Antonio De Mase, Paolo Candelaresi, Emanuele Spina, Flavio Giordano, Stefano Barbato, Giovanna Servillo, Elio Prestipino, Alessandra Fasolino, Gianluigi Guarnieri, Giuseppe Leone, Massimo Muto, Mario Muto, Vincenzo Andreone
Endovascular thrombectomy is the standard treatment in selected patients with acute ischemic stroke and large vessel occlusion, but continuous improvement in angiographic and clinical outcome is still needed. Intra-arterial thrombolysis has been tested as a possible rescue tool in unsuccessful thrombectomy, or as an adjuvant therapy after the endovascular procedure, to pursue complete recanalization. Here we present a case series analysis of intra-arterial alteplase administration (5 mg bolus, repeated up to 15 mg if Thrombolysis in Cerebral Infarction (TICI) scale ≥2c is not achieved) in 15 consecutive anterior circulation stroke patients after unsuccessful thrombectomy, defined as TICI score ≤2b after at least 3 passes or if unsuitable for further endovascular attempts, with the aim of improving recanalization...
April 18, 2023: Neurointervention