keyword
https://read.qxmd.com/read/38323455/no-increase-in-masked-hypertension-prevalence-in-children-with-sickle-cell-disease-in-france
#21
JOURNAL ARTICLE
Plamen Bokov, Berengere Koehl, Chérine Benzouid, Suzanne Verlhac, Florence Missud, Malika Benkerrou, Christophe Delclaux
OBJECTIVES: An important prevalence (32-45%) of masked hypertension has been reported in children with sickle cell disease (SCD). Systemic arterial rigidity has been associated with stroke in SCD. Stroke screening is well-established using transcranial Doppler (TCD) ultrasound. The objectives of our proof-of-concept study in childhood SCD were to evaluate the prevalence of hypertension and its relationships with cerebral vasculopathy (TCD velocity) and to further evaluate in a subgroup of children the correlations of cardiovascular autonomic nervous system indices with TCD velocity...
February 7, 2024: American Journal of Hypertension
https://read.qxmd.com/read/38302121/disease-modifying-therapies-for-sickle-cell-disease-an-overview
#22
JOURNAL ARTICLE
Radhika Peddinti
Sickle cell disease refers to a group of inherited blood disorders in which hemoglobin polymerization leads to hemolysis and vaso-occlusion. This causes a myriad of complications during a patient's life span, ranging from anemia, infections, and acute and chronic pain to stroke and multiorgan dysfunction. Although there have been dramatic improvements in childhood survival thanks to improved supportive care with penicillin prophylaxis, immunizations, and improved transfusion practices, there was a dearth of disease-modifying therapies, with hydroxyurea being the only medication for >20 years...
February 2024: Pediatric Annals
https://read.qxmd.com/read/38292018/lifetime-influences-on-imaging-markers-of-adverse-brain-health-and-vascular-disease
#23
JOURNAL ARTICLE
Ellen V Backhouse, Sarah Bauermeister, Joanna M Wardlaw
Cerebral small vessel disease (cSVD) is highly prevalent in the general population, increases with age and vascular risk factor exposure, and is a common cause of stroke and dementia. There is great variation in cSVD burden experienced in older age, and maintaining brain health across the life course requires looking beyond an individual's current clinical status and traditional vascular risk factors. Of particular importance are social determinants of health which can be more important than healthcare or lifestyle choices in influencing later life health outcomes, including brain health...
2024: Cerebral circulation—cognition and behavior
https://read.qxmd.com/read/38285235/long-term-neurotoxicity-among-childhood-acute-lymphoblastic-leukaemia-survivors-enrolled-between-1971-and-1998-in-eortc-children-leukemia-group-studies
#24
JOURNAL ARTICLE
Maëlle de Ville de Goyet, Michal Kicinski, Stefan Suciu, Els Vandecruys, Anne Uyttebroeck, Alina Ferster, Claire Freycon, Geneviève Plat, Caroline Thomas, Mélissa Barbati, Marie-Françoise Dresse, Catherine Paillard, Claire Pluchart, Pauline Simon, Christophe Chantrain, Odile Minckes, Jutte van der Werff Ten Bosch, Yves Bertrand, Pierre Rohrlich, Frederic Millot, Robert Paulus, Yves Benoit, Caroline Piette
Survival after childhood acute lymphoblastic leukemia (ALL) has increased over the last 40 years with an overall survival above 90%. Survivors may experience neurological late effects secondary to chemotherapy and radiotherapy. This observational retrospective study evaluated the cumulative incidence of neurological late effects among 890 childhood ALL survivors treated in EORTC CLG trials (58741, 58831/2 and 58881) between 1971 and 1998. Median follow-up was 19 years and interquartile range of the follow-up was 15-22 years...
January 29, 2024: Discover. Oncology
https://read.qxmd.com/read/38277122/impaired-sting-activation-due-to-a-variant-in-the-e3-ubiquitin-ligase-amfr-in-a-patient-with-severe-vzv-infection-and-hemophagocytic-lymphohistiocytosis
#25
JOURNAL ARTICLE
Michelle Mølgaard Thomsen, Morten Kelder Skouboe, Michelle Møhlenberg, Jian Zhao, Kerstin de Keukeleere, Johanna Laura Heinz, Marvin Werner, Anne Kruse Hollensen, Jonas Lønskov, Ian Nielsen, Madalina Elena Carter-Timofte, Baocun Zhang, Jacob Giehm Mikkelsen, Niels Fisker, Søren R Paludan, Kristian Assing, Trine H Mogensen
Varicella zoster virus (VZV) is a neurotropic alphaherpesvirus exclusively infecting humans, causing two distinct pathologies: varicella (chickenpox) upon primary infection and herpes zoster (shingles) following reactivation. In susceptible individuals, VZV can give rise to more severe clinical manifestations, including disseminated infection, pneumonitis, encephalitis, and vasculopathy with stroke. Here, we describe a 3-year-old boy in whom varicella followed a complicated course with thrombocytopenia, hemorrhagic and necrotic lesions, pneumonitis, and intermittent encephalopathy...
January 26, 2024: Journal of Clinical Immunology
https://read.qxmd.com/read/38266515/unveiling-mortality-risk-factors-in-paediatric-sickle-cell-disease-patients-during-acute-crises-in-the-democratic-republic-of-the-congo
#26
JOURNAL ARTICLE
Paul Muteb Boma, Stéphanie Luntadila Ngimbi, Junior Makiese Kindundu, Jean Israël Wela, Nathalie Lukanke Ngoie, Valentin Mukeba Ngwamah, Sandra Mbuyi Tshiswaka, Joséphine Kalenga Monga, Jules Mulefu Panda, Bruno Bonnechère
Sickle cell disease (SCD) is a significant health burden in the Democratic Republic of the Congo (DRC). This study aims to identify predictive factors of mortality in SCD children admitted to emergency care in Lubumbashi, DRC. We performed a non-interventional cohort follow-up on SCD patients aged 0 to 16 admitted for a "true emergency". Demographic, clinical, and biological data were collected. Univariate and multivariate logistic regression analyses were performed to identify significant risk factors associated with mortality...
January 20, 2024: Blood Cells, Molecules & Diseases
https://read.qxmd.com/read/38263888/cardiovascular-disease-and-risk-factors-in-individuals-with-a-history-of-out-of-home-care
#27
JOURNAL ARTICLE
Anders Hjern, Bo Vinnerljung, Lars Brännström
BACKGROUND: Exposure to childhood out-of-home care (foster family and residential care) is associated with an increased risk of ill-health and disability in adulthood, but the risk for cardiovascular disease has not previously been studied longitudinally. METHODS: This was a national cohort study generated from linkage of a range of population-based registers, resulting in a national cohort of 881 731 of whom 26 310 (3.0%) had a history of out-of-home care...
January 24, 2024: Pediatrics
https://read.qxmd.com/read/38263886/reversal-of-cerebral-arteriopathy-post-hematopoietic-stem-cell-transplant-for-sickle-cell-disease
#28
JOURNAL ARTICLE
Natalie Booth, Alexander Ngwube, Brian Appavu, Sanjay Shah, Todd Abruzzo
Sickle cell disease (SCD) is a chronic hematologic disorder which causes progressive cerebral arteriopathy beginning in childhood. As a result, arterial ischemic stroke is a major cause of morbidity and mortality in SCD, and SCD is a leading cause of childhood stroke worldwide. Allogenic hematopoietic stem cell transplant (HSCT) may be curative for individuals with SCD. Long-term outcomes and effects are currently being studied. In this report, we describe a child with SCD who presented with arterial ischemic stroke at 6 years of age and was found to have a severe form of cerebral large vessel arteriopathy by catheter-directed angiography...
January 24, 2024: Pediatrics
https://read.qxmd.com/read/38263607/cow-s-milk-anemia-in-childhood-manifesting-as-severe-cerebral-venous-sinus-thrombosis
#29
JOURNAL ARTICLE
Kristin Maher, Catherine Amlie-Lefond
We describe a series of 7 toddler-aged children with iron deficiency anemia from excessive cow's milk consumption who presented with cerebral venous sinus thrombosis and no other identifiable risk factors for thrombosis. The deep venous system was involved in 6 patients, 6 had venous infarcts, and 5 have significant neurocognitive sequelae.
January 23, 2024: Journal of Child Neurology
https://read.qxmd.com/read/38252757/immune-neurovascular-interactions-in-experimental-perinatal-and-childhood-arterial-ischemic-stroke
#30
REVIEW
Carina Mallard, Donna M Ferriero, Zinaida S Vexler
Emerging clinical and preclinical data have demonstrated that the pathophysiology of arterial ischemic stroke in the adult, neonates, and children share similar mechanisms that regulate brain damage but also have distinct molecular signatures and involved cellular pathways due to the maturational stage of the central nervous system and the immune system at the time of the insult. In this review, we discuss similarities and differences identified thus far in rodent models of 2 different diseases-neonatal (perinatal) and childhood arterial ischemic stroke...
February 2024: Stroke; a Journal of Cerebral Circulation
https://read.qxmd.com/read/38248273/enhancing-speech-rehabilitation-in-a-young-adult-with-trisomy-21-integrating-transcranial-direct-current-stimulation-tdcs-with-rapid-syllable-transition-training-for-apraxia-of-speech
#31
Ester Miyuki Nakamura-Palacios, Aldren Thomazini Falçoni Júnior, Gabriela Lolli Tanese, Ana Carla Estellita Vogeley, Aravind Kumar Namasivayam
Apraxia of speech is a persistent speech motor disorder that affects speech intelligibility. Studies on speech motor disorders with transcranial Direct Current Stimulation (tDCS) have been mostly directed toward examining post-stroke aphasia. Only a few tDCS studies have focused on apraxia of speech or childhood apraxia of speech (CAS), and no study has investigated individuals with CAS and Trisomy 21 (T21, Down syndrome). This N-of-1 randomized trial examined the effects of tDCS combined with a motor learning task in developmental apraxia of speech co-existing with T21 (ReBEC RBR-5435x9)...
January 6, 2024: Brain Sciences
https://read.qxmd.com/read/38246729/impaired-monoamine-neural-system-in-the-mpfc-of-shrsp-ezo-as-an-animal-model-of-attention-deficit-hyperactivity-disorder
#32
JOURNAL ARTICLE
Naoya Suzuki, Sachiko Hiraide, Hiroki Shikanai, Takeru Isshiki, Taku Yamaguchi, Takeshi Izumi, Kenji Iizuka
Attention-deficit/hyperactivity disorder (ADHD) is the most common childhood-onset psychiatric disorder. We investigated the effects of systemic administration of monoamine reuptake inhibitors on long-term potentiation (LTP) formation and monoamine release in the medial prefrontal cortex (mPFC) of the stroke-prone spontaneously hypertensive rat (SHRSP)/Ezo, an animal model of ADHD, and its genetic control, Wistar Kyoto (WKY)/Ezo, to elucidate the functional changes in the mPFC monoamine neural system. Methylphenidate (dopamine (DA) and noradrenaline (NA) reuptake inhibitor) and desipramine (NA reuptake inhibitor) improved LTP formation defects in the mPFC of SHRSP/Ezo, suggesting that NA or both DA and NA are required for improvement of impaired LTP...
February 2024: Journal of Pharmacological Sciences
https://read.qxmd.com/read/38227982/massive-spontaneous-subdural-hemorrhage-mimicking-dural-venous-thrombosis-in-a-sickle-cell-adolescent-a-rare-case-report
#33
Hilary Chipongo, Abizer Sarkar, Kenan Bosco, Esmail Sangey
INTRODUCTION: Sickle cell disease is one of the most common hemoglobinopathies in Africa. Tanzania alone accounts for about 11,000 sickle cell births annually making it one of the most common disorders in eastern Africa. The affected individuals are prone to several complications since childhood as a result of the defective hemoglobin structure, these include neurological complications such as ischemic stroke due to hypercoagulability state caused by the disease. Spontaneous intracranial hemorrhage such as subdural hemorrhage in the absence of predisposing factors such as trauma, anticoagulant use, or recent blood transfusions is rare...
January 12, 2024: International Journal of Surgery Case Reports
https://read.qxmd.com/read/38180509/evidence-of-pial-synagiosis-through-ventriculoperitoneal-shunt-entry-site-in-a-patient-who-manifested-moyamoya-syndrome-later-in-childhood-a-case-report-and-historical-perspective
#34
JOURNAL ARTICLE
Awn AlEssa, Alaa AlSahli, Tariq AlJared
The term Moyamoya , or "puff of smoke" in Japanese , was first used in 1969 by Suzuki and Takaku to describe the classical appearance of collateral blood vessels in response to progressive vascular stenosis of distal internal carotid artery (ICA). Such condition may result in various clinical presentations ranging from strokes to developmental delays. In order to cease the progression of such stenotic vasculopathy, several means of revascularization have been developed over the years. In this paper we present a case of a two-year-old girl with history of myelomeningocele repair and ventriculoperitoneal shunt insertion followed by manifestation of Moyamoya syndrome later in childhood as an evidence of revascularization through a burr hole...
January 5, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/38170290/three-year-incidence-and-acute-setting-predictors-of-epilepsy-after-neonatal-and-childhood-arterial-ischaemic-stroke-a-disease-based-cohort-study
#35
JOURNAL ARTICLE
Mauricio Lopez-Espejo, Ilona Skorin, Tomas Mesa, Marta I Hernandez-Chavez
UNLABELLED: To assess the association between clinical and MRI characteristics of arterial ischaemic stroke (AIS) and the 3-year risk of post-stroke epilepsy (PSE) in paediatric patients. Retrospective cohort study. Database from a single tertiary referral centre for paediatric stroke in Chile. Two hundred seven neonates and children (1 day to 18 years) with a first-ever supratentorial AIS diagnosed between January 2003 and December 2019 were evaluated. Diagnosis of PSE and explanatory variables were consecutively recorded from hospital inpatient and annual outpatient records in a predesigned database...
January 3, 2024: European Journal of Pediatrics
https://read.qxmd.com/read/38154237/transcranial-doppler-in-childhood-moyamoya-an-underutilized-tool
#36
JOURNAL ARTICLE
Lisa R Sun, John R Gatti, Syed Ameen Ahmad, Noah Burton, Wendy Ziai, Rebecca F Gottesman, Lori C Jordan
BACKGROUND: Children with moyamoya are at high risk for incident and recurrent stroke. Transcranial Doppler (TCD) ultrasound is an attractive option to screen high-risk populations for moyamoya and to provide stroke risk stratification information due to its safety and cost-effectiveness. We used TCD to evaluate cerebral blood flow velocities in children with presurgical moyamoya and to determine if velocities differ between children with stable and unstable disease. METHODS: Fourteen participants aged ≤21 years with a radiographic diagnosis of moyamoya or moyamoya-like arteriopathy underwent a research TCD at a median age of 7...
February 2024: Pediatric Neurology
https://read.qxmd.com/read/38113603/distinct-manifestations-and-potential-mechanisms-of-seizures-due-to-cortical-versus-white-matter-injury-in-children
#37
JOURNAL ARTICLE
Monica S Cooper, Mark T Mackay, Daisy A Shepherd, Charuta Dagia, Michael C Fahey, Dinah Reddihough, Susan M Reid, A Simon Harvey
PURPOSE: To study seizure manifestations and outcomes in children with cortical versus white matter injury, differences potentially explaining variability of epilepsy in children with cerebral palsy. METHODS: In this population-based retrospective cohort study, MRIs of children with cerebral palsy due to ischemia or haemorrhage were classified according to presence or absence of cortical injury. MRI findings were then correlated with history of neonatal seizures, seizures during childhood, epilepsy syndromes, and seizure outcomes...
December 7, 2023: Epilepsy Research
https://read.qxmd.com/read/38107212/overview-of-the-association-between-the-pathophysiology-types-and-management-of-sickle-cell-disease-and-stroke
#38
REVIEW
Faisal Hakami, Essam Alhazmi, Wafa M Busayli, Sultan Althurwi, Abdulrahman M Darraj, Mohammed A Alamir, Alyaj Hakami, Renad A Othman, Amal I Moafa, Hassan A Mahasi, Mohammed Ali Madkhali
Sickle cell disease (SCD) is a genetic blood disorder that affects hemoglobin and increases stroke risk, particularly in childhood. This review examines the pathophysiological association between SCD and stroke, the classification of stroke types, risk factors, diagnosis, management, prevention, and prognosis. A comprehensive literature search was conducted via PubMed, Scopus, and Cochrane databases. Relevant studies on SCD and stroke pathophysiology, classification, epidemiology, diagnosis, treatment, and prevention were identified...
December 2023: Curēus
https://read.qxmd.com/read/38105610/determinants-of-multimorbidity-in-low-and-middle-income-countries-a-systematic-review-of-longitudinal-studies-and-discovery-of-evidence-gaps
#39
REVIEW
Michelle M C Tan, Matheus G Barbosa, Pedro J M R Pinho, Esubalew Assefa, Ana Á M Keinert, Charlotte Hanlon, Barbara Barrett, Alexandru Dregan, Tin Tin Su, Devi Mohan, Cleusa Ferri, Graciela Muniz-Terrera, Matthew Prina
Multimorbidity-the coexistence of at least two chronic health conditions within the same individual-is an important global health challenge. In high-income countries (HICs), multimorbidity is dominated by non-communicable diseases (NCDs); whereas, the situation may be different in low- and middle-income countries (LMICs), where chronic communicable diseases remain prominent. The aim of this systematic review was to identify determinants (including risk and protective factors) and potential mechanisms underlying multimorbidity from published longitudinal studies across diverse population-based or community-dwelling populations in LMICs...
February 2024: Obesity Reviews
https://read.qxmd.com/read/38091552/prediabetes-and-associated-risk-of-cardiovascular-events-and-chronic-kidney-disease-among-adult-survivors-of-childhood-cancer-in-the-st-jude-lifetime-cohort
#40
JOURNAL ARTICLE
Stephanie B Dixon, Fang Wang, Lu Lu, Carmen L Wilson, Daniel M Green, Thomas E Merchant, Deo Kumar Srivastava, Angela Delaney, Rebecca M Howell, John L Jefferies, Leslie L Robison, Kirsten K Ness, Melissa M Hudson, Wassim Chemaitilly, Gregory T Armstrong
PURPOSE: Little is known about the prevalence of prediabetes and associated risk of cardiovascular events and chronic kidney disease (CKD) with this reversable condition in survivors. METHODS: Prevalence of prediabetes (fasting plasma glucose 100-125 mg/dL or hemoglobin A1c 5.7%-6.4%) and diabetes was clinically assessed in 3,529 adults ≥5 years from childhood cancer diagnosis and 448 controls stratified by age. Cox proportional hazards regression estimated progression from prediabetes to diabetes, and risk of future cardiac events, stroke, CKD, and death...
December 13, 2023: Journal of Clinical Oncology
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