Ji Young Ha, Young Hun Choi, Yeon Jin Cho, Seunghyun Lee, Seul Bi Lee, Gayoung Choi, Jung Eun Cheon, Woo Sun Kim
OBJECTIVE: To evaluate the incidence and risk factors of emetic complications associated with the intravenous administration of low-osmolality iodinated contrast media (ICM) in children undergoing computed tomography (CT). MATERIALS AND METHODS: All children who underwent contrast-enhanced CT between April 2017 and July 2019 were included. Pediatric patients were instructed on the preparative dietary protocol at our institution. Experienced nurses in the radiology department monitored the children during the CT scans and recorded any emetic complications in their electronic medical records...
August 4, 2020: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
Semra Şen, Zülal Ülger, Zümrüt Şahbudak Bal, Mustafa Özbaran
BACKGROUND: There are limited data about pediatric left ventricular assist device (VAD) infections in developing countries. This study aimed to investigate device postimplantation infectious complications and their pathogenic profile. METHODS: Data were analyzed from patient charts involving 27 patients with dilated cardiomyopathy who underwentleft VAD implantation at a leading tertiary care center in Turkey. RESULTS: The study included 17 boys and ten girls with a median age of 12...
August 7, 2020: Transplant Infectious Disease: An Official Journal of the Transplantation Society
Frank Weber, Bharat K Rashmi, Gülhan Karaoz-Bulut, Jaap Dogger, Iris J de Heer, Christopher Prasser
BACKGROUND: In children the preoperative hydration status is an important part of the overall clinical assessment. The assumed preoperative fluid deficit is often routinely replaced during induction without knowing the child's actual fluid status. AIM: We investigated the predictive value of the Pleth Variability Index as a measure of fluid responsiveness in spontaneously breathing anesthetized children. METHODS: Pleth Variability Index, stroke volume and cardiac index, measured by electrovelocimetry, mean blood pressure and heart rate were recorded during anesthesia induction in 50 pediatric patients < 6 years...
August 7, 2020: Paediatric Anaesthesia
Jennifer W McVige, Rebecca M Hogan, Clayton M Shanahan, Diane L Amend, Shawn M Ferger
OBJECTIVE: To evaluate the pharmacokinetics, safety, and tolerability of a single 50-mg oral dose of diclofenac potassium for oral solution (OS) in a pediatric cohort with a diagnosis of episodic migraine; the 3-month safety trial following an outpatient dosing period was also evaluated. BACKGROUND: Children and adolescents often experience migraine pain that is poorly controlled, which may affect their emotional and psychological well-being. Diclofenac potassium for OS is approved for the treatment of migraine with aura (MWA) or migraine without aura (MWoA) in adults 18 years of age or older...
August 7, 2020: Headache
Vyshnavi Vasantham, Garima Singh, Aarzoo Jahan, Ruchika Gupta, Rakesh K Dogra, Namrata Sarin, Sompal Singh
BACKGROUND: Toxoplasmosis causes serious and sometimes life-threatening disease in immunocompromised patients like organ transplant recipients, immunodeficiency disorders or HIV-infected individuals. The co-occurrence of toxoplasmosis in a respiratory sample harboring tuberculosis (TB) may be missed especially in an area endemic for the latter infection. CASE REPORT: A 10-year-old child presented with complaints of fever with loss of appetite and weight. Based on radiological and clinical features, a presumptive diagnosis of pulmonary TB was made and bronchoalveolar lavage (BAL) performed for cytological and microbiological confirmation...
August 7, 2020: Diagnostic Cytopathology
P Goussard, L Van Wyk, J Burke, A Malherbe, F Retief, S Andronikou, L Mfingwana, D Ruttens, Van Zalm, A Dramowski, A Da Costa, H Rabie
INTRODUCTION: The COVID-19 era is a challenging time for respiratory teams to protect their patients and staff. COVID-19 is predominantly transmitted by respiratory droplets; in the clinical setting, aerosol generating procedures (AGP) pose the greatest risk for COVID-19 transmission. Bronchoscopy is associated with increased risk of patient-to-healthcare worker transmission, owing to aerosolized viral particles which may be inhaled and also result in environmental contamination of surfaces...
August 7, 2020: Pediatric Pulmonology
Aniko Sabo, David Murdock, Shannon Dugan, Qingchang Meng, Marie-Claude Gingras, Jianhong Hu, Donna Muzny, Richard Gibbs
BACKGROUND: Establishing a genetic diagnosis for individuals with intellectual disability (ID) benefits patients and their families as it may inform the prognosis, lead to appropriate therapy, and facilitate access to medical and supportive services. Exome sequencing has been successfully applied in a diagnostic setting, but most clinical exome referrals are pediatric patients, with many adults with ID lacking a comprehensive genetic evaluation. METHODS: Our unique recruitment strategy involved partnering with service and education providers for individuals with ID...
August 7, 2020: Molecular Genetics & Genomic Medicine
Ajay K Jain, Ravinder Anand, Stacee Lerret, George Yanni, Jia-Yuh Chen, Saeed Mohammad, Majella Doyle, Greg Telega, Simon Horslen
Liver transplantation (LT) in young patients is being performed with greater frequency. We hypothesized that objective analysis of pre, intra and post-operative events would help understand contributors to successful outcomes and guide transplant decision processes. We queried SPLIT registry for pediatric transplants between 2011 and 2018. Outcomes were compared for age groups: 0-<3, 3-<6, 6-<12 months and 1-<3 years (Groups A, B, C, D respectively) and by weight categories: <5, 5-10, >10 kg...
August 7, 2020: American Journal of Transplantation
Gil Hardy, Theodoric Wong, Hana Morrissey, Collin Anderson, Sissel J Moltu, Brenda Poindexter, Alexandre Lapillonne, Patrick A Ball
INTRODUCTION: Micronutrients (vitamins and trace elements) are essential to all nutrition. For children and neonates who are dependent upon nutrition support therapies for growth and development, the prescribed regimen must supply all essential components. This paper aims to facilitate interpretation of existing clinical guidelines into practical approaches for the provision of micronutrients in pediatric parenteral nutrition. METHODS: An international, interdisciplinary expert panel was convened to review recent evidence-based guidelines and published literature to develop consensus- based recommendation on practical micronutrient provision in pediatric parenteral nutrition...
August 7, 2020: JPEN. Journal of Parenteral and Enteral Nutrition
Emily Burns, Rosie Qin, Denise Metry
Idiopathic facial aseptic granuloma (IFAG) is an uncommon, benign lesion that presents in the pediatric population. The diagnosis is classically associated with preschool-aged children. Herein, we present a case of IFAG in a pre-adolescent boy, emphasizing the importance of diagnostic consideration in older children.
August 7, 2020: Pediatric Dermatology
Yuto Tanaka, Noritaka Yoshino, Kazuki Sako, Yoshiaki Ono, Yoshinobu Maeda
BACKGROUND: The relationship between uneven occlusal contact and fall risk has been described in elderly participants; however, multiple confounding factors, such as systemic disease or deterioration in vestibular function have not been well considered. This study aimed to investigate this relationship in pediatric participants at the age of approximately 9-12, where these confounding factors are absent and the replacement of primary molars by permanent ones generally occurs and transiently results in uneven occlusal contact...
August 6, 2020: Pediatrics International: Official Journal of the Japan Pediatric Society
Michelle Reed, Kathleen Mullaney, Christy Ruhmann, Peter March, Virginia H Conte, Lore Noyes, Mark Bleazard
BACKGROUND: The impact of malnutrition on pediatric patients in the acute care setting is significant. Hospitalized patients with malnutrition have been shown to have poor clinical outcomes. Nutrition screening is the first critical step in identifying and treating malnutrition. Although several pediatric nutrition screening tools exist, none incorporate both electronic health record (EHR) compatibility and the recommended indicators of pediatric malnutrition, a gap recently identified in a systematic review by the Academy of Nutrition and Dietetics...
August 6, 2020: Nutrition in Clinical Practice
Anastasia Anagnostou, Lothar Schrod, Judith Jochim, Jürgen Enenkel, Winfried Krill, Rolf Lambert Schlößer
BACKGROUND: The neonatal period can be associated with a multitude of medical and social problems. Little is known about the reasons that lead to neonatal readmissions in a pediatric hospital and their individual outcomes. OBJECTIVE: To record the diagnosis of neonatal admissions in a pediatric hospital after discharge from a maternity unit. Predictive parameters are to be identified and a possible trend over the years is to be examined. METHODS: The medical history of newborns admitted to a pediatric hospital in the Rhine-Main area from 01/01/2004 to 31/12/2013 was retrospectively analyzed based on provided medical files...
August 6, 2020: Zeitschrift Für Geburtshilfe und Neonatologie
Michael Silverman, Robert Sibbald, Saverio Stranges
COVID-19 mitigation strategies have led to widespread school closures around the world. Initially, these were undertaken based on data from influenza outbreaks in which children were highly susceptible and important in community-wide transmission. An argument was made that school closures were necessary to prevent harm to vulnerable adults, especially the elderly. Although data are still accumulating, the recently described complication, pediatric multisystem inflammatory syndrome, is extremely rare and children remain remarkably unaffected by COVID-19...
August 7, 2020: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
Song-Mi Wang, Fang Tao, Yan Hou, Ai Zhang, Hao Xiong, Jun-Jie Sun, Xiao-Ping Luo, Yan Hao, Jian-Xin Li, Qun Hu, Ai-Guo Liu
The SARS-CoV-2 infection status of hospitalized children was surveyed in the department of pediatric hematology and oncology in three different hospitals of epidemic areas in Hubei, China. A cross-sectional study was performed to investigate the clinical characteristics, lung CT scan, SARS-CoV-2 nucleic acid test and serum antibodies of hospitalized children with hemato-oncological diseases from January 23 to April 24, 2020. 299 children were enrolled in this study, including 176 males (58.9%) and 123 females (41...
August 7, 2020: Current medical science
Swati Mahich, Suresh Kumar Angurana, Renu Suthar, Venkataseshan Sundaram, Vimal Singh Munda, Vikas Gautam
OBJECTIVES: To study the clinical profile, complications, antibiotic resistance pattern, treatment, and outcome of out-born neonates with Acinetobacter spp. sepsis admitted in Pediatric emergency of a tertiary care hospital in North India. METHODS: In this subgroup analysis of a prospective study (conducted over 1 y, February 2018 through January 2019), neonates with Acinetobacter spp. sepsis were included. The data collection included demographic details, clinical features, pre-referral treatment, complications, antibiotic resistance pattern, treatment, and final outcome...
August 7, 2020: Indian Journal of Pediatrics
Ya-Chiao Hu, Bor-Luen Chiang, Yao-Hsu Yang
Behçet's disease (BD) is a chronic, vasculitic disorder affecting all sizes of vessels. The disease rarely onsets at childhood and an early diagnosis is often challenging. Oral ulceration and fever of unknown cause are common initial manifestations that might confuse other inflammatory disorders. The clinical manifestation pattern in pediatric BD is heterogeneous and varies in different genders, ethnicities, and geographic regions. There are also some differences in clinical presentations and prognosis between pediatric and adult BD...
August 7, 2020: Clinical Reviews in Allergy & Immunology
Maria Elena Cavicchiolo, Daniele Trevisanuto, Elisabetta Lolli, Veronica Mardegan, Anna Maria Saieva, Elisa Franchin, Mario Plebani, Daniele Donato, Eugenio Baraldi
Since February 21, 2020, SARS-CoV-2 has spread exponentially worldwide. Neonatal patients needing intensive care are considered a vulnerable population. To report the results of a policy based on multi-timepoint surveillance for SARS-CoV-2 of all neonates admitted to the neonatal intensive care unit (NICU), their parents, and all healthcare providers in a part of Italy with a high prevalence of the infection. Observational study conducted from 21 February to 21 April 2020. Intervention consisted of (a) parental triage on arrival at the neonatal ward; (b) universal testing with nasopharyngeal swabs and blood testing for SARS-CoV-2 IgM and IgG antibodies; (c) use of continuous personal protective equipment at the NICU by parents and staff...
August 7, 2020: European Journal of Pediatrics
Ai Muroi, Takao Enomoto, Satoshi Ihara, Eiichi Ishikawa, Takayuki Inagaki, Akira Matsumura
PURPOSE: The occipital bone is located on the boundary between the membranous and cartilage bones and contains a wide variety of accessory sutures. In this study, we describe the age distribution of pediatric patients who are less than 2 years of age with occipital cranial sutures using a three-dimensional computed tomography (3D-CT). METHODS: A total of 167 consecutive patients who are less than 2 years of age and underwent computed tomography for head trauma were included in this study...
August 7, 2020: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
Vinicius Fernandes Oliveira, Graziella Ribeiro De Sousa, Antonio Carlos Dos Santos, Fabiano Pinto Saggioro, Helio Rubens Machado, Ricardo Santos de Oliveira, Luiz Gonzaga Tone, Elvis Terci Valera
PURPOSE: Somatic mutations on H3 histone are currently considered a genetic hallmark for midline pediatric high-grade gliomas (HGGs). Yet, different tumor histologies have been occasionally described to carry these mutations. Since histone modifications can lead to major epigenetic changes with direct impact on prognosis and treatment, we thought to investigate the occurrence of H3F3A K27M and G34R/V mutations in a cohort of pediatric tumors which included HGGs, low-grade gliomas, ependymomas, medulloblastomas, and a series of rare brain tumor lesions of different histologies...
August 7, 2020: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
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