Rongzhen Ding, Yichao Wang, Ling Xu, Shuliu Sang, Guanjin Wu, Wenxiao Yang, Yilu Zhang, Chengyan Wang, Ao Qi, Haiping Xie, Yi Liu, Aiguo Dai, Lijing Jiao
Non-small-cell lung cancer (NSCLC) is a major cause of worldwide cancer death, posing a challenge for effective treatment. Our previous findings showed that Chinese herbal medicine (CHM) QiDongNing (QDN) could upregulate the expression of p53 and trigger cell apoptosis in NSCLC. Here, our objective was to investigate the mechanisms of QDN-induced apoptosis enhancement. We chose A549 and NCI-H460 cells for validation in vitro, and LLC cells were applied to form a subcutaneous transplantation tumour model for validation in more depth...
May 2024: Journal of Cellular and Molecular Medicine