Mancusi Gianluca, Miuli Andrea, Santorelli Mario, Cavallotto Clara, Susini Ottavia, Pernaci Giulia, Výborová Eliška, Rosa Ilenia, d'Onofrio Antonio Maria, Camardese Giovanni, Pettorruso Mauro, Stefano L Sensi, Martinotti Giovanni
BACKGROUND: This systematic review aims to comprehensively explore the impact of psychostimulant substances on neurotrophic and inflammatory pathways, including brain-derived neurotrophic factor (BDNF), pro-BDNF, cortisol, dehydroepiandrosterone sulfate (DHEAS), thiobarbituric acid reactive substances (TBARS), interleukins, and the role of genetic factors. The study seeks to address existing gaps in the literature by providing a thorough evaluation of neurotrophic and inflammatory system alterations associated with different stages of psychostimulant dependence for a more nuanced understanding of substance use disorder (SUD) neurobiology...
May 16, 2024: Behavioural Brain Research