Stefano Fumagalli, Giulia Ricciardi, Claudia Di Serio, Giancarlo La Marca, Giuseppe Pieraccini, Riccardo Franci Montorzi, Emanuele Santamaria, Giulia Spanalatte, Francesca Marchetti, Ginevra Corti, Laura Pinton, Niccolò Marchionni
BACKGROUND: Atrial fibrillation (AF) is associated with chronic inflammation, a hallmark of ageing process. The aim of this study was to determine interleukin-6 (IL-6)-associated variables, also exploring acylcarnitines, expression of mitochondrial abnormalities. METHODS: We evaluated 22 controls and 50 patients with persistent AF. IL-6 and acylcarnitines were measured with ELISA kits and mass spectrometry techniques. RESULTS: IL-6 concentration (mean: 3...
September 21, 2023: Aging Clinical and Experimental Research
Andrew Holmes, Matthew Preszler, Luke Smith, Jazmin Newton, Tayt Boeckholt, Divyajot Sandhu
INTRODUCTION: To describe the impact of multiple risk factors on stroke outcomes among American Indians in South Dakota. METHODS: This is a retrospective chart review of 189 American Indian patients treated for stroke in South Dakota between Jan 1, 2016, to May 1, 2021, at a single hospital system. RESULTS: Risk factor prevalence in the population: hypertension (76.1%), smoking (74.2%), diabetes mellitus (56.8%), dyslipidemia (55.4%), alcohol use (43...
June 2023: South Dakota Medicine: the Journal of the South Dakota State Medical Association
Matthew Preszler, Luke Smith, Jazmin Newton, Andrew Holmes, Tayt Boeckholt, Divyajot Sandhu
OBJECTIVE: To describe the impact of multiple risk factors on stroke outcomes among Native Americans in South Dakota. METHODS: This is a retrospective chart review of 189 Native American patients treated for stroke in South Dakota between Jan. 1, 2016, to May 1, 2021 at a single hospital system. RESULTS: Risk factor prevalence in the population: hypertension (76.1%), smoking (74.2%), diabetes mellitus (56.8%), dyslipidemia (55.4%), alcohol use (43...
June 2023: South Dakota Medicine: the Journal of the South Dakota State Medical Association
Stuart J Connolly, Jeff S Healey, Emilie P Belley-Cote, Kumar Balasubramanian, Domenico Paparella, Katheryn Brady, Wilko Reents, Bernhard C Danner, P J Devereaux, Mukul Sharma, Chinthanie Ramasundarahettige, Salim Yusuf, Richard P Whitlock
BACKGROUND: LAAOS III (Left Atrial Appendage Occlusion Study III) showed that left atrial appendage (LAA) occlusion reduces the risk of ischemic stroke or systemic embolism in patients with atrial fibrillation undergoing cardiac surgery. This article examines the effect of LAA occlusion on stroke reduction according to variation in the use of oral anticoagulants (OACs). METHODS: Information regarding OAC use was collected at every follow-up visit. Adjusted proportional hazards modeling, including using landmarks of hospital discharge, 1 and 2 years after randomization, evaluated the effect of LAA occlusion on the risk of ischemic stroke or systemic embolism, according to OAC use...
September 21, 2023: Circulation
Alvaro Alonso, Alanna A Morris, Ashley I Naimi, Aniqa B Alam, Linzi Li, Vinita Subramanya, Lin Yee Chen, Pamela L Lutsey
OBJECTIVE: To evaluate utilization of sodium-glucose cotransporter-2 inhibitors (SGLT2i) and angiotensin receptor neprilysin inhibitors (ARNi) in patients with atrial fibrillation (AF) and heart failure (HF). METHODS: We analyzed the MarketScan databases for the period 1/1/2021 to 6/30/2022. Validated algorithms were used to identify patients with AF and HF, and to classify patients into HF with reduced ejection fraction (HFrEF) or preserved ejection fraction (HFpEF)...
September 10, 2023: medRxiv
Qiubo Wang, Zhimiao Wang, Mingyou Chen, Wei Mu, Zhenxing Xu, Mei Xue
BACKGROUND: Previous observational studies have shown that the prevalence of cardiovascular diseases (CVDs) is related to particulate matter (PM). However, given the methodological limitations of conventional observational research, it is difficult to identify causality conclusively. To explore the causality of PM on CVDs and cardiovascular biomarkers, we conducted a Mendelian randomization (MR) analysis. METHOD: In this study, we obtained summary-level data for CVDs and cardiovascular biomarkers including atrial fibrillation (AF), heart failure (HF), myocardial infarction (MI), ischemic stroke (IS), stroke subtypes, body mass index (BMI), lipid traits, fasting glucose, fasting insulin, and blood pressure from several large genome-wide association studies (GWASs)...
2023: Frontiers in Public Health
Yun Young Choi, Jong-Il Choi, Joo Hee Jeong, Hyoung Seok Lee, Yun Gi Kim, Mi-Na Kim, Seung-Young Roh, Jaemin Shim, Jin Seok Kim, Seong-Mi Park, Young-Hoon Kim
BACKGROUND: The pulmonary veins play a major role in the pathogenesis of atrial fibrillation (AF) and may be affected by cardiac remodeling due to pulmonary vascular dysfunction. It remains to be determined whether pulmonary artery pressure (PAP) is associated with the recurrence of AF after radiofrequency catheter ablation (RFCA). METHODS: Consecutive patients with paroxysmal and persistent AF who underwent RFCA, including wide circumferential pulmonary vein isolation, were analyzed...
2023: Frontiers in Cardiovascular Medicine
Dayang Wang, Xiaoqing Xu, Xiaowan Han, Jing Xie, Hufang Zhou, Wenhua Peng, Guozhong Pan
BACKGROUND: The management of atrial fibrillation (AF) with oral anticoagulants (OAC) is generally recommended to reduce the risk of stroke. However, the decision to prescribe these medications for patients with AF and dementia remains controversial. METHODS: A systematic review and meta-analysis of retrospective cohort studies were conducted. The search encompassed PubMed, Cochrane Library, Web of Science, and Embase databases from inception until May 1st, 2023, with language limited to English...
2023: Frontiers in Cardiovascular Medicine
Daniel Rodríguez Muñoz, María Generosa Crespo-Leiro, Ignacio Fernández Lozano, José Luis Zamorano Gómez, Rafael Peinado Peinado, Luis Manzano Espinosa, Javier de Juan Bagudá, Álvaro Marco Del Castillo, Fernando Arribas Ynsaurriaga, Rafael Salguero Bodes
AIMS: Atrial fibrillation (AF) worsens the prognosis of patients with heart failure (HF). Successful treatments are still very scarce for those with permanent AF and preserved (HFpEF) or mildly reduced (HFmrEF) ejection fraction. In this study, the long-term benefits and safety profile of heart rate regularization through left-bundle branch pacing (LBBP) and atrioventricular node ablation (AVNA) will be explored in comparison with pharmacological rate-control strategy. METHODS AND RESULTS: The PACE-FIB trial is a multicentre, prospective, open-label, randomized (1:1) clinical study that will take place between March 2022 and February 2027...
September 20, 2023: ESC Heart Failure
Koichi Inoue
No abstract text is available yet for this article.
September 21, 2023: Circulation Journal: Official Journal of the Japanese Circulation Society
Óscar Cano, Víctor Bazán, Eduardo Arana
INTRODUCTION AND OBJECTIVES: This article presents results of the Spanish catheter ablation registry for the year 2022. METHODS: Data were retrospectively entered into a REDCap platform using a specific form. RESULTS: A total of 103 centers participated (75 public, 28 private), which reported 23 360 ablation procedures, with a mean of 227 ± 173 and a median of 202 [interquartile range, 77-312] procedures per center...
September 18, 2023: Revista Española de Cardiología
Amine Tas, Emil Loldrup Fosbøl, Jawad Haider Butt, Peter Ejvin Weeke, Søren Lund Kristensen, Jakob Burcharth, Naja Emborg Vinding, Jeppe Kofoed Petersen, Lars Køber, Morten Vester-Andersen, Anna Gundlund
The prevalence and impact of perioperative atrial fibrillation (AF) during an admission for major emergency abdominal surgery are sparsely examined. Therefore, this study aimed to compare the 30-day and 1-year outcomes (AF-related hospitalization, stroke, and all-cause mortality) in patients with and without perioperative AF to their major emergency abdominal surgery. All patients without a history of AF who underwent major emergency abdominal surgery from 2000 to 2019 and discharged alive were identified using Danish nationwide registries...
September 18, 2023: American Journal of Cardiology
Shinichi Wada, Sohei Yoshimura, Kazunori Toyoda, Michikazu Nakai, Yusuke Sasahara, Kaori Miwa, Junpei Koge, Akiko Ishigami, Masayuki Shiozawa, Kuniaki Ogasawara, Takanari Kitazono, Shigeru Nogawa, Yoshitaka Iwanaga, Yoshihiro Miyamoto, Kazuo Minematsu, Masatoshi Koga
BACKGROUND: Clinical outcomes of unknown onset stroke (UOS) are influenced by the enlargement of the therapeutic time window for reperfusion therapy. This study aimed to investigate and describe the characteristics and clinical outcomes of patients with UOS. METHODS: Patients with acute ischemic stroke (AIS) who were admitted within 24 h of their last known well time, from January 2017 to December 2020, were included. Data were obtained from a long-lasting nationwide hospital-based multicenter prospective registry: the Japan Stroke Data Bank...
September 14, 2023: Journal of the Neurological Sciences
Amanda Vanessa Demarchi, Luciana Vidal Armaganijan, Dalmo Antonio Ribeiro Moreira, Mariane Higa Shinzato, Kelvin Henrique Vilalva, Pablo Santos Graffitti, Rodrigo Augusto de Miranda Bertin, Mathias Antonio Haruno de Vilhena, Murilo Amato David, Guilherme Dagostin de Carvalho
OBJECTIVE: The aim of this study was to evaluate the correlation between P-wave indexes, echocardiographic parameters, and CHA2DS2-VASc score in patients without atrial fibrillation and valvular disease. METHODS: This retrospective cross-sectional study included patients of a tertiary hospital with no history of atrial fibrillation, atrial flutter, or valve disease and collected data from June 2021 to May 2022. The exclusion criteria were as follows: unavailable medical records, pacemaker carriers, absence of echocardiogram report, or uninterpretable ECG...
2023: Revista da Associação Médica Brasileira
Ibrahim Donmez, Ayhan Muduroglu
OBJECTIVE: The objective of this study was to reveal whether there was a possible relationship between the blood group and postoperative atrial fibrillation after off-pump coronary artery bypass grafting. METHODS: Between January 2020 and January 2022, 452 patients undergoing off-pump coronary artery bypass grafting surgery consisted of the research population. Patients were divided into two groups based on the occurrence of new-onset atrial fibrillation from the time of operation until discharge...
2023: Revista da Associação Médica Brasileira
Jean-Luc Balligand, Dulce Brito, Oana Brosteanu, Barbara Casadei, Christophe Depoix, Frank Edelmann, Vanessa Ferreira, Gerasimos Filippatos, Bernhard Gerber, Damien Gruson, Dirk Hasenclever, Kristian Hellenkamp, Ignatios Ikonomidis, Bartosz Krakowiak, Renaud Lhommel, Masliza Mahmod, Stefan Neubauer, Alexandre Persu, Stefan Piechnik, Burkert Pieske, Elisabeth Pieske-Kraigher, Fausto Pinto, Piotr Ponikowski, Michele Senni, Jean-Noël Trochu, Nancy Van Overstraeten, Rolf Wachter, Anne-Catherine Pouleur
IMPORTANCE: Left ventricular (LV) hypertrophy contributes to the onset and progression of heart failure (HF), particularly for patients with pre-HF (stage B) for whom no treatment has yet proven effective to prevent transition to overt HF (stage C). The β3-adrenergic receptors (β3ARs) may represent a new target, as their activation attenuates LV remodeling. OBJECTIVE: To determine whether activation of β3ARs by repurposing a β3AR agonist, mirabegron, is safe and effective in preventing progression of LV hypertrophy and diastolic dysfunction among patients with pre- or mild HF...
September 20, 2023: JAMA Cardiology
De-Gang Mo
No abstract text is available yet for this article.
September 20, 2023: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Bharat Narasimhan, Kruti Gandhi, Errol Moras, Lingling Wu, Akanibo Da Wariboko, Wilbert Aronow
INTRODUCTION: Supraventricular tachycardias (SVT) are a diverse group of commonly encountered arrhythmias arising at or above the atrioventricular (AV) node. Conventional anti-arrhythmic medications are restricted by extensive side-effect profiles and limited efficacy. Catheter ablation has emerged as a first-line therapy for many arrhythmias, but is not a suitable option for all patients. This has prompted the exploration of novel pharmacological approaches targeting specific molecular mechanisms of SVT...
September 20, 2023: Expert Opinion on Investigational Drugs
Jeroen Walpot, Paul Van Herck, Caroline M Van de Heyning, Johan Bosmans, Samia Massalha, Manu L N G Malbrain, Hein Heidbuchel, João R Inácio
Over the last two decades, the potential role of epicardial adipocyte tissue (EAT) as a marker for major adverse cardiovascular events has been extensively studied. Unlike other visceral adipocyte tissues (VAT), EAT is not separated from the adjacent myocardium by a fascial layer and shares the same microcirculation with the myocardium. Adipocytokines, secreted by EAT, interact directly with the myocardium through paracrine and vasocrine pathways. The role of the Randle cycle, linking VAT accumulation to insulin resistance, and the relevance of blood flow and mitochondrial function of VAT, are briefly discussed...
2023: Anaesthesiology Intensive Therapy
HsunYu Kuo, Tsai-Wei Liu, Yo-Ping Huang, Shy-Chyi Chin, Long-Sun Ro, Hung-Chou Kuo
Cancer-associated thrombosis (CAT) and atrial fibrillation (AF)-related stroke are two subtypes of acute embolic stroke with distinct lesion patterns on diffusion weighted imaging (DWI). This pilot study aimed to evaluate the feasibility and performance of DWI-based machine learning models for differentiating between CAT and AF-related stroke. Patients with CAT and AF-related stroke were enrolled. In this pilot study with a small sample size, DWI images were augmented by flipping and/or contrast shifting to build convolutional neural network (CNN) predicative models...
2023: Clinical and Applied Thrombosis/hemostasis
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