde R van Andel, Renato Richard Hilário, Juan Fernando Phillips, Gonzalo Rivas-Torres, Janaína Costa Noronha, Adriana Prieto, Therany Gonzales, Rainiellene de Sá Carpanedo, George Pepe Gallardo Gonzales, Ricardo Zárate Gómez, Domingos de Jesus Rodrigues, Egleé L Zent, Ademir R Ruschel, Vincent Antoine Vos, Émile Fonty, André Braga Junqueira, Hilda Paulette Dávila Doza, Bruce Hoffman, Stanford Zent, Edelcilio Marques Barbosa, Yadvinder Malhi, Luiz Carlos de Matos Bonates, Ires Paula de Andrade Miranda, Natalino Silva, Flávia Rodrigues Barbosa, César I A Vela, Linder Felipe Mozombite Pinto, Agustín Rudas, Bianca Weiss Albuquerque, Maria Natalia Umaña, Yrma Andreina Carrero Márquez, Geertje van der Heijden, Kenneth R Young, Milton Tirado, Diego F Correa, Rodrigo Sierra, Janaina Barbosa Pedrosa Costa, Maira Rocha, Emilio Vilanova Torre, Ophelia Wang, Alexandre A Oliveira, Michelle Kalamandeen, Corine Vriesendorp, Hirma Ramirez-Angulo, Milena Holmgren, Marcelo Trindade Nascimento, David Galbraith, Bernardo Monteiro Flores, Veridiana Vizoni Scudeller, Angela Cano, Manuel Augusto Ahuite Reategui, Italo Mesones, Cláudia Baider, Casimiro Mendoza, Roderick Zagt, Ligia Estela Urrego Giraldo, Cid Ferreira, Daniel Villarroel, Reynaldo Linares-Palomino, William Farfan-Rios, William Farfan-Rios, Luisa Fernanda Casas, Sasha Cárdenas, Henrik Balslev, Armando Torres-Lezama, Miguel N Alexiades, Karina Garcia-Cabrera, Luis Valenzuela Gamarra, Elvis H Valderrama Sandoval, Freddy Ramirez Arevalo, Lionel Hernandez, Adeilza Felipe Sampaio, Susamar Pansini, Walter Palacios Cuenca, Edmar Almeida de Oliveira, Daniela Pauletto, Aurora Levesley, Karina Melgaço, Georgia Pickavance
Amazonian forests are extraordinarily diverse, but the estimated species richness is very much debated. Here, we apply an ensemble of parametric estimators and a novel technique that includes conspecific spatial aggregation to an extended database of forest plots with up-to-date taxonomy. We show that the species abundance distribution of Amazonia is best approximated by a logseries with aggregated individuals, where aggregation increases with rarity. By averaging several methods to estimate total richness, we confirm that over 15,000 tree species are expected to occur in Amazonia...
June 23, 2020: Scientific Reports
#13
JOURNAL ARTICLE
Robinson Ramírez-Vélez, Miguel Ángel Pérez-Sousa, Antonio García-Hermoso, Fabricio Zambom-Ferraresi, Nicolas Martínez-Velilla, Mikel L Sáez de Asteasu, Carlos A Cano-Gutiérrez, David Rincón-Pabón, Mikel Izquierdo
The adverse effects of fat mass on functional dependence might be attenuated or worsened, depending on the level of muscular strength. The aim of this study was to determine (i) the detrimental effect of excess adiposity on dependence in activities of daily living (ADL), and (ii) whether relative handgrip strength (HGS) moderates the adverse effect of excess adiposity on dependence, and to provide the threshold of relative HGS from which the adverse effect could be improved or worsened. A total of 4169 participants (69...
April 17, 2020: Journal of Clinical Medicine
#14
JOURNAL ARTICLE
María Correa-Rodríguez, Katherine González-Ruíz, David Rincón-Pabón, Mikel Izquierdo, Antonio García-Hermoso, Cesar Agostinis-Sobrinho, Nohora Sánchez-Capacho, Marcela América Roa-Cubaque, Robinson Ramírez-Vélez
Normal-weight obesity (NWO) has been shown to be associated with cardiometabolic dysfunction. However, little is known regarding this potential relationship in early adulthood. The aim of this study was to investigate the associations between NWO and cardiometabolic risk factors in a large population of Colombian young adults. A cross-sectional study was conducted on 1354 subjects (61% women), aged from 18 to 30. Anthropometric data, including body mass index (BMI) and waist circumference (WC), were estimated, and the percentage of fat mass was measured through bioelectrical impedance analysis (BIA)...
April 16, 2020: Nutrients
#15
JOURNAL ARTICLE
Carolina Fernández Biscay, Pedro David Arini, Anderson Iván Rincón Soler, María Paula Bonomini
Holter recordings are widely used to detect cardiac events that occur transiently, such as ischemic events. Much effort has been made to detect early ischemia, thus preventing myocardial infarction. However, after detection, classification of ischemia has still not been fully solved. The main difficulty relies on the false positives produced because of non-ischemic events, such as changes in the heart rate, the intraventricular conduction or the cardiac electrical axis. In this work, the classification of ischemic and non-ischemic events from the long-term ST database has been improved, using novel spectral parameters based on the continuous wavelet transform (CWT) together with temporal parameters (such as ST level and slope, T wave width and peak, R wave peak, QRS complex width)...
March 9, 2020: Medical & Biological Engineering & Computing
#16
REVIEW
Jose A L Calbet, Saúl Martín-Rodríguez, Marcos Martin-Rincon, David Morales-Alamo
During exercise, muscle ATP demand increases with intensity, and at the highest power output, ATP consumption may increase more than 100-fold above the resting level. The rate of mitochondrial ATP production during exercise depends on the availability of O2 , carbon substrates, reducing equivalents, ADP, Pi , free creatine, and Ca2+ . It may also be modulated by acidosis, nitric oxide and reactive oxygen and nitrogen species (RONS). During fatiguing and repeated sprint exercise, RONS production may cause oxidative stress and damage to cellular structures and may reduce mitochondrial efficiency...
August 2020: Redox Biology
#17
JOURNAL ARTICLE
Robinson Ramírez-Vélez, Miguel A Pérez-Sousa, Luis C Venegas-Sanabria, Carlos A Cano-Gutierrez, Paula A Hernández-Quiñonez, David Rincón-Pabón, Antonio García-Hermoso, Fabricio Zambom-Ferraresi, Mikel L Sáez de Asteasu, Mikel Izquierdo
Background: The short physical performance battery (SPPB) is a physical performance test of lower extremity function designed for non-disabled older adults. We aimed to establish reference values for community-dwelling Colombian adults aged 60 years or older in terms of (1) the total score; (2) the three subtest scores (walking speed, standing balance performance, and five times sit-to-stand test); and (3) the time to complete the five times sit-to-stand test, s and the walking speed test. Additionally, we sought to explore how much of the variance in the SPPB subtest scores could be explained by anthropometric variables (age, body mass, height, body mass index, and calf circumference)...
2020: Frontiers in Medicine
#18
JOURNAL ARTICLE
Asunción Martín-Ruiz, Carmen Fiuza-Luces, Cecilia Rincón-Castanedo, David Fernández-Moreno, Beatriz G Gálvez, Esther Martínez-Martínez, Paloma Martín-Acosta, Maria José Coronado, Lidia Franco-Luzón, África González-Murillo, Manuel Ramírez, Mariano Provencio, Alejandro Lucia
BACKGROUND: Lung cancer has the highest incidence and mortality rate in the world. One of the most promising new cancer therapies in recent years is immunotherapy, which is based on the blockade of immune checkpoints such as programmed cell death protein 1 (PD-1). Exercise training is beneficial to maintain and improve the quality of life of cancer patients, and it might also modulate the anti-tumoral efficiency of some chemotherapeutic agents. However, the potential of exercise combined with immunotherapy as a cancer therapy remains to be elucidated...
2020: Exercise Immunology Review
#19
RANDOMIZED CONTROLLED TRIAL
Marcos Martin-Rincon, Miriam Gelabert-Rebato, Victor Galvan-Alvarez, Angel Gallego-Selles, Miriam Martinez-Canton, Laura Lopez-Rios, Julia C Wiebe, Saul Martin-Rodriguez, Rafael Arteaga-Ortiz, Cecilia Dorado, Sergio Perez-Regalado, Alfredo Santana, David Morales-Alamo, Jose A L Calbet
Prolonged or unusual exercise may cause exercise-induced muscle damage (EIMD). To test whether Zynamite®, a mango leaf extract rich in the natural polyphenol mangiferin, administered in combination with quercetin facilitates recovery after EIMD, 24 women and 33 men were randomly assigned to two treatment groups matched by sex and 5 km running performance, and ran a 10 km race followed by 100 drop jumps to elicit EIMD. One hour before the competition, and every 8 hours thereafter for 24 hours, they ingested placebo (728 mg of maltodextrin) or 140 mg of Zynamite® combined with 140 mg of quercetin (double-blind)...
February 26, 2020: Nutrients
#20
JOURNAL ARTICLE
Javier Martin-Broto, Nadia Hindi, Antonio Lopez-Pousa, Javier Peinado-Serrano, Rosa Alvarez, Ana Alvarez-Gonzalez, Antoine Italiano, Paul Sargos, Josefina Cruz-Jurado, Josep Isern-Verdum, Maria Carmen Dolado, Inmaculada Rincon-Pérez, Paloma Sanchez-Bustos, Antonio Gutierrez, Cleofe Romagosa, Carlo Morosi, Giovanni Grignani, Marco Gatti, Pablo Luna, Ignacio Alastuey, Andres Redondo, Belen Belinchon, Jordi Martinez-Serra, Marie-Pierre Sunyach, Jean-Michel Coindre, Angelo P Dei Tos, Jesus Romero, Alessandro Gronchi, Jean-Yves Blay, David S Moura
Importance: Active therapeutic combinations, such as trabectedin and radiotherapy, offer potentially higher dimensional response in second-line treatment of advanced soft-tissue sarcomas. Dimensional response can be relevant both for symptom relief and for survival. Objective: To assess the combined use of trabectedin and radiotherapy in treating patients with progressing metastatic soft-tissue sarcomas. Design, Setting, and Participants: Phase 1 of this nonrandomized clinical trial followed the classic 3 + 3 design, with planned radiotherapy at a fixed dose of 30 Gy (3 Gy/d for 10 days) and infusion of trabectedin at 1...
February 20, 2020: JAMA Oncology
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