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JOURNAL ARTICLE
Jason Bugno, Liangliang Wang, Xianbin Yu, Xuezhi Cao, Jiaai Wang, Xiaona Huang, Kaiting Yang, Andras Piffko, Katherine Chen, Stephen Y Luo, Emile Naccasha, Yuzhu Hou, Sherry Fu, Chuan He, Yang-Xin Fu, Hua Laura Liang, Ralph R Weichselbaum
PURPOSE: Radiation-mediated immune suppression limits efficacy and is a barrier in cancer therapy. Radiation induces negative regulators of tumor immunity including regulatory T cells (Treg). Mechanisms underlying Treg infiltration after radiotherapy (RT) are poorly defined. Given that dendritic cells (cDC) maintain Treg we sought to identify and target cDC signaling to block Treg infiltration after radiation. EXPERIMENTAL DESIGN: Transcriptomics and high dimensional flow cytometry revealed changes in murine tumor cDC that not only mediate Treg infiltration after RT, but associate with worse survival in human cancer datasets...
May 1, 2024: Clinical Cancer Research
#42
JOURNAL ARTICLE
Hui Li, Yuan Fan, Yizhe Shen, Huashan Xu, Huijie Zhang, Fuxue Chen, Shini Feng
The evolution of nano-drug delivery systems addresses the limitations of conventional cancer treatments with stimulus-responsive nanomaterial-based delivery systems presenting temporal and spatial advantages. Among various nanomaterials, boron nitride nanoparticles (BNNs) demonstrate significant potential in drug delivery and cancer treatment, providing a high drug loading capacity, multifunctionality, and low toxicity. However, the challenge lies in augmenting nanomaterial accumulation exclusively within tumors while preserving healthy tissues...
May 1, 2024: ACS Applied Materials & Interfaces
#43
JOURNAL ARTICLE
Ahmet Anil Ozluk, Damla Gunenc, Saadet Sim Yildirim, Burcak Karaca
With the widespread use of immune checkpoint inhibitors, management of immune-related adverse effects specific to these treatments became an important research era in patient management. Among these, immune-related hepatotoxicity (IRH) is an adverse event that can be fatal. While the first-line treatment of IRH is well established, there is still no consensus regarding the management approach for steroid-refractory, severe IRH. Here, we report four patients with metastatic melanoma who developed IRH during antiprogrammed cell death protein-1 plus anticytotoxic T-lymphocyte-associated protein-4 combination therapy and review of the literature...
April 29, 2024: Melanoma Research
#44
JOURNAL ARTICLE
Melissa Dolan, Yuhao Shi, Michalis Mastri, Mark D Long, Amber McKenery, James W Hill, Cristina Vaghi, Sebastien Benzekry, Joseph Barbi, John M L Ebos
Tyrosine kinase inhibitors (TKIs) that block the vascular endothelial growth factor receptors (VEGFRs) disrupt tumor angiogenesis but also have many unexpected side-effects that impact tumor cells directly. This includes the induction of molecular markers associated with senescence, a form of cellular aging that typically involves growth arrest. We have shown that VEGFR TKIs can hijack these aging programs by transiently inducting senescence-markers (SMs) in tumor cells to activate senescence-associated secretory programs that fuel drug resistance...
May 1, 2024: Molecular Cancer Therapeutics
#45
JOURNAL ARTICLE
Jeremy P Gygi, Cole Maguire, Ravi K Patel, Pramod Shinde, Anna Konstorum, Casey P Shannon, Leqi Xu, Annmarie Hoch, Naresh Doni Jayavelu, Elias K Haddad, Elaine F Reed, Monica Kraft, Grace A McComsey, Jordan P Metcalf, Al Ozonoff, Denise Esserman, Charles B Cairns, Nadine Rouphael, Steven E Bosinger, Seunghee Kim-Schulze, Florian Krammer, Lindsey B Rosen, Harm van Bakel, Michael Wilson, Walter L Eckalbar, Holden T Maecker, Charles R Langelier, Hanno Steen, Matthew C Altman, Ruth R Montgomery, Ofer Levy, Esther Melamed, Bali Pulendran, Joann Diray-Arce, Kinga K Smolen, Gabriela K Fragiadakis, Patrice M Becker, Rafick P Sekaly, Lauren Ir Ehrlich, Slim Fourati, Bjoern Peters, Steven H Kleinstein, Leying Guan
BACKGROUNDPatients hospitalized for COVID-19 exhibit diverse clinical outcomes, with outcomes for some individuals diverging over time even though their initial disease severity appears similar to that of other patients. A systematic evaluation of molecular and cellular profiles over the full disease course can link immune programs and their coordination with progression heterogeneity.METHODSWe performed deep immunophenotyping and conducted longitudinal multiomics modeling, integrating 10 assays for 1,152 Immunophenotyping Assessment in a COVID-19 Cohort (IMPACC) study participants and identifying several immune cascades that were significant drivers of differential clinical outcomes...
May 1, 2024: Journal of Clinical Investigation
#46
REVIEW
Bahareh Kashani, Zahra Zandi, Atieh Pourbagheri-Sigaroodi, Amir-Mohammad Yousefi, Seyed H Ghaffari, Davood Bashash
INTRODUCTION: As a vital mechanism of survival, lymphopoiesis requires the collaboration of different signaling molecules to orchestrate each step of cell development and maturation. The PI3K pathway is considerably involved in the maturation of lymphatic cells and therefore, its dysregulation can immensely affect human well-being and cause some of the most prevalent malignancies. As a result, studies that investigate this pathway could pave the way for a better understanding of the lymphopoiesis mechanisms, the undesired changes that lead to cancer progression, and how to design drugs to solve this issue...
May 1, 2024: Expert Review of Anticancer Therapy
#47
Yasufumi Yorichika, Shuichiro Neshige, Taro Edahiro, Shiro Aoki, Hirofumi Maruyama
We herein report a 58-year-old female patient undergoing chimeric antigen receptor T-cell (CAR-T) therapy for refractory diffuse large B-cell lymphoma (DLBCL). Following the CAR-T infusion, the patient experienced Cytokine Release Syndrome (CRS), which was subsequently remitted. However, aphasia was observed five days post-infusion, and a loss of consciousness occurred on the sixth day. Brain MRI revealed a possibly high signal intensity in the mesial temporal region. The patient was diagnosed with immune effector cell-associated neurotoxicity syndrome (ICANS) secondary to CRS and received treatment with dexamethasone, which promptly improved her consciousness...
March 2024: Curēus
#48
REVIEW
Die Lv, Yujie Fei, Hongli Chen, Junfeng Wang, Wenwen Han, Bomiao Cui, Yun Feng, Ping Zhang, Jiao Chen
The extracellular matrix (ECM) is a complex three-dimensional structure composed of proteins, glycans, and proteoglycans, constituting a critical component of the tumor microenvironment. Complex interactions among immune cells, extracellular matrix, and tumor cells promote tumor development and metastasis, consequently influencing therapeutic efficacy. Hence, elucidating these interaction mechanisms is pivotal for precision cancer therapy. T lymphocytes are an important component of the immune system, exerting direct anti-tumor effects by attacking tumor cells or releasing lymphokines to enhance immune effects...
2024: Frontiers in Immunology
#49
JOURNAL ARTICLE
Shreya J Raut, Lakshmi Shetty, Adnan Chhatriwala, Trivina K Domah, Gauri Camblay
CONTEXT: The diagnosis of oral squamous cell carcinoma [OSCC] and its treatment phase is emotionally demanding for the patient and challenging for the surgeon. The induction of stress and anxiety is unavoidable in these patients. It becomes very important for the patient to have psychological as well as physical stability during this treatment phase. Various studies have reported the beneficial effect of meditation along with relaxation therapy on healthy individuals but the beneficial effect of meditation and relaxation therapy [MRT] to reduce stress and anxiety preoperatively in OSCC patients has not been reported in scientific literature...
2024: National Journal of Maxillofacial Surgery
#50
JOURNAL ARTICLE
Kelsey J Oeler, Richard L Blackmon, Silvia M Kreda, Taylor Robinson, Melanie Ghelardini, Brian S Chapman, Joseph Tracy, David B Hill, Amy L Oldenburg
SIGNIFICANCE: Assessing the nanostructure of polymer solutions and biofluids is broadly useful for understanding drug delivery and disease progression and for monitoring therapy. AIM: Our objective is to quantify bronchial mucus solids concentration (wt. %) during hypertonic saline (HTS) treatment in vitro via nanostructurally constrained diffusion of gold nanorods (GNRs) monitored by polarization-sensitive optical coherence tomography (PS-OCT). APPROACH: Using PS-OCT, we quantified GNR translational (<mml:math xmlns:mml="https://www...
April 2024: Journal of Biomedical Optics
#51
JOURNAL ARTICLE
Tobias Zrzavy, Kerstin Rieder, Viktoria Wuketich, Renate Thalhammer, Helmuth Haslacher, Patrick Altmann, Barbara Kornek, Nik Krajnc, Tobias Monschein, Christiane Schmied, Karin Zebenholzer, Gudrun Zulehner, Thomas Berger, Paulus Rommer, Fritz Leutmezer, Gabriel Bsteh
BACKGROUND: Recent studies proposed cellular immunoprofiling as a surrogate for predicting treatment response and/or stratifying the occurrence of adverse events (AEs) in persons with multiple sclerosis (pwMS). However, applicability in real-world circumstances is not sufficiently addressed. OBJECTIVE: We aimed to explore whether standard routine clinical leukocyte phenotyping before treatment initiation could help stratify patients according to treatment response or AEs in a real-world MS cohort...
2024: Frontiers in Neurology
#52
REVIEW
Ayenew Berhan, Shewaneh Damtie, Andargachew Almaw, Biruk Legesse, Bekele Sharew, Birhanu Getie, Mulat Erkihun, Yenealem Solomon
Hematopoietic stem cell donation is a method used to treat both blood-related and non-blood-related malignancies. Graft-versus-host disease is a potentially life-threatening complication that can occur following a stem cell transplant from a donor. This happens after the transplanted grafts attack the recipient's body as foreign cells, causing significant morbidity and mortality. Clinically, this condition can be classified as acute or chronic based on onset and pathophysiology. This review aims to provide an overview of recent studies on extracorporeal photopheresis as a treatment strategy option for graft-versus-host-diseased patients...
2024: ImmunoTargets and Therapy
#53
JOURNAL ARTICLE
Tan Li, Xingyu Zhang, Chengyu Shi, Qiao Liu, Yuetao Zhao
Combination of tumor immunotherapy with photothermal therapy (PTT) is a feasible tactic to overcome the drawback of immunotherapy such as poor immune response. Via triggering the immunogenic cells death (ICD), PTT can stimulate the activity of immune cells, but meanwhile, the level of adenosine is elevated via the CD73-induced decomposition of ATP which is overexpressed accompanying with the PTT process, resulting in negative feedback to impair the immune stimulation. Herein, we developed a novel biomimetic photothermal nanodrug to specifically block CD73 for inhibition of adenosine production and more efficient priming of the suppressive immune microenvironments...
April 30, 2024: Journal of Nanobiotechnology
#54
JOURNAL ARTICLE
Wan-Ru Chao, Ming-Yung Lee, Gwo-Tarng Sheu, Yi-Ju Lee, Huang-Pin Shen, Chih-Ping Han
Recent clinical evidence shows that the antibody-drug conjugate (ADC) trastuzumab deruxtecan (T-DXd) can successfully treat patients with advanced HER2-mutant non-small cell lung cancer (NSCLC). We aimed to characterize HER2 mutations in cervical neuroendocrine carcinoma (NEC) among Taiwanese women to provide the rationale for exploring T-DXd as a tumor-agnostic targeted therapy option. We analyzed 12 archived primary cervical NEC samples from Taiwanese patients. Tumor-rich areas were marked for microdissection on 10 μm unstained sections...
April 30, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
#55
Cassandra Willyard
No abstract text is available yet for this article.
May 2024: Nature
#56
JOURNAL ARTICLE
Daniela Cesana, Maria Pia Cicalese, Andrea Calabria, Pietro Merli, Roberta Caruso, Monica Volpin, Laura Rudilosso, Maddalena Migliavacca, Federica Barzaghi, Claudia Fossati, Francesco Gazzo, Simone Pizzi, Andrea Ciolfi, Alessandro Bruselles, Francesca Tucci, Giulio Spinozzi, Giulia Pais, Fabrizio Benedicenti, Matteo Barcella, Ivan Merelli, Pierangela Gallina, Stefania Giannelli, Francesca Dionisio, Serena Scala, Miriam Casiraghi, Luisa Strocchio, Luciana Vinti, Lucia Pacillo, Eleonora Draghi, Marcella Cesana, Sara Riccardo, Chiara Colantuono, Emmanuelle Six, Marina Cavazzana, Filippo Carlucci, Manfred Schmidt, Caterina Cancrini, Fabio Ciceri, Luca Vago, Davide Cacchiarelli, Bernhard Gentner, Luigi Naldini, Marco Tartaglia, Eugenio Montini, Franco Locatelli, Alessandro Aiuti
Hematopoietic stem cell gene therapy (GT) using a γ-retroviral vector (γ-RV) is an effective treatment for Severe Combined Immunodeficiency due to Adenosine Deaminase deficiency. Here, we describe a case of GT-related T-cell acute lymphoblastic leukemia (T-ALL) that developed 4.7 years after treatment. The patient underwent chemotherapy and haploidentical transplantation and is currently in remission. Blast cells contain a single vector insertion activating the LIM-only protein 2 (LMO2) proto-oncogene, confirmed by physical interaction, and low Adenosine Deaminase (ADA) activity resulting from methylation of viral promoter...
April 30, 2024: Nature Communications
#57
JOURNAL ARTICLE
Justin W Ingram, Rainjade Chung, Caroline Laplaca, James M McKiernan, Andrew T Lenis, Christopher B Anderson
PURPOSE: To describe the incidence and management of patients who develop a prostatic urethral (PU) urothelial carcinoma recurrence after Bacillus Calmette-Guerin (BCG) induction for non-muscle invasive bladder cancer (NMIBC). MATERIALS AND METHODS: We performed a retrospective cohort study of all patients who received BCG induction at our institution from 1996 to 2021 (N = 642) for NMIBC. All patients with pathologically confirmed PU involvement following BCG induction with no known PU involvement pre-BCG were included...
April 29, 2024: Urologic Oncology
#58
JOURNAL ARTICLE
Shan-Wen Lui, Jeng-Wei Lu, Yi-Jung Ho, Shih-En Tang, Kai-Hsiung Ko, Ting-Yu Hsieh, Feng-Cheng Liu
BACKGROUND/AIM: Progressive fibrosing interstitial lung disease (PF-ILD) refers to a group of chronic lung conditions commonly associated with immunoglobulin G4-related disorders. It is characterized by progressive scarring (fibrosis) within the pulmonary interstitium, resulting in respiratory failure and early mortality. Some patients do not respond to standard therapeutic interventions. Numerous studies have confirmed the anti-inflammatory and antioxidant properties of molecular hydrogen in various disease models...
2024: In Vivo
#59
JOURNAL ARTICLE
Sachiko Hasebe, Kota Maekawa, Yukiko Shishido-Hara, Kazuo Nakamichi, Nobuaki Funata, Makio Takahashi
A middle-aged man with progressive multifocal leukoencephalopathy (PML) in a human T-cell lymphotropic virus type-1 (HTLV-1) carrier on haemodialysis presented with mild dysarthria and ataxia. Brain MRI revealed asymmetric T2 -hyperintense lesions in the cerebral white matter, cerebellum and brainstem. A small amount of JC virus (JCV) genome in cerebrospinal fluid was detected by PCR and cerebellar biopsy demonstrated JCV-DNA presence. Pathological findings showed demyelinating lesions and glial cells with mildly enlarged nuclei, accompanied by T-lymphocytes, neutrophils and plasma cell infiltration...
April 30, 2024: BMJ Case Reports
#60
JOURNAL ARTICLE
Damian Jacenik
No abstract text is available yet for this article.
April 28, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease
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