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JOURNAL ARTICLE
Clare Moffatt, Solymar Torres Maldonado, Lauran K Evans, Avetis Azizyan, Keith E Blackwell
OBJECTIVE: This scoping review seeks to understand the existing research in otolaryngological mucosal emphysematous infections and to elucidate gaps in knowledge in the field. We also present a case of bilateral necrotizing tonsillitis in an immunocompromised patient with the first reported imaging findings of emphysematous abscess of the tonsils. DATA SOURCES: PubMed, Embase, Web of Science. REVIEW METHODS: We conducted our review according to the Preferred Reporting Items for Systematic Reviews extension for Scoping Reviews...
June 2024: Laryngoscope Investigative Otolaryngology
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JOURNAL ARTICLE
John Baker, Sarah Kendal, Chris Bojke, Gemma Louch, Daisy Halligan, Saba Shafiq, Charlotte Sturley, Lauren Walker, Mark Brown, Kathryn Berzins, Lyn Brierley-Jones, Jane K O'Hara, Kirstin Blackwell, Gemma Wormald, Krysia Canvin, Charles Vincent
BACKGROUND: Acute inpatient mental health services report high levels of safety incidents. The application of patient safety theory has been sparse, particularly concerning interventions that proactively seek patient perspectives. OBJECTIVE(S): Develop and evaluate a theoretically based, digital monitoring tool to collect real-time information from patients on acute adult mental health wards about their perceptions of ward safety. DESIGN: Theory-informed mixed-methods study...
May 2024: Health Soc Care Deliv Res
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JOURNAL ARTICLE
Rebecca Keener, Surya B Chhetri, Carla J Connelly, Margaret A Taub, Matthew P Conomos, Joshua Weinstock, Bohan Ni, Benjamin Strober, Stella Aslibekyan, Paul L Auer, Lucas Barwick, Lewis C Becker, John Blangero, Eugene R Bleecker, Jennifer A Brody, Brian E Cade, Juan C Celedon, Yi-Cheng Chang, L Adrienne Cupples, Brian Custer, Barry I Freedman, Mark T Gladwin, Susan R Heckbert, Lifang Hou, Marguerite R Irvin, Carmen R Isasi, Jill M Johnsen, Eimear E Kenny, Charles Kooperberg, Ryan L Minster, Take Naseri, Satupa'itea Viali, Sergei Nekhai, Nathan Pankratz, Patricia A Peyser, Kent D Taylor, Marilyn J Telen, Baojun Wu, Lisa R Yanek, Ivana V Yang, Christine Albert, Donna K Arnett, Allison E Ashley-Koch, Kathleen C Barnes, Joshua C Bis, Thomas W Blackwell, Eric Boerwinkle, Esteban G Burchard, April P Carson, Zhanghua Chen, Yii-Der Ida Chen, Dawood Darbar, Mariza de Andrade, Patrick T Ellinor, Myriam Fornage, Bruce D Gelb, Frank D Gilliland, Jiang He, Talat Islam, Stefan Kaab, Sharon L R Kardia, Shannon Kelly, Barbara A Konkle, Rajesh Kumar, Ruth J F Loos, Fernando D Martinez, Stephen T McGarvey, Deborah A Meyers, Braxton D Mitchell, Courtney G Montgomery, Kari E North, Nicholette D Palmer, Juan M Peralta, Benjamin A Raby, Susan Redline, Stephen S Rich, Dan Roden, Jerome I Rotter, Ingo Ruczinski, David Schwartz, Frank Sciurba, M Benjamin Shoemaker, Edwin K Silverman, Moritz F Sinner, Nicholas L Smith, Albert V Smith, Hemant K Tiwari, Ramachandran S Vasan, Scott T Weiss, L Keoki Williams, Yingze Zhang, Elad Ziv, Laura M Raffield, Alexander P Reiner, Marios Arvanitis, Carol W Greider, Rasika A Mathias, Alexis Battle
Genome-wide association studies (GWAS) have become well-powered to detect loci associated with telomere length. However, no prior work has validated genes nominated by GWAS to examine their role in telomere length regulation. We conducted a multi-ancestry meta-analysis of 211,369 individuals and identified five novel association signals. Enrichment analyses of chromatin state and cell-type heritability suggested that blood/immune cells are the most relevant cell type to examine telomere length association signals...
May 24, 2024: Nature Communications
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JOURNAL ARTICLE
Sugeet K Jagpal, Abdullah Alismail, Erica Lin, Lauren Blackwell, Nayla Ahmed, May M Lee, Jared Chiarchiaro
Health profession educators readily identify with the goal of fostering healthcare providers who are critical thinkers focused on quality patient care. In the following paper, we aim to delve into critical thinking at the team level and help educators begin the process of creating a shared mental model focusing on cognition to identify gaps and opportunities for growth in their trainees. We will distinguish between microcognition (an individual's own critical thinking process in a controlled environment), macrocognition (critical thinking process in a real-world environment), and team cognition (the interaction and relationship among team members to augment macrocognition)...
2024: Advances in Medical Education and Practice
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JOURNAL ARTICLE
Andrew Reisner, Youssef M Zohdy, Joshua J Chern, Laura S Blackwell, Jacob R Lepard, Ali Alawieh, Meena S Verma, Firas Kobeissy, Makda G Mulugeta, Joseph A Tyndall, Brendan J Klein, Olubunmi A Fariyike, Rebekah Mannix, Jennifer C Munoz Pareja, Kevin K Wang
No abstract text is available yet for this article.
May 17, 2024: Journal of Neurosurgery. Pediatrics
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Yasminka A Jakubek, Xiaolong Ma, Adrienne M Stilp, Fulong Yu, Jason Bacon, Justin W Wong, Francois Aguet, Kristin Ardlie, Donna Arnett, Kathleen Barnes, Joshua C Bis, Tom Blackwell, Lewis C Becker, Eric Boerwinkle, Russell P Bowler, Matthew J Budoff, April P Carson, Jiawen Chen, Michael H Cho, Josef Coresh, Nancy Cox, Paul S de Vries, Dawn L DeMeo, David W Fardo, Myriam Fornage, Xiuqing Guo, Michael E Hall, Nancy Heard-Costa, Bertha Hidalgo, Marguerite Ryan Irvin, Andrew D Johnson, Eimear E Kenny, Dan Levy, Yun Li, Joao Ac Lima, Yongmei Liu, Ruth J F Loos, Mitchell J Machiela, Rasika A Mathias, Braxton D Mitchell, Joanne Murabito, Josyf C Mychaleckyj, Kari North, Peter Orchard, Stephen Cj Parker, Yash Pershad, Patricia A Peyser, Katherine A Pratte, Bruce M Psaty, Laura M Raffield, Susan Redline, Stephen S Rich, Jerome I Rotter, Sanjiv J Shah, Jennifer A Smith, Aaron P Smith, Albert Smith, Margaret Taub, Hemant K Tiwari, Russell Tracy, Bjoernar Tuftin, Alexander G Bick, Vijay G Sankaran, Alexander P Reiner, Paul Scheet, Paul L Auer
Mosaic loss of Y (mLOY) is the most common somatic chromosomal alteration detected in human blood. The presence of mLOY is associated with altered blood cell counts and increased risk of Alzheimer's disease, solid tumors, and other age-related diseases. We sought to gain a better understanding of genetic drivers and associated phenotypes of mLOY through analyses of whole genome sequencing of a large set of genetically diverse males from the Trans-Omics for Precision Medicine (TOPMed) program. This approach enabled us to identify differences in mLOY frequencies across populations defined by genetic similarity, revealing a higher frequency of mLOY in the European American (EA) ancestry group compared to those of Hispanic American (HA), African American (AA), and East Asian (EAS) ancestry...
April 19, 2024: medRxiv
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JOURNAL ARTICLE
Lue Williams, Veronica Oro, Courtney K Blackwell, Chang Liu, Elizabeth B Miller, Jody Ganiban, Jenae M Neiderhiser, David S DeGarmo, Daniel S Shaw, Tong Chen, Misaki N Natsuaki, Leslie D Leve
INTRODUCTION: Children and adolescents with elevated internalizing symptoms are at increased risk for depression, anxiety, and other psychopathology later in life. The present study examined the predictive links between two bioecological factors in early childhood-parental hostility and socioeconomic stress-and children's internalizing symptom class outcomes, while considering the effects of child sex assigned at birth on internalizing symptom development from childhood to adolescence...
2024: Frontiers in Psychiatry
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JOURNAL ARTICLE
David R Glass, Koshlan Mayer-Blackwell, Nirasha Ramchurren, K Rachael Parks, George E Duran, Anna K Wright, Armando N Bastidas Torres, Laura Islas, Youn H Kim, Steven P Fling, Michael S Khodadoust, Evan W Newell
Cutaneous T cell lymphomas (CTCLs) are skin cancers with poor survival rates and limited treatments. While immunotherapies have shown some efficacy, the immunological consequences of administering immune-activating agents to CTCL patients have not been systematically characterized. We apply a suite of high-dimensional technologies to investigate the local, cellular, and systemic responses in CTCL patients receiving either mono- or combination anti-PD-1 plus interferon-gamma (IFN-γ) therapy. Neoplastic T cells display no evidence of activation after immunotherapy...
April 22, 2024: Cell reports medicine
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Heini M Natri, Christina B Del Azodi, Lance Peter, Chase J Taylor, Sagrika Chugh, Robert Kendle, Mei-I Chung, David K Flaherty, Brittany K Matlock, Carla L Calvi, Timothy S Blackwell, Lorraine B Ware, Matthew Bacchetta, Rajat Walia, Ciara M Shaver, Jonathan A Kropski, Davis J McCarthy, Nicholas E Banovich
No abstract text is available yet for this article.
April 25, 2024: Nature Genetics
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JOURNAL ARTICLE
Cynthia Gyamfi-Bannerman, Rebecca G Clifton, Alan T N Tita, Sean C Blackwell, Monica Longo, Jessica A de Voest, T Michael O'Shea, Sabine Z Bousleiman, Felecia Ortiz, Dwight J Rouse, Torri D Metz, George R Saade, Kara M Rood, Kent D Heyborne, John M Thorp, Geeta K Swamy, William A Grobman, Kelly S Gibson, Yasser Y El-Sayed, George A Macones
IMPORTANCE: The Antenatal Late Preterm Steroids (ALPS) trial changed clinical practice in the United States by finding that antenatal betamethasone at 34 to 36 weeks decreased short-term neonatal respiratory morbidity. However, the trial also found increased risk of neonatal hypoglycemia after betamethasone. This follow-up study focused on long-term neurodevelopmental outcomes after late preterm steroids. OBJECTIVE: To evaluate whether administration of late preterm (34-36 completed weeks) corticosteroids affected childhood neurodevelopmental outcomes...
April 24, 2024: JAMA
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JOURNAL ARTICLE
Anna K M Blackwell, Shadi Daryan, Deborah Roy, Daniel Duffy, Garrett Hisler, Katherine Sawyer, Ben Ainsworth, Derek Richards, Douglas Hiscock, Sophia Papadakis, Jamie Brown, Marcus R Munafò, Pamela Jacobsen, Paul Aveyard, Gemma Taylor
BACKGROUND: In the UK, smoking prevalence in people with depression (34%) and anxiety (29%) is more than double that of the general population (13%). People who stop smoking improve their mental health with comparable effect sizes found for antidepressants. In England, online psychological therapy is a standard treatment for depression and anxiety. Online therapy is an acceptable setting for smoking cessation support; however, integrated smoking and mental health support is not available...
April 19, 2024: Contemporary Clinical Trials
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JOURNAL ARTICLE
Sergey S Gutor, Bradley W Richmond, Vineet Agrawal, Evan L Brittain, Ciara M Shaver, Pingsheng Wu, Taryn K Boyle, Ravinder R Mallugari, Katrina Douglas, Robert N Piana, Joyce E Johnson, Robert F Miller, John H Newman, Timothy S Blackwell, Vasiliy V Polosukhin
Exertional dyspnea has been documented in U.S. military personnel after deployment to Iraq and Afghanistan. We studied whether continued exertional dyspnea in this patient population is associated with pulmonary vascular disease (PVD). We performed detailed histomorphometry of pulmonary vasculature in 52 Veterans with biopsy-proven post-deployment respiratory syndrome (PDRS) and then recruited five of these same Veterans with continued exertional dyspnea to undergo a follow-up clinical evaluation, including symptom questionnaire, pulmonary function testing, surface echocardiography, and right heart catheterization (RHC)...
April 9, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
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JOURNAL ARTICLE
Ayodeji Adegunsoye, Jonathan A Kropski, Juergen Behr, Timothy S Blackwell, Tamera J Corte, Vincent Cottin, Allan Glanville, Marilyn K Glassberg, Matthias Griese, Gary M Hunninghake, Kerri A Johannson, Michael P Keane, John S Kim, Martin Kolb, Toby M Maher, Justin M Oldham, Anna J Podolanczuk, Ivan O Rosas, Fernando J Martinez, Imre Noth, David A Schwartz
Recent genetic and genomic advancements have elucidated the complex etiology of idiopathic pulmonary fibrosis (IPF) and other progressive fibrotic interstitial lung diseases (ILDs), emphasizing the contribution of heritable factors. This state-of-the-art review synthesizes evidence on significant genetic contributors to pulmonary fibrosis (PF), including rare genetic variants and common single nucleotide polymorphisms (SNPs). The MUC5B promoter variant is unusual, a common SNP that markedly elevates the risk of early and established PF...
April 4, 2024: American Journal of Respiratory and Critical Care Medicine
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JOURNAL ARTICLE
Ingrid Pretzer-Aboff, R K Elswick, Arnaud Gouelle, Noah Helm, GinaMari Blackwell, Leslie Cloud
INTRODUCTION: Most people with Parkinson's disease (PD) will experience gait problems. Previous studies demonstrated improved gait and balance after vibration stimulation was applied to the feet of PD patients. However, not all study participants showed improvement, perhaps due to sub-optimal vibration stimulus. Thus far, the optimal frequency and amplitude of vibration for mitigating gait dysfunction in PD have yet to be systematically explored. This study aimed to deliver vibration to the feet of 26 people with PD gait disturbances...
2024: Clinical parkinsonism & related disorders
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JOURNAL ARTICLE
Heini M Natri, Christina B Del Azodi, Lance Peter, Chase J Taylor, Sagrika Chugh, Robert Kendle, Mei-I Chung, David K Flaherty, Brittany K Matlock, Carla L Calvi, Timothy S Blackwell, Lorraine B Ware, Matthew Bacchetta, Rajat Walia, Ciara M Shaver, Jonathan A Kropski, Davis J McCarthy, Nicholas E Banovich
Common genetic variants confer substantial risk for chronic lung diseases, including pulmonary fibrosis. Defining the genetic control of gene expression in a cell-type-specific and context-dependent manner is critical for understanding the mechanisms through which genetic variation influences complex traits and disease pathobiology. To this end, we performed single-cell RNA sequencing of lung tissue from 66 individuals with pulmonary fibrosis and 48 unaffected donors. Using a pseudobulk approach, we mapped expression quantitative trait loci (eQTLs) across 38 cell types, observing both shared and cell-type-specific regulatory effects...
March 28, 2024: Nature Genetics
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JOURNAL ARTICLE
Xueying Zhang, Courtney K Blackwell, Janet Moore, Shelley H Liu, Chang Liu, Christopher B Forrest, Jody Ganiban, Annemarie Stroustrup, Judy L Aschner, Leonardo Trasande, SeanC L Deoni, Amy J Elliott, Jyoti Angal, Catherine J Karr, Barry M Lester, Cindy T McEvoy, T Michael O'Shea, Rebecca C Fry, Gayle M Shipp, James E Gern, Julie Herbstman, Kecia N Carroll, Susan L Teitelbaum, Robert O Wright, Rosalind J Wright
The corona virus disease (COVID-19) pandemic disrupted daily life worldwide, and its impact on child well-being remains a major concern. Neighborhood characteristics affect child well-being, but how these associations were affected by the pandemic is not well understood. We analyzed data from 1039 children enrolled in the Environmental influences on Child Health Outcomes Program whose well-being was assessed using the Patient-Reported Outcomes Measurement Information System Global Health questionnaire and linked these data to American Community Survey (ACS) data to evaluate the impacts of neighborhood characteristics on child well-being before and during the pandemic...
March 26, 2024: Environmental Research
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JOURNAL ARTICLE
Sigmund J Degitz, Philip P Degoey, Jonathan T Haselman, Jennifer H Olker, Emma H Stacy, Chad Blanksma, Scott Meyer, Kali Z Mattingly, Brett Blackwell, Anne S Opseth, Michael W Hornung
As part of the US Environmental Protection Agency's perfluoroalkyl and polyfluoroalkyl substances (PFAS) Action Plan, the agency is committed to increasing our understanding of the potential ecological effects of PFAS. The objective of these studies was to examine the developmental toxicity of PFAS using the laboratory model amphibian species Xenopus laevis. We had two primary aims: (1) to understand the developmental toxicity of a structurally diverse set of PFAS compounds in developing embryos and (2) to characterize the potential impacts of perfluorooctanesulfonic acid (PFOS), perfluorohexanesulfonic acid (PFHxS), perfluorooctanoic acid (PFOA), and hexafluoropropylene oxide-dimer acid (HFPO-DA a...
March 26, 2024: Journal of Applied Toxicology: JAT
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JOURNAL ARTICLE
Maddy L Dyer, Steph F Suddell, Jasmine N Khouja, Michelle A Havill, Anna K M Blackwell, Olivia M Maynard, Marcus R Munafò, Angela S Attwood
INTRODUCTION: Youth use of electronic cigarettes (e-cigarettes) is rising globally and is associated with health harms. Flavour descriptions on e-liquid packaging may contribute to the appeal of e-cigarettes among youth. This study compared subjective ratings of e-liquid packaging flavour descriptions among non-smoking and non-vaping UK adolescents. METHODS: This was an online observational study in a UK sample of non-smoking and non-vaping adolescents aged 11-17 years...
March 12, 2024: Nicotine & Tobacco Research
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JOURNAL ARTICLE
Sharoda Dasgupta, Stacy M Crim, John K Weiser, Angela Blackwell, Jen-Feng Lu, Margaret A Lampe, Ada Dieke, Robyn Neblett Fanfair
INTRODUCTION: The sexual and reproductive health of cisgender women with HIV is essential for overall health and well-being. Nationally representative estimates of sexual and reproductive health outcomes among women with HIV were assessed in this study. METHODS: Data from the Centers for Disease Control and Prevention's Medical Monitoring Project-including data on sexual and reproductive health-were collected during June 2018-May 2021 through interviews and medical record abstraction among women with HIV and analyzed in 2023...
February 27, 2024: American Journal of Preventive Medicine
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JOURNAL ARTICLE
Matthew B Murphy, Zhenjiang Yang, Tuerdi Subati, Eric Farber-Eger, Kyungsoo Kim, Daniel J Blackwell, Matthew R Fleming, Joshua M Stark, Joseph C Van Amburg, Kaylen K Woodall, Justin P Van Beusecum, Vineet Agrawal, Charles D Smart, Ashley Pitzer, James B Atkinson, Agnes B Fogo, Julie A Bastarache, Annet Kirabo, Quinn S Wells, Meena S Madhur, Joey V Barnett, Katherine T Murray
AIMS: The lymphocyte adaptor protein (LNK) is a negative regulator of cytokine and growth factor signaling. The rs3184504 variant in SH2B3 reduces LNK function and is linked to cardiovascular, inflammatory, and hematologic disorders including stroke. In mice, deletion of Lnk causes inflammation and oxidative stress. We hypothesized that Lnk-/- mice are susceptible to atrial fibrillation (AF) and that rs3184504 is associated with AF and AF-related stroke in humans. During inflammation, reactive lipid dicarbonyls are a major component of oxidative injury, and we further hypothesized that these mediators are critical drivers of the AF substrate in Lnk-/- mice...
February 20, 2024: Cardiovascular Research
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