Nonkanyiso Mboweni, Muzi Maseko, Nqoba Tsabedze
Cardiovascular diseases are a well-established cause of death in high-income countries. In the last 20 years, Sub-Saharan Africa (SSA) has seen one of the sharpest increases in cardiovascular disease-related mortality, superseding that of infectious diseases, including HIV/AIDS, in South Africa. This increase is evidenced by a growing burden of heart failure and atrial fibrillation (AF) risk factors. AF is a common comorbidity of heart failure with reduced ejection fraction (HFrEF), which predisposes to an increased risk of stroke, rehospitalizations, and mortality compared with patients in sinus rhythm...
March 19, 2023: ESC Heart Failure
Michael Ghannam, Krit Jongnarangsin, Hamed Emami, Miki Yokokawa, Jackson J Liang, Mohammed Saeed, Hakan Oral, Fred Morady, Aman Chugh
BACKGROUND: Incidental left atrial appendage (LAA) isolation may occur during radiofrequency ablation of persistent atrial fibrillation (AF). OBJECTIVE: The study aims to describe the mechanisms and long-term thromboembolic risk related to incidental LAA isolation. METHODS: Patients who experienced incidental LAA isolation after AF ablation were included. Culprit sites where ablation resulted in LAA isolation were identified. Thromboembolic risk despite oral anticoagulation (OAC) was compared to that in a propensity-matched control group without LAA isolation...
March 19, 2023: Journal of Cardiovascular Electrophysiology
Orod Razeghi, Ridhima Kapoor, Mahmood I Alhusseini, Muhammad Fazal, Siyi Tang, Caroline H Roney, Albert J Rogers, Anson Lee, Paul J Wang, Paul Clopton, Daniel L Rubin, Sanjiv M Narayan, Steven Niederer, Tina Baykaner
BACKGROUND: Structural changes in the left atrium (LA) modestly predict outcomes in patients undergoing catheter ablation for atrial fibrillation (AF). Machine learning (ML) is a promising approach to personalize AF management strategies and improve predictive risk models after catheter ablation by integrating atrial geometry from cardiac computed tomography (CT) scans and patient-specific clinical data. We hypothesized that ML approaches based on a patient's specific data can identify responders to AF ablation...
March 19, 2023: Journal of Cardiovascular Electrophysiology
Maxim Grymonprez, Mirko Petrovic, Tine L De Backer, M Arfan Ikram, Stephane Steurbaut, Lies Lahousse
BACKGROUND: Atrial fibrillation (AF) is associated with cognitive decline, with anticoagulated subjects potentially having a reduced risk compared with non-anticoagulated subjects. However, whether non-vitamin K antagonist oral anticoagulants (NOACs) may reduce the risk of dementia compared with vitamin K antagonists (VKAs) is unclear yet. Therefore, the risk of dementia was compared between AF subjects on NOACs versus VKAs. METHODS: AF subjects initiating anticoagulation between 2013 and 2019 were identified in Belgian nationwide data...
March 1, 2023: Age and Ageing
Dixon Yang, Mitchell S V Elkind
INTRODUCTION: Cryptogenic stroke is a heterogeneous entity defined as an ischemic stroke for which no probable cause is identified despite thorough diagnostic evaluation. Since about a quarter of all ischemic strokes are classified as cryptogenic, it is a commonly encountered problem for providers as secondary stroke prevention is guided by stroke etiology. AREAS COVERED: In this review, the authors provide an overview of stroke subtype classification schemes and diagnostic evaluation in cryptogenic stroke...
March 19, 2023: Expert Review of Neurotherapeutics
Na Lin, Liping Xu, Qiaoding Dai
Macrophage activation syndrome (MAS), a secondary hemophagocytic lymphohistiocytosis characterized by an excessive systemic inflammatory response, is a life-threatening and rare disease. Cardiovascular damage is a common and severe complication of the disease, however, it is easily ignored and not well studied. Herein, we report two cases of patients with MAS-associated heart damage and review the clinical characteristics, mechanism, and treatment. Case 1 along with systemic lupus erythematosus and Kikuchi necrotizing lymphadenitis occurred in fatal acute heart failure, and case 2 complicated adult-onset Still's Disease began with atrial fibrillation and had some improvement with the treatment of high dose corticosteroids...
March 14, 2023: Iranian Journal of Immunology: IJI
Sunyoung Kim, So Young Park, Bongseong Kim, Chanyang Min, Wonyoung Cho, Dong Keon Yon, Joo Young Kim, Kyung-Do Han, Eun-Jung Rhee, Won-Young Lee, Sang Youl Rhee
BACKGROUND: Although diabetes is a risk factor for atrial fibrillation (AF), studies on the AF risk according to the antidiabetic drugs are lacking. This study evaluated the effects of antidiabetic drugs on AF incidence in Korean patients with type 2 diabetes. METHODS: We included 2,515,468 patients with type 2 diabetes from the Korean National Insurance Service database without a history of AF who underwent health check-ups between 2009 and 2012. Newly diagnosed AF incidence was recorded until December 2018 according to the main antidiabetic drug combinations used in the real world...
March 16, 2023: Diabetes Research and Clinical Practice
Charles L Willekes, Justin S Fanning, John C Heiser, Stephane Leung Wai Sang, Tomasz A Timek, Jessica Parker, Mary K Ragagni
OBJECTIVE: Evaluate the feasibility of prophylactic radiofrequency isolation of the pulmonary veins, with left atrial appendage amputation, to reduce the incidence of postoperative atrial fibrillation (POAF) after cardiac surgery in patients aged 70 and older. METHODS: The Federal Food and Drug Administration granted an investigational device exemption to utilize a bipolar radiofrequency clamp for prophylactic pulmonary vein isolation in a limited, feasibility trial...
March 16, 2023: Journal of Thoracic and Cardiovascular Surgery
Amanda L Banaag, Harvey B Pollard, Tracey P Koehlmoos
BACKGROUND: Cardiac glycosides such as digoxin, digitoxin and ouabain are still used around the world to treat patients with chronic heart failure with reduced ejection fraction (HFrEF) and/or atrial fibrillation (AF). However, in the US, only digoxin is licensed for treating these illnesses, and the use of digoxin for this group of patients is increasingly being replaced in the US by a new standard of care with groups of more expensive drugs. However, ouabain and digitoxin, and less potently digoxin, have also recently been reported to inhibit SARS-CoV-2 virus penetration into human lung cells, thus blocking COVID-19 infection...
March 18, 2023: Drugs—Real World Outcomes
Don Mathew, Siddharth Agarwal, Akil Sherif
BACKGROUND: The implications of LBBB in heart failure with preserved ejection fraction (HFpEF) is unclear. Our study assesses clinical outcomes among patients with LBBB and HFpEF who were admitted with acute decompensated heart failure. METHODS: This is a cross-sectional study was conducted using the National Inpatient Sample (NIS) database from 2016-2019. RESULTS: We found 74,365 hospitalizations with HFpEF and LBBB and 3,892,354 hospitalizations with HFpEF without LBBB...
March 18, 2023: Pacing and Clinical Electrophysiology: PACE
Prasanth Ganesan, Brototo Deb, Ruibin Feng, Miguel Rodrigo, Samuel Ruiperez-Campillo, Albert J Rogers, Paul Clopton, Paul J Wang, Stef Zeemering, Ulrich Schotten, Wouter-Jan Rappel, Sanjiv M Narayan
AIMS: There is a clinical spectrum for atrial tachyarrhythmias wherein most patients with atrial tachycardia (AT) and some with atrial fibrillation (AF) respond to ablation, while others do not. It is undefined if this clinical spectrum has pathophysiological signatures. This study aims to test the hypothesis that the size of spatial regions showing repetitive synchronized electrogram (EGM) shapes over time reveals a spectrum from AT, to AF patients who respond acutely to ablation, to AF patients without acute response...
March 18, 2023: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Nicola Bottoni, Fabio Quartieri, Matteo Iori, Antonella Battista, Alessandro Navazio, Michele Brignole
AIMS: While several studies in the literature have reported results of catheter ablation of AF, few is known regarding outcome for more than 10 years. METHODS AND RESULTS: The complete population of patients who underwent AF ablation in the years 2002-2021 in the department of cardiology of the hospital of Reggio Emilia has been analysed. The last follow-up was made in the second half of 2022. During this period the technique of ablation remained relatively unchanged as well the physicians performing ablation...
March 18, 2023: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Masanori Harada, Kazuyo Yasuda, Kazumi Uruchida, Ryoma Yamashita, Keisuke Morikawa, Yutaro Ito, Eisuke Mochizuki, Shun Matsuura, Masaru Tsukui, Naoki Koshimizu
BACKGROUND: Recently, deaths due to mucormycosis in immunocompromised hosts have increased; however, the clinical and pathological features of mucormycosis are not fully understood, especially in view of the associated high mortality and rare incidence in immunocompetent patients. CASE PRESENTATION: We have described a rare autopsy case of a 67-year-old Japanese man with chronic obstructive pulmonary disease who contracted mucormycosis. He had not been on any immunosuppressants, and his immune functions were intact...
March 17, 2023: BMC Pulmonary Medicine
Shany Biton, Mohsin Aldhafeeri, Erez Marcusohn, Kenta Tsutsui, Tom Szwagier, Adi Elias, Julien Oster, Jean Marc Sellal, Mahmoud Suleiman, Joachim A Behar
To drive health innovation that meets the needs of all and democratize healthcare, there is a need to assess the generalization performance of deep learning (DL) algorithms across various distribution shifts to ensure that these algorithms are robust. This retrospective study is, to the best of our knowledge, an original attempt to develop and assess the generalization performance of a DL model for AF events detection from long term beat-to-beat intervals across geography, ages and sexes. The new recurrent DL model, denoted ArNet2, is developed on a large retrospective dataset of 2,147 patients totaling 51,386 h obtained from continuous electrocardiogram (ECG)...
March 17, 2023: NPJ Digital Medicine
James K Chow, Akshay Bagai, Mary K Tan, Bryan J Har, Amelia M C Yip, Mario Paniagua, Basem Elbarouni, Kevin R Bainey, Jean-Michel Paradis, Robert Maranda, Warren J Cantor, Mark J Eisenberg, Jean-Pierre Dery, Mina Madan, Tomas Cieza, Alexis Matteau, Sherryn Roth, Shahar Lavi, Anthony Glanz, Dongsheng Gao, Ravi Tahiliani, Robert C Welsh, Hahn Hoe Kim, Simon D Robinson, Benoit Daneault, Aun-Yeong Chong, Michel R Le May, Vineeta Ahooja, Jean C Gregoire, Pierre-Louis Nadeau, Zachary Laksman, Brett Heilbron, Derek Yung, Kunal Minhas, Ronald Bourgeois, Christopher B Overgaard, Hamid Bonakdar, Giridhar Logsetty, Andrea J Lavoie, Robert De LaRochelliere, Samer Mansour, Caroline Spindler, Andrew T Yan, Shaun G Goodman
BACKGROUND: Selecting the appropriate antithrombotic regimen for patients with atrial fibrillation (AF) who have undergone percutaneous coronary intervention (PCI) or have had medically managed acute coronary syndrome (ACS) remains complex. This multi-centre observational study evaluated patterns of antithrombotic therapies utilized among Canadian patients with AF post-PCI or ACS. METHODS AND RESULTS: By retrospective chart audit, 611 non-valvular AF patients [median (interquartile range) age 76 (69-83) years, CHADS2 score 2 (1-3)] who underwent PCI or had medically managed ACS between August 2018 and December 2020 were identified by 68 cardiologists across eight provinces in Canada...
March 15, 2023: Journal of Cardiology
Permesh Singh Dhillon, Waleed Butt, Omar Marei, Anna Podlasek, Norman McConachie, Robert Lenthall, Sujit Nair, Luqman Malik, Pervinder Bhogal, Hegoda Levansri Dilrukshan Makalanda, Robert A Dineen, Timothy J England
BACKGROUND: Numerous ischaemic stroke patients experience poor functional outcome despite successful recanalisation following endovascular thrombectomy (EVT). We aimed to identify the incidence and predictors of futile complete recanalisation (FCR) in a national stroke registry. METHODS: Patients who achieved complete recanalisation (mTICI 3) following EVT, between October 2015 and March 2020, were included from a United Kingdom national stroke registry. Modified Rankin Scale of 4-6 at discharge was defined as a 'poor/futile outcome'...
March 15, 2023: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Manuel A Baños-González, Antonio González-Hermosillo, Milton E Guevara-Valdivia, Jorge A Vázquez-Acosta, Manuel O de Los Ríos-Ibarra, Julio A Aguilar-Linares, Carlos Cantú-Brito, José L Leiva-Pons, Gerardo Pozas-Garza, Eddie A Favela-Pérez, Luis Molina, Reynaldo Magaña-Magaña, Rocío Camacho-Casillas, Eduardo Chuquiure-Valenzuela, Janneth Manzano-Cabada, Manlio F Márquez-Murillo
INTRODUCTION: Heart failure in patients with non-valvular atrial fibrillation (NVAF) is two to three times more common than in individuals without NVAF. OBJECTIVE: To identify cardiometabolic risk factors (CMRF) and antithrombotic treatment in patients with NVAF and heart failure with reduced ejection fraction (HFrEF), and to determine if there were differences according to gender. METHODS: CMRF, pro-thrombotic risk, bleeding risk, and antithrombotic therapy were globally analyzed and according to gender...
2023: Gaceta Médica de México
Yu-Juei Hsu, Gwo-Jyh Chang, Ying-Ju Lai, Yi-Hsin Chan, Wei-Jan Chen, Chi-Tai Kuo, Yung-Hsin Yeh
AIM: Hyperphosphatemia is associated with adverse cardiovascular outcomes in both the general population and patients with end-stage renal disease. We evaluated whether high inorganic phosphate (Pi) intake causes atrial remodeling and increased atrial fibrillation (AF) risk. METHODS: The 5/6 nephrectomized chronic kidney disease (CKD) mice were fed a high-Pi (2%) diet for 10 weeks. AF vulnerability was evaluated through transesophageal burst atrial pacing...
March 17, 2023: Acta Physiologica
(no author information available yet)
No abstract text is available yet for this article.
March 17, 2023: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Sandra Öberg, Linda Johansson, Mattias Georgsson, Jonas Sandberg, Anders Broström
AIM: To describe demographic, physical and psychological characteristics associated with insomnia in patients with cardiovascular disease (CVD) participating in nurse-led Internet-based cognitive behavioural therapy for insomnia (I-CBTI), and their motives and expectations regarding participation in I-CBTI. DESIGN: A mixed method design was applied, including primary care patients with angina pectoris, myocardial infarction, heart failure, atrial fibrillation and atrial flutter or arrhythmia in southern Sweden...
March 17, 2023: Nursing Open
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.