Carolyn D Drews-Botsch, Scott R Lambert
No abstract text is available yet for this article.
October 22, 2020: JAMA Ophthalmology
Nara L Lopes, Carolina P B Gracitelli, Christiane Rolim-de-Moura
PURPOSE: To apply the Childhood Glaucoma Research Network (CGRN) classification in children from a pediatric glaucoma outpatient clinic in a tertiary Brazilian care center to better understand the prevalence and the demographic and clinical characteristics of each subtype of childhood glaucoma. METHODS: This was a retrospective study in which medical records were collected from patients assisted in childhood glaucoma's clinic at the Department of Ophthalmology and Visual Sciences, Federal University of São Paulo from January 2010 to January 2018...
October 20, 2020: Journal of Glaucoma
Rui Pei, Peng-Fei Liang, Wei Ye, Ji Li, Ji-Yuan Ma, Jian Zhou
AIM: To identify mutations in the genes of a four-generation Chinese family with congenital membranous cataracts and investigate the morphologic changes and possible functional damage underlying the role of the mutant gene. METHODS: Whole exome analysis of thirteen members of a four-generation pedigree affected with congenital membranous cataracts was performed; co-segregation analysis of identified variants was validated by Sanger sequencing. All members underwent detailed physical and complete eye examinations...
2020: International Journal of Ophthalmology
Kevin J Scully, Joseph I Wolfsdorf
BACKGROUND: Wolfram syndrome is a rare neurodegenerative disorder, characterized by the presence of diabetes insipidus, diabetes mellitus, optic atrophy, and sensorineural deafness. The majority of cases are due to autosomal recessive biallelic variants in the WFS1 gene; however, pathogenic autosomal dominant (AD) mutations have also been described. Glucagon-like peptide (GLP-1) agonists have been studied in both animal models and humans with classic Wolfram syndrome. CASE: We present a 15-year-old female with a personal and family history of congenital strabismus, bilateral cataracts, low-frequency sensorineural hearing loss, and diabetes mellitus...
October 19, 2020: Hormone Research in Pædiatrics
Suddha Sourav, Davide Bottari, Idris Shareef, Ramesh Kekunnaya, Brigitte Röder
Background: Untreated congenital blindness through cataracts leads to lasting visual brain system changes, including substantial alterations of extrastriate visual areas. Consequently, late-treated individuals (> 5 months of age) with dense congenital bilateral cataracts (CC) exhibit poorer visual function recovery compared to individuals with bilateral developmental cataracts (DC). Reliable methods to differentiate between patients with congenital and developmental cataracts are often lacking, impeding efficient rehabilitation management and introducing confounds in clinical and basic research on recovery prognosis and optimal timing of surgery...
October 2020: EClinicalMedicine
Eileen E Birch, Reed M Jost, Serena X Wang, Krista R Kelly
BACKGROUND: Binocular neural architecture may be preserved in children with deprivation amblyopia due to unilateral cataract. The purpose of this study was to investigate whether a contrast-rebalanced binocular treatment, recently used with success to treat the interocular suppression and amblyopia in strabismic and anisometropic children, can contribute to rehabilitation of visual acuity in children with deprivation amblyopia secondary to monocular cataract. METHODS: In a pilot randomized trial, 15 children (4-13 years of age) were enrolled and randomized to continue with their current treatment only (n = 7) or to continue with their current treatment and add contrast-rebalanced binocular iPad game play 5 hours/week for 4 weeks (n = 8)...
October 15, 2020: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
J P López, M M Barriga, D Lecea, C Parada, G Stephens
INTRODUCTION: The red reflex examination (RRE) and visual acuity testing (VA) is a mandatory part of the examination during the well-child visits (WCV) in primary health care centres of the public system of health in Chile. The eye examination is aimed at the early detection of severe eye diseases in children, such as retinoblastoma, congenital cataracts, and amblyopia. The knowledge and difficulties experienced by health workers in primary care health centres for evaluating the red reflex during WCV in Chile is unknown...
October 13, 2020: Archivos de la Sociedad Española de Oftalmología
Siddhart S Rajendran, Davide Bottari, Idris Shareef, Kabilan Pitchaimuthu, Suddha Sourav, Nikolaus F Troje, Ramesh Kekunnaya, Brigitte Röder
Visual input during the first years of life is vital for the development of numerous visual functions. While normal development of global motion perception seems to require visual input during an early sensitive period, the detection of biological motion (BM) does not seem to do so. A more complex form of BM processing is the identification of human actions. Here we tested whether identification rather than detection of BM is experience dependent. A group of human participants who had been treated for congenital cataracts (of up to 18 year duration, CC group) had to identify ten actions performed by human line figures...
October 15, 2020: ENeuro
Stéphane Schurmans, Charles-Andrew Vande Catsyne, Christophe Desmet, Bastien Moës
INPP5K (Inositol Polyphosphate 5-Phosphatase K, or SKIP (for Skeletal muscle and Kidney enriched Inositol Phosphatase) is a member of the phosphoinositide 5-phosphatases family. Its protein structure is comprised of a N-terminal catalytic domain which hydrolyses both PtdIns(4,5)P2 and PtdIns(3,4,5)P3, followed by a SKICH domain at the C-terminus which is responsible for protein-protein interactions and subcellular localization of INPP5K. Strikingly, INPP5K is mostly concentrated in the endoplasmic reticulum, although it is also detected at the plasma membrane, in the cytosol and the nucleus...
October 10, 2020: Advances in Biological Regulation
Inês Q Saraiva, Esmeralda Delgado
OBJECTIVE: Provide epidemiological data regarding the prevalence of congenital ocular malformations in dogs and cats. ANIMALS STUDIED: A population of 32 974 dogs and 13 977 cats that presented for consultation at the veterinary teaching hospital. PROCEDURES: Medical records from 2011 to 2018 were reviewed. A retrospective and prospective epidemiological clinical study addressing congenital ocular malformations was conducted. Signalment, medical history, reason for presentation, clinical findings, vision impairment, and treatment options were analyzed...
October 15, 2020: Veterinary Ophthalmology
Eva Biewald, Sabrina Schlüter, Nikolaos E Bechrakis, Tobias Kiefer, Philipp Rating, Dirk Geismar, Klaus A Metz, Sophia Göricke, Petra Ketteler, Norbert Bornfeld
Introduction: Given the rarity of retinoblastoma and the consequences of accidental vitrectomy in the event of misdiagnosis, reporting on clinical experience in this area is important. Objective: The aim of this study was to analyse the management and complications with a focus on local orbital recurrence and metastatic disease in 10 children vitrectomized in an undetected retinoblastoma eye. Methods: This is a retrospective descriptive case series conducted in a single-centre referral university hospital...
August 2020: Ocular Oncology and Pathology
Orna Geyer, Adi Segal, Alina Melamud, Alvit Wolf
PRéCIS:: Ahmed valve success for glaucoma following congenital cataract surgery lasts at least 5 years in most eyes, and more than 10 years in some cases. The procedure is a valuable option for these patients. PURPOSE: To report on results of Ahmed Valve Implantation in children with glaucoma following congenital cataract surgery. PATIENTS AND METHODS: Medical records were reviewed for 41 pediatric eyes (27 patients) with glaucoma following congenital cataract surgery with Ahmed Glaucoma Valve implantation between 2007 and 2018...
September 29, 2020: Journal of Glaucoma
Wolf A Lagrèze
The successful outcome of treatment for infant and childhood cataract depends on many factors. It is crucial that the treatment falls into a phase in which neither the eye nor the visual pathway and visual cortex are fully developed. This review summarizes the current state of knowledge and provides an overview of the epidemiology, causes and clinical forms, early detection and, above all, treatment options. Special attention is paid to time-critical stages of development, according to which the therapeutic concepts are based...
October 1, 2020: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
Jylan Gouda, Reham H Tomairek, Abdelrahman M Elhusseiny, Dina Elfayoumi, Ahmed Awadein, Ghada Gawdat, Hala Elhilali
PRéCIS:: Anterior chamber angle narrowing continues to occur for at least 2 years after congenital cataract surgery. Risk factors for IOP elevation after congenital cataract surgery were higher central corneal thickness and surgery at <2 months. PURPOSE: To study the changes in intraocular pressure (IOP) and in the anterior chamber angle (ACA) during the first 2 years after pediatric cataract surgery and to determine risk factors for such changes. METHODS: A retrospective observational study was done on infants who underwent pediatric cataract surgery in Cairo University Hospitals and completed a 1-year follow-up...
September 22, 2020: Journal of Glaucoma
Yao-Lung Chang, An-Shine Chao, Ching-Yu Chou, Shuenn-Dyh Chang, Ming-Chou Chiang, Yung-Sung Lee
BACKGROUND: Peters anomaly is a rare form of anterior segment ocular dysgenesis, the antenatal image of Peters anomaly had not been reported. We herein showcased a discordant finding of Peters anomaly in a monozygotic twin complicated with twin-twin transfusion syndrome (TTTS) and exhibited its antenatal sonographic images, CASE PRESENTATION: A 38-year-old gravida 2 para 1 pregnant woman visited our clinic at the gestational age of 18 weeks where TTTS stage III was diagnosed and the following laser therapy was done successfully...
September 23, 2020: BMC Pregnancy and Childbirth
Sirisha Senthil, Nkechinyere Judith Uche, Ashik Mohamed, Rashmi Krishnamurthy, Swathi Badakere, Anil K Mandal, Chandrasekhar Garudadari
PURPOSE: To report clinical features and treatment outcomes of primary combined trabeculotomy with trabeculectomy (CTT) in congenital aniridia with glaucoma in children aged 3 years or less. DESIGN: Retrospective study PARTICIPANTS: Sixty-six eyes (35 children) with congenital aniridia and early onset glaucoma who underwent CTT between May-1997 and June-2015 were included. METHODS: Success was defined as complete when intraocular pressure (IOP) was >5 mm Hg and ≤21 or ≤16 mm Hg without antiglaucoma medications (AGMs), and qualified when AGMs were required...
September 20, 2020: Ophthalmology. Glaucoma
Karina Spiess, Jesús Peralta Calvo
PURPOSE: To analyze clinical characteristics, treatment, and long-term outcomes of pediatric patients with glaucoma after congenital cataract surgery at a single tertiary care hospital. METHODS: Medical records of pediatric patients diagnosed as having glaucoma secondary to congenital cataract surgery between 1996 and 2016 were reviewed retrospectively. RESULTS: A total of 58 eyes of 42 patients were included with a median follow-up time of 55 months (interquartile range [IQR]: 27 to 128) after glaucoma diagnosis...
September 1, 2020: Journal of Pediatric Ophthalmology and Strabismus
Parth R Vaidya, Madeline L DʼAquila, Nicholas A Ramey, Douglas J Grider
Caruncular dacryops is a rare cyst of lacrimal tissue most commonly found in the palpebral lobe of the lacrimal gland. The exact cause of dacryops is unclear, although it may be congenital or associated with trauma, infection, or inflammation. The pathophysiology and histology of a caruncular dacryops of the left lacrimal gland in a 68-year-old woman is reported. The patient presented 3 months after a cataract surgery with symptoms of irritation and pruritus of the left eye. A 6- × 6-mm clear cyst of the lacrimal gland prolapsing into the lateral fornix was noted on physical exam...
September 17, 2020: American Journal of Dermatopathology
Nicolas Cesário Pereira, José Álvaro Pereira Gomes, Camile Tonin, Fabiana Orondjian Verardo, Rodolpho Sueiro Felippe, Adriana Dos Santos Forseto
PURPOSE: To describe the outcomes of Descemet membrane endothelial keratoplasty (DMEK) performed in amblyopic aged (younger than 8 years) children. METHODS: This is a single-center retrospective study, including 11 eyes (7 congenital hereditary endothelial dystrophy and 4 congenital glaucoma) of 6 children in amblyopic age undergoing DMEK by a single surgeon (N.C.P.) at Sorocaba Eye Hospital from December 2015 to November 2017. Best spectacle-corrected visual acuity, biomicroscopy, pachymetry, endothelial cell density, and complications were evaluated...
September 16, 2020: Cornea
Gregory S H Ogawa
Congenital iris colobomas do not usually present a major optical issue until the time of cataract surgery, when an intraocular lens (IOL) is placed in the eye that is roughly half the diameter of the crystalline lens. Leaving the coloboma unrepaired or sutured closed without addressing the sphincter muscle in the coloboma often creates visual challenges for the eye postoperatively. The problem has previously been addressed, in part, with a technique that creates a scissor snip between the normal iris sphincter and the colobomatous iris sphincter, but still requires notable peripheral iris traction and root disinsertion for closure of the defect...
September 16, 2020: Journal of Cataract and Refractive Surgery
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