keyword
https://read.qxmd.com/read/100001003/emergency-management-of-sepsis-the-simple-stuff-saves-lives
#1
David Sweet , Julian Marsden , Kendall Ho , Christina Krause , James A Russell
Many emergency departments have implemented sepsis protocols since the 2001 publication of results from the early goal-directed therapy trial, which showed early targeted resuscitation lowers mortality. As part of an attempt to improve clinical and operational outcomes for emergency departments across British Columbia, we reviewed sepsis management literature and considered sepsis protocol implementation in the province’s emergency departments. During the literature review we found that many observational studies confirmed an association between implementation of emergency sepsis protocols and decreased mortality...
May 2012: British Columbia Medical Journal
https://read.qxmd.com/read/38621307/primary-intracranial-peripheral-primitive-neuroectodermal-tumor-lessons-from-an-exceptionally-rare-neoplasm-illustrative-case
#2
JOURNAL ARTICLE
Jhon E Bocanegra-Becerra, Luis Felipe Novoa-Ramírez, Alan Jesús Latorre-Zúñiga, Norka Tacas-Gil, Rolando Rojas-Apaza
BACKGROUND: The primary intracranial peripheral primitive neuroectodermal tumor (pPNET) is a lesion subtype within the Ewing sarcoma family of tumors. pPNETs are extremely uncommon pathologies, accounting for 0.03% of intracranial tumors and 1% to 2% of Ewing sarcoma cases. Given its histological aspect similar to other highly proliferative malignant neuroectodermal neoplasms, pPNET merits extensive workup for accurate diagnosis and treatment. OBSERVATIONS: A 36-year-old male presented to the emergency department with a 1-year history of headaches in the right frontoparietal area, generalized tonic-clonic seizures, and a history of the resection of a tumor labeled as a meningioma 5 years before admission...
April 15, 2024: J Neurosurg Case Lessons
https://read.qxmd.com/read/38621301/epidural-lipomatosis-with-foci-of-hemorrhage-and-acute-compression-of-the-spinal-cord-in-a-child-with-cloves-syndrome-illustrative-case
#3
JOURNAL ARTICLE
Dmytro Ishchenko, Iryna Benzar, Andrii Holoborodko
BACKGROUND: Congenital lipomatous overgrowth, vascular malformations, epidermal nevi, spinal/skeletal anomalies, and/or scoliosis (CLOVES) syndrome is the most recently described combined vascular anomaly characterized by congenital excessive growth of adipose tissue, vascular malformations, epidermal nevi, and skeletal deformities. This condition exhibits a significant variability in clinical manifestations and a tendency for rapid progression and affects extensive anatomical regions...
April 15, 2024: J Neurosurg Case Lessons
https://read.qxmd.com/read/38621298/electronegative-phosphorus-integrated-co-2-active-sites-for-enhanced-electrocatalytic-nitrogen-reduction
#4
JOURNAL ARTICLE
Yuanyuan Xiong, Jingxian Li, Xiaoxuan Wang, Xinyue Chi, Shuyuan Li, Yanfei Sun, Zheng Tang, Zishan Hou, Jiangzhou Xie, Zhiyu Yang, Yi-Ming Yan
In the quest for proficient electrocatalysts for ammonia's electrocatalytic nitrogen reduction, cobalt oxides, endowed with a rich d-electron reservoir, have emerged as frontrunners. Despite the previously evidenced prowess of CoO in this realm, its ammonia yield witnesses a pronounced decline as the reaction unfolds, a phenomenon linked to the electron attrition from its Co2+ active sites during electrocatalytic nitrogen reduction reaction (ENRR). To counteract this vulnerability, we harnessed electron-laden phosphorus (P) elements as dopants, aiming to recalibrate the electronic equilibrium of the pivotal Co active site, thereby bolstering both its catalytic performance and stability...
April 15, 2024: Inorganic Chemistry
https://read.qxmd.com/read/38621292/surface-and-bulk-stabilization-of-silicon-anodes-with-mixed-multivalent-additives-ca-tfsi-2-and-mg-tfsi-2
#5
JOURNAL ARTICLE
Sohyun Park, Haoyu Liu, Joseph Quinn, Saul H Lapidus, Yunya Zhang, Stephen E Trask, Chongmin Wang, Baris Key, Fulya Dogan
Silicon is drawing attention as an emerging anode material for the next generation of lithium-ion batteries due to its higher capacity compared with commercial graphite. However, silicon anions formed during lithiation are highly reactive with binder and electrolyte components, creating an unstable SEI layer and limiting the calendar life of silicon anodes. The reactivity of lithium silicide and the formation of an unstable SEI layer are mitigated by utilizing a mixture of Ca and Mg multivalent cations as an electrolyte additive for Si anodes to improve their calendar life...
April 15, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38621251/presynaptic-proteins-and-their-roles-in-visual-processing-by-the-retina
#6
REVIEW
Wallace B Thoreson, David Zenisek
The sense of vision begins in the retina, where light is detected and processed through a complex series of synaptic connections into meaningful information relayed to the brain via retinal ganglion cells. Light responses begin as tonic and graded signals in photoreceptors, later emerging from the retina as a series of spikes from ganglion cells. Processing by the retina extracts critical features of the visual world, including spatial frequency, temporal frequency, motion direction, color, contrast, and luminance...
April 15, 2024: Annual Review of Vision Science
https://read.qxmd.com/read/38621242/cardiology-what-you-may-have-missed-in-2023
#7
JOURNAL ARTICLE
Abdulrahman Alfraih, Achieng Tago, Michael Lacombe, William G Kussmaul
Cardiology and all its subspecialties continue to push the envelope in developing new treatment strategies for a wide variety of diseases. After screening more than 1300 articles, we highlight a selection of important cardiology articles published in 2023. Starting with prevention, we note articles that look at the effect of semaglutide in patients with obesity as well as a first-in-class drug, bempedoic acid, on cardiovascular outcomes. We have also examined new evidence comparing conservative management with invasive management of frail, older patients with non-ST-segment elevation myocardial infarction (NSTEMI)...
April 16, 2024: Annals of Internal Medicine
https://read.qxmd.com/read/38621231/application-of-ai-in-sepsis-citation-network-analysis-and-evidence-synthesis
#8
JOURNAL ARTICLE
MeiJung Wu, Md Mohaimenul Islam, Tahmina Nasrin Poly, Ming-Chin Lin
BACKGROUND: Artificial intelligence (AI) has garnered considerable attention in the context of sepsis research, particularly in personalized diagnosis and treatment. Conducting a bibliometric analysis of existing publications can offer a broad overview of the field and identify current research trends and future research directions. OBJECTIVE: The objective of this study is to leverage bibliometric data to provide a comprehensive overview of the application of AI in sepsis...
April 15, 2024: Interactive Journal of Medical Research
https://read.qxmd.com/read/38621224/spot-based-global-registration-for-subpixel-stitching-of-single-molecule-resolution-images-for-tissue-scale-spatial-transcriptomics
#9
JOURNAL ARTICLE
Seokjin Yeo, Alex W Schrader, Juyeon Lee, Marisa Asadian, Hee-Sun Han
Single-molecule imaging at the tissue scale has revolutionized our understanding of biology by providing unprecedented insight into the molecular expression of individual cells and their spatial organization within tissues. However, achieving precise image stitching at the single-molecule level remains a challenge, primarily due to heterogeneous background signals and dim labeling signals in single-molecule images. This paper introduces Spot-Based Global Registration (SBGR), a novel strategy that shifts the focus from raw images to identified molecular spots for high-resolution image alignment...
April 15, 2024: Analytical Chemistry
https://read.qxmd.com/read/38621177/molecular-insights-into-sequence-specific-protein-hydrolysis-by-a-soluble-zirconium-oxo-cluster-catalyst
#10
JOURNAL ARTICLE
Kilian Declerck, Nada D Savić, Mhamad Aly Moussawi, Carlotta Seno, Rohan Pokratath, Jonathan De Roo, Tatjana N Parac-Vogt
The development of catalysts for controlled fragmentation of proteins is a critical undertaking in modern proteomics and biotechnology. {Zr6 O8 }-based metal-organic frameworks (MOFs) have emerged as promising candidates for catalysis of peptide bond hydrolysis due to their high reactivity, stability, and recyclability. However, emerging evidence suggests that protein hydrolysis mainly occurs on the MOF surface, thereby questioning the need for their highly porous 3D nature. In this work, we show that the discrete and water-soluble [Zr6 O4 (OH)4 (CH3 CO2 )8 (H2 O)2 Cl3 ]+ (Zr6 ) metal-oxo cluster (MOC), which is based on the same hexamer motif found in various {Zr6 O8 }-based MOFs, shows excellent activity toward selective hydrolysis of equine skeletal muscle myoglobin...
April 15, 2024: Journal of the American Chemical Society
https://read.qxmd.com/read/38621153/telehealth-utilization-for-opioid-use-disorder-a-nationwide-analysis-before-and-after-the-covid-19-public-health-emergency-declaration
#11
JOURNAL ARTICLE
Kanna N Lewis, Dong Zhang, German Corrales, Hari Eswaran, Corey J Hayes, Laura E Gressler
Introduction: The COVID-19 pandemic has led to the rapid and widespread adoption of telehealth services. Telehealth may aid in bridging gaps in access to care. The specific impact of telehealth on opioid use disorder (OUD) and its treatment remains uncertain. Methods: A retrospective review of commercial insurance claim records within the United States was conducted to investigate the association between the COVID-19 pandemic and changes in the rates of(a) OUD treatments with and without telehealth support and (b) prescriptions for medications for opioid use disorder (MOUD) with and without telehealth support among individuals diagnosed with OUD...
April 15, 2024: Telemedicine Journal and E-health
https://read.qxmd.com/read/38621150/catheter-related-infections-in-pediatric-patients-due-to-a-rare-pathogen-herbaspirillum-huttiense
#12
JOURNAL ARTICLE
Seval Özen, Saliha Kanik Yüksek, Bedia Dinç, Fatih Üçkardeş, Hatice Kübra Konca, Tuğba Erat, Ahmet Yasin Güney, Ömer Güneş, Zehra Nihan Coşkun, Belgin Gülhan, Gülsüm İclal Bayhan, Nilay Çöplü, Asli Nur Özkaya Parlakay, Namik Yaşar Özbek
BACKGROUND: Herbaspirillum species are nonfermenting, aerobic, helical or curved, Gram-negative bacteria belonging to the class Betaproteobacteria, order Burkholderiales. To date, only a few studies have reported on the epidemiology, clinical symptoms, antibiotic susceptibility profiles, treatment and outcomes of Herbaspirillum huttiense-related infections in pediatric patients. METHODS: The aim of this study was to present 3 years of H.Huntiense data, antibiotic susceptibility profiles, systemic antibiotics and antibiotic lock therapy (ALT) options and clinical outcomes...
April 8, 2024: Pediatric Infectious Disease Journal
https://read.qxmd.com/read/38621130/substrate-geometry-affects-population-dynamics-in-a-bacterial-biofilm
#13
JOURNAL ARTICLE
Witold Postek, Klaudia Staśkiewicz, Elin Lilja, Bartłomiej Wacław
Biofilms inhabit a range of environments, such as dental plaques or soil micropores, often characterized by noneven surfaces. However, the impact of surface irregularities on the population dynamics of biofilms remains elusive, as most experiments are conducted on flat surfaces. Here, we show that the shape of the surface on which a biofilm grows influences genetic drift and selection within the biofilm. We culture E scherichia coli biofilms in microwells with a corrugated bottom surface and observe the emergence of clonal sectors whose size corresponds to that of the corrugations, despite no physical barrier separating different areas of the biofilm...
April 23, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38621109/integrated-segmented-iq-modulator-for-orthogonal-sampling-and-multi-level-high-bandwidth-signal-generation
#14
JOURNAL ARTICLE
Younus Mandalawi, Mohamed I Hosni, Janosch Meier, Karanveer Singh, Souvaraj De, Ranjan Das, Thomas Schneider
Photonic-assisted signal processing of high-bandwidth signals emerges as a solution for challenges encountered in electronic-based processing. Here we present a concept for a compact, photonic-assisted digital-to-analog converter (DAC) and optical IQ-modulator in one single integrated device based on two innovative concepts: a segmented Mach-Zehnder modulator and orthogonal sampling. For electrically driving the modulator, only a single radio frequency oscillator and no pulse source or electrical DAC are required...
April 15, 2024: Optics Letters
https://read.qxmd.com/read/38621092/isochemical-crystallization-in-condensed-borate-lamgb-5-o-10-glass-ceramics-doped-with-optical-probe-eu-3
#15
JOURNAL ARTICLE
Bartosz Bondzior
The isochemical glass-ceramics doped with Eu3+ were prepared by the heat treatment of lanthanum magnesium borate glass. The crystalline phase was chemically identical to a glass matrix and consisted of condensed borate LaMgB5 O10 . The isochemical crystallization process begins with the formation of rings by BO4 groups. The emergence of ordered crystalline phase gives rise to intense charge transfer absorption of Eu3+ , allowing the efficient luminescence under UV. The analysis of Judd-Ofelt parameters and comparison to purely crystalline samples obtained by solid-state synthesis reveal a switch of parameter relations from Ω2  > Ω4 for glass to Ω2  < Ω4 for crystals but also a maximum value of Ω6 for glass-ceramic sample, which indicates enhanced structural rigidity and results in superior luminescence output...
April 15, 2024: Optics Letters
https://read.qxmd.com/read/38621065/fractional-topological-charge-measurement-through-optical-correlation
#16
JOURNAL ARTICLE
Allarakha Shikder, Jyoti Bikash Mohapatra, Naveen K Nishchal
The emerging field of optical vortex beams having fractional topological charges (TCs) is of high interest due to its usefulness in various applications. The efficiency of the result depends on the precise measurement of the orbital angular momentum information tied to the fractional TC. This Letter demonstrates, to our knowledge, a novel and simple technique to measure the fractional TC of optical vortex beams through a hybrid digital-optical correlator with the help of auto-correlation between fork-shaped interference patterns corresponding to integer and fractional TCs...
April 15, 2024: Optics Letters
https://read.qxmd.com/read/38621040/vortex-ring-beams-in-nonlinear-p-t-symmetric-systems
#17
JOURNAL ARTICLE
Cristian Mejía-Cortés, Jesús Muñoz-Muñoz, Mario I Molina
In this paper, we investigate a two-dimensional photonic array featuring a circular shape and an alternating gain and loss pattern. Our analysis revolves around determining the presence and resilience of optical ring modes with varying vorticity values. This investigation is conducted with respect to both the array's length and the strength of the non-Hermitian parameter. For larger values of the array's length, we observe a reduction in the stability domain as the non-Hermitian parameter increases. Interestingly, upon increasing the vorticity of the optical modes, full stability windows emerge for shorter lattice size regime...
April 15, 2024: Optics Letters
https://read.qxmd.com/read/38620160/improving-quality-of-care-for-patients-receiving-care-through-telehealth-in-the-time-of-covid-19-global-pandemic-and-beyond-hci-based-leading-indicators-for-virtual-visits
#18
JOURNAL ARTICLE
Yalda Khashe, Maryam Tabibzadeh, Najmedin Meshkati
The COVID-19 pandemic expedited the growing rate of reliance on telehealth, as it provided a safer option for patients to seek the care they need and avoid potential negative consequences of being exposed to the COVID-19 virus. The aim of this study is to develop a series of Human-Computer Interaction (HCI)-based leading indicators to proactively analyze and evaluate the user interface in telehealth and virtual visits. Building on Nielsen's usability heuristics and mapping them to the six aspects of quality of care introduced by the Institute of Medicine, we identified the design features that had the highest impact on the quality of care and developed a list of leading indicators for each feature...
June 24, 2023: Hum Factors Health
https://read.qxmd.com/read/38620137/high-sensitivity-graphene-based-health-sensor-with-self-warning-function
#19
JOURNAL ARTICLE
Lu-Qi Tao, Chenwei Gao, Guanya Wang, Hao Sun, Liang-Yan Guo, Tian-Ling Ren
In order to reduce the damage to people's health from diseases that attack the respiratory system such as COVID-19, asthma, and pneumonia, it is desired that patients' breathing can be monitored and alerted in real-time. The emergence of wearable health detection sensing devices has provided a relatively good response to this problem. However, there are still problems such as complex structure and poor performance. This paper introduces a laser-induced graphene (LIG) device that is attached to PDMS. The LIG is produced by laser irradiation of Nomex and subsequently transferred and attached to the PDMS...
June 28, 2023: Composites Science and Technology
https://read.qxmd.com/read/38620125/a-new-hybrid-prediction-model-of-covid-19-daily-new-case-data
#20
JOURNAL ARTICLE
Guohui Li, Jin Lu, Kang Chen, Hong Yang
With the emergence of new mutant corona virus disease 2019 (COVID-19) strains such as Delta and Omicron, the number of infected people in various countries has reached a new high. Accurate prediction of the number of infected people is of far-reaching sig Nificance to epidemiological prevention in all countries of the world. In order to improve the prediction accuracy of COVID-19 daily new case data, a new hybrid prediction model of COVID-19 is proposed, which consists of four modules: decomposition, complexity judgment, prediction and error correction...
June 26, 2023: Engineering Applications of Artificial Intelligence
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