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RANDOMIZED CONTROLLED TRIAL
Ran An, Ellen Wilms, Jacoline Gerritsen, Hye Kyong Kim, Celia Seguí Pérez, Isolde Besseling-van der Vaart, Daisy M A E Jonkers, Ger T Rijkers, Willem M de Vos, Ad A M Masclee, Erwin G Zoetendal, Freddy J Troost, Hauke Smidt
Although fecal microbiota composition is considered to preserve relevant and representative information for distal colonic content, it is evident that it does not represent microbial communities inhabiting the small intestine. Nevertheless, studies investigating the human small intestinal microbiome and its response to dietary intervention are still scarce. The current study investigated the spatio-temporal dynamics of the small intestinal microbiome within a day and over 20 days, as well as its responses to a 14-day synbiotic or placebo control supplementation in 20 healthy subjects...
2024: Gut Microbes
#2
JOURNAL ARTICLE
Nancy D Marin, Michelle Becker-Hapak, Wilbur M Song, Quazim A Alayo, Lynne Marsala, Naomi Sonnek, Melissa M Berrien-Elliott, Mark Foster, Jennifer A Foltz, Jennifer Tran, Pamela Wong, Celia C Cubitt, Patrick Pence, Kimberly Hwang, Alice Y Zhou, Miriam T Jacobs, Timothy Schappe, David A Russler-Germain, Ryan C Fields, Matthew A Ciorba, Todd A Fehniger
Metastatic (m) colorectal cancer (CRC) is an incurable disease with a poor prognosis and thus remains an unmet clinical need. Immune checkpoint blockade (ICB)-based immunotherapy is effective for mismatch repair-deficient (dMMR)/microsatellite instability-high (MSI-H) mCRC patients, but it does not benefit the majority of mCRC patients. NK cells are innate lymphoid cells with potent effector responses against a variety of tumor cells but are frequently dysfunctional in cancer patients. Memory-like (ML) NK cells differentiated after IL-12/IL-15/IL-18 activation overcome many challenges to effective NK cell anti-tumor responses, exhibiting enhanced recognition, function, and in vivo persistence...
2024: Oncoimmunology
#3
JOURNAL ARTICLE
Cristina Peixoto de Sousa, Catarina Carvalho, Célia Sousa, Ricardo Amaral
Acute gastric variceal bleeding is a life-threatening condition that could be effectively treated with endoscopic cyanoacrylate injection diluted with lipiodol. The mixture acts as a tissue adhesive that polymerizes when in contact with blood in a gastric varix. This work reports a patient that presented to the emergency department with upper gastrointestinal bleeding due to acute variceal bleeding, who developed systemic embolization following cyanoacrylate injection therapy. This complication culminated in cerebral, splenic and renal infarctions with a fatal outcome...
2024: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
#4
REVIEW
Joana Vilela, Célia Rasga, João Xavier Santos, Hugo Martiniano, Ana Rita Marques, Guiomar Oliveira, Astrid Moura Vicente
Autism Spectrum Disorder (ASD) is an early onset neurodevelopmental disorder characterized by impaired social interaction and communication, and repetitive patterns of behavior. Family studies show that ASD is highly heritable, and hundreds of genes have previously been implicated in the disorder; however, the etiology is still not fully clear. Brain imaging and electroencephalography (EEG) are key techniques that study alterations in brain structure and function. Combined with genetic analysis, these techniques have the potential to help in the clarification of the neurobiological mechanisms contributing to ASD and help in defining novel therapeutic targets...
April 30, 2024: International Journal of Molecular Sciences
#5
JOURNAL ARTICLE
Mario Serradilla-Martín, Celia Villodre, Laia Falgueras-Verdaguer, Natalia Zambudio-Carroll, José T Castell-Gómez, Juan L Blas-Laina, Vicente Borrego-Estella, Carlos Domingo-Del-Pozo, Gabriel García-Plaza, Francisco J González-Rodríguez, Eva M Montalvá-Orón, Ángel Moya-Herraiz, Sandra Paterna-López, Miguel A Suárez-Muñoz, Maialen Alkorta-Zuloaga, Gerardo Blanco-Fernández, Enrique Dabán-Collado, Miguel A Gómez-Bravo, José I Miota-de-Llamas, Fernando Rotellar, Belinda Sánchez-Pérez, Santiago Sánchez-Cabús, David Pacheco-Sánchez, Juan C Rodríguez-Sanjuan, María A Varona-Bosque, Lucía Carrión-Álvarez, Sofía de la Serna-Esteban, Cristina Dopazo, Elena Martín-Pérez, David Martínez-Cecilia, María J Castro-Santiago, Dimitri Dorcaratto, Marta L Gutiérrez-Díaz, José M Asencio-Pascual, Fernando Burdío-Pinilla, Roberto Carracedo-Iglesias, Alfredo Escartín-Arias, Benedetto Ielpo, Gonzalo Rodríguez-Laiz, Andrés Valdivieso-López, Emilio De-Vicente-López, Vicente Alonso-Orduña, José M Ramia
(1) Background: The liver-first approach may be indicated for colorectal cancer patients with synchronous liver metastases to whom preoperative chemotherapy opens a potential window in which liver resection may be undertaken. This study aims to present the data of feasibility and short-term outcomes in the liver-first approach. (2) Methods: A prospective observational study was performed in Spanish hospitals that had a medium/high-volume of HPB surgeries from 1 June 2019 to 31 August 2020. (3) Results: In total, 40 hospitals participated, including a total of 2288 hepatectomies, 1350 for colorectal liver metastases, 150 of them (11...
April 26, 2024: Cancers
#6
RANDOMIZED CONTROLLED TRIAL
Patricia Martínez-Ibáñez, Irene Marco-Moreno, Aníbal García-Sempere, Salvador Peiró, Lucia Martínez-Ibáñez, Ignacio Barreira-Franch, Laura Bellot-Pujalte, Eugenia Avelino-Hidalgo, Marina Escrig-Veses, María Bóveda-García, Mercedes Calleja-Del-Ser, Celia Robles-Cabaniñas, Isabel Hurtado, Clara L Rodríguez-Bernal, Margarita Giménez-Loreiro, Gabriel Sanfélix-Gimeno, José Sanfélix-Genovés
IMPORTANCE: Patient empowerment through pharmacologic self-management is a common strategy for some chronic diseases such as diabetes, but it is rarely used for controlling blood pressure (BP). Several trials have shown its potential for reducing BP in the short term, but evidence in the longer term is scarce. OBJECTIVE: To evaluate the longer-term effectiveness of BP self-monitoring plus self-titration of antihypertensive medication vs usual care for patients with poorly controlled hypertension, with passive follow-up and primary-care nursing involvement...
May 1, 2024: JAMA Network Open
#7
JOURNAL ARTICLE
Edward Riley-Gibson, Alix Hall, Adam Shoesmith, Luke Wolfenden, Rachel C Shelton, Emma Doherty, Emma Pollock, Debbie Booth, Ramzi G Salloum, Celia Laur, Byron J Powell, Melanie Kingsland, Cassandra Lane, Maji Hailemariam, Rachel Sutherland, Nicole Nathan
BACKGROUND: The primary purpose of this review is to synthesise the effect of strategies aiming to sustain the implementation of evidenced-based interventions (EBIs) targeting key health behaviours associated with chronic disease (i.e. physical inactivity, poor diet, harmful alcohol use, and tobacco smoking) in clinical and community settings. The field of implementation science is bereft of an evidence base of effective sustainment strategies, and as such, this review will provide important evidence to advance the field of sustainability research...
May 9, 2024: Systematic Reviews
#8
REVIEW
Liliana Santos, João Nuno Moreira, Antero Abrunhosa, Célia Gomes
Brain metastases (BrM) are common malignant lesions in the central nervous system, and pose a significant threat in advanced-stage malignancies due to delayed diagnosis and limited therapeutic options. Their distinct genomic profiles underscore the need for molecular profiling to tailor effective treatments. Recent advances in cancer biology have uncovered molecular drivers underlying tumor initiation, progression, and metastasis. This, coupled with the advances in molecular imaging technology and radiotracer synthesis, has paved the way for the development of innovative radiopharmaceuticals with enhanced specificity and affinity for BrM specific targets...
May 4, 2024: Critical Reviews in Oncology/hematology
#9
JOURNAL ARTICLE
Marta Rivero, María Fernández-Vidal, Justo Sandino, Raquel Berzal Rico, Candela Moliz, José Enrique Ruiz-Cabello, Lucía Cordero Garcia-Galán, Celia González-García, Paúl Hernández-Velasco, Julián Segura, Eduardo Gutiérrez, Enrique Morales
INTRODUCTION: Intravitreal administration of vascular endothelial growth factor inhibitors (anti-VEGF) is the treatment of choice in retinal pathology associated with type 2 diabetes mellitus (DM2). We aimed to analyze the effect of intravitreal anti-VEGF administration on renal function in patients with DM2. METHODS: This is a single-center retrospective and observational study of patients with DM2 with and without chronic kidney disease (CKD). We analyzed the evolution of renal function after anti-VEGF onset, compared with a control group...
May 2024: KI Reports
#10
REVIEW
Celia Pinedo Sierra, Elena Curto Sánchez, Rocio Diaz Campos, Tamara Hermida Valverde, Silvia Sánchez-Cuellar, Ana Fernández Tena
Asthma is a chronic inflammatory disease that affects about 5% of the world's population and generates high health and social costs. Proper management of the disease requires a correct diagnosis, based on objective measures of functional impairment, as well as symptom control and assessment of the future risk of exacerbations.It has been estimated that 18% of asthma patients in Western Europe have severe asthma and approximately 50% of them have poor control. The severity of asthma is established based on the minimum maintenance treatment needs to achieve control...
2024: Open Respir Arch
#11
Dapinder Kaur, Tapan Behl, Sridevi Chigurupati, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Vishnu Nayak Badavath, Celia Vargas-De-La-Cruz, Saurabh Bhatia, Ahmed Al-Harrasi, Abhijit Dey, Lotfi Aleya, Simona Bungau
No abstract text is available yet for this article.
May 6, 2024: Environmental Science and Pollution Research International
#12
JOURNAL ARTICLE
Franziska Haderk, Yu-Ting Chou, Lauren Cech, Celia Fernández-Méndez, Johnny Yu, Victor Olivas, Ismail M Meraz, Dora Barbosa Rabago, D Lucas Kerr, Carlos Gomez, David V Allegakoen, Juan Guan, Khyati N Shah, Kari A Herrington, Oghenekevwe M Gbenedio, Shigeki Nanjo, Mourad Majidi, Whitney Tamaki, Yashar K Pourmoghadam, Julia K Rotow, Caroline E McCoach, Jonathan W Riess, J Silvio Gutkind, Tracy T Tang, Leonard Post, Bo Huang, Pilar Santisteban, Hani Goodarzi, Sourav Bandyopadhyay, Calvin J Kuo, Jeroen P Roose, Wei Wu, Collin M Blakely, Jack A Roth, Trever G Bivona
Targeted therapy is effective in many tumor types including lung cancer, the leading cause of cancer mortality. Paradigm defining examples are targeted therapies directed against non-small cell lung cancer (NSCLC) subtypes with oncogenic alterations in EGFR, ALK and KRAS. The success of targeted therapy is limited by drug-tolerant persister cells (DTPs) which withstand and adapt to treatment and comprise the residual disease state that is typical during treatment with clinical targeted therapies. Here, we integrate studies in patient-derived and immunocompetent lung cancer models and clinical specimens obtained from patients on targeted therapy to uncover a focal adhesion kinase (FAK)-YAP signaling axis that promotes residual disease during oncogenic EGFR-, ALK-, and KRAS-targeted therapies...
May 3, 2024: Nature Communications
#13
JOURNAL ARTICLE
Yassir Boulaamane, Irene Molina Panadero, Abdelkrim Hmadcha, Celia Atalaya Rey, Soukayna Baammi, Achraf El Allali, Amal Maurady, Younes Smani
UNLABELLED: Global challenges presented by multidrug-resistant Acinetobacter baumannii infections have stimulated the development of new treatment strategies. We reported that outer membrane protein W (OmpW) is a potential therapeutic target in A. baumannii . Here, a library of 11,648 natural compounds was subjected to a primary screening using quantitative structure-activity relationship (QSAR) models generated from a ChEMBL data set with >7,000 compounds with their reported minimal inhibitory concentration (MIC) values against A...
May 3, 2024: MSystems
#14
REVIEW
Gordon Xin Hua Liu, Tony Milne, William Xu, Chris Varghese, Celia Keane, Greg O'Grady, Ian P Bissett, Cameron I Wells
AIM: Prolonged postoperative ileus (PPOI) is common and is associated with a significant healthcare burden. Previous studies have attempted to predict PPOI clinically using risk prediction algorithms. The aim of this work was to systematically review and compare risk prediction algorithms for PPOI following colorectal surgery. METHOD: A systematic literature search was conducted using MEDLINE, Embase, Web of Science and CINAHL Plus. Studies that developed and/or validated a risk prediction algorithm for PPOI in adults following colorectal surgery were included...
May 2, 2024: Colorectal Disease
#15
JOURNAL ARTICLE
Cèlia Dobaño-López, Juan García Valero, Ferran Araujo-Ayala, Ferran Nadeu, Fabien Gava, Carla Faria, Marine Norlund, Renaud Morin, Pascale Bernes-Lasserre, Fabian Arenas, Marta Grau, Cristina López, Irene López-Oreja, Neus Serrat, Ares Martínez-Farran, Lluís Hernández, Heribert Playa-Albinyana, Rubén Giménez, Silvia Beà, Elías Campo, Jean-Michel Lagarde, Armando López-Guillermo, Laura Magnano, Dolors Colomer, Christine Bezombes, Patricia Pérez-Galán
Follicular lymphoma (FL), the most common indolent non-Hodgkin lymphoma, constitutes a paradigm of immune tumor microenvironment (TME) contribution to disease onset, progression, and heterogenous clinical outcome. Here we present the first FL-Patient Derived Lymphoma Spheroid (FL-PDLS), including fundamental immune actors and features of TME in FL lymph nodes (LNs). FL-PDLS is organized in disc-shaped 3D structures composed of proliferating B and T cells, together with macrophages with an intermediate M1/M2 phenotype...
May 2, 2024: Blood Cancer Journal
#16
JOURNAL ARTICLE
William Xu, Lucy Williams, Gabrielle Sebaratnam, Chris Varghese, Chris Cedarwall, Charlotte Daker, Celia Keane
BACKGROUND: Chronic nausea and vomiting syndromes (CNVS), gastroparesis and functional dyspepsia (FD) are complex disorders. Body Surface Gastric Mapping (BSGM), a new test of gastric function, using Gastric Alimetry® (Alimetry, New Zealand) may be useful for de-escalating healthcare utilisation. This study aimed to define healthcare costs and estimate health economic impacts of implementing this test in patients with chronic gastroduodenal symptoms. METHODS: Consecutive patients at a tertiary referral centre evaluated with Gastric Alimetry were included...
April 30, 2024: Digestive Diseases and Sciences
#17
JOURNAL ARTICLE
Giovanna de Carvalho, Walter Sepúlveda-Loyola, Luana Oliveira de Lima, Stheace Kelly Fernandes Szezerbaty, Regina Célia Poli-Frederico, Héctor Gutiérrez-Espinoza, Juan José Valenzuela-Fuenzalida, Vanessa Suziane Probst
INTRODUCTION: Chronic obstructive pulmonary disease is a systemic disease characterized not only by respiratory symptoms but also by physical deconditioning and muscle weakness. One prominent manifestation of this disease is the decline in respiratory muscle strength. Previous studies have linked the genotypes of insulin-like growth factor 1 and 2 (IGF-1 and IGF-2) to muscle weakness in other populations without this disease. However, there is a notable knowledge gap regarding the biological mechanisms underlying respiratory muscle weakness, particularly the role of IGF-1 and IGF-2 genotypes in this pulmonary disease...
April 30, 2024: Medwave
#18
JOURNAL ARTICLE
Irene H Flønes, Lilah Toker, Dagny Ann Sandnes, Martina Castelli, Sepideh Mostafavi, Njål Lura, Omnia Shadad, Erika Fernandez-Vizarra, Cèlia Painous, Alexandra Pérez-Soriano, Yaroslau Compta, Laura Molina-Porcel, Guido Alves, Ole-Bjørn Tysnes, Christian Dölle, Gonzalo S Nido, Charalampos Tzoulis
Idiopathic Parkinson's disease (iPD) is believed to have a heterogeneous pathophysiology, but molecular disease subtypes have not been identified. Here, we show that iPD can be stratified according to the severity of neuronal respiratory complex I (CI) deficiency, and identify two emerging disease subtypes with distinct molecular and clinical profiles. The CI deficient (CI-PD) subtype accounts for approximately a fourth of all cases, and is characterized by anatomically widespread neuronal CI deficiency, a distinct cell type-specific gene expression profile, increased load of neuronal mtDNA deletions, and a predilection for non-tremor dominant motor phenotypes...
April 29, 2024: Nature Communications
#19
JOURNAL ARTICLE
Azam Majidi, Maria Celia B Hughes, Imogen K Webb, Kyoko Miura, Jolieke C van der Pols
OBJECTIVE: Inflammation is implicated in chronic diseases including cancer and cardiovascular diseases (CVD), which are major causes of mortality. Diet can influence inflammation status. We therefore examined whether the inflammatory potential of a person's diet is associated with mortality. DESIGN: Inflammatory potential of usual diet was assessed by calculating dietary inflammatory index (DII) scores from repeated food frequency (FFQ) data (collected in 1992, 1994, 1996), placing each participant's diet on a continuum from anti- to pro-inflammatory...
April 29, 2024: Public Health Nutrition
#20
JOURNAL ARTICLE
Vera Manageiro, Vítor Borges, Raquel Rodrigues, Célia Bettencourt, Cecília Silva, João Paulo Gomes, Paulo Gonçalves
We investigated molecular evolution and spatiotemporal dynamics of atypical Legionella pneumophila serogroup 1 sequence type 1905 and determined its long-term persistence and linkage to human disease in dispersed locations, far beyond the large 2014 outbreak epicenter in Portugal. Our finding highlights the need for public health interventions to prevent further disease spread.
May 2024: Emerging Infectious Diseases
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