Yinan Liang, Dezhong Lv, Kefan Liu, Liting Yang, Huan Shu, Luan Wen, Chongwen Lv, Qisen Sun, Jiaqi Yin, Hui Liu, Juan Xu, Zhigang Liu, Na Ding
Omics-based technologies have revolutionized our comprehension of microproteins encoded by ncRNAs, revealing their abundant presence and pivotal roles within complex functional landscapes. Here, we developed MicroProteinDB (https://bio-bigdata.hrbmu.edu.cn/MicroProteinDB), which offers and visualizes the extensive knowledge to aid retrieval and analysis of computationally predicted and experimentally validated microproteins originating from various ncRNA types. Employing prediction algorithms grounded in diverse deep learning approaches, MicroProteinDB comprehensively documents the fundamental physicochemical properties, secondary and tertiary structures, interactions with functional proteins, family domains, and inter-species conservation of microproteins...
May 27, 2024: Computers in Biology and Medicine