keyword
https://read.qxmd.com/read/38542220/the-role-of-neutral-sphingomyelinase-2-nsm2-in-the-control-of-neutral-lipid-storage-in-t-cells
#21
JOURNAL ARTICLE
Rebekka Schempp, Janna Eilts, Marie Schöl, Maria Fernanda Grijalva Yépez, Agnes Fekete, Dominik Wigger, Fabian Schumacher, Burkhard Kleuser, Marco van Ham, Lothar Jänsch, Markus Sauer, Elita Avota
The accumulation of lipid droplets (LDs) and ceramides (Cer) is linked to non-alcoholic fatty liver disease (NAFLD), regularly co-existing with type 2 diabetes and decreased immune function. Chronic inflammation and increased disease severity in viral infections are the hallmarks of the obesity-related immunopathology. The upregulation of neutral sphingomyelinase-2 (NSM2) has shown to be associated with the pathology of obesity in tissues. Nevertheless, the role of sphingolipids and specifically of NSM2 in the regulation of immune cell response to a fatty acid (FA) rich environment is poorly studied...
March 13, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542126/research-progress-on-lipophagy-mediated-exercise-intervention-in-non-alcoholic-fatty-liver-disease
#22
REVIEW
Xi Li, Yangjun Yang, Yi Sun, Shuzhe Ding
Lipophagy is a cellular pathway targeting the lysosomal degradation of lipid droplets, playing a role in promoting lipid turnover and renewal. Abnormal lipophagy processes can lead to the occurrence and development of non-alcoholic fatty liver disease (NAFLD), characterized by the deposition of lipid droplets (LDs) in the liver. The importance of exercise training in preventing and improving NAFLD has been well-established, but the exact mechanisms remain unclear. Recent research findings suggest that lipophagy may serve as a crucial hub for liver lipid turnover under exercise conditions...
March 9, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542065/regeneration-of-non-alcoholic-fatty-liver-cells-using-chimeric-fgf21-hgfr-a-novel-therapeutic-approach
#23
JOURNAL ARTICLE
Sung-Jun Kim, So-Jung Kim, Jeongeun Hyun, Hae-Won Kim, Jun-Hyeog Jang
Non-alcoholic fatty liver disease (NAFLD) has emerged as a significant liver ailment attributed to factors like obesity and diabetes. While ongoing research explores treatments for NAFLD, further investigation is imperative to address this escalating health concern. NAFLD manifests as hepatic steatosis, precipitating insulin resistance and metabolic syndrome. This study aims to validate the regenerative potential of chimeric fibroblast growth factor 21 (FGF21) and Hepatocyte Growth Factor Receptor (HGFR) in NAFLD-afflicted liver cells...
March 7, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38541842/the-fatty-liver-index-s-association-with-incident-chronic-kidney-disease-in-korean-middle-aged-adults-a-community-based-cohort-study
#24
JOURNAL ARTICLE
Hyun Hee Lee, Han Ro, Ji Yong Jung, Jae Hyun Chang, Wookyung Chung, Ae Jin Kim
(1) Background : The relationship between nonalcoholic fatty liver disease (NAFLD) and incident chronic kidney disease (CKD) is unclear, and long-term follow-up data are limited. Therefore, this study aimed to evaluate whether NAFLD, as assessed by the fatty liver index (FLI), could predict the development of CKD in a community-based Korean cohort over 16 years. (2) Methods : Among the 10,030 total participants, 7778 patients without CKD were selected from the Korean Genome and Epidemiology Study (KoGES). The FLI grade ranged from 0 to 100 and was divided into three groups: low (FLI, <30), intermediate (FLI, 30-59), and high (FLI, ≥60)...
March 12, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541155/insulin-like-growth-factor-binding-proteins-and-cellular-senescence-are-involved-in-the-progression-of-non-alcoholic-fatty-liver-disease-and-fibrosis-in-a-mouse-model
#25
JOURNAL ARTICLE
Carolina Guzmán, Miriam G Bautista-Ubaldo, Adriana Campos-Espinosa, Ivette I Romero-Bello, Ángel Daniel Santana-Vargas, Gabriela Gutierrez-Reyes
Background and Objectives : Non-alcoholic fatty liver disease (NAFLD) is highly prevalent worldwide. It progresses from simple steatosis to non-alcoholic steatohepatitis (NASH). Fibrosis is often present during NAFLD progression; however, factors determining which subjects develop NASH or fibrosis are unclear. Insulin-like growth factor binding proteins (IGFBPs) are a family of secreted proteins involved in senescence and scarring, mainly synthetized in the liver. Here, we aimed to study the association of IGFBPs and their induced senescence with the progression of NAFLD and liver fibrosis...
March 2, 2024: Medicina
https://read.qxmd.com/read/38541107/alcoholic-liver-disease-nonalcoholic-fatty-liver-disease-index-at-diagnosis-is-associated-with-all-cause-mortality-during-follow-up-in-patients-with-antineutrophil-cytoplasmic-antibody-associated-vasculitis
#26
JOURNAL ARTICLE
Minsuk Cho, Woongchan Rah, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee
Background and Objectives : The purpose of this study was to investigate whether a new index related to chronic liver disease, the alcoholic liver disease/nonalcoholic fatty liver disease index (ANI) at diagnosis, is associated with all-cause mortality during follow-up in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). Materials and Methods : In this study, we included 270 patients with AAV. ANI was calculated using the following equation: ANI = -58.5 + 0.637 (adjusted mean corpuscular volume) + 3...
February 24, 2024: Medicina
https://read.qxmd.com/read/38541057/significant-increase-in-oxidative-stress-indices-in-erythrocyte-membranes-of-obese-patients-with-metabolically-associated-fatty-liver-disease
#27
JOURNAL ARTICLE
Valeria Tutino, Valentina De Nunzio, Rossella Donghia, Emanuela Aloisio Caruso, Anna Maria Cisternino, Palma Aurelia Iacovazzi, Anna Margherita Mastrosimini, Elizabeth Alicia Fernandez, Vito Giannuzzi, Maria Notarnicola
Metabolic dysfunction-associated hepatic steatosis (MAFLD) indicates the metabolic risk associated with hepatic steatosis, overweight and obesity, and clinical evidence of metabolic dysregulation. Since MAFLD is one of the diseases that show a high frequency of alterations in the lipid content of cell membranes, the aim of this study was to evaluate the indices of oxidative damage of erythrocyte membranes in overweight and obese MAFLD subjects. The study was conducted on serum samples and red blood cell membranes of overweight and obese MAFLD subjects...
March 18, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38541023/telemedicine-as-an-option-for-monitoring-metabolic-dysfunction-associated-fatty-liver-disease-mafld-patients-facing-the-covid-19-pandemic-a-systematic-review-and-meta-analysis
#28
REVIEW
Femmy Nurul Akbar, Safira Rosiana Choirida, Ahmad Zaqi Muttaqin, Fika Ekayanti, Hoirun Nisa, Hari Hendarto
Healthcare visits were reduced during the COVID-19 pandemic, causing disturbances in sustainable MAFLD monitoring. Telemedicine acts to maintain connectivity between patients and healthcare professionals. This review aimed to assess the role of telemedicine in monitoring MAFLD during the pandemic. Databases searched included l PubMed Central and ScienceDirect from 2020 to 2023. Assessment with The Cochrane Risk of Bias for randomized controlled trials (RCTs) and the Newcastle-Ottawa scale for non-RCTs systematic reviews...
March 2, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38540416/whole-exome-sequencing-wes-reveals-novel-sex-specific-gene-variants-in-non-alcoholic-steatohepatitis-mash
#29
JOURNAL ARTICLE
Jing Wei, Boyang Jason Wu, Sayed S Daoud
Non-alcoholic steatohepatitis (NASH, also known as MASH) is a severe form of non-alcoholic fatty liver disease (NAFLD, also known as MASLD). Emerging data indicate that the progression of the disease to MASH is higher in postmenopausal women and that genetic susceptibility increases the risk of MASH-related cirrhosis. This study aimed to investigate the association between genetic polymorphisms in MASH and sexual dimorphism. We applied whole-exome sequencing (WES) to identify gene variants in 8 age-adjusted matched pairs of livers from both male and female patients...
March 13, 2024: Genes
https://read.qxmd.com/read/38540406/unveiling-the-impact-of-apof-deficiency-on-liver-and-lipid-metabolism-insights-from-transcriptome-wide-m6a-methylome-analysis-in-mice
#30
JOURNAL ARTICLE
Xuebin Shen, Mengting Chen, Jian Zhang, Yifan Lin, Xinyue Gao, Jionghong Tu, Kunqi Chen, An Zhu, Shanghua Xu
Lipid metabolism participates in various physiological processes and has been shown to be connected to the development and progression of multiple diseases, especially metabolic hepatopathy. Apolipoproteins (Apos) act as vectors that combine with lipids, such as cholesterol and triglycerides (TGs). Despite being involved in lipid transportation and metabolism, the critical role of Apos in the maintenance of lipid metabolism has still not been fully revealed. This study sought to clarify variations related to m6A methylome in ApoF gene knockout mice with disordered lipid metabolism based on the bioinformatics method of transcriptome-wide m6A methylome epitranscriptomics...
March 9, 2024: Genes
https://read.qxmd.com/read/38540305/bridging-metabolic-associated-steatotic-liver-disease-and-cardiovascular-risk-a-potential-role-for-ketogenesis
#31
REVIEW
Rafael Suárez Del Villar-Carrero, Agustín Blanco, Lidia Daimiel Ruiz, Maria J García-Blanco, Ramón Costa Segovia, Rocío García de la Garza, Diego Martínez-Urbistondo
The prevalence of cardiovascular diseases (CVDs) is a growing global health concern. Recent advances have demonstrated significant reductions in acute cardiovascular events through the management of modifiable cardiovascular risk factors. However, these factors are responsible for about 50% of the global cardiovascular disease burden. Considering that CVDs are one of the top mortality causes worldwide, the concept of residual cardiovascular risk is an important emerging area of study. Different factors have been proposed as sources of residual risk markers, including non-HDL particles characterization, as well as inflammation measured by serum and imaging technics...
March 20, 2024: Biomedicines
https://read.qxmd.com/read/38540237/different-coactivator-recruitment-to-human-ppar%C3%AE-%C3%AE-%C3%AE-ligand-binding-domains-by-eight-ppar-agonists-to-treat-nonalcoholic-fatty-liver-disease
#32
JOURNAL ARTICLE
Shotaro Kamata, Akihiro Honda, Nonoka Kashiwagi, Ayumi Shimamura, Sayaka Yashiro, Yuna Komori, Aoi Hosoda, Noriyuki Akahoshi, Isao Ishii
Three peroxisome proliferator-activated receptor subtypes, PPARα, PPAR(ß/)δ, and PPARγ, exert ligand-dependent transcriptional control in concert with retinoid X receptors (RXRs) on various gene sets harboring PPAR response elements (PPREs) in their promoter regions. Ligand-bound PPAR/RXR complexes do not directly regulate transcription; instead, they recruit multiprotein coactivator complexes to specific genomic regulatory loci to cooperatively activate gene transcription. Several coactivators are expressed in a single cell; however, a ligand-bound PPAR can be associated with only one coactivator through a consensus LXXLL motif...
March 11, 2024: Biomedicines
https://read.qxmd.com/read/38540163/double-trouble-how-microbiome-dysbiosis-and-mitochondrial-dysfunction-drive-non-alcoholic-fatty-liver-disease-and-non-alcoholic-steatohepatitis
#33
REVIEW
Wesam Bahitham, Siraj Alghamdi, Ibrahim Omer, Ali Alsudais, Ilana Hakeem, Arwa Alghamdi, Reema Abualnaja, Faisal M Sanai, Alexandre S Rosado, Consolato M Sergi
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are closely related liver conditions that have become more prevalent globally. This review examines the intricate interplay between microbiome dysbiosis and mitochondrial dysfunction in the development of NAFLD and NASH. The combination of these two factors creates a synergistic situation referred to as "double trouble", which promotes the accumulation of lipids in the liver and the subsequent progression from simple steatosis (NAFLD) to inflammation (NASH)...
February 29, 2024: Biomedicines
https://read.qxmd.com/read/38540128/updated-insights-into-probiotics-and-hepatobiliary-diseases
#34
REVIEW
Xiaoyu Xu, Cheng Zhang, Guoyi Tang, Ning Wang, Yibin Feng
Hepatobiliary diseases have a high prevalence worldwide, with a wide range of diseases involved in the liver and biliary system. Modifications in gut microbiota have been proven to have an association with unbalanced intestinal homeostasis and the dysfunction of host metabolism and the immune system, which can be the risk factors for many hepatobiliary diseases, such as nonalcoholic fatty liver disease (NAFLD), alcoholic liver disease (ALD), nonalcoholic fatty steatohepatitis (NASH), hepatitis, cirrhosis, hepatocellular carcinoma (HCC) and cholestasis, as well as infection due to liver transplantation...
February 25, 2024: Biomedicines
https://read.qxmd.com/read/38540097/genistein-and-sex-hormone-supplementation-modulated-hepatic-ppar%C3%AE-%C3%AE-and-%C3%AE-subtypes-and-stat1-expressions-in-a-nash-rat-model-with-bilateral-orchidectomy
#35
JOURNAL ARTICLE
Fatist Okrit, Maneerat Chayanupatkul, Prasong Siriviriyakul, Natcha Wanpiyarat, Duangporn Werawatganon
Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease (NAFLD) that is characterized by hepatic inflammation and steatosis. Currently, limited data exist regarding the risk of NASH in transgender women and the treatment options for this particular population. The use of testosterone supplementation is unfavorable for transgender women, and estrogen supplementation is linked to an increased risk of breast cancer; thus, an isoflavone derivative compound known as "genistein" could serve as a viable substitute for a hormone supplement in this context...
February 21, 2024: Biomedicines
https://read.qxmd.com/read/38539902/effect-of-gracilaria-vermiculophylla-macroalga-on-non-alcoholic-fatty-liver-disease-in-obese-rats
#36
JOURNAL ARTICLE
Maitane González-Arceo, Leixuri Aguirre, María Teresa Macarulla, Clàudia Gil-Pitarch, María Luz Martínez-Chantar, María P Portillo, Saioa Gómez-Zorita
Marine algae are valuable sources of bioactive compounds that have the potential to be used in the management of various pathologies. Despite the increasing prevalence of NAFLD, the absence of an approved effective pharmacological treatment with demonstrable effectiveness persists. In this context, the aim of the present study is to assess the effect of Gracilaria vermiculophylla red seaweed dietary supplementation on hepatic lipid accumulation, as well as on oxidative stress, inflammation and fibrosis- related markers on obese fa / fa Zucker rats fed with a standard diet, supplemented or not with 2...
March 18, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38539888/nanoemulsions-of-phoenix-dactylifera-l-decaffeinated-and-coffea-arabica-l-extracts-as-a-novel-approach-for-the-treatment-of-carbon-tetrachloride-mediated-liver-fibrosis
#37
JOURNAL ARTICLE
Eman S Alamri, Hala M Bayomy, Mohamed A Mohamady Hussein, Nawal A Ozaybi, Seham E Almasoudi, Nahla S Zidan, Renad A Albalwi, Hebatallah H Atteia, Fayza M El-Ezaly
Liver fibrosis is a condition characterized by the excessive buildup of scar tissue in the liver. This scarring occurs as a result of chronic liver damage, often caused by conditions such as hepatitis, alcohol abuse, certain metabolic disorders, genetic abnormalities, autoimmunity, and noninfectious diseases such as fatty liver which leads to liver fibrosis. Nanoparticles have gained attention in recent years as potential therapeutic agents for liver fibrosis. They offer unique advantages due to their small size, large surface area, and ability to carry drugs or target specific cells or tissues...
March 16, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38539862/roles-of-traditional-and-next-generation-probiotics-on-non-alcoholic-fatty-liver-disease-nafld-and-non-alcoholic-steatohepatitis-nash-a-systematic-review-and-network-meta-analysis
#38
REVIEW
Yuezhi Zhu, Jen Kit Tan, Jia Liu, Jo Aan Goon
Non-alcoholic fatty liver disease (NAFLD) and its progressive stage, non-alcoholic steatohepatitis (NASH), are becoming one of the most common chronic liver diseases globally. Lifestyle interventions such as weight reduction, increased physical activity, and maintaining healthy diets play a pivotal role in managing NAFLD/NASH. Recent studies suggest that the gut microbiome is associated with the pathogenesis of NAFLD/NASH, prompting microbiome-targeted therapy to emerge as a new therapeutic option for NAFLD/NASH...
March 7, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38539808/a-novel-plant-based-nutraceutical-combined-with-exercise-can-revert-oxidative-status-in-plasma-and-liver-in-a-diet-induced-obesity-animal-model
#39
JOURNAL ARTICLE
Ana Guzmán-Carrasco, Garyfallia Kapravelou, María López-Jurado, Francisco Bermúdez, Eduardo Andrés-León, Laura C Terrón-Camero, José Prados, Consolación Melguizo, Jesus M Porres, Rosario Martínez
The prevalence of obesity increases alarmingly every year mostly due to external factors such as high-fat and high-refined sugar intake associated with a sedentary lifestyle. It triggers metabolic disorders such as insulin resistance, hyperlipemia, non-alcoholic fatty liver disease, chronic inflammation, oxidative stress, and gut microbiota dysbiosis. The aim of this study was to evaluate the beneficial effects of a combined intervention with caloric restriction, nutraceutical intake, and a mixed training protocol on oxidative stress, inflammation, and gut dysbiosis derived from the development of obesity in a C57BL6/J mouse experimental model of diet-induced obesity (4...
February 23, 2024: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/38539547/metabolic-dysfunction-associated-steatohepatitis-and-progression-to-hepatocellular-carcinoma-a-literature-review
#40
REVIEW
Haider Ghazanfar, Nismat Javed, Abeer Qasim, George Sarin Zacharia, Ali Ghazanfar, Abhilasha Jyala, Elona Shehi, Harish Patel
The prevalence of metabolic-associated fatty liver disease (MAFLD) is increasing globally due to factors such as urbanization, obesity, poor nutrition, sedentary lifestyles, healthcare accessibility, diagnostic advancements, and genetic influences. Research on MAFLD and HCC risk factors, pathogenesis, and biomarkers has been conducted through a narrative review of relevant studies, with a focus on PubMed and Web of Science databases and exclusion criteria based on article availability and language. Steatosis marks the early stage of MASH advancement, commonly associated with factors of metabolic syndrome such as obesity and type 2 diabetes...
March 20, 2024: Cancers
keyword
keyword
4599
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.