neutrophil transfusion

D Robert Sutherland, Stephen J Richards, Fernando Ortiz, Rakesh Nayyar, Miroslav Benko, Iuri Marinov, Andrea Illingworth
BACKGROUND: The diagnosis of paroxysmal nocturnal hemoglobinuria (PNH) relies on flow cytometric demonstration of loss of glycosyl-phosphatidyl inositol (GPI)-anchored proteins from red blood cells (RBC) and white blood cells (WBC). High-sensitivity multiparameter assays have been developed to detect loss of GPI-linked structures on PNH neutrophils and monocytes. High-sensitivity assays to detect PNH phenotypes in RBCs have also been developed that rely on the loss of GPI-linked CD59 on CD235a-gated mature RBCs...
November 8, 2019: Cytometry. Part B, Clinical Cytometry
Zhong-Fang He, Lin Chen, Jian-Ping Zhang, Qing-Qing Wang
RATIONALE: Fusidic acid (FA) is an active agent against gram-positive bacteria such as Staphylococcus, it is generally well tolerated and the major adverse effects are mild gastrointestinal discomfort, diarrhea, and headache. However, some rare side effects such as granulocytopenia and thrombocytopenia have also been reported. Here we report a case of FA-induced hepatotoxicity and hematologic toxicity. PATIENT CONCERNS: A 54-year-old woman with hepatitis B cirrhosis was referred to us because of fever, Staphylococcus aureus was identified in the twice blood culture, and intravenous FA was given (0...
November 2019: Medicine (Baltimore)
Fouad Madhi, Annie Kamdem, Camille Jung, Adele Carlier-Gonod, Sandra Biscardi, Jeremy Busca, Cecile Arnaud, Isabelle Hau, David Narbey, Ralph Epaud, Corinne Pondarre
This prospective observational study sought to ascertain clinical and laboratory parameters associated with the development of acute chest syndrome (ACS) during vaso-occlusive episodes (VOE) in children with sickle cell disease (SCD). It was performed at the pediatric department of the university Intercommunal Créteil hospital. All children with SCD (all sickle genotypes) consecutively admitted from November 2013 to December 2016 for painful VOEs and no evidence of ACS were included. Clinical and laboratory parameters collected at admission and within 48 h after admission were compared for children in whom ACS developed or not...
November 1, 2019: Journal of Clinical Medicine
Ilse Jongerius, Leendert Porcelijn, Anna E van Beek, John W Semple, C Ellen van der Schoot, Alexander P J Vlaar, Rick Kapur
Transfusion-related acute lung injury (TRALI) is a life-threatening complication of acute respiratory distress occurring within 6 hours of blood transfusion. TRALI is one of the leading causes of transfusion-related fatalities and specific therapies are unavailable. Neutrophils are recognized as the major pathogenic cells, whereas T regulatory cells and dendritic cells appear to be important for protection against TRALI. The pathogenesis, however, is complex and incompletely understood. It is frequently postulated that the complement system plays an important role in the TRALI pathogenesis...
October 18, 2019: Transfusion Medicine Reviews
Xue Li, Dan Liu, Lijie Zhao, Linlin Wang, Yuanmin Li, Kenka Cho, Chunlei Tao, Baohong Jiang
AIM: Aortic dissection (AD) is a devastating disease with rapid progression and high mortality, while the initiation mechanism of AD is far from clear. MAIN METHODS: AD was established by feeding mice with β-aminopropionitrile in the diet and usage of angiotensin II (AngII) to trigger the rupture of aorta. LysMiDTR mice were constructed by crossing of LysM-Cre mice with ROSA26iDTR mice and characterized by diphtheria toxin receptor (DTR) expression in monocytes/macrophages specifically...
October 28, 2019: Life Sciences
Forat Lutfi, William Paul Skelton Iv, Yu Wang, Emma Rosenau, Nosha Farhadfar, Hemant Murthy, Christopher R Cogle, Ranadall Brown, John Hiemenz, John R Wingard, Maxim Norkin
OBJECTIVE/BACKGROUND: Clinical predictors of delayed engraftment following autologous hematopoietic cell transplantation (AHCT) are poorly described in the literature. The purpose of this study was to identify pretransplant characteristics contributing to delayed engraftment (DE) following AHCT. METHODS: A retrospective, single institution study of 1162 consecutive patients undergoing AHCT from January 1996 to August 2016 was studied for DE. DE was defined as platelet count ≤ 50,000/µl, hemoglobin ≤ 8 g/dL, or absolute neutrophil count ≤ 1000/mm3 ...
October 10, 2019: Hematology/oncology and Stem Cell Therapy
Saeyoung Kim, Jongyoon Baek, Sangyoung Park, Eun-Kyung Choi, Suk-Hwan Baek, Joon-Hyuk Choi, Chae-Hoon Lee, Eon-Gi Sung, Keuk-Jun Kim, Daelim Jee
OBJECTIVES: Hepatic ischemia-reperfusion injury and transfusion of red blood cells in liver surgery are wellknown risk factors to induce acute tubular injury. Transfusion of stored red blood cells may affect hepatic ischemia-reperfusion injury-induced acute tubular injury. Here, we hypothesized whether preischemic (due to increased severity of hepatic injury) and postischemic (due to renal uptake of free heme and iron) transfusion of stored red blood cells may potentiate acute tubular injury in rats subjected to hepatic ischemia-reperfusion injury...
October 11, 2019: Experimental and Clinical Transplantation
Sibel Ozler, Efser Oztas, Basak Gumus Guler, Ali Turhan Caglar
Purpose: IL-33 is associated with invasion, proliferation, and metastasis of various cancers. The trophoblastic cells of placenta previa accreta (PPA) invade into the myometrium in a similar way to the invasion of cancers. We studied the role of IL-33 in PPA and also aimed to investigate its relation with adverse maternal outcome in this placental disorder. Methods: A total of 87 pregnant patients were enrolled in this prospective case-control study [27 with PPA, 30 with placenta previa totalis (PPT; nonadherent placenta previa) and 30 controls]...
October 13, 2019: Journal of Maternal-fetal & Neonatal Medicine
Mariam Taha, Dana Kyluik-Price, Dilini Kumaran, Mark D Scott, Wendy Toyofuku, Sandra Ramirez-Arcos
BACKGROUND: Whole blood (WB) is held at room temperature for not more than 24 hours before blood component manufacturing. The ability of several culture collection, skin-derived, and transfusion-related bacteria to survive in WB stored at 22 ± 2°C for 24 hours was investigated in this study. STUDY DESIGN AND METHODS: Twenty-one bacteria of the species Staphylococcus epidermidis, Staphylococcus aureus, Staphylococcus capitis, Streptococcus agalactiae, Serratia liquefaciens, Serratia marcescens, Klebsiella pneumoniae, Escherichia coli, and Yersinia enterocolitica were inoculated into 7-mL aliquots of WB at a concentration of 500 colony-forming units (CFU)/mL...
October 13, 2019: Transfusion
Yao Zhang, Na Diao, Christina K Lee, Hong Wei Chu, Lan Bai, Liwu Li
Tumor-associated immune-suppressive neutrophils are prevalent in various cancers, including colorectal cancer. However, mechanisms of immune-suppressive neutrophils are not well understood. We report that a key innate suppressor, IRAK-M (interleukin-1 receptor-associated kinase M), is critically involved in the establishment of immune-suppressive neutrophils. In contrast to the wild-type (WT) neutrophils exhibiting immune-suppressive signatures of CD11bhigh PD-L1high CD80low , IRAK-M-deficient neutrophils are rewired with reduced levels of inhibitory molecules PD-L1 and CD11b, as well as enhanced expression of stimulatory molecules CD80 and CD40...
September 23, 2019: Molecular Therapy
Lidia Hermida-Nogueira, María N Barrachina, Irene Izquierdo, María García-Vence, Serena Lacerenza, Susana Bravo, Azucena Castrillo, Ángel García
In blood banks, platelets are stored until 7 days after a pathogen reduction technology (PRT) treatment, Mirasol® (vitamin B2 plus UVB light) in the present case. The storage time under these conditions may have an impact on platelets and their releasate leading to potential adverse reactions following transfusion to patients. The aim of this study was to analyze the proteome of extracellular vesicles generated by platelets at different storage days (2 and 7) to gain deeper information on the platelet concentrates state at those moments...
October 9, 2019: Journal of Proteomics
Mai Nanya, Kimiko Yurugi, Itaru Kato, Hidefumi Hiramatsu, Hiroshi Kawabata, Tadakazu Kondo, Tomoki Iemura, Rie Hishida, Erika Shibutani, Keiko Matsui, Yoko Nakagawa, Norimi Niwa, Yasunari Kasai, Joseph M Roig, Yasuyuki Arai, Yasuo Miura, Akifumi Takaori-Kondo, Taira Maekawa, Hideyo Hirai
Granulocyte transfusion (GTX) is a therapeutic option for severe bacterial or fungal infection in patients with sustained neutropenia after chemotherapy or stem cell transplantation. However, high molecular weight hydroxyethyl starch (HES), which has been used for selective sedimentation of red blood cells during apheresis, is not easily available in many countries including Japan. In this study, we evaluated the efficiency of granulocyte collection using medium molecular weight HES (130 kDa) in combination with the Spectra Optia apheresis system...
October 10, 2019: International Journal of Hematology
Jun Zhu, Si-Guo Hao, Jiong Hu, Jing-Li Zhuang, Chun Wang, Hai-Tao Bai
Objective: The mobilization and collection of sufficient autologous peripheral blood stem cells (APBSCs) are important for the fast and sustained reconstruction of hematopoietic function after autologous transplantation. This study aims to evaluate the mobilization effect and safety of thrombopoietin (TPO) combined with chemotherapy + G-CSF for APBSCs in patients with refractory/relapsed non-Hodgkin's lymphoma. Methods: A total of 78 patients were included in the present study...
2019: Cancer Management and Research
Vaibhav Sahai, M Wasif Saif, Aparna Kalyan, Philip A Philip, Caio M Rocha-Lima, Allyson Ocean, Michael S Ondovik, Diane M Simeone, Sibabrata Banerjee, Rafia Bhore, Chrystal U Louis, Vincent Picozzi
Purpose: To evaluate safety and preliminary efficacy of metronomic 5-fluorouracil plus nab -paclitaxel, bevacizumab, leucovorin, and oxaliplatin (FABLOx) in patients with newly diagnosed metastatic pancreatic cancer (MPC). Methods: A total of 12 treatment-naive patients (aged 18-65 years, Eastern Cooperative Oncology Group performance status [ECOG PS] ≤1) with MPC received 5-fluorouracil 180 mg/m2 per day (days 1-14 continuous infusion); nab -paclitaxel 75 mg/m2 , leucovorin 20 mg/m2 , and oxaliplatin 40 mg/m2 (days 1, 8, and 15); and bevacizumab 5 mg/kg (days 1 and 15) administered intravenously in each 28-day cycle...
2019: Journal of Pancreatic Cancer
Andrei Colita, Anca Colita, Horia Bumbea, Adina Croitoru, Carmen Orban, Lavinia Eugenia Lipan, Oana-Gabriela Craciun, Dan Soare, Cecilia Ghimici, Raluca Manolache, Ionel Gelatu, Ana-Maria Vladareanu, Sergiu Pasca, Patric Teodorescu, Delia Dima, Anca Lupu, Daniel Coriu, Ciprian Tomuleasa, Alina Tanase
High-dose chemotherapy (HDT) followed by autologous hematopoietic stem cell transplantation (ASCT) is widely used in patients with malignant lymphomas. In Europe over 8,000 ASCTs for lymphoma were performed out of a total of 40,000 transplants according to the European Bone Marrow Transplant (EBMT) activity survey in 2017. ASCT is considered the standard treatment for eligible patients failing to achieve remission after first line chemotherapy or patients with relapsed or refractory lymphomas, including classical Hodkin's lymphoma, diffuse large B-cell lymphoma, mantle cell lymphoma, and follicular lymphoma, as well as consolidation therapy in first remission in mantle cell lymphoma...
2019: Frontiers in Oncology
Rémi Favier, Xavier Roussel, Sylvain Audia, Jean Claude Bordet, Emmanuel De Maistre, Pierre Hirsch, Anne Neuhart, Isabelle Bedgedjian, Vasiliki Gkalea, Marie Favier, Etienne Daguindau, Paquita Nurden, Eric Deconinck
Gray platelet syndrome (GPS) is an inherited disorder. Patients harboring GPS have thrombocytopenia with large platelets lacking α-granules. A long-term complication is myelofibrosis with pancytopenia. Hematopoietic stem cell transplant (HSCT) could be a curative treatment. We report a male GPS patient with severe pancytopenia, splenomegaly and a secondary myelofibrosis needing red blood cells transfusion. He received an HSCT from a 10/10 matched HLA-unrelated donor after a myeloablative conditioning regimen...
September 10, 2019: Platelets
Jong Wook Lee, Sung-Eun Lee, Chul Won Jung, Silvia Park, Hiroyuki Keta, Soo Kyeong Park, Jin-A Kim, Il-Hoan Oh, Jun Ho Jang
BACKGROUND: Aplastic anaemia is a rare, life-threatening condition, characterised by pancytopenia with hypocellular bone marrow. Haematopoietic stem cells and most progenitor cells express thrombopoietin receptor (c-MPL). Romiplostim is a peptibody with c-MPL agonist activity that stimulates endogenous thrombopoietin production and leads to promoting the proliferation and differentiation of megakaryocytes in the bone marrow. In this phase 2 trial we aimed to assess the activity and safety of romiplostim in patients with aplastic anaemia who were previously treated with immunosuppressive therapy...
August 29, 2019: Lancet Haematology
Mario Schietroma, Beatrice Pessia, Antonella Mattei, Lucia Romano, Antonio Giuliani, Francesco Carlei
Background: The grading systems for intra-abdominal sepsis (IAS) are not employed commonly in clinical practice because they are too complicated or too specific. We propose to grade IAS with a simple grading system: the TNM system, which is an acronym borrowed from cancer staging, where T indicates Temperature, N indicates Neutrophils, and M indicates Multiple organ failure (MOF). The aim of this prospective observational study is to assess the predictive value of the TNM score on deaths of patients with complicated IAS...
August 28, 2019: Surgical Infections
Ya-Xue Wu, Xiao-Hui Hu, Su-Ning Chen, Hui-Ying Qiu, Cheng-Cheng Fu, Yue Han, Cai-Xia Li, Xiao Ma, Ai-Ning Sun, Xiao-Wen Tang, De-Pei Wu
]Objective:To investigate the efficacy and safety of induction regimens containing arsenite, allo-transretinoic acid (ATRA) and anthracyclines of different doses as induction chemotherapy for acute promyelocytic leukemia (APL). METHODS: The clinical data of 129 consecutive hospitalized newly diagnosed APL patients from January 2011 to December 2017 were collected and retrospectively analyzed. Sixty-six patients received arsenite, ATRA and anthracyclines of low doses (low dose group), while other 63 patients received arsenite, ATRA and anthracyclines of standard doses (standard dose group), the efficacy and safety were compared and analyzed in 2 groups...
August 2019: Zhongguo Shi Yan Xue Ye Xue za Zhi
Kamuran Karaman, Serdar Şahin, Hadi Geylan, Akkiz Şahin Yaşar, Mecnun Çetin, Ahmet U Kömüroğlu, Ahmet F Öner
BACKGROUND AND AIM: Neutrophil gelatinase-associated lipocalin (NGAL) is found in the granules of human neutrophils, with many diverse functions. Expression of NGAL is induced under various pathophysiological conditions, for example, infection, inflammation, kidney injury, cardiovascular disease, burn injury, and intoxication, and it has an important antiapoptotic and anti-inflammatory role. PATIENTS AND METHODS: A total of 37 patients with thalassemia disease β-thalassemia major (24 male and 13 female individuals) and 37 healthy controls (17 male and 20 female) were enrolled in this study...
August 8, 2019: Journal of Pediatric Hematology/oncology
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