keyword
https://read.qxmd.com/read/38537007/independent-predictors-for-non-alcoholic-fatty-liver-disease-in-patients-with-treatment-na%C3%A3-ve-chronic-hepatitis-b
#1
JOURNAL ARTICLE
Gulsah Tuncer, Ceyda Geyiktepe-Guclu, Osman Faruk Bayramlar, Burcu Atasoy Bozan, Cigdem Yucel, Betul Copur, Kadir Gorkem Guclu, Mustafa Yıldırım, Gonul Sengöz, Filiz Pehlivanoglu
OBJECTIVE: There are limited data on non-alcoholic fatty liver disease in chronic hepatitis B virus infection. We aimed to determine the predictors for non-alcoholic fatty liver disease in patients with treatment-naïve chronic hepatitis B virus infection. METHODS: All consecutive treatment-naïve patients with chronic hepatitis B virus infection at the Haseki Training and Research Hospital between October 1, 2021, and September 31, 2022, were retrospectively enrolled...
2024: Revista da Associação Médica Brasileira
https://read.qxmd.com/read/38536569/trimethylamine-n-oxide-a-new-risk-factor-for-non-alcoholic-fatty-liver-disease-changes-the-expression-of-mirna-34a-and-mirna-122-in-the-fatty-liver-cell-model
#2
JOURNAL ARTICLE
Zhila Bahramirad, Mohammad Raman Moloudi, Mohammad Moradzad, Alina Abdollahi, Zakaria Vahabzadeh
Non-alcoholic fatty liver disease is a multifactorial disorder with complicated pathophysiology ranging from simple steatosis to steatohepatitis and liver fibrosis. Trimethylamine-N-oxide (TMAO) production is believed to be correlated with choline deficiency. This study investigated the expression of miRNA-34a, miRNA-122, and miRNA-192 in the fatty liver cell model treated with different concentrations of TMAO. A fatty liver cell model was developed by exposing HepG2 cells to a mixture of palmitate and oleate in a ratio of 1:2 at a final concentration of 1200 μM for 24 h...
March 27, 2024: Biochemical Genetics
https://read.qxmd.com/read/38535961/investigation-of-the-association-between-air-pollution-and-non-alcoholic-fatty-liver-disease-in-the-european-population-a-mendelian-randomization-study
#3
JOURNAL ARTICLE
Jing Yang, Yaqi Zhang, Yin Yuan, Zhongyang Xie, Lanjuan Li
Non-alcoholic fatty liver disease (NAFLD) is currently the most prevalent chronic liver disease worldwide. At the same time, the relationship between air pollution and the likelihood of developing NAFLD has been a subject of debate due to conflicting findings in previous observational research. Our objective was to examine the potential correlation between air pollutant levels and the risk of NAFLD in the European population by employing a two-sample Mendelian randomization (MR) analysis. The UK Biobank Consortium provided the summary statistics for various air pollution indicators (PM2...
March 21, 2024: Toxics
https://read.qxmd.com/read/38535313/interleukins-pathogenesis-in-non-alcoholic-fatty-liver-disease
#4
REVIEW
Saira Rafaqat, Sanja Gluscevic, Filiz Mercantepe, Sana Rafaqat, Aleksandra Klisic
Inflammatory cytokines have been implicated as crucial contributors to the onset and progression of non-alcoholic fatty liver disease (NAFLD). The exact mechanisms by which interleukins (ILs) contribute to NAFLD may vary, and ongoing research is aimed at understanding the specific roles of different ILs in the pathogenesis of this condition. In addition, variations in environmental factors and genetics in each individual can influence the onset and/or progression of NAFLD. The lack of clinical studies related to the potential therapeutic properties of IL-1 inhibitors currently does not allow us to conclude their validity as a therapeutic option, although preclinical studies show promising results...
March 6, 2024: Metabolites
https://read.qxmd.com/read/38535100/metabolic-dysfunction-associated-liver-disease-in-patients-undergoing-coronary-computed-tomography-angiography
#5
JOURNAL ARTICLE
Rares Ilie Orzan, Rares Ioan Gligor, Renata Agoston, Carmen Cionca, Alexandru Zlibut, Raluca Pais, Andrada Seicean, Lucia Agoston-Coldea
In this single-center cross-sectional study on patients undergoing coronary computed tomography angiography (CCTA), we assessed the prognostic significance of metabolic dysfunction associated steatotic liver disease (MASLD), metabolic syndrome (MetS), and CCTA-derived parameters for predicting major adverse cardiovascular events (MACE). Over a mean follow-up of 26.9 months, 2038 patients were analyzed, with 361 (17.7%) experiencing MACE. MASLD was associated with a higher MACE incidence (25.90% vs. 14.71% without MASLD, p < 0...
February 26, 2024: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/38534968/clinical-practice-guidelines-for-the-diagnosis-and-management-of-hereditary-fructose-intolerance
#6
JOURNAL ARTICLE
Félix Úbeda, Sonia Santander, María José Luesma
INTRODUCTION: Hereditary fructose intolerance or hereditary fructosemia is an autosomal recessive metabolic disorder caused by a loss of function in the aldolase B gene. This disorder affects 1 in 20,000 people, constituting a rare disease with a favorable prognosis through adherence to a fructose-free diet. Despite dietary management, chronic pathology may manifest, underscoring the importance of early diagnosis to mitigate adverse effects. However, early detection of the disease poses significant challenges...
February 23, 2024: Diseases (Basel)
https://read.qxmd.com/read/38534764/bioconversion-pharmacokinetics-and-therapeutic-mechanisms-of-ginsenoside-compound-k-and-its-analogues-for-treating-metabolic-diseases
#7
REVIEW
Md Niaj Morshed, Reshmi Akter, Md Rezaul Karim, Safia Iqbal, Se Chan Kang, Deok Chun Yang
Rare ginsenoside compound K (CK) is an intestinal microbial metabolite with a low natural abundance that is primarily produced by physicochemical processing, side chain modification, or metabolic transformation in the gut. Moreover, CK exhibits potent biological activity compared to primary ginsenosides, which has raised concerns in the field of ginseng research and development, as well as ginsenoside-related dietary supplements and natural products. Ginsenosides Rb1, Rb2, and Rc are generally used as a substrate to generate CK via several bioconversion processes...
March 11, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534735/microbial-based-bioactive-compounds-to-alleviate-inflammation-in-obesity
#8
REVIEW
Oladayo Emmanuel Apalowo, Grace Adeola Adegoye, Tolulope Mobolaji Obuotor
The increased prevalence of obesity with several other metabolic disorders, including diabetes and non-alcoholic fatty liver disease, has reached global pandemic proportions. Lifestyle changes may result in a persistent positive energy balance, hastening the onset of these age-related disorders and consequently leading to a diminished lifespan. Although suggestions have been raised on the possible link between obesity and the gut microbiota, progress has been hampered due to the extensive diversity and complexities of the gut microbiota...
February 28, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38533910/unveiling-global-research-trends-and-hotspots-on-mitochondria-in-nafld-from-2000-to-2023-a-bibliometric-analysis
#9
JOURNAL ARTICLE
Jingqin Hu, Ze Chen, Yibing Zhou, Yinglun Li, Jing Liu, Yuqiang Mi, Li Wang, Feng Jiang, Ping Li
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) has garnered significant attention in the past decade as a prevalent chronic liver condition. Despite a growing body of evidence implicating mitochondria in NAFLD development, comprehensive bibliometric analyses within this research domain are scarce. This study aims to provide a thorough overview of the knowledge framework and key research areas related to mitochondria in the context of NAFLD, utilizing bibliometric techniques. METHODS: A comprehensive search of publications on mitochondria in NAFLD from 2000 to 2023 was conducted using the Web of Science Core Collection database...
March 2024: Immunity, Inflammation and Disease
https://read.qxmd.com/read/38533551/inhibitory-protein-protein-interactions-of-the-sirt1-deacetylase-are-choreographed-by-post-translational-modification
#10
JOURNAL ARTICLE
Troy C Krzysiak, You-Jin Choi, Yong Joon Kim, Yunhan Yang, Christopher DeHaven, Lariah Thompson, Ryan Ponticelli, Mara M Mermigos, Laurel Thomas, Andrea Marquez, Ian Sipula, Jongsook Kim Kemper, Michael Jurczak, Gary Thomas, Angela M Gronenborn
Regulation of SIRT1 activity is vital to energy homeostasis and plays important roles in many diseases. We previously showed that insulin triggers the epigenetic regulator DBC1 to prime SIRT1 for repression by the multifunctional trafficking protein PACS-2. Here, we show that liver DBC1/PACS-2 regulates the diurnal inhibition of SIRT1, which is critically important for insulin-dependent switch in fuel metabolism from fat to glucose oxidation. We present the x-ray structure of the DBC1 S1-like domain that binds SIRT1 and an NMR characterization of how the SIRT1 N-terminal region engages DBC1...
April 2024: Protein Science
https://read.qxmd.com/read/38533529/adar2-deficiency-ameliorates-non-alcoholic-fatty-liver-disease-and-muscle-atrophy-through-modulating-serum-amyloid-a1
#11
JOURNAL ARTICLE
Mei-Lang Kung, Tai-Hua Yang, Chia-Chi Lin, Jia-Yun Ho, Tzu-Chi Hung, Chih-Hsiang Chang, Kuan-Wen Huang, Chien-Chin Chen, Yun-Wen Chen
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease worldwide. Sarcopenia is a syndrome characterized by progressive and generalized loss of skeletal muscle mass and strength, which is commonly associated with NAFLD. Adenosine-to-inosine editing, catalysed by adenosine deaminase acting on RNA (ADAR), is an important post-transcriptional modification of genome-encoded RNA transcripts. Three ADAR gene family members, including ADAR1, ADAR2 and ADAR3, have been identified...
March 27, 2024: Journal of Cachexia, Sarcopenia and Muscle
https://read.qxmd.com/read/38533281/efficacy-of-pistacia-lentiscus-plant-rumi-mastagi-in-comparison-to-levosulpiride-in-patients-with-diabetic-gastroparesis-a-double-blind-non-inferior-randomised-control-trial-study
#12
JOURNAL ARTICLE
Ajaypal Singh, Ravi Kant, Rohit Raina, Vandana Dhingra, Rajeev Nema, Mukesh Chand Bairwa, Varsha Kanwar, Rifika L Sukhes Mukherjee, Anissa Atif Mirza, Mayank Agarwal
INTRODUCTION: Gastrointestinal neuropathies are frequently found in diabetic patients. The pathogenesis of diabetic gastroparesis (DG) is multifactorial. The usual treatment for DG includes dietary modifications, prokinetic and antiemetic agents. There is increasing demand for more effective medicines to treat DG. The current study was conducted on the Pistacia lentiscus stem extract to add to the armamentarium of DG treatment and to find the efficacy of P. lentiscus plant extract (mastic gum) in comparison to levosulpiride in DG for improvement in gastroparesis symptoms and gastric emptying scintigraphy (GES) in a single centric double-blind non-inferiority randomised control trial...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38533279/sglt2-inhibitors-paradigm-shift-from-diabetes-care-to-metabolic-care-an-indian-perspective
#13
REVIEW
K M Prasanna Kumar, A G Unnikrishnan, Pankaj Jariwala, Ashwani Mehta, Richa Chaturvedi, Sagar Panchal, Preet Lakhani, Rachana Acharya, Jitendra Dixit
The prevalence and burden of diabetes are on the rise in India, making it 'the diabetes capital of the world'. Comorbidities such as obesity, cardiovascular (CV) complications, chronic kidney disease (CKD), non-alcoholic fatty liver disease (NAFLD), and neurodegenerative diseases are common in patients with diabetes. Recent breakthroughs in diabetes medications and continuous glucose monitoring have resulted in a paradigm shift in diabetes care. Hence, a review in the Indian context is warranted. This review focuses on the existing evidence (gathered by a systematic literature search utilising online databases such as PubMed) on the metabolic, cardio-renoprotective, and hepatoprotective effects of sodium-glucose co-transporter 2 (SGLT2) inhibition, particularly in the Indian setting...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38532896/investigating-the-impact-of-elevated-urinary-trace-elements-on-non-alcoholic-fatty-liver-disease-using-vibration-controlled-transient-elastography
#14
JOURNAL ARTICLE
Chenxiao Wang, Xin Shang, Yu Fu, Panpan Guo, Ping Wang, Shuxun Yan
INTRODUCTION: Non-alcoholic fatty liver disease (NAFLD) is a global public health concern. However, limited data are available on urinary trace elements and NAFLD caused by various exposure factors. This study aimed to investigate the relationship between the presence of 16 trace elements in urine and NAFLD using data from the National Health and Nutrition Examination Survey (NHANES). METHODS: By utilizing the NHANES data from 2017 to 2018, 1613 participants who fulfilled the research criteria were identified from the initial pool of 2979 participants with available urine trace element detection data...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38532480/dihydromyricetin-ameliorates-hepatic-steatosis-and-insulin-resistance-via-ampk-pgc-1%C3%AE-and-ppar%C3%AE-mediated-autophagy-pathway
#15
JOURNAL ARTICLE
Yan Yang, Wen Qiu, Jiyuan Xiao, Jie Sun, Xuan Ren, Luxia Jiang
BACKGROUND: Dihydromyricetin (DHM), a flavonoid compound of natural origin, has been identified in high concentrations in ampelopsis grossedentata and has a broad spectrum of biological and pharmacological functions, particularly in regulating glucose and lipid metabolism. The objective of this research was to examine how DHM affected nonalcoholic fatty liver disease (NAFLD) and its underlying mechanisms involved in the progression of NAFLD in a rat model subjected to a high-fat diet (HFD)...
March 26, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38532322/glp-1-glp-1ras-new-options-for-the-drug-treatment-of-nafld
#16
REVIEW
Haoran Jiang, Linquan Zang
Non-alcoholic fatty liver disease (NAFLD) has recently emerged as a global public health concern. Currently, the cornerstone of NAFLD treatment is lifestyle modification and, if necessary, weight loss. However, compliance is a challenge, and this approach alone may not be sufficient to halt and treat the more serious disease development, so medication is urgently needed. Nevertheless, no medicines are approved to treat NAFLD. Glucagon-like peptide-1 (GLP-1) is an enteropeptide hormone that inhibits glucagon synthesis, promotes insulin secretion, and delays gastric emptying...
2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38531925/comparative-evaluation-of-non-invasive-tests-for-risk-stratification-for-cause-specific-mortality-in-at-risk-population-of-hepatic-fibrosis
#17
JOURNAL ARTICLE
Huiyul Park, Eileen L Yoon, Mimi Kim, Hye-Lin Kim, Mi Kyung Kim, Yu-Mi Kim, Dae Won Jun
Our study aimed to conduct a comparative evaluation of various noninvasive tests (NITs) for risk stratification in at-risk population for non-alcoholic fatty liver disease (NAFLD), focusing on cardiovascular and liver-related mortality. A total of 21,715 adults aged 40 years and older were enrolled at baseline. The mean follow-up period was 12.39 years. Three types of NITs (fibrosis-4 index [FIB-4], NAFLD fibrosis score [NFS], and steatosis-associated fibrosis estimator [SAFE] score) were used. When using the low cut-off as a 'rule-out' strategy, there were no significant differences in cardiovascular mortality between the 'rule-out' (low-risk) group and the 'rule-in' (intermediate- or high-risk) group based on FIB-4 (aHR = 1...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531529/molecularly-imprinted-polymers-for-sensing-depleting-human-serum-albumin-hsa-a-critical-review-of-recent-advances-and-current-challenges
#18
REVIEW
Ali Jahanban-Esfahlan, Ryszard Amarowicz
Human serum albumin (HSA) is an essential biomacromolecule in the blood circulatory system because it carries numerous molecules, including fatty acids (FAs), bilirubin, metal ions, hormones, and different pharmaceuticals, and plays a significant role in regulating blood osmotic pressure. Fluctuations in HSA levels in human biofluids, particularly urine and serum, are associated with several disorders, such as elevated blood pressure, diabetes mellitus (DM), liver dysfunction, and a wide range of renal diseases...
March 24, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38531378/new-nomenclature-for-nonalcoholic-fatty-liver-disease-understanding-metabolic-dysfunction-associated-steatotic-liver-disease-metabolic-dysfunction-and-alcohol-associated-liver-disease-and-their-implications-in-clinical-practice
#19
JOURNAL ARTICLE
Clémence M Canivet, Jérôme Boursier, Rohit Loomba
In June 2023, under the patronage of the American Association for Study of Liver Disease, the European Association for Study of the Liver, and the Asociación Latinoamericana para el Estudio del Hígado with the involvement of 236 participants from around the world, a new nomenclature and definition for nonalcoholic fatty liver disease (NAFLD) has been proposed. Metabolic dysfunction-associated steatotic liver disease (MASLD) was defined as presence of hepatic steatosis and at least one of the cardiometabolic risk factors with alcohol intake less than 140 g/wk for women and 210 g/wk for men and no other causes of steatosis...
March 26, 2024: Seminars in Liver Disease
https://read.qxmd.com/read/38531251/machine-learning-based-predictive-model-for-abdominal-diseases-using-physical-examination-datasets
#20
JOURNAL ARTICLE
Wei Chen, YuJie Zhang, Weili Wu, Hui Yang, Wenxiu Huang
Abdominal ultrasound is a key non-invasive imaging method for diagnosing liver, kidney, and gallbladder diseases, despite its clinical significance, not all individuals can undergo abdominal ultrasonography during routine health check-ups due to limitations in equipment, cost, and time. This study aims to use basic physical examination data to predict the risk of diseases of the liver, kidney, and gallbladder that can be diagnosed via abdominal ultrasound. Basic physical examination data contain gender, age, height, weight, BMI, pulse, systolic blood pressure (SBP), diastolic blood pressure (DBP), high-density lipoprotein (HDL), low-density lipoprotein (LDL), total cholesterol, triglycerides, fasting blood glucose (FBG), and uric acid-we established seven single-label predictive models and one multi-label predictive model...
March 11, 2024: Computers in Biology and Medicine
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