Odilia I Woudstra, Tjitske E Zandstra, Rosanne F Vogel, Arie P J van Dijk, Hubert W Vliegen, Philippine Kiès, Monique R M Jongbloed, Anastasia D Egorova, Pieter A F M Doevendans, Thelma C Konings, Barbara J M Mulder, Michael W T Tanck, Folkert J Meijboom, Berto J Bouma
Background Patients with transposition of the great arteries corrected by an atrial switch operation experience major clinical events during adulthood, mainly heart failure (HF) and arrhythmias, but data on the emerging risks remain scarce. We assessed the risk for events during the clinical course in adulthood, and provided a novel risk score for event-free survival. Methods and Results This multicenter study observed 167 patients with transposition of the great arteries corrected by an atrial switch operation (61% Mustard procedure; age, 28 [interquartile range, 24-36] years) for 13 (interquartile range, 9-16) years, during which 16 (10%) patients died, 33 (20%) had HF events, defined as HF hospitalizations, heart transplantation, ventricular assist device implantation, or HF-related death, and 15 (9%) had symptomatic ventricular arrhythmias...
February 22, 2021: Journal of the American Heart Association