Daniele Ghezzi, Gabriela Graziani, Martina Cappelletti, Inna V Fadeeva, Matteo Montesissa, Enrico Sassoni, Giorgia Borciani, Katia Barbaro, Marco Boi, Nicola Baldini, Julietta V Rau
Infections of implants and prostheses represent relevant complications associated with the implantation of biomedical devices in spine surgery. Indeed, due to the length of the surgical procedures and the need to implant invasive devices, infections have high incidence, interfere with osseointegration, and are becoming increasingly difficult to threat with common therapies due to the acquisition of antibiotic resistance genes by pathogenic bacteria. The application of metal-substituted tricalcium phosphate coatings onto the biomedical devices is a promising strategy to simultaneously prevent bacterial infections and promote osseointegration/osseoinduction...
2024: Frontiers in Bioengineering and Biotechnology