Kseniya Perepelina, Aleksandra Kostina, Polina Klauzen, Aleksandr Khudiakov, Martina Rabino, Silvia Crasto, Anna Zlotina, Yulia Fomicheva, Alexey Sergushichev, Mari Oganesian, Alexander Dmitriev, Anna Kostareva, Elisa Di Pasquale, Anna Malashicheva
Human iPSC lines were generated from peripheral blood mononuclear cells of patient carrying LMNA mutation associated with Emery-Dreifuss muscular dystrophy accompanied by atrioventricular block and paroxysmal atrial fibrillation. Reprogramming factors OCT4, KLF4, SOX2, CMYC were delivered using Sendai virus transduction. iPSCs were characterized in order to prove the pluripotency markers expression, normal karyotype, ability to differentiate into three embryonic germ layers. Generated iPSC lines would be useful model to investigate disease development associated with genetic variants in LMNA gene...
June 29, 2020: Stem Cell Research
Na Zhao, Qince Li, Kevin Zhang, Kuanquan Wang, Runnan He, Yongfeng Yuan, Henggui Zhang
Heart failure (HF) is associated with an increased propensity for atrial fibrillation (AF), causing higher mortality than AF or HF alone. It is hypothesized that HF-induced remodelling of atrial cellular and tissue properties promotes the genesis of atrial action potential (AP) alternans and conduction alternans that perpetuate AF. However, the mechanism underlying the increased susceptibility to atrial alternans in HF remains incompletely elucidated. In this study, we investigated the effects of how HF-induced atrial cellular electrophysiological (with prolonged AP duration) and tissue structural (reduced cell-to-cell coupling caused by atrial fibrosis) remodelling can have an effect on the generation of atrial AP alternans and their conduction at the cellular and one-dimensional (1D) tissue levels...
July 13, 2020: PLoS Computational Biology
José Miguel Rivera-Caravaca, María Asunción Esteve-Pastor, Anny Camelo-Castillo, Inmaculada Ramírez-Macías, Gregory Y H Lip, Vanessa Roldán, Francisco Marín
INTRODUCTION: Oral anticoagulants (OAC) reduce stroke/systemic embolism and mortality risks in atrial fibrillation (AF). However, there is an inherent bleeding risk with OAC, where intracranial hemorrhage (ICH) is the most feared, disabling, and lethal complication of this therapy. Therefore, the optimal management of OAC-associated ICH is not well defined despite multiple suggested strategies. AREAS COVERED: In this review, the authors describe the severity and risk factors for OAC-associated ICH and the associated implications for using DOACs in AF patients...
July 13, 2020: Expert Opinion on Pharmacotherapy
Justin A Edward, Ravi K Gopal
No abstract text is available yet for this article.
July 13, 2020: JAMA Internal Medicine
R D Van Zyl, M C Burger, J D Jordaan
BACKGROUND: Patients undergoing arthroplasty may have comorbidities that put them at risk of myocardial injury after non-cardiac surgery (MINS). MINS, a new clinical concept that has a different pathophysiology from conventional myocardial infarction, is related to a supply-demand mismatch ischaemia in the perioperative setting. MINS is often a silent event, and the diagnosis relies on cardiac biomarker testing such as troponin T. The incidence is estimated at 40%, with a fourfold increase in morbidity and mortality risk 1 year post surgery...
March 30, 2020: South African Medical Journal
Matteo Anselmino, Simone Frea, Sebastiano Gili, Chiara Rovera, Mara Morello, Marcella Jorfida, Julien Teodori, Jacopo Perversi, Ilaria Salvetti, Walter Grosso Marra, Riccardo Faletti, Dorico Righi, Fiorenzo Gaita, Gaetano M De Ferrari
BACKGROUND: Left atrial appendage (LAA) morphology, investigated by computed tomography and magnetic resonance imaging, has proved to relate to the risk of cerebrovascular events in patients with Atrial Fibrillation (AF). Aim of the present study was to assess reproducibility of Transesophageal Echocardiography (TEE) imaging in describing LAA morphology. METHODS: Two hundred consecutive patients referred for TEE were enrolled. In the first group of 47 (23.5%) patients LAA morphology was analyzed by conventional TEE and described as Chicken Wing, Windsock, Cactus or Cauliflower...
July 10, 2020: Minerva Cardioangiologica
Mariya N Negreva, Krasimira S Prodanova, Katerina D Vitlianova
BACKGROUND: Paroxysmal atrial fibrillation (PAF) is associated with an increased incidence of embolic events, even in patients with no embologenic risk factors. This fact raises the question for the hypercoagulability in PAF as a state closely related to the arrhythmia itself, independent of other well established embologenic risk factors. The scarce data on that topic predisposed our aim that was to study coagulation activity in the early hours (up to the twenty-fourth hour) of the disease...
July 10, 2020: Minerva Cardioangiologica
Kevin Bowrin, Jean-Baptiste Briere, Pierre Levy, Mondher Toumi, Aurélie Millier
Real-world evidence (RWE) provides external validity, supplementing and enhancing the randomized controlled trial (RCT) data with valuable information on patient behaviours and outcomes, turning efficacy and safety results into real-world effectiveness and risks, but the use of RWE is associated with challenges.The objectives of this communication were to (1) summarise all guidance on how to conduct an RWE meta-analysis (MA) and how to develop an RWE cost-effectiveness model, (2) to describe our experience, challenges faced and solutions identified, (3) to provide recommendations on how to conduct such analyses...
July 13, 2020: Journal of Medical Economics
Shadi Yaghi, Tushar Trivedi, Nils Henninger, James Giles, Angela Liu, Muhammad Nagy, Ashutosh Kaushal, Idrees Azher, Brian Mac Grory, Hiba Fakhri, Kiersten Brown Espaillat, Syed Daniyal Asad, Hemanth Pasupuleti, Heather Martin, Jose Tan, Manivannan Veerasamy, Ava L Liberman, Charles Esenwa, Natalie Cheng, Khadean Moncrieffe, Iman Moeini-Naghani, Mithilesh Siddu, Erica Scher, Christopher R Leon Guerrero, Muhib Khan, Amre Nouh, Eva Mistry, Salah Keyrouz, Karen Furie
OBJECTIVES: Guidelines recommend to initiate anticoagulation within 4-14 days after cardioembolic stroke. Data supporting this did not account for key factors potentially affecting the decision to initiate anticoagulation such as infarct size, hemorrhagic transformation, or high risk features on echocardiography. METHODS: We pooled data from stroke registries of 8 comprehensive stroke centers across the United States. We included consecutive patients admitted with ischemic stroke and atrial fibrillation...
July 12, 2020: Annals of Neurology
Hawa O Abu, Jane S Saczynski, John Ware, Jordy Mehawej, Tenes Paul, Hamza Awad, Benita A Bamgbade, Isabelle C Pierre-Louis, Mayra Tisminetzky, Catarina I Kiefe, Robert J Goldberg, David D McManus
BACKGROUND: Older persons with atrial fibrillation (AF) experience significant impairment in quality of life (QoL), which may be partly attributable to their comorbid diseases. A greater understanding of the impact of comorbidities on QoL could optimize patient-centered care among older persons with AF. OBJECTIVE: To assess impairment in disease-specific QoL due to comorbid conditions in older adults with AF. METHODS: Patients aged ≥ 65 years diagnosed with AF were recruited from five medical centers in Massachusetts and Georgia between 2015 and 2018...
July 11, 2020: Quality of Life Research
Meghan Reading Turchioe, Victoria Jimenez, Samuel Isaac, Munther Alshalabi, David Slotwiner, Ruth Masterson Creber
BACKGROUND: Free mobile applications (apps) that use photoplethysmography (PPG) waveforms may extend atrial fibrillation (AF) detection to underserved populations, but they have not been rigorously evaluated. OBJECTIVE: The purpose of this study was to systematically review and evaluate the quality, functionality, and adherence to self-management behaviors of existing mobile apps for AF. METHODS: We systematically searched 3 app stores for apps that were free, available in English, and intended for use by patients to detect and manage AF...
April 2020: Heart Rhythm O2
Indranill Basu Ray, Dibbendhu Khanra, Sumit Shah, Sudhanva Char, Xiaoming Jia, Wilson Lam, Nilesh Mathuria, Mehdi Razavi, Bhavna Jain, Dhanunjaya Lakkireddy, Saibal Kar, Andrea Natale, Adedayo Adeboye, John Lynn Jefferies, Sripal Bangalore, Samuel Asirvatham, Mohammad Saeed
Background: For patients with atrial fibrillation who are at high risk for bleeding or who cannot tolerate oral anticoagulation, left atrial appendage (LAA) closure represents an alternative therapy for reducing risk for thromboembolic events. Objectives: To compare the efficacy and safety of the Amplatzer and WatchmanTM LAA closure devices. Methods: A meta-analysis was performed of studies comparing the safety and efficacy outcomes of the two devices. The Newcastle-Ottawa Scale was used to appraise study quality...
2020: Frontiers in Cardiovascular Medicine
Silvia Guarguagli, Ilaria Cazzoli, Aleksander Kempny, Michael A Gatzoulis, Sabine Ernst
Introduction: Transseptal puncture (TSP) is a routine access route in patients with left-sided ablation substrates and is performed safely on fluoroscopy (+/- echocardiographic guidance). We report on our experience using a radiofrequency (RF) needle in an unselected group of patients to demonstrate safety and usefulness of direct tip visualization on the 3D electroanatomical mapping (EAM) system with specific emphasis on total radiation exposure. Methods and Results: We retrospectively reviewed 42 consecutive left-sided ablation procedures with TSP performed using an RF needle guided by fluoroscopy and/or EAM visualization by a single operator...
2020: Cardiology Research and Practice
Xue Zhou, Zuolan Wang, Shuang Dou, Kangyin Chen, Enzhao Liu, Tong Liu, Guangping Li, Jingjin Che
Purpose: Although atrial fibrillation (AF) is often associated with thromboembolic complications, there is no definite biomarker for detecting the presence of thrombi in the left atrial (LA) or left atrial appendage (LAA) in patients with nonvalvular atrial fibrillation (NVAF). Methods: NVAF patients who underwent transesophageal echocardiography (TEE) to evaluate LA/LAA thrombus and spontaneous echo contrast (SEC) before AF ablation were included. Multivariate logistic regression and receiver operating characteristic curve (ROC) analyses were performed to explore the independent risk factors of LA/LAA thrombus and indicate the best cutoff point...
2020: Cardiology Research and Practice
Masahide Harada
No abstract text is available yet for this article.
July 11, 2020: Circulation Journal: Official Journal of the Japanese Circulation Society
Pedro Adragão, Daniel Matos, Francisco Moscoso Costa, Pedro Carmo, Diogo Cavaco, Gustavo Rodrigues, João Carmo, Francisco Morgado, Miguel Mendes
INTRODUCTION: Atypical atrial flutter (AFL) is a supraventricular arrhythmia that can be treated with catheter ablation. However, this strategy yields suboptimal results and the best approach is yet to be defined. Carto® electroanatomical mapping (EAM) version 7 displays a histogram of the local activation times (LAT) of the tachycardia cycle length (TCL), in addition to activation and voltage maps. Using these EAM tools, the study aimed to assess the ability of an electrophysiologic triad to identify and localize the critical isthmus in AFL...
July 9, 2020: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
Hualong Liu, Ping Yuan, Xin Zhu, Linghua Fu, Kui Hong, Jinzhu Hu
Background To date, there is no cumulative evidence supporting the association of atrial fibrillation (AF) noninducibility after ablation and freedom from AF. We performed a systematic review and meta-analysis to determine whether AF noninducibility by burst pacing after catheter ablation is associated with reduced AF recurrence. Methods and Results We searched PubMed, Embase, Web of Science, and Cochrane Library databases through July 2019 to identify studies that evaluated AF noninducibility versus inducibility by burst pacing after catheter ablation for freedom from AF...
July 11, 2020: Journal of the American Heart Association
Caroline Kleinecke, Steffen Gloekler, Bernhard Meier
INTRODUCTION: Atrial fibrillation (AF) is associated with an increased risk of stroke, morbidity and overall mortality. So far, oral anticoagulation (OAC) is the standard of care for stroke prevention, either with vitamin K antagonists or with non-vitamin K oral anticoagulants (NOACs). The left atrial appendage (LAA) can be eliminated by epicardial or endocardial exclusion. Left atrial appendage closure (LAAC) represents a mechanical thromboprophylaxis - which has also been termed mechanical vaccination - against stroke, bleeding and death...
July 11, 2020: Expert Review of Cardiovascular Therapy
Domenico Corradi, Jeffrey E Saffitz, Deborah Novelli, Angeliki Asimaki, Caterina Simon, Emanuela Oldoni, Serge Masson, Jennifer M T A Meessen, Rodolfo Monaco, Roberta Manuguerra, Roberto Latini, Peter Libby, Luigi Tavazzi, Roberto Marchioli, Luca Dozza, Laura Cavallotti, Aneta Aleksova, Renato Gregorini, Dariush Mozaffarian
Background - Post-operative atrial fibrillation (POAF) occurs in 30-50% of patients undergoing cardiac surgery and is associated with increased morbidity and mortality. Prospective identification of structural/molecular changes in atrial myocardium that correlate with myocardial injury and precede and predict risk of POAF may identify new molecular pathways and targets for prevention of this common morbid complication. Methods - Right atrial appendage (RAA) samples were prospectively collected during cardiac surgery from 239 patients enrolled in the OPERA trial, fixed in 10% buffered formalin and embedded in paraffin for histology...
July 12, 2020: Circulation. Arrhythmia and Electrophysiology
Mark D McCauley, Liang Hong, Arvind Sridhar, Ambili Menon, Srikanth Perike, Meihong Zhang, Ivson Bezerra da Silva, JiaJie Yan, Marcelo G Bonini, Xun Ai, Jalees Rehman, Dawood Darbar
Background - Epidemiological studies have established obesity as an independent risk factor for atrial fibrillation (AF) but the underlying pathophysiological mechanisms remain unclear. Reduced cardiac sodium channel expression is a known causal mechanism in AF. We hypothesized that obesity decreases Nav1.5 expression via enhanced oxidative stress, thus reducing INa , and enhancing susceptibility to AF. Methods - To elucidate the underlying electrophysiologic (EP) mechanisms a diet-induced obese (DIO) mouse model was used...
July 12, 2020: Circulation. Arrhythmia and Electrophysiology
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