Yongjie Zhou, Yuwei Chen, Xiaoyun Zhang, Qing Xu, Zhenru Wu, Xiaoyue Cao, Mingyang Shao, Yuke Shu, Tao Lv, Changli Lu, Mingjun Xie, Tianfu Wen, Jiayin Yang, Yujun Shi, Hong Bu
Intrahepatic cholangiocarcinoma (iCCA) is closely correlated with hepatic progenitor cell (HPC) expansion and liver fibrosis. Brahma-related gene 1 (Brg1), an enzymatic subunit of the SWltch/Sucrose Non-Fermentable (SWI/SNF) complex that is critical in stem cell maintenance and tumor promotion, is prominently up-regulated in both HPCs and iCCA; however, its role in this correlation remains undefined. A retrospective cohort study indicated that high Brg1 expression suggests poor prognosis in iCCA patients. In chronically injured livers induced by a 0...
March 2, 2021: Hepatology: Official Journal of the American Association for the Study of Liver Diseases