Basil S Lewis
No abstract text is available yet for this article.
April 9, 2021: European Heart Journal. Cardiovascular Pharmacotherapy
Heng Lin Tan, Lloyd Wei Tat Tang, Sheng Yuan Chin, Eric Chun Yong Chan
The combination of antiarrhythmic agents, amiodarone or dronedarone, with the anticoagulant rivaroxaban is used clinically in the management of atrial fibrillation for rhythm control and secondary stroke prevention respectively. Renal drug-drug interactions (DDIs) between amiodarone or dronedarone and rivaroxaban were previously ascribed to inhibition of rivaroxaban secretion by P-glycoprotein at the apical membrane of renal proximal tubular epithelial cells. Benzbromarone, a known inhibitor of organic anion transporter 3 (OAT3), shares a benzofuran scaffold with amiodarone and dronedarone...
March 20, 2021: Drug Metabolism and Pharmacokinetics
Ricardo Abad, Orvil Collart, Prasanth Ganesan, A J Rogers, Mahmood I Alhusseini, Miguel Rodrigo, Sanjiv M Narayan, Wouter-Jan Rappel
BACKGROUND: The rotational activation created by spiral waves may be a mechanism for atrial fibrillation (AF), yet it is unclear how activation patterns obtained from endocardial baskets are influenced by the 3D geometric curvature of the atrium or 'unfolding' into 2D maps. We develop algorithms that can visualize spiral waves and their tip locations on curved atrial geometries. We use these algorithms to quantify differences in AF maps and spiral tip locations between 3D basket reconstructions, projection onto 3D anatomical shells and unfolded 2D surfaces...
2021: PloS One
Samuel K Sørensen, Arne Johannessen, René Worck, Morten L Hansen, Jim Hansen
Background - Recurrent paroxysmal atrial fibrillation (PAF) after catheter ablation is presumably caused by failure to achieve durable pulmonary vein isolation (PVI). The primary methods of PVI are radiofrequency (RF) and cryoballoon (CRYO) catheter ablation, but these methods have not been directly compared with respect to PVI durability and the effect thereof on AF burden (% of time in AF). Methods - Accordingly, we performed a randomized trial including 98 patients (68% male, 61 [55-67] years) with PAF assigned 1:1 to PVI by contact-force sensing, irrigated RF catheter or second-generation CRYO catheter...
April 9, 2021: Circulation. Arrhythmia and Electrophysiology
Ji Hyun Lee, In Tae Moon, Youngjin Cho, Jun Yup Kim, Jihoon Kang, Beom Joon Kim, Moon Ku Han, Il Young Oh, Hee Joon Bae
BACKGROUND AND PURPOSE: An insertable cardiac monitor (ICM) has been demonstrated to be a useful tool for detecting subclinical atrial fibrillation (AF) in patients with embolic stroke of undetermined source (ESUS). This study aimed to identify the clinical predictors of AF in ESUS patients with ICMs. METHODS: We retrospectively selected consecutive patients with an ICM implanted for AF detection following ESUS. The primary endpoint was defined as any AF episode lasting for longer than 5 min...
April 2021: Journal of Clinical Neurology
Christine Chow, Robert J Mentz, Stephen J Greene
PURPOSE OF REVIEW: Multiple newer medications benefit patients with heart failure with reduced ejection fraction (HFrEF). While these therapies benefit the broad population with HFrEF, the efficacy and safety of these therapies have been less well characterized in patients with significant comorbidities. RECENT FINDINGS: Common comorbidities of high interest in heart failure (HF) include diabetes mellitus, chronic kidney disease (CKD), atrial fibrillation, and obesity, and each has potential implications for clinical management...
April 9, 2021: Current Heart Failure Reports
Tien Yun Yang, Li Huang, Shwetambara Malwade, Chien-Yi Hsu, Yang Ching Chen
BACKGROUND: Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide. Early diagnosis of AF is crucial for preventing AF-related morbidity, mortality, and economic burden, yet the detection of the disease remains challenging. The 12-lead electrocardiogram (ECG) is the gold standard for the diagnosis of AF. Because of technological advances, ambulatory devices may serve as convenient screening tools for AF. OBJECTIVE: The objective of this review was to investigate the diagnostic accuracy of 2 relatively new technologies used in ambulatory devices, non-12-lead ECG and photoplethysmography (PPG), in detecting AF...
April 9, 2021: JMIR MHealth and UHealth
Ivana Jurin, Marko Lucijanić, Vedran Radonić, Tomislav Letilović, Josip Pejić, Jelena Lucijanić, Ida Tješić-Drinković, Sanda Sokol Tomić, Irzal Hadžibegović
Objective : To investigate differences in clinical presentation, anticoagulation pattern and outcomes in patients with dementia and atrial fibrillation (AF). Methods : A total of 1217 hospitalized patients with non-valvular AF from two institutions were retrospectively evaluated. Diagnosis of dementia was established by a psychiatrist or a neurologist prior to or during hospitalization. Adequacy of warfarin anticoagulation was assessed during follow-up using at least 10 standardized international ratio values...
April 9, 2021: Acta Clinica Belgica
Manuela Silva, Nuno Banazol, António Fiarresga, José Fragata
59-year-old women with permanent atrial fibrillation and previous haemorrhagic stroke was admitted for percutaneous left atrial appendage occlusion. Shortly after, AmplatzerTM device migration into the left ventricular outflow tract was confirmed. Unsuccessful transcatheter mobilization led to an emergent surgery for device retrieval and LAA closure. No events at 6-month follow-up.
April 8, 2021: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
Li Liu, Jianjun Huang, Baomin Wei, Jianjiao Mo, Qinjiang Wei, Chengcai Chen, Wei Yan, Xiannan Huang, Fengzhen He, Lingling Qin, Hehua Huang, Xue Li, Xingshou Pan
Objective: This study is aimed at understanding the molecular mechanisms and exploring potential therapeutic targets for atrial fibrillation (AF) by multiomics analysis. Methods: Transcriptomics and methylation data of AF patients were retrieved from the Gene Expression Omnibus (GEO). Differentially expressed genes (DEGs) and differentially methylated sites between AF and normal samples were screened. Then, highly expressed and hypomethylated and lowly expressed and hypermethylated genes were identified for AF...
2021: BioMed Research International
Li-Zhen Liao, Xiu-Yun Wen, Shao-Zhao Zhang, Wei-Dong Li, Xiao-Dong Zhuang
Introduction: Hypertension (HT) and atrial fibrillation (AF) often coexist. However, the causality between these two conditions remains to be determined. Methods: We used individual participant data from the Atherosclerosis Risk in Communities (ARIC) prospective cohort with 9,474 participants. HT was ascertained at visit 1 (1987-1989), and incident AF was identified by ECGs conducted during study examinations at each visit, hospital discharge codes, and death certificates. We used the Kaplan-Meier estimate to compute the cumulative incidence of AF by the HT subgroup...
2021: Frontiers in Cardiovascular Medicine
Jiandong Zhou, Sharen Lee, Xiansong Wang, Yi Li, William Ka Kei Wu, Tong Liu, Zhidong Cao, Daniel Dajun Zeng, Keith Sai Kit Leung, Abraham Ka Chung Wai, Ian Chi Kei Wong, Bernard Man Yung Cheung, Qingpeng Zhang, Gary Tse
Recent studies have reported numerous predictors for adverse outcomes in COVID-19 disease. However, there have been few simple clinical risk scores available for prompt risk stratification. The objective is to develop a simple risk score for predicting severe COVID-19 disease using territory-wide data based on simple clinical and laboratory variables. Consecutive patients admitted to Hong Kong's public hospitals between 1 January and 22 August 2020 and diagnosed with COVID-19, as confirmed by RT-PCR, were included...
April 8, 2021: NPJ Digital Medicine
Lavinia Duica, Elisabeta Antonescu, Maria Totan, Mihail Pirlog, Sinziana Calina Silisteanu
Stroke represents the third - leading cause of death after heart and neoplastic is ease and is one of the biggest cause of disability worldwide. Cardioembolism, through its principal mechanism - atrial fibrillation - constitute an important cause of ischemic stroke. Otherwise, left ventricular hypertrophy (LVH) has been associated with a twofold increase in stroke risk. The study aims at highlighting significant associations between several risk factors of stroke -LVH and atrial fibrillation (AF), respectively LVH and cardiac stenosis contributeng to ischemic stroke...
September 2020: Pakistan Journal of Pharmaceutical Sciences
Alberto Pérez-Rubio, J Alberto San Román, José María Eiros Bouza
Influenza infection has been identified as a triggering or exacerbating factor for cardiovascular events. To analyse the effect of influenza vaccination on cardiovascular disease, a systematic search of studies published between 2009-2019 was conducted. All the studies that evaluated the effect of vaccination against influenza on cardiovascular events and their outcome were considered. Finally, 30 of the 1147 identified studies were included. These studies show a protective effect of the influenza vaccine on the development of cardiovascular events (myocardial infarction, cerebrovascular accidents, atrial fibrillation, and heart failure) and on the worsening of these conditions...
April 5, 2021: Medicina Clínica
Patrizio Lancellotti, Yun Yun Go
No abstract text is available yet for this article.
April 2021: JACC. Cardiovascular Imaging
Oltion Mesi, Mohamed M Gad, Alejandro D Crane, Jay Ramchand, Rishi Puri, Habib Layoun, Rhonda Miyasaka, Marc A Gillinov, Per Wierup, Brian P Griffin, Samir R Kapadia, Serge C Harb
OBJECTIVES: This study was designed to compare the clinical and echocardiographic characteristics, management, and outcomes of severe atrial functional mitral regurgitation (AFMR) to primary mitral regurgitation (PMR). BACKGROUND: AFMR remains poorly defined clinically. METHODS: Consecutive patients who underwent transesophageal echocardiography at our institution between 2011 and 2018 for severe mitral regurgitation with preserved left ventricular function were screened...
April 2021: JACC. Cardiovascular Imaging
Adelina Yafasova, Emil L Fosbøl, Morten Schou, Bo Baslund, Mikkel Faurschou, Kieran F Docherty, Pardeep S Jhund, John J V McMurray, Guoli Sun, Søren L Kristensen, Christian Torp-Pedersen, Lars Køber, Jawad H Butt
BACKGROUND: Data on long-term cardiovascular outcomes in systemic lupus erythematosus (SLE) are sparse. OBJECTIVES: This study sought to examine the long-term risk and prognosis associated with cardiovascular outcomes, including heart failure (HF), in patients with SLE. METHODS: Using Danish administrative registries, risks of outcomes were compared between SLE patients (diagnosed 1996 to 2018, no history of cardiovascular disease) and age-, sex-, and comorbidity-matched control subjects from the background population (matched 1:4)...
April 13, 2021: Journal of the American College of Cardiology
Ying Bai, Zhen-Zhou Wang, Gai-Gai Zhang, Shi-Dong Guo, José Miguel Rivera-Caravaca, Yue-Li Wang, Yuan-Yuan Jin, Yue Liu
BACKGROUND: Several scores were available for predicting atrial fibrillation (AF) recurrence post radiofrequency ablation. However, the role of different scores predicting AF recurrence after ablation in patients with concurrent AF and pulmonary diseases (PDs) remained obscure. Herein, we aimed to investigate their predicting values and differences in patients with concurrent AF and PDs. METHODS: From January 2008 to April 2015, 304 patients with concurrent AF and PDs treated with catheter ablation were divided into 2 groups according to whether they experienced AF recurrence in our centers...
April 1, 2021: Annals of Palliative Medicine
Paolo Alboni, Mario Bo, Stefano Fumagalli, Francesco Vetta, Gianluca Isaia, Enrico Brunetti, Samuele Baldasseroni, Alessandro Boccanelli, Giovambattista Desideri, Niccolò Marchionni, Renzo Rozzini, Pierfranco Terrosu, Andrea Ungar, Giovanni Zito
INTRODUCTION: Atrial fibrillation (AF) is the most common cardiac sustained arrhythmia, whose incidence and prevalence increase with age, representing a significant burden for health services in western countries. Older people contribute to the vast majority of patients affected from AF. EVIDENCE ACQUISITION: Although oral anticoagulant therapy represents the cornerstone for the prevention of ischemic stroke and its disabling consequences, several other interventions - including left atrial appendage occlusion (LAAO), catheter ablation (CA) of AF, and rhythm control strategy (RCS) - have proved to be potentially effective in reducing the incidence of AF-associated clinical complications...
April 9, 2021: Minerva Medica
Chengming Ma, Xiaomeng Yin, Yunlong Xia, Wenwen Li, Lianjun Gao, Shiyu Dai, Xiaohong Yu
RATIONALE: Dual atrioventricular node non-reentrant tachycardia (DAVNNRT) is a rare arrhythmia. We present a case of inappropriate implantable cardioverter defibrillator (ICD) therapy caused by DAVNNRT. DAVNNRT is easily misdiagnosed as atrial fibrillation and is often identified as ventricular tachycardia (VT) by the supraventricular tachycardia-ventricular tachycardia (SVT-VT) discriminator of the ICD. PATIENT CONCERNS: A 73-year-old man with ischemic heart disease (IHD) presented with palpitations accompanied by dyspnea and syncope...
April 9, 2021: Medicine (Baltimore)
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