Maria Efthymia Katsa, Eirini Kostopoulou, Maria Magana, Anastasios Ioannidis, Stylianos Chatzipanagiotou, Athanasios Sachlas, Ioannis Dimopoulos, Bessie E Spiliotis, Andrea Paola Rojas Gil
BACKGROUND: Apoptosis antigen 1/FAS receptor (APO1/Fas) signaling in endothelial cells plays a significant role in angiogenesis while increased mean platelet volume (MPV) is an important marker for platelet activation. We investigated the possible correlation between APO1/Fas and both metabolic parameters and platelet activity (indicated by the MPV) in a healthy pediatric population. METHODS: One hundred and eighty-five children, aged 5-17 years old, were enrolled in the study...
August 2, 2021: Journal of Pediatric Endocrinology & Metabolism: JPEM
G Sh Tufatulin, I V Koroleva, S A Artyushkin, Y K Yanov
INTRODUCTION: Early intervention is crucial for the optimal speech and language development of children with impaired hearing. Underwater vibrostimulation could help develop behavioural reactions to low-frequency stimuli immediately after diagnosis and facilitate aural rehabilitation after hearing aid (HA) or cochlear implant (CI) activation. GOALS: To determine the limits of underwater vibrotactile stimuli perception and to measure the effect of vibrostimulation training on the aural rehabilitation of young children...
July 24, 2021: International Journal of Pediatric Otorhinolaryngology
Chia-Hsiung Liu, Zheng-Hua Huang, Shu-Chien Huang, Tzuu-Shuh Jou
After cardiopulmonary bypass (CPB), the occurrence of systemic inflammatory response is often accompanied by a persistent compensatory anti-inflammatory response syndrome that can lead to a compromised immune competence termed immunoparalysis, rendering the patients susceptible to infections which is a leading complication following cardiac surgery. However, the underlying mechanisms of CPB-elicited immunoparalysis remain obscure. In this study we showed that peroxiredoxin 1 (Prdx1), a putative cytosolic antioxidant, was released immediately after CPB in a cohort of pediatric patients receiving congenital cardiac surgery...
July 28, 2021: Redox Biology
Eve Bedouelle, Benoit Ben Said, Florence Tetart, Brigitte Milpied, Anne Welfringer-Morin, Annabel Maruani, Benoit Catteau, Frédéric Dezoteux, Delphine Staumont-Sallé, Juliette Mazereeuw-Hautier, Claire Abasq, Christine Chiaverini, Juliette Delaunay, Stéphanie Mallet, Benoit Sterling, Eve Puzenat, Margot Raynal, Evelyne Collet, Claire Bernier
BACKGROUND: Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare and potentially fatal adverse drug reaction. It can be difficult to diagnose, even more so among children, since symptoms may mimic other commonly encountered pediatric conditions. OBJECTIVE: To describe clinical and laboratory features of DRESS syndrome in the pediatric population (≤ 18 years of age), establish causative agents and treatment modalities. METHODS: Multicenter retrospective study of probable and definite DRESS cases (RegiSCAR ≥ 4) in children hospitalized in 15 French University Hospitals between 2000 and 2020...
July 28, 2021: Journal of Allergy and Clinical Immunology in Practice
M R Augustine, S M Thompson, G M Powell, E Knavel, D A Adamo, E C Bendel, K R Anderson, H Bjarnason, M Tollefson, D A Woodrum
PURPOSE: To evaluate the safety and effectiveness of percutaneous MRI-guided laser ablation and cryoablation for the treatment of symptomatic soft tissue vascular anomalies (VA) of the trunk and extremities. MATERIALS AND METHODS: An IRB-approved retrospective review was undertaken of all pediatric and adult patients who underwent MRI-guided and monitored laser ablation and/or cryoablation for treatment of symptomatic, peripheral soft tissue VA. Pre- and post-ablation MR imaging was independently reviewed...
July 28, 2021: Journal of Vascular and Interventional Radiology: JVIR
Sabina Rodriguez Velásquez, Léa Jacques, Jyoti Dalal, Paolo Sestito, Zahra Habibi, Akarsh Venkatasubramanian, Benedict Nguimbis, Sara Botero Mesa, Cleophas Chimbetete, Olivia Keiser, Benido Impouma, Franck Mboussou, George Sie William, Nsenga Ngoy, Ambrose Talisuna, Abdou Salam Gueye, Cristina Barroso Hofer, Joseph Waogodo Cabore
INTRODUCTION: Few data on the COVID-19 epidemiological characteristics among the pediatric population in Africa exists. This paper examines the age and sex distribution of the morbidity and mortality rate in children with COVID-19 and compares it to the adult population within 15 Sub-Saharan African countries. METHODS: A merge line listing dataset shared by countries within the Regional Office for Africa was analyzed. Patients diagnosed within 1 March and 1 September 2020 with confirmed positive RT-PCR test for SARS-CoV-2 were analyzed...
July 28, 2021: International Journal of Infectious Diseases: IJID
April Litchford, Heidi Wengreen, Mateja R Savoie-Roskos
INTRODUCTION: The aim of this systematic review is to identify existing pediatric feeding screening tools that have been shown to be valid and reliable in identifying feeding dysfunction in children. METHOD: A database search produced 5862 relevant articles to be screened based on pre-determined inclusion/exclusion criteria. After full text review of 183 articles, 64 articles were included in the review. RESULTS: Forty-four studies detailed development and validation of unique feeding screening tools for the pediatric population...
July 28, 2021: Appetite
Lombardo Fortunato, Salzano Giuseppina, Bombaci Bruno, Basile Pietro, Lucania Giovanni, Alibrandi Angela, Passanisi Stefano
AIMS: Our observational study aimed to evaluate the impact of the lockdown period due to 2019 Coronavirus disease pandemic on glycaemic control in a cohort of paediatric patients with type 1 diabetes (T1D). METHODS: Eighty-five patients with T1D aged 5-18 years using continuous glucose monitoring (CGM) systems were enrolled. Demographic and clinical data, including glucose metrics generated by CGM-specific web-based cloud platforms, were collected in three different periods (pre-lockdown phase, lockdown phase, and post-lockdown phase) of 90 days each and were statistically analysed...
July 28, 2021: Diabetes Research and Clinical Practice
Guillaume Pouessel, Marion Couvreur, Antoine Deschildre
In Europe, the prevalence of food allergy is estimated at 6-8% of children. Ten to 20% of pediatric food-induced anaphylaxis reactions occur at school. Individual healthcare plans (IHP) for food allergy aim at: identifying children at risk of allergic reactions, reducing the risk of allergen exposure, providing emergency kits containing adrenaline auto-injectors (AAI) if needed with emergency action plans and instructions about when and how to use AAI. In France, IHP were introduced into law in 2003 and was updated in 2021...
July 28, 2021: Annales Pharmaceutiques Françaises
Ayşe Ulusoy, Cansel Atinkaya Baytemir, Murat Kavas, Sümeyye Alparslan Bekir, Elçin Ersöz, Sipan Bilek, İrfan Yalçınkaya
Surgery is still used as the first choice in the treatment of pulmonary hydatid cysts. Video-assisted thoracoscopic surgery (VATS) has started to be performed as a minimally invasive surgical option in recent years for lung hydatid cyst, few cases have been reported in the literature, especially in children. Thoracoscopic surgery experience is limited in pulmonary hydatid cyst for both adult and child patients. We present a pediatric case of giant lung hydatid cyst, in that we had partial capitonnage with VATS and fibrin glue...
July 28, 2021: Annals of Thoracic Surgery
Koichi Sughimoto, Tara Pidborochynski, Holger Buchholz, Darren H Freed, Mohammed Al-Aklabi, Devilliers Jonker, Vijay Anand, Paula Holinski, Jennifer Conway
BACKGROUND: Ventricular assist devices (VADs) are important in the treatment of pediatric heart failure. While paracorporeal pulsatile (PP) devices have historically been used, there has been increased use of paracorporeal continuous (PC) devices. We sought to compare the outcomes of children supported with a PP, PC, or combination of devices. METHODS: Retrospective review (2005-19) of patients <19 years of age from a single center, who received a PC, PP or combination of devices...
July 28, 2021: Annals of Thoracic Surgery
Apurva Sakarde, Roshan Takhelmayum, Seema Garg, Arvind S Kushwaha
OBJECTIVES: To understand the dynamics of infectivity of COVID-19 and allay the fear and anxiety associated with it in healthcare workers and the society. CASE PRESENTATION: Three individuals accompanied their pediatric patients in the COVID ward but did not develop infection. Information about their knowledge and perspective about the disease and the protective measures undertaken by them during their stay in the hospital was gathered by administering a questionnaire 14 days after discharge...
July 30, 2021: Hormone Molecular Biology and Clinical Investigation
Amirah H Daher, Iyad Al-Ammouri, Nour Ghanem, Mahmood Abu Zahra, Enas Zayadneh, Montaha Al-Iede
BACKGROUND: The aim of this study is to describe the main causes of admission to a general Pediatric Intensive Care Unit (PICU), as well as main causes of mortality in this population. In addition, we describe the percentage of patients who died following a failed cardiopulmonary resuscitation (CPR) vs. Do Not Resuscitate (DNR) orders METHODS: This is a retrospective cohort study with chart review of admissions and mortality cases that occurred in the pediatric intensive care unit. Mortality rates in the pediatric admissions are reported with description of demographics, diagnosis, length of stay, use of mechanical ventilation, use of vasoactive agents, preexisting comorbidities, the presence of a DNR order, and final cause of mortality...
July 31, 2021: Pediatrics International: Official Journal of the Japan Pediatric Society
Mina Tamura, Shizuka Seki, Yasuyuki Kakurai, Shuichi Chikada, Kento Wada
BACKGROUND: To assess the long-term safety and efficacy of sapropterin in a real-world setting in Japanese patients with tetrahydrobiopterin (BH4)-responsive phenylketonuria (PKU). METHODS: This post-marketing surveillance study enrolled all patients in Japan with confirmed BH4-responsive PKU who were administrated sapropterin between July 2008 and October 2017. Patients were observed at least every 3 months during follow-up, with key data collected on treatment exposure/duration, effectiveness according to physician judgement, serum phenylalanine levels, and adverse events...
July 31, 2021: Pediatrics International: Official Journal of the Japan Pediatric Society
Magdalena Okarska-Napierała, Joanna Mańdziuk, Wojciech Feleszko, Anna Stelmaszczyk-Emmel, Mariusz Panczyk, Urszula Demkow, Ernest Kuchar
BACKGROUND: Lymphopenia is a hallmark of multisystem inflammatory syndrome in children (MIS-C). We aimed to characterize lymphocyte subsets' shifts and their correlations with other severity markers of MIS-C. METHODS: In this prospective cross-sectional study, we performed peripheral lymphocyte phenotyping in 32 patients with MIS-C. We analyzed lymphocyte subsets at three time-points of the disease: the acute (A), convalescent (B), and recovery (C) phases. Based on age-normalized lymphocyte counts, we distinguished two groups of patients: "the mild" (higher lymphocyte counts) and "the severe" (lower lymphocyte counts)...
July 31, 2021: Pediatric Allergy and Immunology
Lisa-Maria Steurer, Gerald Schlager, Kambis Sadeghi, Johann Golej, Dominik Wiedemann, Michael Hermon
BACKGROUND: Hemadsorption via the cytokine-adsorber CytoSorb® has successfully been used as an adjunctive method in adults, mainly for the purpose of immunomodulation under acute inflammatory conditions such as sepsis and cardiac surgery. In recent years, there has been growing interest in its use in pediatric intensive care to improve outcomes in patients with multiple organ failure following inflammatory illness. Literature on the application of CytoSorb® in neonatal and pediatric patients is scarce, though the implication is that it could be an effective last-resort treatment option in critically ill pediatric patients...
July 31, 2021: Artificial Organs
Hui Zhong, Xiang-Geng Wang, Jing Wang, Yan-Jie Chen, Huan-Long Qin, Rong Yang
BACKGROUND: Antibiotics, a common strategy used for neonatal infection, show consistent effect on the gut microbiota of neonates. Supplementation with probiotics has become increasingly popular in mitigating the loss of the gut microbiota. However, no clear consensus recommending the use of probiotics in the infection of neonates currently exists. This study examined the effects of probiotics on the gut microbiota of infectious neonates when used concurrently with or during the recovery period following antibiotic therapy...
July 31, 2021: World Journal of Pediatrics: WJP
Mark A Ferro, Saad A Qureshi, Lilly Shanahan, Christiane Otto, Ulrike Ravens-Sieberer
PURPOSE: This study examined health-related quality of life (HRQL) in children across different physical illnesses; estimated parent-child agreement on HRQL reports; compared HRQL between children with and without physical-mental multimorbidity; and tested if multimorbidity was associated with HRQL. METHODS: Children aged 6-16 years (mean = 11.1; n = 198) with one physical illness and their parents were recruited from a pediatric hospital. Physical illnesses were classified according to the International Statistical Classification of Diseases and Related Health Problems (ICD)-10, mental illnesses were assessed using the Mini International Neuropsychiatric Interview for Children and Adolescents, and HRQL was measured using the KIDSCREEN-27...
July 31, 2021: Quality of Life Research
Leah M Mann, Sarah A Angus, Connor J Doherty, Paolo B Dominelli
Recent evidence suggests healthy females have significantly smaller central conducting airways than males when matched for either height or lung volume during analysis. This anatomical sex-based difference could impact the integrative response to exercise. Our review critically evaluates the literature on direct and indirect techniques to measure central conducting airway size and their limitations. We present multiple sources highlighting the difference between male and female central conducting airway size in both pediatric and adult populations...
July 31, 2021: European Journal of Applied Physiology
Ayse Balat, Beltinge Demircioglu Kilic, Bagdagul Aksu, Mehtap Akbalik Kara, Mithat Buyukcelik, Ayse Agbas, Fehime Kara Eroglu, Tulin Gungor, Demet Alaygut, Nurdan Yildiz, Funda Bastug, Bahriye Atmis, Engin Melek, Midhat Elmaci, Sebahat Tulpar, Cemile Pehlivanoglu, Serra Surmeli Doven, Elif Comak, Yilmaz Tabel, Atilla Gemici, Berfin Uysal, Gamze Seval Ozzorlar, Nuran Kuçuk, Ali Delibas, Gul Ozcelik, Nilufer Goknar, Ismail Dursun, Pelin Ertan, Ipek Akil Ozunan, Ferah Sonmez
BACKGROUND: Children are one of the most vulnerable groups in conflict zones, especially those with chronic diseases. This study aimed to investigate kidney disease profiles and problems during follow-up in a population of Syrian refugee children residing in Turkey. METHODS: Syrian refugee children aged between 0 and 18 years were included in the study. Demographic data, diagnosis, particular interventions due to nephrological problems, and problems encountered during follow-up were obtained from all participating pediatric nephrology centers...
July 31, 2021: Pediatric Nephrology
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