Rosendo Pérez-Isidoro, Alejandra Gabriela Valdez-Lara, Alma Jessica Díaz-Salazar, Stephanie Hoeppener, Carlos Guerrero-Sánchez, Patricia Quintana-Owen, Jesus Carlos Ruiz-Suárez, Ulrich S Schubert, Guadalupe Ayora-Talavera, Marco Antonio De Jesús-Téllez, Enrique Saldívar-Guerra
Liposome-based technologies derived from lipids and polymers ( e.g. , PEGylated liposomes) have been recognized because of their applications in nanomedicine. However, since such systems represent myriad challenges and may promote immune responses, investigation of new biomaterials is mandatory. Here, we report on a biophysical investigation of liposomes decorated with bioconjugated copolymers in the presence (or absence) of amantadine (an antiviral medication). First, copolymers of poly( N , N -dimethylacrylamide- co -fluoresceinacrylate- co -acrylic acid- N -succinimide ester)- block -poly( N -isopropylacrylamide) (PDMA- b -PNIPAM) containing a fluorescence label were biofunctionalized with short peptides that resemble the sequence of the loops 220 and 130 of the binding receptor of the hemagglutinin (HA) protein of the influenza A virus...
May 17, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine