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JOURNAL ARTICLE
B Schneider, B Hüttel, C Zübert, M Kube
A recent survey in Germany revealed the wide presence of 'Candidatus Phytoplasma ulmi' in native elm stands. Accessions were studied for their genetic variability and phylogenetic relationship based on the conserved groEL and the variable imp gene. While the groEL sequences revealed a high intraspecific homology of more than 99%, the homology of the imp gene dropped to 71% between distantly related sequences. Twenty-nine groEL and 74 imp genotypes were distinguished based on polymorphic sites. Phylogenetic analysis of the groEL gene clustered all 'Ca...
December 14, 2020: Scientific Reports
#42
JOURNAL ARTICLE
Jiri Kudrna, Frantisek Hnilicka, Jan Kubes, Pavla Vachova, Helena Hnilickova, Margita Kuklova
This study analyzes the effects of acetaminophen (APAP) as a contaminant on physiological characteristics of lettuce plants ( Lactuca sativa L.). Experiments were provided in an experimental greenhouse with semi-controlled conditions. The effect of different amounts of contaminant was evaluated by using regression analysis. Plants were grown in five concentrations of APAP: 0 µM, 5 µM, 50 µM, 500 µM, and 5 mM for 14 days in two variants, acute and chronic. The obtained results show that the monitored parameters were demonstrably influenced by the experimental variant...
November 23, 2020: Life
#43
JOURNAL ARTICLE
Hannah Kube, Ronald Herrera, Gisela Dietrich-Gümperlein, Rudolf Schierl, Dennis Nowak, Katja Radon, Laura Wengenroth, Jessica Gerlich
PURPOSE: Laboratory animal workers (LAW) working with laboratory mice are exposed to mouse allergens (MA). If MA are spread to home environments, this might increase the risk for allergies in LAW and their families. This study aimed to assess 1. whether spreading of MA from workplace to home environment takes place; 2. which factors increase spreading of MA. METHODS: In a cross-sectional study, dust samples were taken on the mattress and seating in homes of LAW (n = 105) and an unexposed comparison group (n = 13)...
November 21, 2020: International Archives of Occupational and Environmental Health
#44
JOURNAL ARTICLE
Regina Becker, Kristina Ulrich, Undine Behrendt, Michael Kube, Andreas Ulrich
The invasive ascomycete Hymenoscyphus fraxineus has been threatening Fraxinus excelsior populations throughout Europe for over two decades. Since the infection and first colonization by the pathogen occurs in leaves, leaf-colonizing microorganisms have been discussed as a barrier and as possible biocontrol agents against the disease. To identify fungal groups with health-supporting potential, we compared the fungal microbiota of compound leaves from susceptible and tolerant ash trees in four ash stands with high H...
2020: Frontiers in Microbiology
#45
JOURNAL ARTICLE
Živko Ćurčić, Jelena Mitrovic, Christina Zuebert, Ksenija Taški Ajduković, Andrea Kosovac, Emil Rekanovic, Michael Kube, Bojan Duduk
Rubbery taproot disease (RTD) of sugar beet was observed in Serbia for the first time in the 1960s. The disease was already described in neighbouring Bulgaria and Romania at the time, but it was associated with abiotic factors. In this study on RTD of sugar beet in its main growing area of Serbia, we provide evidence of the association between 'Ca. P. solani' (stolbur phytoplasma) infection and the occurrence of typical RTD symptomatology. 'Ca. P. solani' was identified by PCR and the sequence analyses of 16S rRNA, tuf, secY and stamp genes...
October 6, 2020: Plant Disease
#46
JOURNAL ARTICLE
Arpan Sharma Neupane, Michelle Willson, Andrew Krzysztof Chojnacki, Fernanda Vargas E Silva Castanheira, Christopher Morehouse, Agostina Carestia, Ashley Elaine Keller, Moritz Peiseler, Antonio DiGiandomenico, Margaret Mary Kelly, Matthias Amrein, Craig Jenne, Ajitha Thanabalasuriar, Paul Kubes
During respiration, humans breathe in more than 10,000 liters of non-sterile air daily, allowing some pathogens access to alveoli. Interestingly, alveoli outnumber alveolar macrophages (AMs), which favors alveoli devoid of AMs. If AMs, like most tissue macrophages, are sessile, then this numerical advantage would be exploited by pathogens unless neutrophils from the blood stream intervened. However, this would translate to omnipresent persistent inflammation. Developing in vivo real-time intravital imaging of alveoli revealed AMs crawling in and between alveoli using the pores of Kohn...
October 1, 2020: Cell
#47
JOURNAL ARTICLE
Johann Steinmeier, Sophie Kube, Gabriele Karger, Eric Ehrke, Ralf Dringen
β-lapachone (β-lap) is reduced in tumor cells by the enzyme NAD(P)H: quinone acceptor oxidoreductase 1 (NQO1) to a labile hydroquinone which spontaneously reoxidises to β-lap, thereby generating reactive oxygen species (ROS) and oxidative stress. To test for the consequences of an acute exposure of brain cells to β-lap, cultured primary rat astrocytes were incubated with β-lap for up to 4 h. The presence of β-lap in concentrations of up to 10 µM had no detectable adverse consequences, while higher concentrations of β-lap compromised the cell viability and the metabolism of astrocytes in a concentration- and time-dependent manner with half-maximal effects observed for around 15 µM β-lap after a 4 h incubation...
August 13, 2020: Neurochemical Research
#48
JOURNAL ARTICLE
Bernd Schneider, Ralf Kätzel, Michael Kube
BACKGROUND: 'Candidatus Phytoplasma ulmi' is the agent associated with elm yellows and has been categorised in the European Union as a quarantine pathogen. For central and northern European countries, information on the occurrence and distribution of the pathogen and its impact on elms is scarce, so a survey of native elm trees has been conducted in Germany. RESULTS: About 6500 samples from Ulmus minor, Ulmus laevis and Ulmus glabra, were collected nationwide. Phytoplasma detection was performed by applying a universal 16Sr DNA-based quantitative PCR (qPCR) assay and a novel 'Ca...
March 31, 2020: BMC Microbiology
#49
RANDOMIZED CONTROLLED TRIAL
Kamal K Pourmoghadam, Stacey Kubovec, William M DeCampli, Bertha Ben Khallouq, Kurt Piggott, Carlos Blanco, Harun Fakioglu, Alicia Kube, Sukumar Suguna Narasimhulu
BACKGROUND: Infants after cardiopulmonary bypass are exposed to increasing inflammatory mediator release and are at risk of developing fluid overload. The aim of this pilot study was to evaluate the impact of passive peritoneal drainage on achieving negative fluid balance and its ability to dispose of inflammatory cytokines. METHODS: From September 2014 to November 2016, infants undergoing STAT category 3, 4, and 5 operations were randomized to receive or not receive intraoperative prophylactic peritoneal drain...
March 2020: World Journal for Pediatric & Congenital Heart Surgery
#50
JOURNAL ARTICLE
Christopher M Kube, Andrea P Arguelles
Traditionally, the acoustoelastic effect refers to the influence of stress in a solid on an elastic wave's phase velocity. Since the phase velocity can be represented by the real part of the complex wave number, a natural question arises regarding the effect of stress on the imaginary part or dissipation of the wave. In this article, the influence of pressure on the elastic wave's attenuation in polycrystalline materials is modeled. The constitutive behavior of an initially stressed solid is coupled into Weaver's scattering-based attenuation model [J...
December 2019: Journal of the Acoustical Society of America
#51
JOURNAL ARTICLE
L Jakl, M Skorvaga, K Beresova, P Kosik, M Durdik, J Jakubikova, M Holop, M Kubes, L Zastko, E Markova, I Beliaev
The BCR/ABL preleukemic fusion gene (PFG) is one of the most frequent fusion genes in acute lymphoblastic leukemia (ALL) and was also detected in hematopoietic cells from umbilical cord blood (UCB) of healthy newborns. Since hematopoietic stem/progenitor cells (HSPC) are considered to be a critical cellular target for origination of leukemia, we have studied the presence of BCR/ABL PFG in expanded subpopulations of HSPC and differentiated cells from UCB of those healthy newborns, who have previously been tested positive for BCR/ABL by screening of their UCB mononuclear cells using RT-qPCR and FISH methods...
December 23, 2019: Neoplasma
#52
JOURNAL ARTICLE
Raquel Blazquez, Eva Rietkötter, Britta Wenske, Darius Wlochowitz, Daniela Sparrer, Elena Vollmer, Gunnar Müller, Julia Seegerer, Xueni Sun, Katja Dettmer, Alonso Barrantes-Freer, Lena Stange, Kirsten Utpatel, Annalen Bleckmann, Hannes Treiber, Hanibal Bohnenberger, Christof Lenz, Matthias Schulz, Christian Reimelt, Christina Hackl, Marian Grade, Deram Büyüktas, Laila Siam, Marko Balkenhol, Christine Stadelmann, Dieter Kube, Michael P Krahn, Martin A Proescholdt, Markus J Riemenschneider, Matthias Evert, Peter J Oefner, Chistoph A Klein, Uwe K Hanisch, Claudia Binder, Tobias Pukrop
More than half of all brain metastases show infiltrating rather than displacing growth at the macro-metastasis/organ parenchyma interface (MMPI), a finding associated with shorter survival. The lymphoid enhancer-binding factor-1 (LEF1) is an epithelial-mesenchymal transition (EMT) transcription factor that is commonly overexpressed in brain-colonizing cancer cells. Here, we overexpressed LEF1 in an in vivo breast cancer brain colonization model. It shortened survival, albeit without engaging EMT at the MMPI...
June 1, 2020: International Journal of Cancer. Journal International du Cancer
#53
JOURNAL ARTICLE
Elizabeth L Prado, Leila M Larson, Katherine Cox, Kory Bettencourt, Julianne N Kubes, Anuraj H Shankar
BACKGROUND: Faltering in linear growth and neurobehavioural development during early childhood are often assumed to have common causes because of their consistent association. This notion has contributed to a global focus on the promotion of nutrition during pregnancy and childhood to improve both conditions. Our aim was to assess whether effects of interventions on linear growth are associated with effects on developmental scores and to quantify these associations. METHODS: In this systematic review and meta-analysis, we included randomised trials done during pregnancy and in children aged 0-5 years that reported effects of any intervention on length-for-age or height-for-age Z scores (LAZ or HAZ) and on any of the following outcomes: motor, cognitive or mental, language, and social-emotional or behavioural development...
October 2019: Lancet Global Health
#54
JOURNAL ARTICLE
J W Kijas, A P Gutierrez, R D Houston, S McWilliam, T P Bean, K Soyano, J E Symonds, N King, C Lind, P Kube
The recent development of Pacific oyster (Crassostrea gigas) SNP genotyping arrays has allowed detailed characterisation of genetic diversity and population structure within and between oyster populations. It also raises the potential of harnessing genomic selection for genetic improvement in oyster breeding programmes. The aim of this study was to characterise a breeding population of Australian oysters through genotyping and analysis of 18 027 SNPs, followed by comparison with genotypes of oyster sampled from Europe and Asia...
September 13, 2019: Animal Genetics
#55
JOURNAL ARTICLE
Tobias Kube, Julia Meyer, Philippe Grieshaber, Rainer Moosdorf, Andreas Böning, Winfried Rief
The aim of this study was to investigate not only preoperative expectations (as shown previously), but also postoperative expectations of patients predict clinical outcomes six months after cardiac surgery. Furthermore, the study sought to examine illness behavior as a possible pathway through which expectations may affect postoperative well-being. Seventy patients scheduled for cardiac surgery were examined one day before surgery, ~7-10 days after surgery, and six months after surgery. Regression analyses indicated that disability at follow-up (primary outcome) was significantly predicted by postoperative ( β = -...
August 2020: Psychology, Health & Medicine
#56
JOURNAL ARTICLE
Bojan Duduk, Natasa Duduk, Ivana Vico, Jelena Stepanovic, Tatjana Markovic, Emil Rekanovic, Michael Kube, Dragoja Radanovic
Floricolous downy mildews ( Peronospora , Oomycetes) are a small, monophyletic group of mostly inconspicuous plant pathogens that induce symptoms exclusively on flowers. Characterisation of this group of pathogens, and information on their biology, is particularly sparse. The recurrent presence of a disease causing flower malformation, which in turn leads to high production losses of the medicinal herb Matricaria chamomilla in Serbia, has enabled continuous experiments focusing on the pathogen and its biology...
August 1, 2019: Phytopathology
#57
JOURNAL ARTICLE
A Beddok, A Vela, V Calugaru, T Tessonnier, J Kubes, P Dutheil, A Gérard, M Vidal, F Goudjil, C Florescu, E Kammerer, K Bénézery, J Hérault, J Bourhis, J Thariat
Intensity-modulated radiation therapy (IMRT) is presently the recommended technique for the treatment of locally advanced head and neck carcinomas. Proton therapy would allow to reduce the volume of irradiated normal tissue and, thus, to decrease the risk of late dysphagia, xerostomia, dysgeusia and hypothyroidism. An exhaustive research was performed with the search engine PubMed by focusing on the papers about the physical difficulties that slow down use of proton therapy for head and neck carcinomas. Range uncertainties in proton therapy (±3 %) paradoxically limit the use of the steep dose gradient in distality...
July 26, 2019: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
#58
JOURNAL ARTICLE
Christopher F Tirotta, Richard G Lagueruela, Daria Salyakina, Weize Wang, Thomas Taylor, Jorge Ojito, Kathleen Kubes, Hyunsoo Lim, Robert Hannan, Redmond Burke
INTRODUCTION: Rotational thromboelastometry (ROTEM) has been shown to reduce the need for transfused blood products in adult and pediatric cardiac surgery patients. However, similar evidence in newborns, neonates, and young infants is lacking. We quantified ROTEM value changes in pediatric patients on cardiopulmonary bypass (CPB) before, during and after blood product transfusion. METHODS: Each surgery had at least four interventions: initiating CPB; platelet administration during rewarming phase; post-CPB and following protamine and human fibrinogen concentrate (HFC) administration; and further component therapy if bleeding persisted and ROTEM indicated a deficiency...
July 22, 2019: Journal of Cardiothoracic Surgery
#59
JOURNAL ARTICLE
Mohsen Malehmir, Dominik Pfister, Suchira Gallage, Marta Szydlowska, Donato Inverso, Elena Kotsiliti, Valentina Leone, Moritz Peiseler, Bas G J Surewaard, Dominik Rath, Adnan Ali, Monika Julia Wolf, Hannah Drescher, Marc E Healy, Daniel Dauch, Daniela Kroy, Oliver Krenkel, Marlene Kohlhepp, Thomas Engleitner, Alexander Olkus, Tjeerd Sijmonsma, Julia Volz, Carsten Deppermann, David Stegner, Patrick Helbling, César Nombela-Arrieta, Anahita Rafiei, Martina Hinterleitner, Marcel Rall, Florian Baku, Oliver Borst, Caroline L Wilson, Jack Leslie, Tracy O'Connor, Christopher J Weston, David H Adams, Lozan Sheriff, Ana Teijeiro, Marco Prinz, Ruzhica Bogeska, Natasha Anstee, Malte N Bongers, Mike Notohamiprodjo, Tobias Geisler, Dominic J Withers, Jerry Ware, Derek A Mann, Hellmut G Augustin, Alexandros Vegiopoulos, Michael D Milsom, Adam J Rose, Patricia F Lalor, Josep M Llovet, Roser Pinyol, Frank Tacke, Roland Rad, Matthias Matter, Nabil Djouder, Paul Kubes, Percy A Knolle, Kristian Unger, Lars Zender, Bernhard Nieswandt, Meinrad Gawaz, Achim Weber, Mathias Heikenwalder
Non-alcoholic fatty liver disease ranges from steatosis to non-alcoholic steatohepatitis (NASH), potentially progressing to cirrhosis and hepatocellular carcinoma (HCC). Here, we show that platelet number, platelet activation and platelet aggregation are increased in NASH but not in steatosis or insulin resistance. Antiplatelet therapy (APT; aspirin/clopidogrel, ticagrelor) but not nonsteroidal anti-inflammatory drug (NSAID) treatment with sulindac prevented NASH and subsequent HCC development. Intravital microscopy showed that liver colonization by platelets depended primarily on Kupffer cells at early and late stages of NASH, involving hyaluronan-CD44 binding...
April 2019: Nature Medicine
#60
JOURNAL ARTICLE
Ajitha Thanabalasuriar, Brittney Noelle Vivian Scott, Moritz Peiseler, Michelle Elizabeth Willson, Zhutian Zeng, Paul Warrener, Ashley Elaine Keller, Bas Gerardus Johannes Surewaard, Elizabeth Ashley Dozier, Juha Tapio Korhonen, Lily I-Ting Cheng, Mihaela Gadjeva, C Kendall Stover, Antonio DiGiandomenico, Paul Kubes
Bacterial biofilm infections are difficult to eradicate because of antibiotic insusceptibility and high recurrence rates. Biofilm formation by Pseudomonas aeruginosa, a leading cause of bacterial keratitis, is facilitated by the bacterial Psl exopolysaccharide and associated with heightened virulence. Using intravital microscopy, we observed that neutrophilic recruitment to corneal infections limits P. aeruginosa biofilms to the outer eye surface, preventing bacterial dissemination. Neutrophils moved to the base of forming biofilms, where they underwent neutrophil extracellular trap formation (NETosis) in response to high expression of the bacterial type-3 secretion system (T3SS)...
April 10, 2019: Cell Host & Microbe
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