keyword
https://read.qxmd.com/read/100001003/emergency-management-of-sepsis-the-simple-stuff-saves-lives
#1
David Sweet , Julian Marsden , Kendall Ho , Christina Krause , James A Russell
Many emergency departments have implemented sepsis protocols since the 2001 publication of results from the early goal-directed therapy trial, which showed early targeted resuscitation lowers mortality. As part of an attempt to improve clinical and operational outcomes for emergency departments across British Columbia, we reviewed sepsis management literature and considered sepsis protocol implementation in the province’s emergency departments. During the literature review we found that many observational studies confirmed an association between implementation of emergency sepsis protocols and decreased mortality...
May 2012: British Columbia Medical Journal
https://read.qxmd.com/read/38537233/risk-factors-for-readmission-after-a-cholecystectomy-a-case-control-study
#2
JOURNAL ARTICLE
Daniel Garcia, Antonia Pastore, Javier Rodriguez, Fernando Crovari, Jaime Cerda, Patricia Rebolledo, Pablo Achurra, Eduardo Viñuela, Jorge Martinez, Martin Dib, Eduardo Briceño
OBJECTIVE: The aim of this study was to assess the risk factors associated with 30-day hospital readmissions after a cholecystectomy. METHODS: We conducted a case-control study, with data obtained from UC-Christus from Santiago, Chile. All patients who underwent a cholecystectomy between January 2015 and December 2019 were included in the study. We identified all patients readmitted after a cholecystectomy and compared them with a randomized control group. Univariate and multivariate analyses were conducted to identify risk factors...
2024: Cirugia y Cirujanos
https://read.qxmd.com/read/38537228/intestinal-intussusception-as-a-postoperative-complication-of-gastric-bypass
#3
JOURNAL ARTICLE
Perla X López-Almanza, Daniel González-Hermosillo-Cornejo, Gerardo A Montalvo-Domínguez, Enrique Reyes-Rodríguez, Pablo Andrade-Martínez-Garza
The gold standard for bariatric surgery is the laparoscopic gastric bypass, which consists in forming a small gastric pouch and a Roux-en-Y anastomosis. We present the case of a 41-year-old female who underwent a laparoscopic gastric bypass 8 years prior to her admission to the emergency room, where she arrived complaining of severe and colicky epigastric abdominal pain. The abdominal computed tomography showed a jejuno-jejunal intussusception, for which the patient underwent urgent exploratory laparotomy with intussusception reduction...
2024: Cirugia y Cirujanos
https://read.qxmd.com/read/38537225/a-randomized-noninferiority-trial-to-compare-enteral-to-parenteral-phosphate-replacement-on-biochemistry-waste-and-environmental-impact-and-healthcare-cost-in-critically-ill-patients-with-mild-to-moderate-hypophosphatemia
#4
JOURNAL ARTICLE
Chinh D Nguyen, Haustine P Panganiban, Timothy Fazio, Amalia Karahalios, Melissa Akravs, Christopher M MacIsaac, Thomas Rechnitzer, Lucy Arno, An Tran-Duy, Scott McAlister, Yasmine Ali Abdelhamid, Adam M Deane
OBJECTIVES: Hypophosphatemia occurs frequently. Enteral, rather than IV, phosphate replacement may reduce fluid replacement, cost, and waste. DESIGN: Prospective, randomized, parallel group, noninferiority clinical trial. SETTING: Single center, 42-bed state trauma, medical and surgical ICUs, from April 20, 2022, to July 1, 2022. PATIENTS: Patients with serum phosphate concentration between 0.3 and 0.75 mmol/L. INTERVENTIONS: We randomized patients to either enteral or IV phosphate replacement using electronic medical record-embedded program...
March 25, 2024: Critical Care Medicine
https://read.qxmd.com/read/38537182/diagnostic-and-prognostic-efficacy-of-optic-nerve-sheath-diameter-in-patients-with-dysnatremia
#5
JOURNAL ARTICLE
Berika Kavaz Kuru, Ahmet Baydın, Metin Ocak, İskender Aksoy
AIM: This study aimed to investigate the diagnostic and prognostic value of optic nerve sheath diameter (ONSD) measurement in patients with dysnatremia. MATERIAL AND METHODS: This prospective clinical study included patients aged ≥18 years who were diagnosed with dysnatremia on admission to the emergency department. RESULTS: The present study included 65 patients (35 with hypernatremia [hypernatremia group] and 30 with hyponatremia [hyponatremia group]) and 14 healthy volunteers (control group)...
February 13, 2024: Medical Ultrasonography
https://read.qxmd.com/read/38537178/-what-if-i-got-rejected-by-the-girl-i-would-rather-stop-the-pills-barriers-and-facilitators-of-adherence-to-antiretroviral-therapy-for-emerging-adults-aged-18-29-living-with-hiv-in-zimbabwe
#6
JOURNAL ARTICLE
Rebecca Jopling, Wilson Mutsvuke, Madison Fertig, Conall O'Cleirigh, Walter Mangezi, Melanie Abas
Emerging adults aged 18-29 have high rates of viral non-suppression, and poorer adherence to ART when compared to older adults. Semi-structured interviews were conducted with 24 emerging adults in Zimbabwe who had a recent history of viral non-suppression, to explore barriers and facilitators of adherence to ART. Interviews were coded using inductive thematic analysis. The mean age of participants was 23, 65% were male, and 79% reported acquiring HIV at birth. Twelve barriers to adherence were identified. Hiding HIV status due to the possible negative consequences of disclosure had a significant impact on adherence to ART...
March 27, 2024: AIDS Care
https://read.qxmd.com/read/38537154/the-future-of-liver-transplantation
#7
JOURNAL ARTICLE
Sandy Feng, Garrett R Roll, Foad J Rouhani, Alberto Sanchez Fueyo
Over the last 50 years, liver transplantation has evolved into a procedure routinely performed in many countries worldwide. Those able to access this therapy frequently experience a miraculous risk-benefit ratio since, particularly if they face imminently life threatening disease. Over the decades, the success of liver transplantation, with dramatic improvements in early post-transplant survival, has aggressively driven demand. However, in spite of the emergence of living donors to augment deceased donors as a source of organs, supply has lagged far behind demand...
March 27, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://read.qxmd.com/read/38537143/-fusarium-amaranthuense-sp-nov-from-amaranth-is-an-emergent-species-closely-related-to-fusarium-circinatum
#8
JOURNAL ARTICLE
Oliul Hassan, Hyunjoo Ryu, Sang-Yeob Lee, Hyo-Won Choi
Amaranth ( Amaranthus spp. L) is not native to South Korea but cultivated in small scales for ornamental purposes as well as leafy vegetables and pseudo cereals. In this study, a new species within the genus Fusarium was isolated from amaranth, showing stem rot symptoms from a farmer field in Hwaseong, South Korea. The disease is characterized by dark-brown spots with black borders, leading to withering. Phylogenetic analysis based on concatenated sequences of translation elongation factor 1-alpha ( TEF1 ), beta-tubulin ( tub2 ), calmodulin ( cmdA ), RNA polymerase largest subunit ( RPB1 ) and RNA polymerase II second largest subunit ( RPB2 ) genes, revealed that the obtained isolates were formed a distinct clade within the Fusarium fujikuroi species complex and closely related to F ...
March 27, 2024: Plant Disease
https://read.qxmd.com/read/38537116/featured-articles-for-cme-credit-april-2024
#9
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
April 1, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38537107/exploring-psychosocial-distress-in-caregivers-of-children-and-youth-with-special-health-care-needs
#10
JOURNAL ARTICLE
Régine Placide Reaves, Giovanna De Oliveira, Angel Johann Solorzano Martinez
PURPOSE: Caring for a child or youth with special health care needs (CYSHCN) can be overwhelming. Parents and caregivers may experience psychosocial distress, such as depression, frustration, and hopelessness. The purpose of the current study was to gain further insight into families' perspectives on the psychosocial impacts of caring for CYSHCN to identify gaps in health care systems and strengthen systems of support. METHOD: A qualitative descriptive design was used in 16 parents and caregivers...
April 1, 2024: Journal of Psychosocial Nursing and Mental Health Services
https://read.qxmd.com/read/38537081/performance-of-outbreak-management-plans-for-emerging-plant-diseases-the-case-of-almond-leaf-scorch-caused-by-xylella-fastidiosa-in-mainland-spain
#11
JOURNAL ARTICLE
Martina Cendoya, Elena Lázaro, Ana Navarro-Quiles, Antonio López-Quílez, David Conesa, Antonio Vicent
Outbreak response to quarantine pathogens and pests in the European Union (EU) is regulated by the EU Plant Health Law, but the performance of outbreak management plans in terms of their effectiveness and efficiency has been quantified only to a limited extent. As a case study, the disease dynamics of almond leaf scorch, caused by Xylella fastidiosa ( Xf ), in the affected area of Alicante, Spain, were approximated using an individual-based spatial epidemiological model. The emergence of this outbreak was dated based on phylogenetic studies, and official surveys were used to delimit the current extent of the disease...
March 27, 2024: Phytopathology
https://read.qxmd.com/read/38537056/perioperative-outcomes-and-long-term-survival-of-cryosurgery-on-unresectable-pancreatic-cancer-a-systematic-review-and-meta-analysis
#12
JOURNAL ARTICLE
Kang Xue, Xiaofeng Liu, Xiaolin Xu, Li Wang, Bole Tian
BACKGROUND: Pancreatic cancer (PC) continues to rank as one of the deadliest forms of cancer, with the majority of patients being diagnosed with unresectable disease. The implementation of cryoablation-based comprehensive treatment is expected to lead to a reduction in tumor size and potentially achieve complete resection. However, the availability of systematic and evidence-based treatment guidelines for cryoablation in pancreatic cancer is currently limited. MATERIALS AND METHODS: A computerized search was conducted in the Medline, Embase, Cochrane Library databases, and Clinicaltrials to retrieve studies published from August 1987 to June 2023...
April 3, 2024: International Journal of Surgery
https://read.qxmd.com/read/38537052/the-sociocultural-context-of-adolescent-pain-portrayals-of-pain-in-popular-adolescent-media
#13
JOURNAL ARTICLE
Allison Cormier, Kendra Mueri, Maria Pavlova, Anna Hood, Queenie Li, Idia Thurston, Abbie Jordan, Melanie Noel
Research has consistently suggested that media consumption plays a vital role in children's socialization, including the socialization of painful experiences. Past research examining young children's popular media revealed worrisome trends in media depictions of pain; it consisted of narrow depictions of pain, gender stereotypes, and an overwhelming lack of empathy from observers, which could contribute to pain-related stigma. Research has not yet examined how pain is portrayed in adolescent media, despite adolescence being the developmental period when chronic pain often emerges...
March 27, 2024: Pain
https://read.qxmd.com/read/38537050/deep-anterior-lamellar-keratoplasty-and-penetrating-keratoplasty-in-macular-corneal-dystrophy-comparison-of-visual-and-topographic-outcomes-and-complications
#14
JOURNAL ARTICLE
Ayşe Tüfekçi Balıkçı, Ayşe Burcu, Züleyha Yalnız Akkaya, Evin Singar, Selma Uzman
PURPOSES: This study aims to assess and compare the postoperative visual and topographic outcomes, complications, and graft survival rates following deep anterior lamellar keratoplasty and penetrating keratoplasty in patients with macular corneal dystrophy. METHODS: In this study we enrolled 59 patients (23 male; and 36 female) with macular corneal dystrophy comprising 81 eyes. Out of these, 64 eyes underwent penetrating keratoplasty, while 17 eyes underwent deep anterior lamellar keratoplasty...
2024: Arquivos Brasileiros de Oftalmologia
https://read.qxmd.com/read/38537009/transient-receptor-potential-melastatin-7-trpm7-ion-channel-inhibitors-preliminary-sar-and-conformational-studies-of-xenicane-diterpenoids-from-the-hawaiian-soft-coral-sarcothelia-edmondsoni
#15
JOURNAL ARTICLE
Guangmin Yao, Matthew R Parris, W Cedric Kuo, Peter Pörzgen, Brandi Castillo, Evan S Mason, Andres Chinchilla, Junhao Huang, Sayuri Suzuki, Rylee Ross, Ellis Akana, Savana Vander Schuit, Steven P Miller, Reinhold Penner, Hong-Shuo Sun, Zhong-Ping Feng, Kenneth G Hull, Daniel Romo, Andrea Fleig, F David Horgen
Waixenicin A, a xenicane diterpene from the octocoral Sarcothelia edmondsoni , is a selective, potent inhibitor of the TRPM7 ion channel. To study the structure-activity relationship (SAR) of waixenicin A, we isolated and assayed related diterpenes from S. edmondsoni . In addition to known waixenicins A ( 1 ) and B ( 2 ), we purified six xenicane diterpenes, 7 S ,8 S -epoxywaixenicins A ( 3 ) and B ( 4 ), 12-deacetylwaixenicin A ( 5 ), waixenicin E ( 6 ), waixenicin F ( 7 ), and 20-acetoxyxeniafaraunol B ( 8 )...
March 27, 2024: Journal of Natural Products
https://read.qxmd.com/read/38537006/effect-of-mode-of-delivery-on-postpartum-health-related-quality-of-life
#16
JOURNAL ARTICLE
Esra Keles, Leyla Kaya, Neşe Yakşi, Zahide Kaya
OBJECTIVE: The aim of the study was to explore the impact of mode of delivery on health-related quality of life in mothers. METHODS: This cross-sectional study was conducted between May and August 2022 on healthy singleton pregnant women aged between 18 and 45 years. Data on socio-demographic variables, clinic features, pregnancy and birth characteristics, and neonatal outcomes were collected. Health-related quality of life was assessed by using EQ-5D-5L questionnaire...
2024: Revista da Associação Médica Brasileira
https://read.qxmd.com/read/38536999/occurrence-of-arbovirus-infections-in-two-riverine-populations-in-the-municipality-of-humait%C3%A3-amazonas-brazil
#17
JOURNAL ARTICLE
Jaqueline Carvalho de Oliveira Silva, Igor Rodrigo Ferreira Siqueira, Leormando Fortunato Dornelas, Cristhian Magalhães Ribeiro, João Pedro Berno Gomes, Iagor Wingenbah Guadagnin, Antonieta Relvas Pereira, Genimar Rebouças Julião, Juliana de Souza Almeida Aranha Camargo, Sergio Almeida Basano, Luís Marcelo Aranha Camargo
BACKGROUND: The riverine communities of the Amazon comprise different social groups that inhabit the rural areas on the banks of rivers and lakes. Residents usually travel by river to rural and urban areas and are then exposed to urbanized diseases such as those caused by arbovirus infection. In Brazil, emerging diseases such as dengue, Zika, chikungunya, and those caused by infection with Oropouche and Mayaro viruses necessitate epidemiological surveillance. This study was aimed at determining the frequency of positivity for immunoglobulin (Ig)G and IgM antibodies against Zika, chikungunya, and dengue viruses and performing molecular analyses to detect viral RNA for the Zika, chikungunya, dengue virus, Oropouche, and Mayaro viruses, in the same serum samples obtained from riverside populations...
2024: Revista da Sociedade Brasileira de Medicina Tropical
https://read.qxmd.com/read/38536949/combination-nano-delivery-systems-remodel-the-immunosuppressive-tumor-microenvironment-for-metastatic-triple-negative-breast-cancer-therapy
#18
JOURNAL ARTICLE
Liya Bai, Hui Liu, Ran You, Xiaoyu Jiang, Tao Zhang, Yunan Li, Tianhe Shan, Zhanyin Qian, Yinsong Wang, Yuanyuan Liu, Chunyu Li
Triple-negative breast cancer (TNBC) is an aggressive type of breast cancer for which effective therapies are lacking. Targeted remodeling of the immunosuppressive tumor microenvironment (TME) and activation of the body's immune system to fight tumors with well-designed nanoparticles have emerged as pivotal breakthroughs in tumor treatment. To simultaneously remodel the immunosuppressive TME and trigger immune responses, we designed two potential therapeutic nanodelivery systems to inhibit TNBC. First, the bromodomain-containing protein 4 (BRD4) inhibitor JQ1 and the cyclooxygenase-2 (COX-2) inhibitor celecoxib (CXB) were coloaded into chondroitin sulfate (CS) to obtain CS@JQ1/CXB nanoparticles (NPs)...
March 27, 2024: Molecular Pharmaceutics
https://read.qxmd.com/read/38536917/sensitive-detection-of-multiple-blood-biomarkers-via-immunomagnetic-exosomal-pcr-for-the-diagnosis-of-alzheimer-s-disease
#19
JOURNAL ARTICLE
Shun Hu, Liding Zhang, Ying Su, Xiaohan Liang, Jie Yang, Qingming Luo, Haiming Luo
Blood exosomes are emerging as potential biomarkers for diagnosing brain diseases such as Alzheimer's disease (AD). There is currently a lack of an ultrasensitive technology for identifying core AD biomarkers in blood exosomes to optimize the utility of biomarkers in clinical practice. Here, an immunomagnetic exosomal polymerase chain reaction (iMEP) platform was developed using DNA-conjugated antibodies for the rapid detection of amyloid-β (Aβ1-40 and Aβ1-42 ) and phosphorylated tau (p-tau396,404 and p-tau181 ) in clinical blood exosomes...
March 29, 2024: Science Advances
https://read.qxmd.com/read/38536900/optimized-bags-of-artificial-neural-networks-can-predict-the-viability-of-organisms-exposed-to-nanoparticles
#20
JOURNAL ARTICLE
Ravithree D Senanayake, Clyde A Daly, Rigoberto Hernandez
Prediction of organismal viability upon exposure to a nanoparticle in varying environments─as fully specified at the molecular scale─has emerged as a useful figure of merit in the design of engineered nanoparticles. We build on our earlier finding that a bag of artificial neural networks (ANNs) can provide such a prediction when such machines are trained with a relatively small data set (with ca. 200 examples). Therein, viabilities were predicted by consensus using the weighted means of the predictions from the bags...
March 27, 2024: Journal of Physical Chemistry. A
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