Ryota Sakurai, Frederico Pieruccini-Faria, Benjamin Cornish, Julia Fraser, Malcolm A Binns, Derek Beaton, Allison Ann Dilliott, Donna Kwan, Joel Ramirez, Brian Tan, Christopher J M Scott, Kelly M Sunderland, Carmela Tartaglia, Elizabeth Finger, Lorne Zinman, Morris Freedman, Paula M McLaughlin, Richard H Swartz, Sean Symons, Anthony E Lang, Robert Bartha, Sandra E Black, Mario Masellis, Robert A Hegele, William McIlroy, Manuel Montero-Odasso
INTRODUCTION: Apolipoprotein E E4 allele (APOE E4) and slow gait are independently associated with cognitive impairment and dementia. However, it is unknown whether their coexistence is associated with poorer cognitive performance and its underlying mechanism in neurodegenerative diseases. METHODS: Gait speed, APOE E4, cognition, and neuroimaging were assessed in 480 older adults with neurodegeneration. Participants were grouped by APOE E4 presence and slow gait...
March 12, 2024: Alzheimer's & Dementia: the Journal of the Alzheimer's Association