Nitin Agarwal, Diego D Luy, Joanne M Bonaminio, Chris A Philips, Kathryn A Dattomo, Robert F Heary, Charles L Branch, Jon H Robertson, Michael W Groff, Regis W Haid
OBJECTIVE: The Neurosurgery Research & Education Foundation (NREF), previously known as the Research Foundation of the American Association of Neurological Surgeons (AANS), was established in 1980 to encourage and facilitate innovation through financial support to young neurosurgeons in the process of honing their competencies in neurosciences and neurological surgery. This article provides a historical overview of NREF, its mission, and charitable contributions and the ever-expanding avenues for neurosurgeons, neurosurgical residents and fellows, and medical students to supplement clinical training and to further neurosurgical research advances...
August 7, 2020: Journal of Neurosurgery
Russell R Lonser, Luke G F Smith, Michael Tennekoon, Kavon P Rezai-Zadeh, Jeffrey G Ojemann, Stephen J Korn
OBJECTIVE: To increase the number of independent National Institutes of Health (NIH)-funded neurosurgeons and to enhance neurosurgery research, the National Institute of Neurological Disorders and Stroke (NINDS) developed two national comprehensive programs (R25 [established 2009] for residents/fellows and K12 [2013] for early-career neurosurgical faculty) in consultation with neurosurgical leaders and academic departments to support in-training and early-career neurosurgeons. The authors assessed the effectiveness of these NINDS-initiated programs to increase the number of independent NIH-funded neurosurgeon-scientists and grow NIH neurosurgery research funding...
August 7, 2020: Journal of Neurosurgery
Ying Meng, Christopher B Pople, Suneil K Kalia, Lorraine V Kalia, Benjamin Davidson, Luca Bigioni, Daniel Zhengze Li, Suganth Suppiah, Karim Mithani, Nadia Scantlebury, Michael L Schwartz, Clement Hamani, Nir Lipsman
OBJECTIVE: The development of transcranial MR-guided focused ultrasound (MRgFUS) has revitalized the practice of lesioning procedures in functional neurosurgery. Previous health economic analysis found MRgFUS thalamotomy to be a cost-effective treatment for patients with essential tremor, supporting its reimbursement. With the publication of level I evidence in support of MRgFUS thalamotomy for patients with tremor-dominant Parkinson's disease (TDPD), the authors performed a health economic comparison between MRgFUS, deep brain stimulation (DBS), and medical therapy...
August 7, 2020: Journal of Neurosurgery
David M Greer, Sam D Shemie, Ariane Lewis, Sylvia Torrance, Panayiotis Varelas, Fernando D Goldenberg, James L Bernat, Michael Souter, Mehmet Akif Topcuoglu, Anne W Alexandrov, Marie Baldisseri, Thomas Bleck, Giuseppe Citerio, Rosanne Dawson, Arnold Hoppe, Stephen Jacobe, Alex Manara, Thomas A Nakagawa, Thaddeus Mason Pope, William Silvester, David Thomson, Hussain Al Rahma, Rafael Badenes, Andrew J Baker, Vladimir Cerny, Cherylee Chang, Tiffany R Chang, Elena Gnedovskaya, Moon-Ku Han, Stephen Honeybul, Edgar Jimenez, Yasuhiro Kuroda, Gang Liu, Uzzwal Kumar Mallick, Victoria Marquevich, Jorge Mejia-Mantilla, Michael Piradov, Sarah Quayyum, Gentle Sunder Shrestha, Ying-Ying Su, Shelly D Timmons, Jeanne Teitelbaum, Walter Videtta, Kapil Zirpe, Gene Sung
Importance: There are inconsistencies in concept, criteria, practice, and documentation of brain death/death by neurologic criteria (BD/DNC) both internationally and within countries. Objective: To formulate a consensus statement of recommendations on determination of BD/DNC based on review of the literature and expert opinion of a large multidisciplinary, international panel. Process: Relevant international professional societies were recruited to develop recommendations regarding determination of BD/DNC...
August 3, 2020: JAMA: the Journal of the American Medical Association
Tracy M Flanders, Joseph Ifrach, Saurabh Sinha, Disha S Joshi, Ali K Ozturk, Neil R Malhotra, Rachel Pessoa, Michael J Kallan, Lee A Fleisher, Michael A Ashburn, Eileen Maloney, William C Welch, Zarina S Ali
OBJECTIVE: Enhanced recovery after surgery (ERAS) pathways have previously been shown to be feasible and safe in elective spinal procedures. As publications on ERAS pathways have recently emerged in elective neurosurgery, long-term outcomes are limited. We report on our 18-month experience with an ERAS pathway in elective spinal surgery. METHODS: A historical cohort of 149 consecutive patients was identified as the control group, and 1,141 patients were prospectively enrolled in an ERAS protocol...
August 6, 2020: Pain Medicine
V A Lukyanchikov, I V Senko, E S Ryzhkova, A Yu Dmitriev
Literature review is devoted to the role of frameless neuronavigation in surgery of distal aneurysms, cavernomas, arteriovenous malformations, Kimmerle's anomaly and revascularization surgeries. Visualization methods used in preoperative preparation of patients with vascular lesions compatible with frameless neuronavigation and the methods of intraoperative visualization as an addition to navigation are described.
2020: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
R G Khachatryan, V A Bart, L N Maslova, T N Fadeeva, K I Sebelev, M M Tastanbekov, T M Alekseeva, V A Khachatryan
OBJECTIVE: To analyze the characteristics of paroxysmal syndrome in insular and temporal lobe tumors, to determine their relationship with the histological structure of tumor, to assess the effect of tumor growth nature on severity of disease. MATERIAL AND METHODS: A retrospective analysis enrolled 80 patients aged 11 - 80 years with insular and temporal lobe tumors and symptomatic epilepsy. All patients underwent surgery at the Polenov National Research Neurosurgery Center in Almazov National Medical Research Center for the period from 2012 to 2018...
2020: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
Peter A Rozman, David B Kurland, Danielle Golub, Myra Trang, Aaron Rothstein, Ariane Lewis, Donato Pacione
BACKGROUND: Venous thromboembolism (VTE) represents a significant source of morbidity and mortality in the inpatient population and is considered a leading preventable cause of death among inpatients. Neurosurgical inpatients are of particular interest given higher rates of immobility, steroid use, and potential consequences of post-operative hemorrhage. A consensus protocol for VTE screening in this population does not exist, and institutional protocols vary widely. METHODS: We carried out a retrospective review of lower-extremity venous duplex ultrasound (VDUS) usage at our institution and applied this information to the development of a neurosurgery department-wide protocol, taking into account high-risk patient risk factors and indications for VDUS ordering...
August 3, 2020: World Neurosurgery
Alexander Winkler-Schwartz, Recai Yilmaz, Dan Huy Tran, Houssem-Eddine Gueziri, Binbin Ying, Marius Tuznik, Vladimir Fonov, Louis Collins, David A Rudko, Jianyu Li, Patricia Debergue, Valerie Pazos, Rolando Del Maestro
BACKGROUND: The operative environment poses many challenges to studying the relationship between surgical acts and patient outcomes in intracranial oncological neurosurgery. The authors sought to develop a framework whereby neurosurgical performance and extent of resection could be precisely quantified in a controlled setting. METHODS: Stiffness of an alginate hydrogel-based tumor was modified with differing concentration of cross-linking agent calcium sulfate until similar biomechanical properties to human primary brain tumors measured at resection were achieved...
August 3, 2020: World Neurosurgery
Michaela Cellina, Daniele Gibelli, Annalisa Cappella, Tahereh Toluian, Carlo Valenti Pittino, Martinenghi Carlo, Giancarlo Oliva
BACKGROUND: The paranasal sinuses are complex anatomical structures, characterised by highly variable shape, morphology and size. With the introduction of multidetector scanners and the development of many post-processing possibilities, computed tomography became the gold standard technique to image the paranasal sinuses. Segmentation allows the extraction of metrical and shape data of these anatomical components that can be applied for diagnostic, education, surgical planning and simulation, and to plan minimally invasive interventions in otorhinolaryngology and neurosurgery...
August 6, 2020: Neuroradiology Journal
Salvatore Bertino, Gianpaolo Antonio Basile, Alessia Bramanti, Giuseppe Pio Anastasi, Angelo Quartarone, Demetrio Milardi, Alberto Cacciola
Internal and external segments of globus pallidus (GP) exert different functions in basal ganglia circuitry, despite their main connectional systems share the same topographical organization, delineating limbic, associative, and sensorimotor territories. The identification of internal GP sensorimotor territory has therapeutic implications in functional neurosurgery settings. This study is aimed at assessing the spatial coherence of striatopallidal, subthalamopallidal, and pallidothalamic pathways by using tractography-derived connectivity-based parcellation (CBP) on high quality diffusion MRI data of 100 unrelated healthy subjects from the Human Connectome Project...
August 5, 2020: Human Brain Mapping
Aihemaiti Hasimu, Qiang Fu, Hui Wang, Qing-Jiu Zhou, Shao-Shan Li, Dangmu-Jiafu Geng, Chen Liu, Bo Liu
INTRODUCTION: A meningeal hemangiopericytoma (MHPC) is an aggressive tumor characterized by a high rate of local recurrence and late distant metastasis. The objective of this study was to share our experience with the treatment of a MHPC and how to distinguish this tumor from a meningioma. PATIENT CONCERNS: A 62-year-old woman presented with symptoms of hypomnesia, hyperopia, and double vision for 1 month. Complete tumor excision was performed 6 years before. A biopsy sample was diagnosed as an atypical meningioma...
July 31, 2020: Medicine (Baltimore)
Xianfeng Gao, Fagui Yue, Fenglei Zhang, Yang Sun, Yang Zhang, Xiaobo Zhu, Wei Wang
RATIONALE: Intracranial aneurysm with the first manifestation of acute subdural hematoma (aSDH) is rare in the field of neurosurgery. Usually subarachnoid hemorrhage or intracranial hematoma happens after the rupture of an intracranial aneurysm, whereas trauma is the primary cause of aSDH. PATIENT CONCERNS: Here, we present the case of a 71-year-old woman who presented with spontaneous aSDH with progressive headache and vomiting. DIAGNOSIS: Urgent head computed tomography (CT) identified an aSHD, but the patient had no history of trauma...
July 31, 2020: Medicine (Baltimore)
Junting Liu, Jie Lin, Xiaozhen Guan, Li Liu, Xue Pan, Lingling Zhou, Yuanyuan Luo, Deqing Wang
OBJECTIVE: To investigate the prevalence of preoperative anaemia and the risks associated with perioperative anaemia and blood transfusion in patients who underwent neurological surgery. BACKGROUND: Perioperative anaemia has an important impact on neurosurgery patients. The prevalence and risks of perioperative anaemia and blood transfusion in Chinese patients are still unknown. METHODS: Logistic regression was used to predict adverse outcomes of red blood cell (RBC) transfusion and different levels of anaemia...
August 4, 2020: Transfusion Medicine
Ryan F Amidon, Christ Ordookhanian, Talia Vartanian, Paul Kaloostian
While tuberculosis is globally very prevalent, especially in the developing world, tuberculosis of the central nervous system (CNS) (including Pott's `disease) is an extremely rare occurrence for neurology/neurosurgery departments in the modern era. It is normally treated via rifampin, isoniazid, pyrazinamide, and ethambutol (RIPE) therapy with the need for surgical intervention deemed by the presence of neurological deficiency or abscess, spinal instability, or significant kyphosis. Here we describe a case of an elderly woman with Pott's disease and a history of HIV presenting with neurologic deficiencies in both legs and an infected mass causing mid-thoracic compression and kyphotic deformity...
June 27, 2020: Curēus
Yi-Jun Shi, Guang-Hui Zheng, Ling-Ye Qian, Rasha Alsamani Qsman, Guo-Ge Li, Guo-Jun Zhang
Purpose: Our study is a retrospective observational study conducted in one of the largest clinical centers of neurosurgery in China. We aimed to investigate the antimicrobial susceptibility patterns of the Enterobacteriaceae isolates responsible for nosocomial meningitis/encephalitis in post-neurosurgical patients. Meanwhile, we tried to evaluate the risk factors for mortality following Enterobacteriaceae meningitis/encephalitis. Patients and Methods: Medical data on clinical characteristics, antibiotic susceptibilities, and mortality were reviewed until patients' discharge or death in the hospital...
2020: Infection and Drug Resistance
Prasheelkumar Premnarayan Gupta, Atul Manohar Dhok, Salman T Shaikh, Akshay Shrirang Patil, Deepak Gupta, Nitin Nandkumar Jagdhane
Objectives  Craniovertebral junction (CVJ) is a unique, mobile and complicated component of our spine which necessitates specific study pertaining to its structure as well as pathologies. This study aims to report the normative data detailing the CVJ anatomy among the rural population of Central India which would help us in understanding the joint dynamics. Materials and Methods  A retrospective observational study was undertaken in the Department of Neurosurgery and Radiology, Mahatma Gandhi Institute of Medical Sciences, Sewagram, Maharashtra, from December 2018 to May 2019...
July 2020: Journal of Neurosciences in Rural Practice
Aishvarya Shree Nedunchezhian, Neeraja Ajayan, Ajay Prasad Hrishi P, Unnikrishnan Prathapadas, Manikandan Sethuraman, Thomas Koshy
"Coronavirus disease 2019" (COVID-19) transmitted by a novel coronavirus via contact or droplet spread is a highly infectious disease, the containment of which requires vigilance and stringent infection control policies. In the backdrop of hospitals becoming hot zones and an increasing number of health care workers contracting the disease, it is crucial to formulate an approach while administering anesthesia during the testing times of COVID-19 pandemic. In this background, this comprehensive article deals with the perioperative management during this pandemic and includes risk stratification based on an innovative simple scoring system, rationale use of personal protective equipments, and infection prevention protocols...
July 2020: Journal of Neurosciences in Rural Practice
G Virbel, H Cebula, A Coca, B Lhermitte, L Bauchet, G Noël
Neurocytomas represent 0,25 to 0,5 of brain tumours. These tumours have neuronal differentiation. It's a young adult disease. The main treatment is neurosurgery. The place of other therapies is still unclear, noticeably with regards to radiotherapy. This review aim is to determine the place and the modalities of radiotherapy in the management of neurocytomas. A literature search using PubMed allowed to select the most relevant studies. Finally, 22 studies were selected according to pre-established criteria to answer the problem...
August 1, 2020: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
Lise Kjær Andersen, Anne-Mette Hvas, Christine Lodberg Hvas
BACKGROUND AND OBJECTIVE: An increasing number of patients receive antiplatelet therapy. Patients exposed to surgery while receiving platelet inhibitors hold an increased bleeding risk. Especially in neurosurgery and neurocritical care patients, bleeding and hematoma expansion are feared complications as even minor bleedings may be hazardous. The objective of this systematic review was to investigate the effect of desmopressin (1-deamino-8-D-arginine vasopressin, DDAVP) on platelet function during antiplatelet therapy in patients undergoing non-cardiac surgery, patients who experience spontaneous or traumatic hemorrhage, healthy individuals and in animals...
August 4, 2020: Neurocritical Care
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