keyword
https://read.qxmd.com/read/38547473/harnessing-the-potential-of-self-assembled-peptide-hydrogels-for-neural-regeneration-and-tissue-engineering
#1
REVIEW
Haniyeh Najafi, Ghazal Farahavar, Mahboobeh Jafari, Samira Sadat Abolmaali, Negar Azarpira, Ali Mohammad Tamaddon
Spinal cord injury, traumatic brain injury, and neurosurgery procedures usually lead to neural tissue damage. Self-assembled peptide (SAP) hydrogels, a type of innovative hierarchical nanofiber-forming peptide sequences serving as hydrogelators, have emerged as a promising solution for repairing tissue defects and promoting neural tissue regeneration. SAPs possess numerous features such as adaptable morphologies, biocompatibility, injectability, tunable mechanical stability, and mimicking of the native extracellular matrix...
March 28, 2024: Macromolecular Bioscience
https://read.qxmd.com/read/38547383/update-and-approach-to-patients-with-brain-abscess
#2
JOURNAL ARTICLE
Lars Haukali Omland, Henrik Nielsen, Jacob Bodilsen
PURPOSE OF REVIEW: The epidemiology of brain abscess has changed in recent decades. Moreover, acute and long-term management remains challenging with high risks of mortality and neurological sequelae. This review describes recent advances in epidemiology, diagnosis, and treatment of brain abscess. RECENT FINDINGS: The incidence of brain abscess is increasing, especially among elderly individuals. Important predisposing conditions include dental and ear-nose-throat infections, immuno-compromise, and previous neurosurgery...
March 29, 2024: Current Opinion in Infectious Diseases
https://read.qxmd.com/read/38546890/cervical-dorsal-rhizotomy-for-upper-limbs-spasticity-case-report
#3
JOURNAL ARTICLE
Italo Teles de Oliveira Filho, Paulo Cesar Romero, Alexandre Pingarilho Rezende, Bruno Braga Sisnando Costa, Saul Dalla Oliveira, Emílio Afonso França Fontoura, Ricardo Vieira Botelho
Spasticity is a prevalent symptom of upper motor neuron syndrome, becoming debilitating when hindering voluntary movement and motor function and causing contractures and pain. Functional neurosurgery plays a crucial role in treating severe spasticity. Despite extensive literature on SDR for lower limb spasticity, there is a scarcity of papers regarding the procedure in the cervical region to alleviate upper limb spasticity. This case report details a cervical dorsal rhizotomy (CDR) performed for upper limb spasticity, resulting in significant improvement in spasticity with sustained outcomes and low complication rates...
March 28, 2024: Acta Neurochirurgica
https://read.qxmd.com/read/38546884/an-updated-systematic-review-of-neuroprotective-agents-in-the-treatment-of-spinal-cord-injury
#4
REVIEW
Ibrahim Serag, Mohamed Abouzid, Ahmed Elmoghazy, Khalid Sarhan, Saad Ashraf Alsaad, Rashad G Mohamed
This systematic review aims to summarize the findings from all clinical randomized trials assessing the efficacy of potential neuroprotective agents in influencing the outcomes of acute spinal cord injuries (SCI). Following the PRISMA guidelines, we conducted comprehensive searches in four electronic databases (PubMed, Scopus, Cochrane Library, and Web of Science) up to September 5th, 2023. Our analysis included a total of 30 studies. We examined the effects of 15 substances/drugs: methylprednisolone, tirilazad mesylate, erythropoietin, nimodipine, naloxone, Sygen, Rho protein antagonist, granulocyte colony-stimulating factor, autologous macrophages, autologous bone marrow cells, vitamin D, progesterone, riluzole, minocycline, and blood alcohol concentration...
March 28, 2024: Neurosurgical Review
https://read.qxmd.com/read/38546829/long-term-safety-tolerability-and-efficacy-of-apomorphine-sublingual-film-in-patients-with-parkinson-s-disease-complicated-by-off-episodes-a-phase-3-open-label-study
#5
JOURNAL ARTICLE
Jan Kassubek, Stewart A Factor, Ernest Balaguer, Johannes Schwarz, K Ray Chaudhuri, Stuart H Isaacson, Stacy Wu, Carmen Denecke Muhr, Jaime Kulisevsky
BACKGROUND: Apomorphine sublingual film (SL-APO) is an on-demand treatment for OFF episodes in patients with Parkinson's disease (PD). OBJECTIVE: To assess the long-term (≥ 3 years) safety/tolerability and efficacy of SL-APO. METHODS: Study CTH-301 ( https://www. CLINICALTRIALS: gov NCT02542696; registered 2015-09-03) was a phase 3, multicentre, open-label study of SL-APO in PD patients with motor fluctuations, comprised of a dose-titration and long-term safety phase...
March 28, 2024: Journal of Neurology
https://read.qxmd.com/read/38546282/paediatric-endoscopic-endonasal-middle-skull-base-reconstruction-retrospective-analysis-of-78-patients-treated-in-a-single-tertiary-care-paediatric-center
#6
JOURNAL ARTICLE
Danilo Di Giorgio, Filippo Giovannetti, Paolo Priore, Mirko Scagnet, Federico Mussa, Ingrid Raponi, Valentino Valentini, Lorenzo Genitori
INTRODUCTION: Skull base pathologies in the paediatric population are rare and require treatment by multiple qualified specialists. The endoscopic endonasal approach has revolutionized surgical treatment because it is less invasive than existing treatments.The goal of this study was to retrospectively review our experience with the reconstruction of paediatric skull middle base defects and associated complications. MATERIALS AND METHODS: We analysed medical records from patients aged ≤ 18 years who were treated at our centre between 2013 and 2021...
March 28, 2024: British Journal of Neurosurgery
https://read.qxmd.com/read/38545025/diagnostic-value-of-video-electroencephalography-combined-with-magnetic-resonance-imaging-diffusion-tensor-imaging-in-epilepsy
#7
JOURNAL ARTICLE
Lan Wang, Min Fang, Bin Zhu, Xiaoling Wang, Xiang Li
OBJECTIVE: To explore the diagnostic value of video electroencephalography (VEEG) combined with magnetic resonance imaging diffusion tensor imaging (MRI-DTI) in epilepsy. METHODS: In this retrospective observational study, clinical data of 60 patients who underwent both VEEG and MRI examinations at the Neurosurgery Department of Quzhou People's Hospital from December 2020 to March 2023 were retrospectively reviewed, and a total of 55 patients were finally included...
2024: Pakistan Journal of Medical Sciences Quarterly
https://read.qxmd.com/read/38544787/cross-sectional-examination-of-current-and-future-trends-and-attributes-of-the-presidents-of-the-american-association-of-neurological-surgeons-and-the-congress-of-neurological-surgeons-societies
#8
JOURNAL ARTICLE
Othman Bin-Alamer, Tritan Plute, Arka N Mallela, Rachel Jacobs, Constantinos G Hadjipanayis, D Kojo Hamilton, Joseph C Maroon, L Dade Lunsford, Robert M Friedlander, Hussam Abou-Al-Shaar
OBJECTIVE: The present study aimed to analyze the academic attributes of the presidents of the American Association of Neurological Surgeons (AANS) and the Congress of Neurological Surgeons (CNS) over the past four decades to elucidate the trajectories of these societies' leaderships. METHODS: Forty-three AANS and 43 CNS presidents of the past four decades were identified. Demographic and research productivity data were collected from publicly available sources...
July 2024: World neurosurgery: X
https://read.qxmd.com/read/38544786/exoscope-assisted-spine-surgery-current-applications-and-future-directions
#9
REVIEW
Tomas Ferreira, Sakshi Roy, Joecelyn Kirani Tan, Wireko Andrew Awuah, Vallabh Shet, Favour Tope Adebusoye, Nicholas Aderinto, Toufik Abdul-Rahman
Spine surgery is continually evolving, with the application of new technologies often serving as a catalyst for improved clinical outcomes. Exoscope-assisted spinal surgery has recently emerged as a notable technological advancement offering a refined approach to visualisation, thereby potentially contributing to improved surgical precision, reduced complication rates, and optimised patient outcomes. The application of exoscopes have improved spine surgeries such as spinal fusion procedures, decompression surgeries, instrumentation surgeries, minimally invasive and complex surgeries...
July 2024: World neurosurgery: X
https://read.qxmd.com/read/38544491/the-importance-of-social-networks-in-neurosurgery-training-in-low-middle-income-countries
#10
JOURNAL ARTICLE
Manuel de Jesus Encarnacion Ramirez, Jeff Natalaja Mukengeshay, Gennady Chumtin, Renat Nurmukhametov, Matias Baldoncini, Jesus Lafuente, Andreina Rosario Rosario, Siddarth Kannan, Aderehime Haidara, Issael Ramirez, Ismail Bozkurt, Ignatius Esene, Stanislav Kaprovoy, Nikolay Konovalov, Kazadi Kelvin Kalangu, Gerald Musa, Michael T Lawton, Vishal K Chavda, Eric Suero Molina, Nicola Montemurro
INTRODUCTION: Neurosurgery is evolving with new techniques and technologies, relies heavily on high-quality education and training. Social networks like Twitter, Facebook, Instagram and LinkedIn have become integral to this training. These platforms enable sharing of surgical experiences, fostering global knowledge-sharing and collaboration among neurosurgeons. Virtual conferences and courses are accessible, enhancing learning regardless of location. While these networks offer real-time communication and collaborative opportunities, they also pose challenges like the spread of misinformation and potential distractions...
2024: Frontiers in Surgery
https://read.qxmd.com/read/38541116/effects-of-the-covid-19-pandemic-on-everyday-neurosurgical-practice-in-alsace-france-lessons-learned-current-perspectives-and-future-challenges-preliminary-results-of-a-longitudinal-multicentric-study-registry
#11
JOURNAL ARTICLE
Guillaume Dannhoff, Charles-Henry Mallereau, Mario Ganau, Biagio Roberto Carangelo, Giorgio Spatola, Julien Todeschi, Lara Prisco, Rodolfo Maduri, Marie des Neiges Santin, Sandrine Woelffel, Isabella Mastrobuono, Jimmy Voirin, Franco Moruzzi, Beniamino Nannavecchia, Vitaliano Francesco Muzii, Alessandro Zalaffi, Carmen Bruno, Salvatore Chibbaro
Background and Objectives : The global outbreak caused by the SARS-CoV-2 pandemic disrupted healthcare worldwide, impacting the organization of intensive care units and surgical care units. This study aimed to document the daily neurosurgical activity in Alsace, France, one of the European epicenters of the pandemic, and provide evidence of the adaptive strategies deployed during such a critical time for healthcare services. Materials and Methods : The multicentric longitudinal study was based on a prospective cohort of patients requiring neurosurgical care in the Neurosurgical Departments of Alsace, France, between March 2020 and March 2022...
February 25, 2024: Medicina
https://read.qxmd.com/read/38539641/clivus-cervical-stabilization-through-transoral-approach-in-patients-with-craniocervical-tumor-three-cases-and-surgical-technical-note
#12
JOURNAL ARTICLE
Gervith Reyes-Soto, Alfonso Corona De la Torre, Kaori Guadalupe Honda Partida, Renat Nurmukhametov, Manuel De Jesus Encarnacion Ramirez, Nicola Montemurro
Craniocervical tumors lead to cervical pain, instability, and neurological symptoms, reducing the quality of life. Effective surgical intervention at the craniocervical junction (CCJ) is critical and complex, involving comprehensive approaches and advanced reconstructive techniques. This study, conducted at Mexico City's National Institute of Cancerology, focused on three surgical cases that occurred in 2023 involving tumors at the CCJ: two chordomas and one prostate adenocarcinoma. We utilized a specialized technique: clivus-cervical stabilization reinforced with a polymethylmethacrylate (PMMA)-filled cervical mesh...
March 5, 2024: Brain Sciences
https://read.qxmd.com/read/38539621/influence-of-sevoflurane-on-the-neurological-pupil-index-in-surgical-and-critically-ill-patients-a-pilot-study
#13
JOURNAL ARTICLE
Alice Dallemagne, Marco Anderloni, Mathias Havaux, Olivier Duranteau, Fabio Silvio Taccone
BACKGROUND: The aim of this study was to compare the effects of sevoflurane on the neurologic pupil index (NPi), obtained by means of automated pupillometry, between intensive care unit (ICU) and surgical patients. METHODS: This was a prospective single-center study conducted between December 2021 and February 2023. The eligible population comprised all patients undergoing general anesthesia (GA) for visceral surgery (VS) or neurosurgery (NS) and ICU patients receiving inhaled sevoflurane, according to the decision of the treating physician...
February 28, 2024: Brain Sciences
https://read.qxmd.com/read/38539132/delays-in-multiple-sclerosis-diagnosis-dimes-protocol-for-a-multicentre-observational-study-of-multiple-sclerosis-diagnostic-pathways-in-the-united-kingdom-and-republic-of-ireland
#14
JOURNAL ARTICLE
Ashvin Kuri, David E Henshall, Daoud Chaudhry, Setthasorn Zhi Yang Ooi, Qiqi Zhang, Joela Mathews, Alison Thomson, David Rog, Jeremy Hobart, Ruth Dobson
BACKGROUND: Multiple sclerosis (MS) is a leading cause of non-traumatic disability in young adults. Accumulating evidence indicates early diagnosis and early treatment improves long-term outcomes. However, the MS diagnostic pathway is increasingly complex, and delays may occur at several stages. Factors causing delays remain understudied. We aim to quantify the time taken for MS to be diagnosed, and characterise the diagnostic pathway and initial care provided, in the United Kingdom (UK) and Republic of Ireland (ROI)...
March 28, 2024: BMC Neurology
https://read.qxmd.com/read/38538973/cystic-degeneration-of-the-fibrous-dysplasia-presenting-with-loss-of-vision
#15
JOURNAL ARTICLE
M Ozan Durmaz, M Can Ezgu, Egemen Akincioglu, M Tufan Pehlivan, Yusuf Izci
Cystic degeneration of the fibrous dysplasia is a very rare clinical condition and may present with loss of vision when it involved the skull base. A 12-year-old female child presented with an enlargement of the skull. She was diagnosed as large skull base and skull vault tumor. She underwent partial removal of the tumor, and custom-made titanium implant was inserted. The diagnosis was fibrous dysplasia. Two years after the initial diagnosis, she presented with total loss of vision at her right eye. Radiological imaging confirmed the cystic degeneration within the tumor...
March 28, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/38538955/lumbar-percutaneous-transforaminal-endoscopic-discectomy-a-retrospective-survey-on-the-first-172-adult-patients-treated-in-denmark
#16
JOURNAL ARTICLE
Jacob Holmen Terkelsen, Torben Hundsholt, Carsten Reidies Bjarkam
PURPOSE: To evaluate patient demographics, surgery characteristics, and patient-reported clinical outcomes related to the implementation of lumbar PTED in Denmark by surgeons novice to the PTED technique. METHODS: All adult patients treated with a lumbar PTED from our first surgery in October 2020 to December 2021 were included. Data was generated by journal audit and telephone interview. RESULTS: A total of 172 adult patients underwent lumbar PTED...
March 27, 2024: Acta Neurochirurgica
https://read.qxmd.com/read/38538929/molecular-insights-and-the-role-of-18f-fdg-pet-ct-in-the-diagnosis-of-spinal-gliomas
#17
JOURNAL ARTICLE
Yoshitaka Nagashima, Yusuke Nishimura, Kaoru Eguchi, Junya Yamaguchi, Shoichi Haimoto, Fumiharu Ohka, Kazuya Motomura, Takashi Abe, Mamoru Matsuo, Eisuke Tsukamoto, Masahito Hara, Ryuta Saito
BACKGROUND: In recent years, molecular findings on spinal gliomas have become increasingly important. This study aimed to investigate the role of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) in the diagnosis of spinal glioma. METHODS: This study included patients diagnosed with spinal cord glioma who underwent 18F-FDG-PET examination at the Department of Neurosurgery, Nagoya University Hospital between January 2016 and November 2023...
March 27, 2024: Acta Neurochirurgica
https://read.qxmd.com/read/38538863/irrigation-versus-no-irrigation-in-the-treatment-of-chronic-subdural-hematoma-an-updated-systematic-review-and-meta-analysis-of-1581-patients
#18
REVIEW
Ahmed Aljabali, Ibrahim Serag, Sherein Diab, Abdulhameed Zeyad Alhadeethi, Mariam Abdelhady, Ibraheem M Alkhawaldeh, Mohamed Abouzid
Burr hole craniotomy is a common technique employed in the treatment of chronic subdural hematoma. However, its effectiveness and the occurrence of additional complications with various irrigation techniques utilized during the surgery remain unclear. The paper aims to compare the effectiveness and safety of burr hole craniotomy with and without irrigation in the treatment of chronic subdural hematoma. We conducted a systematic review by searching PubMed, Cochrane Library, Scopus, Ovid, and Web of Science for comparative studies that fit the eligibility criteria...
March 28, 2024: Neurosurgical Review
https://read.qxmd.com/read/38538776/brain-microstructure-is-linked-to-cognitive-fatigue-in-early-multiple-sclerosis
#19
JOURNAL ARTICLE
Camille Guillemin, Nora Vandeleene, Maëlle Charonitis, Florence Requier, Gaël Delrue, Emilie Lommers, Pierre Maquet, Christophe Phillips, Fabienne Collette
Cognitive fatigue is a major symptom of Multiple Sclerosis (MS), from the early stages of the disease. This study aims to detect if brain microstructure is altered early in the disease course and is associated with cognitive fatigue in people with MS (pwMS) compared to matched healthy controls (HC). Recently diagnosed pwMS (N = 18, age < 45 years old) with either a Relapsing-Remitting or a Clinically Isolated Syndrome course of the disease, and HC (N = 19) matched for sex, age and education were analyzed...
March 28, 2024: Journal of Neurology
https://read.qxmd.com/read/38538775/vestibular-evoked-myogenic-potential-abnormalities-in-parkinson-s-disease-with-freezing-of-gait
#20
JOURNAL ARTICLE
Yuhan Jiang, Mengxi Zhou, Haibin Sheng, Shuai Xu, Yajing Chen, Li Wu, Qing He, Lei Zhao, Jianren Liu, Wei Chen
BACKGROUND: Vestibular dysfunction is closely associated with the pathophysiology of Parkinson's disease (PD) accompanied by freezing of gait (FOG); however, evidence supporting this clinical association is lacking. Vestibular-evoked myogenic potentials (VEMPs) have been widely acknowledged as a crucial electrophysiological parameter in the clinical evaluation of vestibular function. OBJECTIVE: The present study investigated the possible correlation of FOG occurrence with VEMP observations in patients diagnosed with PD...
March 27, 2024: Journal of Neurology
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