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MULTICENTER STUDY
Federica Turati, Carlotta Galeone, Renato Talamini, Silvia Franceschi, Marco Manzari, Gianfrancesco Gallino, Jerry Polesel, Carlo La Vecchia, Alessandra Tavani
To evaluate the association between coffee, decaffeinated coffee, and tea consumption and pancreatic cancer risk in a pooled analysis of two Italian case-control studies, between 1983 and 2008, we conducted two case-control studies in Northern Italy, including a total of 688 pancreatic cancer cases and 2204 hospital controls with acute, non-neoplastic diseases. We computed multivariate odds ratios (ORs) and 95% confidence intervals (CIs) for coffee drinking (mostly espresso and mocha), adjusting for age, sex, center, year of interview, education, body mass index, tobacco smoking, alcohol drinking, and diabetes...
July 2011: European Journal of Cancer Prevention
#402
JOURNAL ARTICLE
Werner Garavello, Federica Turati, Cristina Bosetti, Renato Talamini, Fabio Levi, Ersilia Lucenteforte, Fausto Chiesa, Silvia Franceschi, Carlo La Vecchia, Eva Negri
Only limited data is available on the relationship between family history of laryngeal and other neoplasms and laryngeal cancer risk. We investigated the issue using data from a multicentre case-control study conducted in Italy and Switzerland between 1992 and 2009 including 852 cases with histologically confirmed laryngeal cancer and 1970 controls admitted to hospital for acute, non neoplastic conditions. Unconditional logistic regression models adjusted for age, sex, study center, education, tobacco smoking, alcohol drinking and number of siblings were used to estimate the odds ratios (ORs) of laryngeal cancer...
February 1, 2012: International Journal of Cancer. Journal International du Cancer
#403
JOURNAL ARTICLE
L Dal Maso, A Tavani, A Zucchetto, M Montella, M Ferraroni, E Negri, J Polesel, A Decarli, R Talamini, C La Vecchia, S Franceschi
BACKGROUND: Endometrial cancer is strongly associated with body mass index (BMI), but the influence of BMI history and of different types of obesity is uncertain. METHODS: A case-control study was carried out in Italy including 454 cases and 908 controls admitted to hospital for acute non-hormone-related conditions. Odds ratios (ORs) and 95% confidence intervals (CIs) were computed using multivariate logistic and spline regression models. RESULTS: The OR for BMI >30 at diagnosis compared with 20 to <25 kg m(-2) was 4...
March 29, 2011: British Journal of Cancer
#404
JOURNAL ARTICLE
Wassim M Bazzi, Oliver Wagner, Sean P Stroup, Jonathan L Silberstein, Noam Belkind, Toshio Katagiri, Julieta Paleari, Agustin Duro, Sonia Ramamoorthy, Mark A Talamini, Santiago Horgan, Ithaar H Derweesh
OBJECTIVE: To examine feasibility of transrectal hybrid natural orifice translumenal endoscopic surgery (NOTES) nephrectomy in the porcine model. NOTES uses ports of entry to the peritoneal cavity instead of abdominal wall incisions, thereby eliminating visible scar and also potentially reducing postoperative pain. METHODS: After obtaining Institutional Animal Care and Use Committee approval, 3 female pigs (45 kg) underwent transrectal hybrid NOTES nephrectomy (2 right, 1 left)...
March 2011: Urology
#405
JOURNAL ARTICLE
David C Chang, Mark A Talamini
In recent years, more and more large, population-level databases have become available for clinical research. The size and complexity of these databases often present a methodological challenge for investigators. We propose that a "protocol" may facilitate the research process using these databases. In addition, much like the structured History and Physical (H&P) helps the audience appreciate the details of a patient case more systematically, a formal outcomes research protocol can also help in the systematic evaluation of an outcomes research manuscript...
July 2011: Surgical Endoscopy
#406
MULTICENTER STUDY
Ersilia Lucenteforte, Antonella Zucchetto, Cristina Bosetti, Renato Talamini, Eva Negri, Diego Serraino, Silvia Franceschi, Loren Lipworth, Carlo La Vecchia
OBJECTIVES: To investigate the role of menstrual, reproductive, and hormonal factors, as well as benign female conditions, on pancreatic cancer risk. METHODS: We analyzed the combined data from 2 Italian case-control studies including 285 female case patients of pancreatic cancer and 713 female controls. All subjects were interviewed by trained interviewers during their hospital stay using similar structured questionnaires. Odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were estimated using multiple logistic regression models adjusted for selected covariates...
April 2011: Pancreas
#407
JOURNAL ARTICLE
Dan Chen, Therese Truong, Valerie Gaborieau, Graham Byrnes, Amelie Chabrier, Shu-chun Chuang, Andrew F Olshan, Mark C Weissler, Jingchun Luo, Marjorie Romkes, Shama Buch, Tomoko Nukui, Silvia Franceschi, Rolando Herrero, Renato Talamini, Karl T Kelsey, Brock Christensen, Michael D McClean, Martin Lacko, Johannes J Manni, Wilbert H M Peters, Jan Lubiński, Joanna Trubicka, Marcin Lener, Joshua E Muscat, Philip Lazarus, Qingyi Wei, Erich M Sturgis, Zuo-Feng Zhang, Shen-Chih Chang, Renyi Wang, Stephen M Schwartz, Chu Chen, Simone Benhamou, Pagona Lagiou, Ivana Holcátová, Lorenzo Richiardi, Kristina Kjaerheim, Antonio Agudo, Xavier Castellsagué, Tatiana V Macfarlane, Luigi Barzan, Cristina Canova, Nalin S Thakker, David I Conway, Ariana Znaor, Claire M Healy, Wolfgang Ahrens, David Zaridze, Neonila Szeszenia-Dabrowska, Jolanta Lissowska, Eleonora Fabianova, Alexandru Bucur, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Maria Paula Curado, Sergio Koifman, Ana Menezes, Victor Wünsch-Filho, José Eluf-Neto, Leticia Fernandez, Stefania Boccia, Mia Hashibe, Richard B Hayes, Paolo Boffetta, Paul Brennan, James D McKay
BACKGROUND: Sequence variants located at 15q25 have been associated with lung cancer and propensity to smoke. We recently reported an association between rs16969968 and risk of upper aerodigestive tract (UADT) cancers (oral cavity, oropharynx, hypopharynx, larynx, and esophagus) in women (OR = 1.24, P = 0.003) with little effect in men (OR = 1.04, P = 0.35). METHODS: In a coordinated genotyping study within the International Head and Neck Cancer Epidemiology (INHANCE) consortium, we have sought to replicate these findings in an additional 4,604 cases and 6,239 controls from 10 independent UADT cancer case-control studies...
April 2011: Cancer Epidemiology, Biomarkers & Prevention
#408
JOURNAL ARTICLE
Loren Lipworth, Antonella Zucchetto, Cristina Bosetti, Silvia Franceschi, Renato Talamini, Diego Serraino, Joseph K McLaughlin, Carlo La Vecchia, Eva Negri
BACKGROUND: Diabetes and other medical conditions have been related to pancreatic cancer, but time risk quantification is unsettled. METHODS: We combined data from two case-control studies conducted in Italy, including 688 pancreatic cancer cases and 2204 controls. All subjects were interviewed by trained interviewers during their hospital stay. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using multiple logistic regression. RESULTS: Overall, 103 cases (15%) and 125 controls (5...
March 2011: Diabetes/metabolism Research and Reviews
#409
JOURNAL ARTICLE
C Pelucchi, C Galeone, R Talamini, E Negri, J Polesel, D Serraino, C La Vecchia
BACKGROUND: Information on the relation between acrylamide exposure and risk of pancreatic cancer is scanty and inconsistent. PATIENTS AND METHODS: We investigated the issue in a case-control study conducted from 1991 to 2008 in Northern Italy. Cases were 326 patients with incident pancreatic cancer, admitted to major teaching and general hospitals. Controls were 652 subjects admitted to the same hospitals with acute non-neoplastic conditions. Acrylamide mean content of various food items was derived from international databases and Italian sources...
August 2011: Annals of Oncology: Official Journal of the European Society for Medical Oncology
#410
JOURNAL ARTICLE
P Bertuccio, C La Vecchia, D T Silverman, G M Petersen, P M Bracci, E Negri, D Li, H A Risch, S H Olson, S Gallinger, A B Miller, H B Bueno-de-Mesquita, R Talamini, J Polesel, P Ghadirian, P A Baghurst, W Zatonski, E T Fontham, W R Bamlet, E A Holly, E Lucenteforte, M Hassan, H Yu, R C Kurtz, M Cotterchio, J Su, P Maisonneuve, E J Duell, C Bosetti, P Boffetta
BACKGROUND: Cigarette smoking is the best-characterized risk factor for pancreatic cancer. However, data are limited for other tobacco smoking products and smokeless tobacco. MATERIALS AND METHODS: We conducted a pooled analysis of cigar and pipe smoking and smokeless tobacco use and risk of pancreatic cancer using data from 11 case-control studies (6056 cases and 11,338 controls) within the International Pancreatic Cancer Case-Control Consortium (PanC4). Pooled odds ratios (OR) and the corresponding 95% confidence intervals (CI) were estimated by unconditional multiple logistic regression models adjusted for study center and selected covariates...
June 2011: Annals of Oncology: Official Journal of the European Society for Medical Oncology
#411
JOURNAL ARTICLE
Willian Marinho Dourado Coelho, Valéria Marçal Felix de Lima, Alessandro Francisco Talamini do Amarante, Helio Langoni, Virgínia Bodelão Richini Pereira, Aziz Abdelnour, Katia Denise Saraiva Bresciani
This work describes natural infection by Leishmania in a domestic cat where amastigote forms of the parasite were observed in the popliteal lymph node imprint. Positive and negative serological reactions were observed by enzyme-linked immunosorbent assay (ELISA) and indirect immunofluorescence assay (IFA), respectively. Polymerase chain reaction (PCR) revealed that the nucleotide sequence of the sample was identical to Leishmania (L.) chagasi. This is the first report of the disease in felines of the city of Andradina, SP, an area considered endemic for canine and human visceral leishmaniasis...
October 2010: Brazilian Journal of Veterinary Parasitology
#412
JOURNAL ARTICLE
P Durando, M Bassetti, G Orengo, P Crimi, A Battistini, G Tiberio, D Bellina, A Talamini, F Dodi, F Ansaldi, C Alicino, R Iudici, L Sticchi, D De Florentiis, C Viscoli, G Icardi
BACKGROUND: A prevalence study aimed to update the epidemiological scenario of Hospital-Acquired Infections (HAI) was performed at the San Martino University Hospital of Genoa, the Regional Reference Adult-care Center in Liguria, Italy, with more than 1300 beds. MATERIALS AND METHODS: The investigation was performed in all the wards, except the Psychiatric Units, between 19th March and 6Ih April, 2007, using a one-day monitoring system for each ward. International standardized criteria and definitions for the surveillance of HAI were used for the collection of data, which were recorded in specific software for subsequent consolidation, analysis and quality control...
June 2010: Journal of Preventive Medicine and Hygiene
#413
JOURNAL ARTICLE
K Thompson, A Spivack, L Fischer, B Wong, G Jacobsen, M Talamini, S Horgan
BACKGROUND: Single-incision laparoscopic surgery (SILS) has been proposed as a minimally invasive technique with the advantages of smaller external scars and reduced pain. Furthermore, usage of the flexible endoscope for SILS in lieu of the standard laparoscope provides distinct visualization advantages. This video shows a single-incision cholecystectomy performed using a single incision placed through the umbilicus. METHODS: A 39-year-old woman with chronic symptomatic cholelithiasis was enrolled under institutional review board protocol to undergo SILS...
May 2011: Surgical Endoscopy
#414
MULTICENTER STUDY
Silvano Gallus, Federica Turati, Alessandra Tavani, Jerry Polesel, Renato Talamini, Silvia Franceschi, Carlo La Vecchia
Soft drinks usually contain sugar and caffeine that might influence pancreatic carcinogenesis. We considered the association between carbonated drink consumption and pancreatic cancer risk in an Italian case-control study conducted in 1991-2008 on 326 pancreatic cancer cases and 652 matched controls. We also combined the results from all the studies on soft drinks or sweetened beverages and pancreatic cancer published before June 2010, using a meta-analytic approach. In the case-control study, compared with non-drinkers, the multivariate odds ratio was 1...
January 2011: Cancer Causes & Control: CCC
#415
JOURNAL ARTICLE
Ricardo Velludo Gomes de Soutello, Wilian Marinho Dourado Coelho, Fernando Paes de Oliveira, José Francisco Fonzar, Brenda Carla Luquetti, Renata Furlan Pereira de Souza, Maria Conceição Zocoller Seno, Alessandro Francisco Talamini do Amarante
To evaluate the necessary time and to identify the differences among anthelmintics for the reduction of parasite eggs shed in feces, five groups of cattle were treated with moxidectin, ivermectin, levamisole phosphate, and albendazole sulphoxide. Levamisole promoted a reduction in egg count per gram (EPG-R) of 97.4% after 24 hours, moxidectin 98.3% after 36 hours, and albendazole sulphoxide 95.9% after 36 hours post- treatment. Cooperia spp. and Haemonchus spp. showed resistance to ivermectin. The results demonstrated that the diagnosis of parasite resistance in cattle can be based on a count of eggs per gram (EPG) carried out as soon as seven days after the treatment...
July 2010: Brazilian Journal of Veterinary Parasitology
#416
JOURNAL ARTICLE
Julia Grabowski, Daniel E Vazquez, Todd Costantini, David M Cauvi, Wisler Charles, Stephen Bickler, Mark A Talamini, Virginia L Vega, Raul Coimbra, Antonio De Maio
BACKGROUND: It has been well established that laparoscopic surgery presents several clinical benefits, including reduced pain and a shorter hospital stay. These effects have been associated with a decrease in the inflammatory response. Previous studies have demonstrated that reduced inflammation after laparoscopic surgery is the product of carbon dioxide insufflation, which decreases peritoneal pH. The objective of this study was to investigate the cellular and molecular mechanisms responsible for the reduced response after exposure to acidic environments...
March 2012: Journal of Surgical Research
#417
JOURNAL ARTICLE
Sabrina Rossi, Daniela Gasparotto, Luisa Toffolatti, Chiara Pastrello, Giovanna Gallina, Alessandra Marzotto, Chiara Sartor, Mattia Barbareschi, Chiara Cantaloni, Luca Messerini, Italo Bearzi, Giannantonio Arrigoni, Guido Mazzoleni, Jonathan A Fletcher, Paolo G Casali, Renato Talamini, Roberta Maestro, Roberta Maestra, Angelo Paolo Dei Tos
Although Gastrointestinal stromal tumors (GISTs) affect about 0.0014% of the population, GISTs smaller than 1 cm (microGISTs) are detectable in about 20% to 30% of elderly individuals. This suggests that microGISTs likely represent premalignant precursors that evolve only in a minute fraction of cases toward overt GISTs. We sought histopathologic and molecular explanations for the infrequent clinical progression in small GISTs. To investigate the mechanisms of GIST progression and identify subsets with differential malignant potential, we carried out a thorough characterization of 170 GISTs <2 cm and compared their KIT/PDGFRA status with overt GISTs...
October 2010: American Journal of Surgical Pathology
#418
JOURNAL ARTICLE
Tatiana V Macfarlane, Gary J Macfarlane, Richard J Oliver, Simone Benhamou, Christine Bouchardy, Wolfgang Ahrens, Hermann Pohlabeln, Pagona Lagiou, Areti Lagiou, Xavier Castellsague, Antonio Agudo, Franco Merletti, Lorenzo Richiardi, Kristina Kjaerheim, Alena Slamova, Miriam Schejbalova, Cristina Canova, Lorenzo Simonato, Renato Talamini, Luigi Barzan, David I Conway, Patricia A McKinney, Ariana Znaor, Raymond J Lowry, Peter Thomson, Claire M Healy, Bernard E McCartan, Manuela Marron, Mia Hashibe, Paul Brennan
BACKGROUND: The incidence of cancers of the upper aerodigestive tract (UADT) is increasing throughout the world. To date the increases have been proportionally greatest among young people. Several reports have suggested that they often do not have a history of tobacco smoking or heavy alcohol consumption. OBJECTIVE: To determine the contribution of lifestyle factors to the etiology of UADT cancers occurring in those aged less than 50 years. METHODS: A case-control study was conducted in 10 European countries...
December 2010: Cancer Causes & Control: CCC
#419
JOURNAL ARTICLE
Monika E Hagen, Oliver J Wagner, Ihsan Inan, Philippe Morel, Jean Fasel, Garth Jacobsen, Adam Spivack, Kari Thompson, Brian Wong, Lauren Fischer, Mark Talamini, Santiago Horgan
BACKGROUND: Single-incision laparoscopic and natural orifice translumenal endoscopic surgery (NOTES) are technically challenging methods. Robotics might have the potential to overcome such hurdles with computer technology. METHODS: The da Vinci Standard and S System (Intuitive, Sunnyvale, USA) were used in human cadavers and pigs to perform single-incision transabdominal and transvaginal surgery. Robotic arms were crossed and control-switched to achieve intuitive control...
September 2010: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
#420
COMPARATIVE STUDY
Santiago Horgan, Kari Thompson, Mark Talamini, Alberto Ferreres, Garth Jacobsen, Georg Spaun, John Cullen, Lee Swanstrom
BACKGROUND: Single-port and incisionless surgical approaches hold the promise of fewer complications, reduced pain, faster recovery, and improved cosmesis compared with traditional open or laparoscopic approaches. The ability to select an access approach (i.e., endolumenal, single-port, transvaginal, or transgastric) with one platform may be important to optimization of individual patient results. The authors report their results using these four separate surgical approaches tailored to three different therapeutic procedures, all with the use of a single flexible platform, the Incisionless Operating Platform (IOP)...
February 2011: Surgical Endoscopy
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