Zak Loring, Jonathan P Piccini
No abstract text is available yet for this article.
May 14, 2020: European Journal of Preventive Cardiology
Xuan Zhang, Mengjie Hu, Xiying Wang, Chi Zhang, Wanwan Chen, Songzan Chen, Jintao Zhou, Yuxiao Chen, Lian Lou, Guoping Chen, Fanghong Dong, Shenjiang Hu, Liangrong Zheng, Jian Yang
BACKGROUND: Anticoagulant therapy is one of the important aspects of atrial fibrillation (AF) management, which can effectively reduce the formation of left atrial thrombosis (LAT) and the occurrence of embolic events. The CHA2DS2-VASc score is a commonly used risk assessment tool for embolic events, and it has guiding significance for anticoagulant therapy. However, a large number of recent studies have clearly shown that some of the markers that are not included in the score affect the formation of LAT...
March 19, 2020: European Journal of Preventive Cardiology
Philip Mar, Joseph S Van Tuyl, Michael J Lim
PURPOSE: The electrocardiogram (ECG) is an invaluable tool for clinicians that provides important information about a patient's heart. As clinical pharmacists play an ever-increasing role in cardiovascular care, ECG interpretation is an important skill with which to become familiar. SUMMARY: The ECG provides information on both electrical and biomechanical aspects of the heart. Electrical information such as the rhythm, rate, and axis of the electrical activity can all be provided by the ECG...
February 21, 2021: American Journal of Health-system Pharmacy: AJHP
Pedro L Valenzuela, Alejandro Santos-Lozano, Javier S Morales, Susana López-Ortiz, José Pinto-Fraga, Adrián Castillo-García, Juan Martín-Hernández, Julián P Villacastín, Araceli Boraita, Alejandro Lucia
No abstract text is available yet for this article.
May 16, 2020: European Journal of Preventive Cardiology
Pascal Meyre, Stefanie Aeschbacher, Steffen Blum, Michael Coslovsky, Jürg H Beer, Giorgio Moschovitis, Nicolas Rodondi, Oliver Baretella, Richard Kobza, Christian Sticherling, Leo H Bonati, Matthias Schwenkglenks, Michael Kühne, Stefan Osswald, David Conen
AIMS: To develop and externally validate a risk score for all-cause hospital admissions in patients with atrial fibrillation. METHODS AND RESULTS: We used a prospective cohort of 2387 patients with established atrial fibrillation as derivation cohort. Independent risk factors were selected from a broad range of variables using the least absolute shrinkage and selection operator method fit to a Cox model. The risk score was validated in a separate prospective cohort of 1300 atrial fibrillation patients...
March 31, 2020: European Journal of Preventive Cardiology
Glenn Van Steenkiste, Jonas Carlson, Annelies Decloedt, Lisse Vera, Rikke Buhl, Pyotr G Platonov, Gunther van Loon
OBJECTIVES: To compare the atrial fibrillatory rate (AFR) derived from a local right atrial intracardiac recording (RA-FR) and from a single-lead surface electrocardiogram (ECG) during atrial fibrillation (AF) and to evaluate the correlation with transvenous electrical cardioversion (TVEC) threshold (in Joules), number of shocks and cardioversion success rate in horses. ANIMALS: ECGs and clinical records of horses with AF treated by TVEC. Horses were included if a simultaneous recording of the right atrial intracardiac electrogram and a modified base-apex ECG were available...
January 11, 2021: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
Christos Voukalis, Gregory Y H Lip, Eduard Shantsila
BACKGROUND: Direct oral anticoagulants (DOACs) are known to prevent thrombosis but there is limited information about their activity on the clot formation and lysis cascade. OBJECTIVES: This study assesses the role of apixaban, one of the four licenced DOACs, on clot dynamics in patients with atrial fibrillation (AF). METHODS: We compared haemostatic and clot lysis characteristics between a group of patients with AF (n = 47) and a "disease control" group with ischaemic heart disease but in sinus rhythm (n = 39)...
February 9, 2021: Thrombosis Research
Rui Shi, Zhong Chen, Michael Tb Pope, Junaid Ab Zaman, Mike Debney, Alessio Marinelli, Vennela Boyalla, Anitha Sathishkumar, Nabeela Karim, Emily Cantor, Haseeb Valli, Shouvik Haldar, David G Jones, Wajid Hussain, Vias Markides, Timothy R Betts, Tom Wong
BACKGROUND: Non-contact charge-density mapping allows rapid real-time global mapping of atrial fibrillation (AF) offering the opportunity of a personalised ablation strategy. OBJECTIVE: We compared the two-year outcome of an individualised strategy consisting of pulmonary vein isolation (PVI) plus Core-to-Boundary ablation (targeting the conduction pattern core with an extension to the nearest non-conducting boundary) guided by charge-density mapping, with an empirical PVI plus posterior wall electrical isolation (PWI) strategy...
February 18, 2021: Heart Rhythm: the Official Journal of the Heart Rhythm Society
William Davies
Turner syndrome (TS) is a rare developmental condition in females caused by complete, or partial, loss of the second sex chromosome; it is associated with a number of phenotypes including short stature, ovarian failure and infertility, as well as neurobehavioural and cognitive manifestations. In contrast, Klinefelter syndrome (KS) arises from an excess of X chromosome material in males (typical karyotype is 47,XXY); like TS, KS is associated with infertility and hormonal imbalance, and behavioural/neurocognitive differences from gonadal sex-matched counterparts...
February 18, 2021: European Journal of Medical Genetics
J Hunter Mehaffey, Robert B Hawkins
No abstract text is available yet for this article.
January 29, 2021: Journal of Thoracic and Cardiovascular Surgery
Jessica Siak, Nir Flint, Hezzy G Shmueli, Robert J Siegel, Florian Rader
The medicinal properties of colchicine have been recognized for centuries. While previously used for gout and familial Mediterranean fever, its immune-modulating, anti-inflammatory, and antifibrotic effects are increasingly recognized to benefit cardiovascular disorders. In this systematic review, we summarize the current evidence on colchicine's effectiveness in 1) pericarditis, 2) coronary artery disease and 3) atrial fibrillation. We also discuss the safety, potential adverse effects and common drug interactions that should be considered during use...
February 17, 2021: American Journal of Medicine
Jose N Nativi-Nicolau, Chafic Karam, Sami Khella, Mathew S Maurer
Amyloid transthyretin (ATTR) amyloidosis is a clinically heterogeneous and fatal disease that results from deposition of insoluble amyloid fibrils in various organs and tissues, causing progressive loss of function. The objective of this review is to increase awareness and diagnosis of ATTR amyloidosis by improving recognition of its overlapping conditions, misdiagnosis, and multiorgan presentation. Cardiac manifestations include heart failure, atrial fibrillation, intolerance to previously prescribed antihypertensives, sinus node dysfunction, and atrioventricular block, resulting in the need for permanent pacing...
February 20, 2021: Heart Failure Reviews
Ahmed Sultan, Michael Jacobson, Ernest Adeghate, Abderrahim Oulhaj, Mohamed Shafiullah, Anwar Qureshi, Frank Christopher Howarth
Obesity and type 2 diabetes mellitus are risk factors for hypertension, coronary heart disease, cardiac arrhythmias including atrial fibrillation, heart failure and sudden cardiac death. The effects of obesity and diabesity on heart rhythm were investigated in the Zucker diabetic fatty (ZDF) and Zucker fatty (ZF) compared to the Zucker lean (ZL) control rat. In vivo biotelemetry techniques were used to assess the electrocardiogram and other cardiac and metabolic parameters. ZDF rats were characterized by age-dependent elevations in fasting and non-fasting blood glucose, glucose intolerance and weight gain and ZF rats were characterized by smaller elevations in fasting and non-fasting blood glucose and greater weight gain compared to ZL rats...
February 20, 2021: Clinical and Experimental Pharmacology & Physiology
Arne van Hunnik, Stef Zeemering, Piotr Podziemski, Pawel Kuklik, Marion Kuiper, Sander Verheule, Ulrich Schotten
AIMS: Complex propagation patterns are observed in patients and models with stable atrial fibrillation (AF). The degree of this complexity is associated with AF stability. Experimental work suggests reduced wavefront turning as an important mechanism for widening of the excitable gap. The aim of this study was to investigate how sodium channel inhibition by vernakalant affects turning behaviour and propagation patterns during AF. METHODS AND RESULTS: Two groups of 8 goats were instrumented with electrodes on the left atrium, and AF was maintained by burst pacing for 3 or 22 weeks...
February 20, 2021: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Daniel Engler, Hein Heidbuchel, Renate B Schnabel
No abstract text is available yet for this article.
February 20, 2021: European Heart Journal
Nuno Cortez-Dias, Pedro Silva Cunha, Francisco Moscoso Costa, Daniel Bonhorst, Mário M Oliveira
INTRODUCTION: The authors present the results of the national cardiac electrophysiology registry of the Portuguese Association of Arrhythmology, Pacing and Electrophysiology (APAPE) and the Portuguese Institute of Cardiac Rhythm (IPRC) for 2017 and 2018. METHODS: The registry is annual, voluntary, and observational. Data are collected retrospectively. Developments over the years and their implications are analyzed and discussed. RESULTS: In the 22 electrophysiology centers, 3407 ablations were performed in 2017 and 3653 ablations in 2018...
February 16, 2021: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
Sibille Lejeune, Clotilde Roy, Alisson Slimani, Agnès Pasquet, David Vancraeynest, Jean-Louis Vanoverschelde, Bernhard L Gerber, Christophe Beauloye, Anne-Catherine Pouleur
BACKGROUND: Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous syndrome, with several underlying etiologic and pathophysiologic factors. The presence of diabetes might identify an important phenotype, with implications for therapeutic strategies. While diabetes is associated with worse prognosis in HFpEF, the prognostic impact of glycemic control is yet unknown. Hence, we investigated phenotypic differences between diabetic and non-diabetic HFpEF patients (pts), and the prognostic impact of glycated hemoglobin (HbA1C)...
February 19, 2021: Cardiovascular Diabetology
Ling Zhang, Yu-Han Kong, Da-Wu Wang, Kai-Ting Li, He-Ping Yu
For patients with nonvalvular atrial fibrillation (NVAF) following hemorrhagic infarction (HI)/hemorrhage transformation (HT) and complicated with venous thrombosis, the management of anticoagulation is controversial. Our study intends to explore the safety and effectiveness of using low-dose of low molecular weight heparin (LMWH) to treat NVAF patients with HI (or HT) and complicated with venous thrombosis.Between January 2018 and January 2019, NVAF related acute ischemic stroke patients with HT/HI, hospitalized in the department of neurology or rehabilitation in our hospital, are enrolled retrospectively...
February 19, 2021: Medicine (Baltimore)
Sajad Mousavi, Fatemeh Afghah, Fatemeh Khadem, U Rajendra Acharya
BACKGROUND: A language is constructed of a finite/infinite set of sentences composing of words. Similar to natural languages, the Electrocardiogram (ECG) signal, the most common noninvasive tool to study the functionality of the heart and diagnose several abnormal arrhythmias, is made up of sequences of three or four distinct waves, including the P-wave, QRS complex, T-wave, and U-wave. An ECG signal may contain several different varieties of each wave (e.g., the QRS complex can have various appearances)...
February 9, 2021: Computer Methods and Programs in Biomedicine
Nicolas Buttinger, Maureen Dooley, James McCready, Justo Julia
The presence of left atrial thrombus is a contraindication to cardioversion or catheter ablation in patients with atrial fibrillation, due to the increased risk of systemic thromboembolism. Management of this situation includes changes in the anticoagulation regimen and repeat imaging tests. Accurate diagnosis of left atrial appendage thrombus is therefore essential but can sometimes be challenging. Multiple imaging modalities may sometimes be required in the setting of anatomical variations of the left atrial appendage and surrounding structures...
February 16, 2021: Indian Pacing and Electrophysiology Journal
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