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REVIEW
Himanshu Arora, Binish Javed, L V Simhachalam Kutikuppala, Mayuri Chaurasia, Kaarvi Khullar, Shreevikaa Kannan, Varshitha Golla
Interleukin-33 (IL-33), belonging to the interleukin-1 cytokine family, has a decoy receptor soluble ST2 (sST2). IL-33 is found in oligodendrocytes and astrocytes and is involved in central nervous system healing and repair, whereas ST2 is found in microglia and astrocytes. Some studies have found a link between changes in the IL-33/ST2 pathway and neurodegenerative disorders. This review article investigates the relationship between the interleukin-33 (IL-33)/ST2 pathway and neurodegenerative disorders. It was discovered that soluble st2 levels were increased...
May 2024: Annals of Medicine and Surgery
#62
JOURNAL ARTICLE
Elaheh Mansouri Ghezelhesari, Mohamad Ali Nahayati, Abbas Heydari, Hosein Ebrahimipour, Talat Khadivzadeh
BACKGROUND: The maternal role is one of the most challenging yet rewarding roles that women experience in their lives. It begins when a woman becomes pregnant, and as the pregnancy progresses, she prepares to fulfill her role as a mother. A woman's health plays a crucial role in her ability to fulfill the maternal role. Multiple sclerosis (MS), as an autoimmune disease, presents unique challenges in achieving this role. Failing to fulfill the maternal role can have lasting consequences for both the mother and the baby...
May 1, 2024: Reproductive Health
#63
JOURNAL ARTICLE
Irina Galperin, David Buzaglo, Eran Gazit, Nathaniel Shimoni, Raz Tamir, Keren Regev, Arnon Karni, Jeffrey M Hausdorff
BACKGROUND: Trait and state physical fatigue (trait-PF and state-PF) negatively impact many people with multiple sclerosis (pwMS) but are challenging symptoms to measure. In this observational study, we explored the role of specific gait and autonomic nervous system (ANS) measures (i.e., heart rate, HR, r-r interval, R-R, HR variability, HRV) in trait-PF and state-PF. METHODS: Forty-eight pwMS [42 ± 1.9 years, 65% female, EDSS 2 (IQR: 0-5.5)] completed the Timed Up and Go test (simple and with dual task, TUG-DT) and the 6-min walk test (6MWT)...
May 2, 2024: Journal of Neurology
#64
Brian Gooley, Ben Willenbring, Jenna Wilkinson
3,4-Aminopyridine or Amifampridine belongs to the aminopyridine class of drugs which is used to treat multiple sclerosis and Lambert-Eaton Myasthenic Syndrome (LEMS). Aminopyridine pharmaceuticals inhibit presynaptic potassium channels. This increases available acetylcholine in the nerve cleft which leads to improved strength in this patient population. While overdoses have been reported of 4-Aminopyridine, no case reports of acute 3.4-Aminopyridine overdose are currently available. A 67 year old man presented to the emergency department 30 min after ingesting 100 mg of amifampridine in a suicide attempt...
April 20, 2024: American Journal of Emergency Medicine
#65
JOURNAL ARTICLE
Yoon Ok Jang, Yeonjeong Roh, Wangyong Shin, Sungyang Jo, Bonhan Koo, Huifang Liu, Myoung Gyu Kim, Hyo Joo Lee, Zhen Qiao, Eun Yeong Lee, Minju Lee, Joonseok Lee, Eun-Jae Lee, Yong Shin
BACKGROUND: Brain-derived exosomes circulate in the bloodstream and other bodily fluids, serving as potential indicators of neurological disease progression. These exosomes present a promising avenue for the early and precise diagnosis of neurodegenerative conditions. Notably, miRNAs found in plasma extracellular vesicles (EVs) offer distinct diagnostic benefits due to their stability, abundance, and resistance to breakdown. RESULTS: In this study, we introduce a method using transferrin conjugated magnetic nanoparticles (TMNs) to isolate these exosomes from the plasma of patients with neurological disorders...
June 1, 2024: Analytica Chimica Acta
#66
JOURNAL ARTICLE
Sitao Hu, Yangyang Hu, Zenglin Tan, Chengyu Zhou, Cheng Zhang, Sheng Yin, Xiaojun Chen, Kai Chen, Lu Wang, Lei Chen
Osteoporosis is the most common bone disorder, in which an imbalance between osteoclastic bone resorption and osteoblastic bone formation disrupts bone homeostasis. Osteoporosis management using anti-osteoclastic agents is a promising strategy; however, this remains an unmet need. Sphingosine-1-phosphate (S1P) and its receptors (S1PRs) are essential for maintaining bone homeostasis. Here, we identified that Siponimod, a Food and Drug Administration-approved S1PR antagonist for the treatment of multiple sclerosis, shows promising therapeutic effects against osteoporosis by inhibiting osteoclast formation and function...
April 29, 2024: European Journal of Pharmacology
#67
REVIEW
Zuber Khan, Sidharth Mehan, Ghanshyam Das Gupta, Acharan S Narula
Multiple sclerosis (MS), a prevalent neurological disorder, predominantly affects young adults and is characterized by chronic autoimmune activity. The study explores the immune system dysregulation in MS, highlighting the crucial roles of immune and non-neuronal cells in the disease's progression. This review examines the dual role of cytokines, with some like IL-6, TNF-α, and interferon-gamma (IFN-γ) promoting inflammation and CNS tissue injury, and others such as IL-4, IL-10, IL-37, and TGF-β fostering remyelination and protecting against MS...
April 29, 2024: Neuroscience
#68
JOURNAL ARTICLE
Mina Mohammadinasr, Soheila Montazersaheb, Vahid Hosseini, Houman Kahroba, Mahnaz Talebi, Ommoleila Molavi, Hormoz Ayromlou, Mohammad Saeid Hejazi
Epstein-Barr virus (EBV) infection is approved as the main environmental trigger of multiple sclerosis (MS). In this path, we quantified ebv-miR-BART9-3p and ebv-miR-BART15 in exosomes of cerebrospinal fluid (CSF) of untreated relapsing-remitting MS (RRMS) patients in comparison with the control group. Interestingly, patients displayed significant upregulation of ebv-miR-BART9-3p (18.4-fold) and ebv-miR-BART15 (3.1-fold) expression in CSF exosomes. Moreover, the expression levels of hsa-miR-21-5p and hsa-miR-146a-5p were found to be significantly elevated in the CSF samples obtained from the patient group compared to those obtained from the HC group...
April 30, 2024: Cytokine
#69
JOURNAL ARTICLE
Mahshad Afsharzadeh, Omid Mirmosayyeb, Saeed Vaheb, Aysa Shaygannejad, Mohammadreza Maracy, Vahid Shaygannejad
OVERVIEW: Dysphagia has been previously discussed as a potential life-threatening condition secondary to chronic neurological diseases such as multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD). However, its impact on the quality of life (QoL) of patients with NMOSD has never been studied before. This study aims to determine the frequency of dysphagia and its impact on QoL in NMOSD patients in comparison with MS people and healthy individuals. METHODS: Seventy-five MS and sixty-five NMOSD patients with an expanded disability status scale (EDSS) score ≥ 3...
April 21, 2024: Multiple Sclerosis and related Disorders
#70
JOURNAL ARTICLE
Felix Kluge, Yonatan E Brand, M Encarna Micó-Amigo, Stefano Bertuletti, Ilaria D'Ascanio, Eran Gazit, Tecla Bonci, Cameron Kirk, Arne Küderle, Luca Palmerini, Anisoara Paraschiv-Ionescu, Francesca Salis, Abolfazl Soltani, Martin Ullrich, Lisa Alcock, Kamiar Aminian, Clemens Becker, Philip Brown, Joren Buekers, Anne-Elie Carsin, Marco Caruso, Brian Caulfield, Andrea Cereatti, Lorenzo Chiari, Carlos Echevarria, Bjoern Eskofier, Jordi Evers, Judith Garcia-Aymerich, Tilo Hache, Clint Hansen, Jeffrey M Hausdorff, Hugo Hiden, Emily Hume, Alison Keogh, Sarah Koch, Walter Maetzler, Dimitrios Megaritis, Martijn Niessen, Or Perlman, Lars Schwickert, Kirsty Scott, Basil Sharrack, David Singleton, Beatrix Vereijken, Ioannis Vogiatzis, Alison Yarnall, Lynn Rochester, Claudia Mazzà, Silvia Del Din, Arne Mueller
BACKGROUND: Wrist-worn inertial sensors are used in digital health for evaluating mobility in real-world environments. Preceding the estimation of spatiotemporal gait parameters within long-term recordings, gait detection is an important step to identify regions of interest where gait occurs, which requires robust algorithms due to the complexity of arm movements. While algorithms exist for other sensor positions, a comparative validation of algorithms applied to the wrist position on real-world data sets across different disease populations is missing...
May 1, 2024: JMIR Formative Research
#71
REVIEW
Maria A Rocca, Francesco Romanò, Nicolò Tedone, Massimo Filippi
INTRODUCTION: Progress in magnetic resonance imaging (MRI) technology and analyses is improving our comprehension of multiple sclerosis (MS) pathophysiology. These advancements, which enable the evaluation of atrophy, microstructural tissue abnormalities, and functional plasticity, are broadening our insights into the effectiveness and working mechanisms of motor and cognitive rehabilitative treatments. AREAS COVERED: This narrative review with selected studies discusses findings derived from the application of advanced MRI techniques to evaluate structural and functional neuroplasticity modifications underlying the effects of motor and cognitive rehabilitative treatments in people with MS (PwMS)...
May 1, 2024: Journal of Neurology
#72
Plamen Penchev, Valentin Dobrev, Petar-Preslav Petrov, Remzi Hyusein, Vladislav Velchev, Kristiyan Georgiev
Raynaud's syndrome is characterized by paroxysmal vasospasm in the digital arterioles, following exposure to cold or stress. Pain, swelling, stiffness, and hypoesthesia are observed as manifestations. The presence of a trophic ulcer is accompanied by a range of severe manifestations. The assaults occur in three distinct phases, namely vasospastic, plethoric, and erythema. Various approaches improve the overall well-being of a patient. It is possible to differentiate between primary and secondary Raynaud's syndrome, the latter being linked to systemic diseases...
March 2024: Curēus
#73
JOURNAL ARTICLE
Jianguo Yang, Yuying Sun, Xinpeng Zhou, Di Zhang, Ziqi Xu, Jiaojiao Cao, Bing Fan
BACKGROUND AND PURPOSE: The objective of this study is to evaluate the risk of secondary autoimmune diseases in multiple sclerosis (MS) patients treated with alemtuzumab (ALZ) through a meta-analysis. METHODS: PubMed, Web of Science, OVID, EMBASE, and Cochrane central register of controlled trials were searched. Information and data were screened and extracted by 2 researchers. The obtained data were analyzed using the R software meta package. Quality assessment was conducted using the Newcastle-Ottawa Scale (NOS)...
2024: Frontiers in Immunology
#74
JOURNAL ARTICLE
Tobias Zrzavy, Kerstin Rieder, Viktoria Wuketich, Renate Thalhammer, Helmuth Haslacher, Patrick Altmann, Barbara Kornek, Nik Krajnc, Tobias Monschein, Christiane Schmied, Karin Zebenholzer, Gudrun Zulehner, Thomas Berger, Paulus Rommer, Fritz Leutmezer, Gabriel Bsteh
BACKGROUND: Recent studies proposed cellular immunoprofiling as a surrogate for predicting treatment response and/or stratifying the occurrence of adverse events (AEs) in persons with multiple sclerosis (pwMS). However, applicability in real-world circumstances is not sufficiently addressed. OBJECTIVE: We aimed to explore whether standard routine clinical leukocyte phenotyping before treatment initiation could help stratify patients according to treatment response or AEs in a real-world MS cohort...
2024: Frontiers in Neurology
#75
JOURNAL ARTICLE
Oliver Carlile, Andrew Briggs, Alasdair D Henderson, Ben F C Butler-Cole, John Tazare, Laurie A Tomlinson, Michael Marks, Mark Jit, Liang-Yu Lin, Chris Bates, John Parry, Sebastian C J Bacon, Iain Dillingham, William A Dennison, Ruth E Costello, Alex J Walker, William Hulme, Ben Goldacre, Amir Mehrkar, Brian MacKenna, Emily Herrett, Rosalind M Eggo
BACKGROUND: Long COVID is a major problem affecting patient health, the health service, and the workforce. To optimise the design of future interventions against COVID-19, and to better plan and allocate health resources, it is critical to quantify the health and economic burden of this novel condition. We aimed to evaluate and estimate the differences in health impacts of long COVID across sociodemographic categories and quantify this in Quality-Adjusted Life-Years (QALYs), widely used measures across health systems...
May 2024: The Lancet regional health. Europe
#76
REVIEW
Kimberly A DiMauro, Carol Swetlik, Jeffrey A Cohen
IMPORTANCE: The prevalence of multiple sclerosis (MS) and aging MS patients is increasing worldwide. There is a need to better understand this MS sub-population, which historically is underrepresented in the literature. This narrative review examines the evolving demographics, disease course, and treatments for older adults with MS (OAMS) to address current knowledge gaps and highlight areas critical for future research. OBSERVATIONS: OAMS populations require special consideration by clinicians...
April 30, 2024: Journal of Neurology
#77
JOURNAL ARTICLE
Jannis Müller, Izanne Roos, Tomas Kalincik, Johannes Lorscheider, Edoardo Galli, Pascal Benkert, Sabine Schädelin, Sifat Sharmin, Maximilian Einsiedler, Peter Hänni, Jürg Schmid, Jens Kuhle, Tobias Derfuss, Cristina Granziera, Tjalf Ziemssen, Timo Siepmann, Özgür Yaldizli
BACKGROUND: In patients with relapsing remitting multiple sclerosis (RRMS) on low-efficacy disease modifying therapies (DMT), the optimal strategy on how to escalate treatment once needed, remains unknown. METHODS: We studied RRMS patients on low-efficacy DMTs listed in the Swiss National Treatment Registry, who underwent escalation to either medium- or high-efficacy DMTs. Propensity score-based matching was applied using 12 clinically relevant variables. Both groups were also separately matched with control subjects who did not escalate therapy...
May 2024: Brain and Behavior
#78
JOURNAL ARTICLE
Anum Zehra, Parvaiz Ahmad Naik, Ali Hasan, Muhammad Farman, Kottakkaran Sooppy Nisar, Faryal Chaudhry, Zhengxin Huang
BACKGROUND AND OBJECTIVE: To study the dynamical system, it is necessary to formulate the mathematical model to understand the dynamics of various diseases that are spread worldwide. The main objective of our work is to examine neurological disorders by early detection and treatment by taking asymptomatic. The central nervous system (CNS) is impacted by the prevalent neurological condition known as multiple sclerosis (MS), which can result in lesions that spread across time and place...
April 24, 2024: Computer Methods and Programs in Biomedicine
#79
JOURNAL ARTICLE
Anthony Feinstein
No abstract text is available yet for this article.
April 30, 2024: Multiple Sclerosis: Clinical and Laboratory Research
#80
JOURNAL ARTICLE
Laura M Hancock
No abstract text is available yet for this article.
April 30, 2024: Multiple Sclerosis: Clinical and Laboratory Research
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