Camila Caram-Deelder, Hellen McKinnon Edwards, Jarmila A Zdanowicz, Thomas van den Akker, Camilla Birkegård, Jan Blatný, Johanna G van der Bom, Giuseppe Colucci, Derek van Duuren, Nan van Geloven, Dacia D C A Henriquez, Marian Knight, Lars Korsholm, Andrea Landorph, Géraldine Lavigne Lissalde, Zoe K McQuilten, Daniel Surbek, Cameron Wellard, Erica M Wood, Frederic J Mercier
Background : Despite a range of available treatments, it is still sometimes challenging to treat patients with severe post-partum hemorrhage (sPPH). Objective: This study evaluated the efficacy and safety of recombinant activated factor VIIa (rFVIIa) in sPPH management. Methods : An open-label, multi-center, randomized controlled trial (RCT; NCT00370877) and four observational studies (OS; OS-1 (NCT04723979), OS-2, OS-3, and OS-4) were analyzed regarding efficacy (need for subsequent invasive procedures, including uterine compression sutures, uterine or iliac artery ligations, arterial embolization, or hysterectomy) and safety (incidence of thromboembolic events (TE) and maternal mortality) of rFVIIa for sPPH...
May 1, 2024: Journal of Clinical Medicine