Alexandra Partenhauser, Kesinee Netsomboon, Gintare Leonaviciute, Andreas Bernkop-Schnürch
CONTEXT: Silicone oils, such as dimethicone, are commonly administered against gastrointestinal gas accumulation and are attributed with mucoprotective features. OBJECTIVE: Evaluation of thiolated silicone oil as advanced antiflatulence with a prolonged retention on small intestinal mucosa as an intended site of action. MATERIALS AND METHODS: 3-Mercaptopropionic acid (MPA) as a thiol ligand was covalently attached to silicone oil. This thiomer was assessed with regard to foam inhibiting action, droplet size of a suitable self-emulsifying system, mucoadhesion and cytotoxicity...
October 2016: Drug Delivery
Kelly Shepherd, David Hillman, Peter Eastwood
No abstract text is available yet for this article.
June 15, 2013: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
Boudewijn F Kessing, Joris A J L Broeders, Nikki Vinke, Marlies P Schijven, Eric J Hazebroek, Ivo A M J Broeders, Albert J Bredenoord, André J P M Smout
BACKGROUND: Gas-related symptoms such as bloating, flatulence, and impaired ability to belch are frequent after antireflux surgery, but it is not known how these symptoms affect patient satisfaction with the procedure or what determines the severity of these complaints. We aimed to assess the impact of gas-related symptoms on patient-perceived success of surgery and to determine whether the severity of gas-related complaints after antireflux surgery is associated with objectively measured abnormalities...
October 2013: Surgical Endoscopy
Jianbo Li, Yinglian Xiao, Sui Peng, Jinkun Lin, Minhu Chen
BACKGROUND AND AIMS: Belching is a common disorder with undetermined pathogenesis. With the combined multichannel intraluminal impedance pH monitoring, two different models of belching have been defined: gastric belching (GB) and supragastric belching (SB). The aim of this study was to assess whether SB was associated with air swallowing as compared with GB or healthy volunteers based on Rome III criteria. METHODS: Consecutive patients who presented with troublesome repetitive belching were recruited...
August 2013: Journal of Gastroenterology and Hepatology
Ivana Bravi, Philip Woodland, Ravinder S Gill, Mohannad Al-Zinaty, Albert J Bredenoord, Daniel Sifrim
BACKGROUND & AIMS: Many patients with gastroesophageal reflux disease (GERD) have persistent reflux despite treatment with proton pump inhibitors (PPIs). Mixed gas-liquid reflux events are more likely to be perceived as symptomatic. We used esophageal impedance monitoring to investigate whether esophageal gas is processed differently among patients with GERD who do and do not respond to PPI therapy. METHODS: We performed a prospective study of 44 patients with typical reflux symptoms with high levels of esophageal acid exposure during a 24-hour period; 18 patients were fully responsive, and 26 did not respond to PPI therapy...
July 2013: Clinical Gastroenterology and Hepatology
Susan M Harding
No abstract text is available yet for this article.
January 15, 2013: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
Kelly Shepherd, David Hillman, Peter Eastwood
STUDY OBJECTIVES: Continuous positive airway pressure (CPAP), the mainstay treatment for obstructive sleep apnea (OSA), involves administration of air under pressure to the upper airway. A well-known but poorly understood side effect of positive airway pressure therapies is aerophagia, air entering the esophagus and stomach rather than the lungs. Gastric distension, a consequence of aerophagia, can increase gastroesophageal reflux (GER) by increasing transient lower esophageal sphincter relaxations, the most common cause of reflux...
January 15, 2013: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
D A Katzka
Chronic belching can be a difficult and socially disabling symptom often attributed to reflux with poor response to therapy. In patients where aerophagia is identified as a clear cause, treatment with baclofen may not be tolerated, and biofeedback therapy is time-intensive and may still not be effective. In this pilot study, an office-based easy-to-perform method based on sustained glottal opening was used in five patients with chronic belching, in whom reflux and other causes had been excluded. Treatment consisted of having the patient breathe slowly and diaphragmatically with his or her mouth open during supine, then sitting periods to prevent belching...
August 2013: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
Toshihiko Sagawa, Shinichi Okamura, Satoru Kakizaki, Yajing Zhang, Kyoko Morita, Masatomo Mori
BACKGROUND AND AIM: The prevalence of functional gastrointestinal disorders (FGID) in adolescents and their relationship to quality of school life (QOSL) are not fully understood. This study investigated the relationship between FGID and QOSL. METHODS: Adolescents (10-17 years) were recruited from 40 schools. FGID diagnoses were based on the Questionnaire on Pediatric Gastrointestinal Symptoms-Rome III version (QPGS-RIII). QOSL was evaluated by a questionnaire and calculated as the QOSL score...
February 2013: Journal of Gastroenterology and Hepatology
Albert J Bredenoord
Although belching and hiccups are regarded as normal behaviors, they can occur at high frequency or become persistent, becoming bothersome and requiring medical care. Patients with excessive belching frequently have supragastric belches. Excessive belching should be treated as a behavioral disorder. Persistent hiccups, however, can be the first presentation of a serious disorder that requires extensive diagnostic testing. When no cause is found, only the symptoms can be treated. Aerophagia is an episodic or chronic disorder in which patients (children and adults) swallow large quantities of air, which accumulate in the gastrointestinal tract to cause abdominal distention and bloating...
January 2013: Clinical Gastroenterology and Hepatology
Albert J Bredenoord
No abstract text is available yet for this article.
December 2011: Journal of Pediatric Gastroenterology and Nutrition
William Cooney, William D Chey
No abstract text is available yet for this article.
November 2011: American Journal of Gastroenterology
Hiroaki Fukuzawa, Naoto Urushihara, Koji Fukumoto, Akihide Sugiyama, Maki Mitsunaga, Kentaro Watanabe, Shiro Hasegawa
Pathologic aerophagia is sometimes seen in patients with neurologic disorders. It rarely causes massive bowel distention, ileus, and volvulus. Here, we report the use of esophagogastric separation and abdominal esophagostomy via jejunal interposition to prevent bowel distention caused by severe aerophagia in 2 patients with neurologic disorders in whom the usual nonoperative methods of management failed. In both cases, swallowed air was evacuated via the jejunostomy, eliminating bowel distention. This operation may be useful in patients with neurologic disorders associated with severe aerophagia...
October 2011: Journal of Pediatric Surgery
Niranga M Devanarayana, Shaman Rajindrajith
OBJECTIVE: Aerophagia is a functional gastrointestinal disorder characterised by repetitive air swallowing, abdominal distension, belching, and flatulence. In severe cases, it can lead to pneumoperitonium, volvulus of the colon, and intestinal perforation. Little is known about the epidemiology and clinical profile of affected children. The main objective of the present study was to assess the epidemiology of aerophagia in 10- to 16-year-olds in Sri Lanka. METHODS: A school-based cross-sectional survey was conducted in 8 randomly selected schools in 4 randomly selected provinces in Sri Lanka...
April 2012: Journal of Pediatric Gastroenterology and Nutrition
Kelly Park, Mara Behlau
PURPOSE: To verify the occurrence of signs and symptoms of autonomic nervous system dysfunction in individuals with behavioral dysphonia, and to compare it with the results obtained by individuals without vocal complaints. METHODS: Participants were 128 adult individuals with ages between 14 and 74 years, divided into two groups: behavioral dysphonia (61 subjects) and without vocal complaints (67 subjects). It was administered the Protocol of Autonomic Dysfunction, containing 46 questions: 22 related to the autonomic nervous system and had no direct relationship with voice, 16 related to both autonomic nervous system and voice, six non-relevant questions, and two reliability questions...
2011: Jornal da Sociedade Brasileira de Fonoaudiologia
H Ozawa, S Nakashima, U Otaki, Y Takahashi, K Arimoto, S Kimiya
No abstract text is available yet for this article.
March 2011: No to Hattatsu. Brain and Development
A W Solomon, J C Bramall, J Ball
Air swallowing can occur as a psychogenic phenomenon, because of abnormal anatomy, or during non-invasive positive pressure ventilation. Gross distension of the stomach with air can have severe consequences for the respiratory and gastrointestinal systems. We report the case of a 62-year-old man with severe dynamic hyperinflation due to chronic obstructive pulmonary disease, who developed respiratory failure requiring intubation a few hours after radical prostatectomy. Following a percutaneous tracheostomy and weaning of sedation on day six, his abdomen began to enlarge progressively...
February 2011: Anaesthesia
S W Smith
No abstract text is available yet for this article.
February 24, 1940: British Medical Journal (1857-1980)
Raúl León Barúa
In the present paper, the author reminds investigations performed, since forty-four years ago, to clarify the etiopathogenesis and to improve the diagnosis and treatment of the flatulence syndrome.
April 2010: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
Niranga Manjuri Devanarayana, Chandralatha Adhikari, Waruni Pannala, Shaman Rajindrajith
Little is known about the prevalence of functional gastrointestinal diseases (FGDs) in adolescents, especially in developing countries. This cross-sectional survey conducted in a semi-urban school in Sri Lanka, assessed the prevalence of whole spectrum of FGDs in 427 adolescents (age 12-16 years) using a validated self-administered questionnaire. According to Rome III criteria, 123 (28.8%) adolescents had FGDs. Of them, 59 (13.8%) had abdominal-pain-related FGDs [irritable bowel syndrome (IBS) 30, functional dyspepsia 15, functional abdominal pain 13 and abdominal migraine 1]...
February 2011: Journal of Tropical Pediatrics
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