Haijiao Wang, Hong Li, Yuanyuan Rong, Hongmei He, Yi Wang, Yujiao Cui, Lin Qi, Chunhui Xiao, Hong Xu, Wenlong Han
Preeclampsia (PE) is a pregnancy complication characterized by placental dysfunction. However, the relationship between maternal blood markers and PE is unclear. It is helpful to improve the diagnosis and treatment of PE using new biomarkers related to PE in the blood. Three PE-related microarray datasets were obtained from the Gene Expression Synthesis database. The limma software package was used to identify differentially expressed genes (DEGs) between PE and control groups. Least absolute shrinkage and selection operator regression, support vector machine, random forest, and multivariate logistic regression analyses were used to determine key diagnostic biomarkers, which were verified using clinical samples...
May 24, 2024: Medicine (Baltimore)