Melissa A Meyer, Huy Q Dinh, Ahmad Alimadadi, Daniel J Araujo, Nandini Chatterjee, Norma A Gutierrez, Yanfang Peipei Zhu, Emma L Hunter, Shu Liang, Gregory Seumois, William B Kiosses, Sergio D Catz, Pandurangan Vijayanand, Christian Ottensmeier, Catherine C Hedrick
PURPOSE: Due to their abundance in the blood, low RNA content, and short lifespan, neutrophils have been classically considered to be one homogenous pool. However, recent work has found that mature neutrophils and neutrophil progenitors are composed of unique subsets exhibiting context-dependent functions. In this study, we ask if neutrophil heterogeneity is associated with melanoma incidence and/or disease stage. EXPERIMENTAL DESIGN: Using mass cytometry, we profiled melanoma patient blood for unique cell surface markers among neutrophils...
2023: Frontiers in Immunology