Jonathan H Galarraga, Hannah M Zlotnick, Ryan C Locke, Sachin Gupta, Natalie L Fogarty, Kendall M Masada, Brendan D Stoeckl, Lorielle Laforest, Miguel Castilho, Jos Malda, Riccardo Levato, James L Carey, Robert L Mauck, Jason A Burdick
The surgical repair of articular cartilage remains an ongoing challenge in orthopedics. Tissue engineering is a promising approach to treat cartilage defects; however, scaffolds must (i) possess the requisite material properties to support neocartilage formation, (ii) exhibit sufficient mechanical integrity for handling during implantation, and (iii) be reliably fixed within cartilage defects during surgery. In this study, we demonstrate the reinforcement of soft norbornene-modified hyaluronic acid (NorHA) hydrogels via the melt electrowriting (MEW) of polycaprolactone to fabricate composite scaffolds that support encapsulated porcine mesenchymal stromal cell (pMSC, three donors) chondrogenesis and cartilage formation and exhibit mechanical properties suitable for handling during implantation...
2023: International journal of bioprinting