Mitchell R Knisely, Rita V Masese, Joacy G Mathias, Qing Yang, Daniel Hatch, Brandon M Lê, Faith Luyster, Melanie E Garrett, Paula J Tanabe, Nirmish R Shah, Allison Ashley-Koch
Objective: Sickle cell disease (SCD), the most common inherited blood disorder in the United States, is associated with severe psychoneurological symptoms. While epigenetic age acceleration has been linked to psychoneurological symptom burden in other diseases, this connection is unexplored in SCD. This study aimed to assess the association between epigenetic age acceleration and psychoneurological symptom burden in SCD. Methods: In this cross-sectional study, emotional impact, pain impact, sleep impact, social functioning, and cognitive function were assessed in 87 adults living with SCD...
April 28, 2024: Biological Research for Nursing