Kijeong Lee, In Hak Choi, Yeji Hong, Hoyoung Lee, Sang Hag Lee, Tae Hoon Kim
OBJECTIVES: Previous studies have shown that sleep and allergic rhinitis (AR) is closely associated, bidirectionally affecting each other. Adolescence is a period that adequate sleep is essential, and the burden of AR increases, both of which greatly affect the quality of life. The aim of the present study was to investigate the correlation between inappropriate sleep duration and each AR-related subjective/objective factor in Korean adolescents. METHODS: We analyzed the data of 1936 adolescents aged between 12 and 18 years who participated in the Korea National Health and Nutrition Examination Survey from 2010 to 2012...
January 4, 2021: International Journal of Pediatric Otorhinolaryngology
Joshua Nagler, Marc Auerbach, Michael C Monuteaux, John A Cheek, Franz E Babl, Ed Oakley, Lucia Nguyen, Arjun Rao, Sarah Dalton, Mark D Lyttle, Santiago Mintegi, Rakesh D Mistry, Andrew Dixon, Pedro Rino, Guillermo Kohn-Loncarica, Stuart R Dalziel, Simon Craig
BACKGROUND: Airway management procedures are critical for emergency medicine (EM) physicians, but rarely performed skills in pediatric patients. Worldwide experience with respect to frequency and confidence in performing airway management skills has not been previously described. OBJECTIVES: Our aims were 1) to determine the frequency with which emergency medicine physicians perform airway procedures including: bag-mask ventilation (BMV), endotracheal intubation (ETI), laryngeal mask airway (LMA) insertion, tracheostomy tube change (TTC), and surgical airways, and 2) to investigate predictors of procedural confidence regarding advanced airway management in children...
December 31, 2020: American Journal of Emergency Medicine
Abigail Van Nuland, Anna Ivanenko, Mary Anne Meskis, Nicole Villas, Kelly G Knupp, Anne T Berg
OBJECTIVES: To describe and quantify the nature and severity of sleep disruptions in young people with Dravet syndrome (DS) based upon parent report. METHODS: Qualitative review of available pediatric sleep instruments with parent members of the Dravet syndrome Foundation led to the design of a series of questions customized to DS and other severe epilepsies. The questionnaire was administered as part of an on-line survey that reflected specific sleep-related concerns of parents of children with severe epilepsy...
January 7, 2021: Seizure: the Journal of the British Epilepsy Association
Ning Liu, Xiaomeng Yang, Sulan Wang, Rui Dong, Yue Li, Yuqiang Lv, Yi Liu, Zhongtao Gai
X-linked agammaglobulinemia (XLA, OMIM #300755) is one of the most common pediatric primary immunodeficiencies characterized by failure to produce mature B lymphocytes and hypogammaglobulinemia, caused by mutation of the gene encoding Bruton's tyrosine kinase (BTK, OMIM *300300), a key regulator in B-cell development. Patientssuffering XLA are prone to recurrentbacterial infection. We established an induced pluripotent stem cells (iPSCs) line from a 3-year-5-month-old boy with XLA caused by a hemizygous in-frame 9-bp deletion in BTK (c...
January 8, 2021: Stem Cell Research
Neta Cohen, Gidon Test, Dennis Scolnik
No abstract text is available yet for this article.
January 13, 2021: Journal of Allergy and Clinical Immunology in Practice
M C Xac, K K Jetelina, J Jarin, E Wilson
STUDY OBJECTIVE: To investigate the incidence, clinical features, tumor markers, radiologic findings, types of surgeries, and histologies for adnexal masses in pediatric and adolescent females. DESIGN: Retrospective chart review. SETTING: Children's Health in Dallas/Plano from 2009-2018. PARTICIPANTS: Female patients <19 years old who underwent surgical management of an adnexal mass. INTERVENTIONS: None...
January 13, 2021: Journal of Pediatric and Adolescent Gynecology
Thomas Clive Edwards, Ali Zain Naqvi, Nina Dela Cruz, Chinmay Gupte
PURPOSE: The purpose of this study was to examine the relationship between posterior tibial slope & lateral meniscal bone angle (LMBA) on anterior cruciate ligament (ACL) tear risk in a pediatric population. METHODS: In this case-control study, non-contact, ACL-injured, pediatric patients with no significant lateral meniscal lesions were age and sex matched in a 1:1 ratio to a group of radiologically normal controls. Knee magnetic resonance imaging (MRI) studies were analysed by 3 independent, blinded observers measuring the medial posterior tibial slope (MTS), lateral posterior tibial slope (LTS) and LMBA...
January 13, 2021: Arthroscopy
Yael Renert-Yuval, Ester Del Duca, Ana B Pavel, Milie Fang, Rachel Lefferdink, Jianni Wu, Aisleen Diaz, Yeriel D Estrada, Talia Canter, Ning Zhang, Annette Wagner, Sarah Chamlin, James G Krueger, Emma Guttman-Yassky, Amy S Paller
BACKGROUND: Although atopic dermatitis (AD) often presents in infancy and persists into adulthood, comparative characterization of AD skin among different pediatric age-groups is lacking. OBJECTIVE: To define skin biopsy profiles of lesional and non-lesional AD across different age-groups (0-5 y/o infants with disease duration <6 months, 6-11 y/o children, 12-17 y/o adolescents, ≥18 y/o adults) versus age-appropriate controls. METHODS: We performed gene expression analyses by RNA-sequencing and real-time polymerase chain reaction (RT-PCR) and protein expression analysis using immunohistochemistry...
January 13, 2021: Journal of Allergy and Clinical Immunology
Elham Delrish, Mahmoud Jabbarvand, Fariba Ghassemi, Fahimeh Asadi Amoli, Fatemeh Atyabi, Alireza Lashay, Masoud Soleimani, Leila Aghajanpour, Rassoul Dinarvand
Retinoblastoma (Rb) is the most common intraocular malignancy in children that accounts for approximately 4% of all pediatric malignancies. Since chemotherapy is a widely practiced treatment for Rb, there is a growing interest in developing new and effective drugs to overcome systemic and local side effects of chemotherapy to improve the quality of life and increase the chances of survival. This study sought to fabricate thiolated chitosan nanoparticles containing topotecan (TPH-TCS-NPs) with a view of enhancing drug loading and release control...
January 13, 2021: Experimental Eye Research
Jennifer Dunnick, Maia Taft, Robert T Tisherman, Andrew J Nowalk, Robert W Hickey, Paria M Wilson
OBJECTIVE: To determine the association between bacteremia and vaccination status in children aged 2-36 months presenting to a pediatric emergency department. STUDY DESIGN: Retrospective cohort study of children aged 2-36 months with blood cultures obtained in the pediatric emergency department between January 2013 and December 2017. The exposure of interest was immunization status, defined as number of H. influenzae type B (Hib) and S. pneumoniae vaccinations, and the main outcome positive blood culture...
January 13, 2021: Journal of Pediatrics
Kendall A Ulbrich, Katelyn Zumpf, Jody D Ciolino, Malika Shah, Emily S Miller, Katherine L Wisner
OBJECTIVE: To determine whether full-term neonates with in utero exposure to selective serotonin reuptake inhibitors (SSRI) require respiratory support in the delivery room, as indicated by the standardized Neonatal Resuscitation Program [NRP] algorithm, significantly more often than non-exposed neonates. STUDY DESIGN: In this retrospective cohort study, we extracted data from medical records of full-term neonates with and without in utero SSRI exposure, defined as documentation of third trimester maternal SSRI treatment...
January 13, 2021: Journal of Pediatrics
Tamara I Arnautovic, Jami L Longo, Elizabeth J Trail-Burns, Richard Tucker, Martin Keszler, Abbot R Laptook
OBJECTIVE: To determine if antenatal variables affect the risk of spontaneous intestinal perforation (SIP) among preterm infants when prophylactic indomethacin is used. STUDY DESIGN: Retrospective case-control study of infants <29 weeks gestational age (GA) between January 2010 and June 2018 at one hospital. SIP was defined as acute abdominal distension and pneumoperitoneum without signs of necrotizing enterocolitis at <14 days of life. Each case (n=57) was matched with two controls (n= 114) for GA and birth year...
January 13, 2021: Journal of Pediatrics
Viral G Jain, Christy Kessler, Linda Lacina, Greg A Szumlas, Clare Crosh, John S Hutton, Robert Needlman, Thomas G Dewitt
OBJECTIVE: To assess whether a citywide structured book-sharing program (NICU Bookworms) designed to promote reading to infants while admitted in the NICU would increase parental reading behaviors (≥3-4 days/week) in the NICU and after discharge home, including high-risk parents who do not themselves enjoy reading. STUDY DESIGN: The NICU Bookworms program comprised staff training, parent education, and building a literacy-rich environment. In this quasi-experimental intervention study, parents of medically high-risk NICU graduates <6 months of age were administered a questionnaire at their first NICU follow-up clinic visit...
January 13, 2021: Journal of Pediatrics
Jeffrey Lo, Kimberlee Gauvreau, Annette L Baker, Sarah D de Ferranti, Kevin G Friedman, Mindy S Lo, Fatma Dedeoglu, Robert P Sundel, Jane W Newburger, Mary Beth F Son
OBJECTIVES: To determine predictors of more than one emergency department (ED) visit for a Kawasaki disease diagnosis in a quaternary care pediatric hospital and compare outcomes between patients with 1 versus > 1 visit for KD diagnosis. STUDY DESIGN: Medical records of patients evaluated for KD between January 2006 and August 2018 at Boston Children's Hospital were abstracted for demographic and clinical data. Predictors of > 1 visit were explored using logistic regression and CART analysis...
January 13, 2021: Journal of Pediatrics
Karen Harpster, Stephanie Merhar, Venkata Sita Priyanka Illapani, Colleen Peyton, Beth Kline-Fath, Nehal A Parikh
OBJECTIVE: To evaluate the prevalence and associations between structural MRI (sMRI) injury/abnormality at term equivalent age and absent fidgety General Movements Assessment (GMA) and abnormal Hammersmith Infant Neurological Examination (HINE) scores among very preterm infants at 3-4 months corrected age. STUDY DESIGN: This prospective cohort study enrolled 392 infants born ≤32 weeks' gestation from five neonatal intensive care units in the greater Cincinnati area between September 2016 and October 2019...
January 13, 2021: Journal of Pediatrics
Megan Dibble, Jin Zhe Ang, Liam Mariga, Eleanor J Molloy, Arun L W Bokde
OBJECTIVE: To examine white matter abnormalities, measured by Diffusion Tensor Imaging (DTI), in very preterm (<32 weeks) and moderate-late preterm neonates (32-37 weeks) at term-equivalent age, compared with healthy full-term controls (≥37 weeks). STUDY DESIGN: A search of Medline (Pubmed) was conducted to identify studies with diffusion data collected on very preterm, moderate-late preterm and full-term neonates, using the guidelines from the Meta-analysis of Observational Studies in Epidemiology (MOOSE) and Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statements...
January 13, 2021: Journal of Pediatrics
Angela Chen, Rajesh Punn, R Thomas Collins, Jonathan H Chen, Katie Jo Stauffer, Rena Wang, Samantha Alexander, Kirstie MacMillen Lechich, Daniel Jerome Murphy, Sukyung Chung, Elif Seda Selamet Tierney
OBJECTIVE: To test feasibility of tele-clinic visits using parentally-acquired vital signs and focused echocardiographic (echo) images in patients with Marfan syndrome. STUDY DESIGN: We included patients with MFS 5-19 years old followed in our clinic. We excluded patients with MFS and history of prior aortic root (AoR) surgery, cardiomyopathy, arrhythmia, or AoR≥4.5 cm. We trained parents in-person to acquire focused echo images on their children using a hand-held device as well as how to use a stadiometer, scale, blood pressure (BP) machine, and a digital stethoscope...
January 13, 2021: Journal of Pediatrics
Guanglun Zhou, Jianchun Yin, Man Jiang, Zhilin Yang, Shoulin Li
OBJECTIVE: To evaluate the clinical data, ultrasonic features, treatment, and long-term outcome of transverse testicular ectopia (TTE) in children. METHODS: Children with TTE were enrolled in the study between November 2009 and August 2019 in Shenzhen Children's Hospital in China. Clinical information, including demographic characteristics, clinical manifestations, TTE-associated anomalies, ultrasonographic findings, and surgical procedures, were collected from all patients...
January 13, 2021: Urology
Bria Nikole Williams, Victoria C Jauk, Jeff M Szychowski, Janeen L Arbuckle
OBJECTIVE: We sought to describe the current usage patterns, knowledge regarding and perception of emergency contraception in adolescent patients. STUDY DESIGN: We surveyed female patients ages 14-21 seen at the Pediatric and Gynecology Clinic regarding emergency contraception. We posed questions to understand adolescent awareness, personal usage, and means of obtaining emergency contraception. We also explored respondent knowledge of emergency contraception and potential barriers to access...
January 13, 2021: Contraception
Cameron C Lee, R John Tannyhill, Zachary S Peacock
PURPOSE: There is a paucity of data with respect to management of pediatric facial fractures. The purpose of this study was to describe the population of pediatric patients with mandibular fractures at our institution and to assess predictors of fractures requiring open reduction and internal fixation (ORIF). PATIENTS AND METHODS: This was a retrospective cohort study of patients aged ≤17 years presenting with mandibular fractures. The primary predictor variable was age ≥13 years and <13 years...
December 24, 2020: Journal of Oral and Maxillofacial Surgery
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